#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9EQJ9	uniprotkb:P01135	intact:EBI-7455245|uniprotkb:Q8C0P8|intact:MINT-1894696|uniprotkb:B0V3N7|intact:UNK-5947369|uniprotkb:Q69ZE1|uniprotkb:B0V3N8	intact:EBI-1034374|uniprotkb:Q15577|uniprotkb:A8K286|uniprotkb:Q53SK7|uniprotkb:Q9BS56|uniprotkb:Q9UEI3|uniprotkb:Q9UKM1|uniprotkb:Q9UKM2|ensembl:ENSP00000295400|uniprotkb:Q9UKM3	psi-mi:magi3_mouse(display_long)|uniprotkb:Magi3(gene name)|psi-mi:Magi3(display_short)|uniprotkb:Membrane-associated guanylate kinase inverted 3(gene name synonym)|uniprotkb:Kiaa1634(gene name synonym)	psi-mi:tgfa_human(display_long)|uniprotkb:TGFA(gene name)|psi-mi:TGFA(display_short)	psi-mi:"MI:0018"(two hybrid)	Franklin et al. (2005)	pubmed:15652357|mint:MINT-5217468	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455275|mint:MINT-1894722	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR030035|mint:Q9EQJ9|interpro:IPR036034|interpro:IPR036020|interpro:IPR020590|interpro:IPR027417|refseq:NP_598614.1|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|go:"GO:0005109"(frizzled binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|mint:MINT-1894724(identity)	refseq:NP_001093161.1|refseq:NP_003227.1|ensembl:ENSG00000163235(gene)|ensembl:ENST00000295400(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P01135|rcsb pdb:1GK5|rcsb pdb:1MOX|rcsb pdb:1YUF|rcsb pdb:1YUG|rcsb pdb:2TGF|rcsb pdb:3E50|rcsb pdb:3TGF|rcsb pdb:4TGF|rcsb pdb:5KN5|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866910|reactome:R-HSA-9009391|reactome:R-HSA-9018519|reactome:R-HSA-9634638|refseq:NP_001295087.1|refseq:NP_001295088.1|dip:DIP-5765N|mint:MINT-1894723(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:NFA|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/05/04	2014/10/16	rogid:LbFYUmxao9TmprW22YUA3GS9nCs10090	rogid:mlXfKDlrB4yc75KnlxjdqCEegYs9606	intact-crc:EFD4520A4447FF29|rigid:sCEBX8toJsD/MeQ2OS9HRW2/71g	false	binding-associated region:384-538(MINT-2838751)|tag:?-?(MINT-1894783)	binding-associated region:122-160(MINT-1894798)|tag:?-?(MINT-1894791)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q5TCQ9	uniprotkb:P01135	intact:EBI-310506|uniprotkb:Q5TCR0|uniprotkb:Q9H2V6|uniprotkb:Q5TCQ8|uniprotkb:Q9H5Y8|uniprotkb:Q9HBC4|intact:EBI-2512710|intact:EBI-991068|ensembl:ENSP00000304604|uniprotkb:Q9HCD8|uniprotkb:A0A024R0E9|uniprotkb:A0A024R0H3	intact:EBI-1034374|uniprotkb:Q15577|uniprotkb:A8K286|uniprotkb:Q53SK7|uniprotkb:Q9BS56|uniprotkb:Q9UEI3|uniprotkb:Q9UKM1|uniprotkb:Q9UKM2|ensembl:ENSP00000295400|uniprotkb:Q9UKM3	psi-mi:magi3_human(display_long)|uniprotkb:MAGI3(gene name)|psi-mi:MAGI3(display_short)|uniprotkb:KIAA1634(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 3(gene name synonym)	psi-mi:tgfa_human(display_long)|uniprotkb:TGFA(gene name)|psi-mi:TGFA(display_short)	psi-mi:"MI:0096"(pull down)	Franklin et al. (2005)	pubmed:15652357|mint:MINT-5217468	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455439|mint:MINT-1894801	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000307546(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|ensembl:ENSG00000081026(gene)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030035|interpro:IPR036020|interpro:IPR036034|mint:Q5TCQ9|rcsb pdb:3SOE|refseq:NP_001136254.1|refseq:NP_690864.2|refseq:XP_005270794.1|mint:MINT-1894812(identity)	refseq:NP_001093161.1|refseq:NP_003227.1|ensembl:ENSG00000163235(gene)|ensembl:ENST00000295400(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P01135|rcsb pdb:1GK5|rcsb pdb:1MOX|rcsb pdb:1YUF|rcsb pdb:1YUG|rcsb pdb:2TGF|rcsb pdb:3E50|rcsb pdb:3TGF|rcsb pdb:4TGF|rcsb pdb:5KN5|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866910|reactome:R-HSA-9009391|reactome:R-HSA-9018519|reactome:R-HSA-9634638|refseq:NP_001295087.1|refseq:NP_001295088.1|dip:DIP-5765N|mint:MINT-1894802(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/04	2018/04/06	rogid:muK+zH3ww4Ve8aJ74iU2be8hRa09606	rogid:mlXfKDlrB4yc75KnlxjdqCEegYs9606	intact-crc:C729521BA5155B1E|rigid:ZDmi3CeDwIgT+cEnxmi47skmQ+E	false	glutathione s tranferase tag:?-?(MINT-1894818)|binding-associated region:410-476(MINT-1894824)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P01135	uniprotkb:Q86UL8	intact:EBI-1034374|uniprotkb:Q15577|uniprotkb:A8K286|uniprotkb:Q53SK7|uniprotkb:Q9BS56|uniprotkb:Q9UEI3|uniprotkb:Q9UKM1|uniprotkb:Q9UKM2|ensembl:ENSP00000295400|uniprotkb:Q9UKM3	intact:EBI-311035|uniprotkb:O60434|uniprotkb:O60510|uniprotkb:Q86UI7|uniprotkb:Q9NP44|uniprotkb:Q9UDQ5|uniprotkb:Q9UDU1|uniprotkb:A4D1C1|uniprotkb:A7E2C3|intact:EBI-28973920|ensembl:ENSP00000346151	psi-mi:tgfa_human(display_long)|uniprotkb:TGFA(gene name)|psi-mi:TGFA(display_short)	psi-mi:magi2_human(display_long)|uniprotkb:MAGI2(gene name)|psi-mi:MAGI2(display_short)|uniprotkb:KIAA0705(gene name synonym)|uniprotkb:ACVRINP1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Atrophin-1-interacting protein A(gene name synonym)|uniprotkb:AIP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Franklin et al. (2005)	pubmed:15652357|mint:MINT-5217468	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455478|mint:MINT-1894829	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093161.1|refseq:NP_003227.1|ensembl:ENSG00000163235(gene)|ensembl:ENST00000295400(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P01135|rcsb pdb:1GK5|rcsb pdb:1MOX|rcsb pdb:1YUF|rcsb pdb:1YUG|rcsb pdb:2TGF|rcsb pdb:3E50|rcsb pdb:3TGF|rcsb pdb:4TGF|rcsb pdb:5KN5|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866910|reactome:R-HSA-9009391|reactome:R-HSA-9018519|reactome:R-HSA-9634638|refseq:NP_001295087.1|refseq:NP_001295088.1|dip:DIP-5765N|mint:MINT-1894830(identity)	ensembl:ENSP00000346151|ensembl:ENST00000419488|ensembl:ENSP00000405766|refseq:NP_036433.2|refseq:NP_001288057.1|ensembl:ENSG00000187391(gene)|ensembl:ENST00000354212(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003402"(planar cell polarity pathway involved in axis elongation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|mint:Q86UL8|rcsb pdb:1UEP|rcsb pdb:1UEQ|rcsb pdb:1UEW|rcsb pdb:1UJV|rcsb pdb:1WFV|reactome:R-HSA-373753|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)|mint:MINT-1894835(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/04	2014/10/16	rogid:mlXfKDlrB4yc75KnlxjdqCEegYs9606	rogid:/uTMSMqB1wrlyHj2P9OVVBCpWcY9606	intact-crc:2EA782F9C5BFB0C0|rigid:dPyZHW/DOR6AkgSHCePPN/hhVDc	false	-	binding-associated region:426-492(MINT-1894836)|glutathione s tranferase tag:?-?(MINT-1894843)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48030	uniprotkb:Q9EQJ9	intact:EBI-7455540|intact:MINT-1894871|ensembl:ENSMUSP00000032066	intact:EBI-7455245|uniprotkb:Q8C0P8|intact:MINT-1894696|uniprotkb:B0V3N7|intact:UNK-5947369|uniprotkb:Q69ZE1|uniprotkb:B0V3N8	psi-mi:tgfa_mouse(display_long)|uniprotkb:Tgfa(gene name)|psi-mi:Tgfa(display_short)	psi-mi:magi3_mouse(display_long)|uniprotkb:Magi3(gene name)|psi-mi:Magi3(display_short)|uniprotkb:Membrane-associated guanylate kinase inverted 3(gene name synonym)|uniprotkb:Kiaa1634(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Franklin et al. (2005)	pubmed:15652357|mint:MINT-5217468	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455574|mint:MINT-1894847	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_112476.1|ensembl:ENSMUSG00000029999(gene)|ensembl:ENSMUST00000032066(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048523"(negative regulation of cellular process)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P48030|reactome:R-MMU-1257604|reactome:R-MMU-177929|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-204005|reactome:R-MMU-212718|reactome:R-MMU-5673001|reactome:R-MMU-5694530|reactome:R-MMU-6811558|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-9009391|mint:MINT-1894858(identity)	interpro:IPR030035|mint:Q9EQJ9|interpro:IPR036034|interpro:IPR036020|interpro:IPR020590|interpro:IPR027417|refseq:NP_598614.1|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|go:"GO:0005109"(frizzled binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|mint:MINT-1894848(identity)	-	comment:mint|function:TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar|comment:"Stoichiometry: 1.0"	comment:mint|comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2006/05/04	2014/10/16	rogid:+bCIPnSIflEDN850urcp/FJqqCM10090	rogid:LbFYUmxao9TmprW22YUA3GS9nCs10090	intact-crc:E84EF3FE832949F1|rigid:/NAQdaxty8QANp6C7OOgMVEMO2k	false	-	-	1	1	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9EQJ9	uniprotkb:P01135	intact:EBI-7455245|uniprotkb:Q8C0P8|intact:MINT-1894696|uniprotkb:B0V3N7|intact:UNK-5947369|uniprotkb:Q69ZE1|uniprotkb:B0V3N8	intact:EBI-1034374|uniprotkb:Q15577|uniprotkb:A8K286|uniprotkb:Q53SK7|uniprotkb:Q9BS56|uniprotkb:Q9UEI3|uniprotkb:Q9UKM1|uniprotkb:Q9UKM2|ensembl:ENSP00000295400|uniprotkb:Q9UKM3	psi-mi:magi3_mouse(display_long)|uniprotkb:Magi3(gene name)|psi-mi:Magi3(display_short)|uniprotkb:Membrane-associated guanylate kinase inverted 3(gene name synonym)|uniprotkb:Kiaa1634(gene name synonym)	psi-mi:tgfa_human(display_long)|uniprotkb:TGFA(gene name)|psi-mi:TGFA(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Franklin et al. (2005)	pubmed:15652357|mint:MINT-5217468	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455655|mint:MINT-1894908	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR030035|mint:Q9EQJ9|interpro:IPR036034|interpro:IPR036020|interpro:IPR020590|interpro:IPR027417|refseq:NP_598614.1|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|go:"GO:0005109"(frizzled binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|mint:MINT-1894909(identity)	refseq:NP_001093161.1|refseq:NP_003227.1|ensembl:ENSG00000163235(gene)|ensembl:ENST00000295400(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P01135|rcsb pdb:1GK5|rcsb pdb:1MOX|rcsb pdb:1YUF|rcsb pdb:1YUG|rcsb pdb:2TGF|rcsb pdb:3E50|rcsb pdb:3TGF|rcsb pdb:4TGF|rcsb pdb:5KN5|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866910|reactome:R-HSA-9009391|reactome:R-HSA-9018519|reactome:R-HSA-9634638|refseq:NP_001295087.1|refseq:NP_001295088.1|dip:DIP-5765N|mint:MINT-1894915(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4Q|figure legend:F4R|comment:homomint|comment:mint	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/05/04	2014/10/16	rogid:LbFYUmxao9TmprW22YUA3GS9nCs10090	rogid:mlXfKDlrB4yc75KnlxjdqCEegYs9606	intact-crc:631A159C635CB1DE|rigid:sCEBX8toJsD/MeQ2OS9HRW2/71g	false	green fluorescent protein tag:?-?(MINT-1894968)	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0708"(monoclonal antibody immunostaining)
uniprotkb:Q9EQJ9	uniprotkb:P01135	intact:EBI-7455245|uniprotkb:Q8C0P8|intact:MINT-1894696|uniprotkb:B0V3N7|intact:UNK-5947369|uniprotkb:Q69ZE1|uniprotkb:B0V3N8	intact:EBI-1034374|uniprotkb:Q15577|uniprotkb:A8K286|uniprotkb:Q53SK7|uniprotkb:Q9BS56|uniprotkb:Q9UEI3|uniprotkb:Q9UKM1|uniprotkb:Q9UKM2|ensembl:ENSP00000295400|uniprotkb:Q9UKM3	psi-mi:magi3_mouse(display_long)|uniprotkb:Magi3(gene name)|psi-mi:Magi3(display_short)|uniprotkb:Membrane-associated guanylate kinase inverted 3(gene name synonym)|uniprotkb:Kiaa1634(gene name synonym)	psi-mi:tgfa_human(display_long)|uniprotkb:TGFA(gene name)|psi-mi:TGFA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Franklin et al. (2005)	pubmed:15652357|mint:MINT-5217468	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455718|mint:MINT-1894995	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR030035|mint:Q9EQJ9|interpro:IPR036034|interpro:IPR036020|interpro:IPR020590|interpro:IPR027417|refseq:NP_598614.1|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|go:"GO:0005109"(frizzled binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|mint:MINT-1894996(identity)	refseq:NP_001093161.1|refseq:NP_003227.1|ensembl:ENSG00000163235(gene)|ensembl:ENST00000295400(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P01135|rcsb pdb:1GK5|rcsb pdb:1MOX|rcsb pdb:1YUF|rcsb pdb:1YUG|rcsb pdb:2TGF|rcsb pdb:3E50|rcsb pdb:3TGF|rcsb pdb:4TGF|rcsb pdb:5KN5|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866910|reactome:R-HSA-9009391|reactome:R-HSA-9018519|reactome:R-HSA-9634638|refseq:NP_001295087.1|refseq:NP_001295088.1|dip:DIP-5765N|mint:MINT-1895004(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5C|figure legend:F5A|comment:homomint|comment:mint	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/05/04	2014/10/16	rogid:LbFYUmxao9TmprW22YUA3GS9nCs10090	rogid:mlXfKDlrB4yc75KnlxjdqCEegYs9606	intact-crc:76384BD4660DFE6E|rigid:sCEBX8toJsD/MeQ2OS9HRW2/71g	false	green fluorescent protein tag:?-?(MINT-1895002)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q9EQJ9	uniprotkb:P01135	intact:EBI-7455245|uniprotkb:Q8C0P8|intact:MINT-1894696|uniprotkb:B0V3N7|intact:UNK-5947369|uniprotkb:Q69ZE1|uniprotkb:B0V3N8	intact:EBI-1034374|uniprotkb:Q15577|uniprotkb:A8K286|uniprotkb:Q53SK7|uniprotkb:Q9BS56|uniprotkb:Q9UEI3|uniprotkb:Q9UKM1|uniprotkb:Q9UKM2|ensembl:ENSP00000295400|uniprotkb:Q9UKM3	psi-mi:magi3_mouse(display_long)|uniprotkb:Magi3(gene name)|psi-mi:Magi3(display_short)|uniprotkb:Membrane-associated guanylate kinase inverted 3(gene name synonym)|uniprotkb:Kiaa1634(gene name synonym)	psi-mi:tgfa_human(display_long)|uniprotkb:TGFA(gene name)|psi-mi:TGFA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Franklin et al. (2005)	pubmed:15652357|mint:MINT-5217468	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7455742|mint:MINT-1895049	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR030035|mint:Q9EQJ9|interpro:IPR036034|interpro:IPR036020|interpro:IPR020590|interpro:IPR027417|refseq:NP_598614.1|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|go:"GO:0005109"(frizzled binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|mint:MINT-1895056(identity)	refseq:NP_001093161.1|refseq:NP_003227.1|ensembl:ENSG00000163235(gene)|ensembl:ENST00000295400(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0072574"(hepatocyte proliferation)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P01135|rcsb pdb:1GK5|rcsb pdb:1MOX|rcsb pdb:1YUF|rcsb pdb:1YUG|rcsb pdb:2TGF|rcsb pdb:3E50|rcsb pdb:3TGF|rcsb pdb:4TGF|rcsb pdb:5KN5|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866910|reactome:R-HSA-9009391|reactome:R-HSA-9018519|reactome:R-HSA-9634638|refseq:NP_001295087.1|refseq:NP_001295088.1|dip:DIP-5765N|mint:MINT-1895050(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F6|comment:"For these studies it as utilized membrane-fixed TGFa (mfTGFa). Membrane-fixed TGFa has a mutation in two cleavage sites distal to the mature 50-amino acid TGFa peptide changed by site-directed mutagenesis to prevent the regulated proteolytic release of the mature 50-amino acid TGFa leaving intact the procleavage site at the Nterminus of the protein."|comment:homomint|comment:mint	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/05/04	2014/10/16	rogid:LbFYUmxao9TmprW22YUA3GS9nCs10090	rogid:mlXfKDlrB4yc75KnlxjdqCEegYs9606	intact-crc:CB3F68AD563C2B5C|rigid:sCEBX8toJsD/MeQ2OS9HRW2/71g	false	myc tag:?-?(MINT-1895062)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)