#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P26039 uniprotkb:O70161 intact:EBI-1039593|uniprotkb:Q8VEF0|uniprotkb:A2AIM8|ensembl:ENSMUSP00000030187 intact:EBI-773657|uniprotkb:Q505A1|uniprotkb:Q80TW9|uniprotkb:Q8VCU5|ensembl:ENSMUSP00000100964 psi-mi:tln1_mouse(display_long)|uniprotkb:Tln1(gene name)|psi-mi:Tln1(display_short)|uniprotkb:Tln(gene name synonym) psi-mi:pi51c_mouse(display_long)|uniprotkb:Pip5k1c(gene name)|psi-mi:Pip5k1c(display_short)|uniprotkb:Kiaa0589(gene name synonym)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I gamma(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Olesen et al. (2004) pubmed:15618517 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1041420|rcsb pdb:1Y19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035732.2|refseq:XP_006537832.2|ensembl:ENSMUSG00000028465(gene)|ensembl:ENSMUST00000030187(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0017166"(vinculin binding)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033622"(integrin activation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002558(I/LWEQ)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR015009(Vinculin Binding Site)|interpro:IPR015224(Talin, central)|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR032425|interpro:IPR035963|interpro:IPR035964|interpro:IPR036476|interpro:IPR036723|interpro:IPR037438|mint:P26039|rcsb pdb:1SJ7|rcsb pdb:1SJ8|rcsb pdb:1T01|rcsb pdb:1U89|rcsb pdb:1XWX|rcsb pdb:1Y19|rcsb pdb:1ZW3|rcsb pdb:2B0H|rcsb pdb:2G35|rcsb pdb:2JSW|rcsb pdb:2KBB|rcsb pdb:2KC1|rcsb pdb:2KC2|rcsb pdb:2KGX|rcsb pdb:2KMA|rcsb pdb:2KVP|rcsb pdb:2L10|rcsb pdb:2L7A|rcsb pdb:2L7N|rcsb pdb:2LQG|rcsb pdb:2QDQ|rcsb pdb:2X0C|rcsb pdb:3DYJ|rcsb pdb:3IVF|rcsb pdb:3S90|rcsb pdb:4F7G|rcsb pdb:4W8P|rcsb pdb:5FZT|rcsb pdb:5IC0|rcsb pdb:5IC1|rcsb pdb:5NL1|rcsb pdb:6BA6|rcsb pdb:6MFS|rcsb pdb:6TWN|rcsb pdb:6VGU|reactome:R-MMU-114608|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-399955|reactome:R-MMU-445355|reactome:R-MMU-5674135|dip:DIP-647N refseq:NP_001140159.1|refseq:NP_032870.2|refseq:NP_001280575.1|refseq:NP_001280576.1|ensembl:ENSMUSG00000034902(gene)|ensembl:ENSMUST00000105327(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001931"(uropod)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007409"(axonogenesis)|go:"GO:0010008"(endosome membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0070527"(platelet aggregation)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|mint:O70161|rcsb pdb:1Y19|rcsb pdb:2H7D|rcsb pdb:2H7E|reactome:R-MMU-1660499|reactome:R-MMU-399955|reactome:R-MMU-6811558|reactome:R-MMU-8856828 - - - assembly:tetrameric, multimeric|3d-r-factors:working 74.700%, free 71.400%|3d-resolution:2.6A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:w9NQrwqUcuVAzeesymnTmhrEtCk10090 rogid:nyRuUZQSpe2dc2XN1CZV8Oy5Yvk10090 intact-crc:DF586489FBD9A90C|rigid:mESRzHDRcxyJaqFLUDxXJejXCg0 false sufficient binding region:209-410 sufficient binding region:638-651 6 6 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)