#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q810W9 uniprotkb:Q9QZZ4 intact:EBI-7417500|intact:MINT-1895259 intact:EBI-4281382|ensembl:ENSMUSP00000071777|uniprotkb:A2A637|uniprotkb:A2A638|uniprotkb:O70395|uniprotkb:Q5SX93|uniprotkb:Q7TMR5|uniprotkb:Q7TMR6|uniprotkb:Q9QWL6 psi-mi:whrn_rat(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:CASK-interacting protein CIP98(gene name synonym)|uniprotkb:Cip98(gene name synonym)|uniprotkb:Dfnb31(gene name synonym) psi-mi:myo15_mouse(display_long)|uniprotkb:Myo15a(gene name)|psi-mi:Myo15a(display_short)|uniprotkb:Myo15(gene name synonym)|uniprotkb:Unconventional myosin-15(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Delprat et al. (2005) pubmed:15590698|mint:MINT-5217399 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7417524|mint:MINT-1895285 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q810W9|interpro:IPR033028|rgd:631330|refseq:NP_851602.1|interpro:IPR001478(PDZ/DHR/GLGF)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR036034|mint:MINT-1895286(identity) ensembl:ENSMUSG00000042678(gene)|ensembl:ENSMUST00000071880(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0098858"(actin-based cell projection)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR027417|interpro:IPR035487|interpro:IPR035963|interpro:IPR036028|interpro:IPR036057|interpro:IPR036961|interpro:IPR038185|interpro:IPR041795|mint:Q9QZZ4|rcsb pdb:6Y38|rcsb pdb:6Y9N|refseq:NP_001096641.1|refseq:NP_034992.2|refseq:NP_874357.2|refseq:XP_017169821.1|refseq:XP_017169822.1|mint:MINT-1895287(identity) - function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1C|comment:homomint|comment:mint taxid:10116(rat-cochlea)|taxid:10116(Rattus norvegicus) - 2006/05/04 2014/10/16 rogid:Y+a/9WYmPgQGWTRtGjsMNtjjvmU10116 rogid:/SZaFfSAvP0AIlBs71OBrx+z59o10090 intact-crc:CC49FAC32133918E|rigid:94bx3P9ZFifG8gEGgdv9lx+r/Lo false - - 1 1 psi-mi:"MI:0708"(monoclonal antibody immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q80VW5 uniprotkb:Q9QZZ4 intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4 intact:EBI-4281382|ensembl:ENSMUSP00000071777|uniprotkb:A2A637|uniprotkb:A2A638|uniprotkb:O70395|uniprotkb:Q5SX93|uniprotkb:Q7TMR5|uniprotkb:Q7TMR6|uniprotkb:Q9QWL6 psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym) psi-mi:myo15_mouse(display_long)|uniprotkb:Myo15a(gene name)|psi-mi:Myo15a(display_short)|uniprotkb:Myo15(gene name synonym)|uniprotkb:Unconventional myosin-15(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Delprat et al. (2005) pubmed:15590698|mint:MINT-5217399 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7417655|mint:MINT-1895331 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N|mint:MINT-1895338(identity) ensembl:ENSMUSG00000042678(gene)|ensembl:ENSMUST00000071880(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0098858"(actin-based cell projection)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR027417|interpro:IPR035487|interpro:IPR035963|interpro:IPR036028|interpro:IPR036057|interpro:IPR036961|interpro:IPR038185|interpro:IPR041795|mint:Q9QZZ4|rcsb pdb:6Y38|rcsb pdb:6Y9N|refseq:NP_001096641.1|refseq:NP_034992.2|refseq:NP_874357.2|refseq:XP_017169821.1|refseq:XP_017169822.1|mint:MINT-1895332(identity) - function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2|comment:homomint|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/05/04 2014/10/16 rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090 rogid:/SZaFfSAvP0AIlBs71OBrx+z59o10090 intact-crc:C967ED430EA7605B|rigid:vtNT9CxN0Wa9PSyTNl60TnWsInE false - myc tag:?-?(MINT-1895348) 1 1 psi-mi:"MI:0708"(monoclonal antibody immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q80VW5 uniprotkb:Q9QZZ4 intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4 intact:EBI-4281382|ensembl:ENSMUSP00000071777|uniprotkb:A2A637|uniprotkb:A2A638|uniprotkb:O70395|uniprotkb:Q5SX93|uniprotkb:Q7TMR5|uniprotkb:Q7TMR6|uniprotkb:Q9QWL6 psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym) psi-mi:myo15_mouse(display_long)|uniprotkb:Myo15a(gene name)|psi-mi:Myo15a(display_short)|uniprotkb:Myo15(gene name synonym)|uniprotkb:Unconventional myosin-15(gene name synonym) psi-mi:"MI:0096"(pull down) Delprat et al. (2005) pubmed:15590698|mint:MINT-5217399 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7417778|mint:MINT-1895377 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N|mint:MINT-1895378(identity) ensembl:ENSMUSG00000042678(gene)|ensembl:ENSMUST00000071880(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0098858"(actin-based cell projection)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR027417|interpro:IPR035487|interpro:IPR035963|interpro:IPR036028|interpro:IPR036057|interpro:IPR036961|interpro:IPR038185|interpro:IPR041795|mint:Q9QZZ4|rcsb pdb:6Y38|rcsb pdb:6Y9N|refseq:NP_001096641.1|refseq:NP_034992.2|refseq:NP_874357.2|refseq:XP_017169821.1|refseq:XP_017169822.1|mint:MINT-1895387(identity) - function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3B|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/04 2014/10/16 rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090 rogid:/SZaFfSAvP0AIlBs71OBrx+z59o10090 intact-crc:8EAC686F2CA24779|rigid:vtNT9CxN0Wa9PSyTNl60TnWsInE false binding-associated region:443-906(MINT-1895379)|glutathione s tranferase tag:?-?(MINT-1895385) myc tag:?-?(MINT-1895393)|binding-associated region:2809-3185(IPR009065) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q80VW5 uniprotkb:Q9QZZ4 intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4 intact:EBI-4281382|ensembl:ENSMUSP00000071777|uniprotkb:A2A637|uniprotkb:A2A638|uniprotkb:O70395|uniprotkb:Q5SX93|uniprotkb:Q7TMR5|uniprotkb:Q7TMR6|uniprotkb:Q9QWL6 psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym) psi-mi:myo15_mouse(display_long)|uniprotkb:Myo15a(gene name)|psi-mi:Myo15a(display_short)|uniprotkb:Myo15(gene name synonym)|uniprotkb:Unconventional myosin-15(gene name synonym) psi-mi:"MI:0096"(pull down) Delprat et al. (2005) pubmed:15590698|mint:MINT-5217399 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7417698|mint:MINT-1895352 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N|mint:MINT-1895353(identity) ensembl:ENSMUSG00000042678(gene)|ensembl:ENSMUST00000071880(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0098858"(actin-based cell projection)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR027417|interpro:IPR035487|interpro:IPR035963|interpro:IPR036028|interpro:IPR036057|interpro:IPR036961|interpro:IPR038185|interpro:IPR041795|mint:Q9QZZ4|rcsb pdb:6Y38|rcsb pdb:6Y9N|refseq:NP_001096641.1|refseq:NP_034992.2|refseq:NP_874357.2|refseq:XP_017169821.1|refseq:XP_017169822.1|mint:MINT-1895359(identity) - function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3B|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/04 2014/10/16 rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090 rogid:/SZaFfSAvP0AIlBs71OBrx+z59o10090 intact-crc:E74DFD60B2DFFC97|rigid:vtNT9CxN0Wa9PSyTNl60TnWsInE false binding-associated region:443-906(MINT-1895374)|glutathione s tranferase tag:?-?(MINT-1895372) myc tag:?-?(MINT-1895365) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0113"(western blot) uniprotkb:Q80VW5 uniprotkb:Q9QZZ4 intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4 intact:EBI-4281382|ensembl:ENSMUSP00000071777|uniprotkb:A2A637|uniprotkb:A2A638|uniprotkb:O70395|uniprotkb:Q5SX93|uniprotkb:Q7TMR5|uniprotkb:Q7TMR6|uniprotkb:Q9QWL6 psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym) psi-mi:myo15_mouse(display_long)|uniprotkb:Myo15a(gene name)|psi-mi:Myo15a(display_short)|uniprotkb:Myo15(gene name synonym)|uniprotkb:Unconventional myosin-15(gene name synonym) psi-mi:"MI:0096"(pull down) Delprat et al. (2005) pubmed:15590698|mint:MINT-5217399 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7417805|mint:MINT-1895407 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N|mint:MINT-1895419(identity) ensembl:ENSMUSG00000042678(gene)|ensembl:ENSMUST00000071880(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0098858"(actin-based cell projection)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR027417|interpro:IPR035487|interpro:IPR035963|interpro:IPR036028|interpro:IPR036057|interpro:IPR036961|interpro:IPR038185|interpro:IPR041795|mint:Q9QZZ4|rcsb pdb:6Y38|rcsb pdb:6Y9N|refseq:NP_001096641.1|refseq:NP_034992.2|refseq:NP_874357.2|refseq:XP_017169821.1|refseq:XP_017169822.1|mint:MINT-1895408(identity) - function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3C|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/04 2014/10/16 rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090 rogid:/SZaFfSAvP0AIlBs71OBrx+z59o10090 intact-crc:E46A9EC48B1F260F|rigid:vtNT9CxN0Wa9PSyTNl60TnWsInE false binding-associated region:1-263(MINT-1895426) glutathione s tranferase tag:?-?(MINT-1895417)|binding-associated region:2950-3511(IPR009065) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q80VW5 uniprotkb:Q9QZZ4 intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4 intact:EBI-4281382|ensembl:ENSMUSP00000071777|uniprotkb:A2A637|uniprotkb:A2A638|uniprotkb:O70395|uniprotkb:Q5SX93|uniprotkb:Q7TMR5|uniprotkb:Q7TMR6|uniprotkb:Q9QWL6 psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym) psi-mi:myo15_mouse(display_long)|uniprotkb:Myo15a(gene name)|psi-mi:Myo15a(display_short)|uniprotkb:Myo15(gene name synonym)|uniprotkb:Unconventional myosin-15(gene name synonym) psi-mi:"MI:0096"(pull down) Delprat et al. (2005) pubmed:15590698|mint:MINT-5217399 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7417830|mint:MINT-1895436 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N|mint:MINT-1895448(identity) ensembl:ENSMUSG00000042678(gene)|ensembl:ENSMUST00000071880(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0098858"(actin-based cell projection)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR027417|interpro:IPR035487|interpro:IPR035963|interpro:IPR036028|interpro:IPR036057|interpro:IPR036961|interpro:IPR038185|interpro:IPR041795|mint:Q9QZZ4|rcsb pdb:6Y38|rcsb pdb:6Y9N|refseq:NP_001096641.1|refseq:NP_034992.2|refseq:NP_874357.2|refseq:XP_017169821.1|refseq:XP_017169822.1|mint:MINT-1895437(identity) - function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3C|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/04 2014/10/16 rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090 rogid:/SZaFfSAvP0AIlBs71OBrx+z59o10090 intact-crc:68FE4F8A1C0070B6|rigid:vtNT9CxN0Wa9PSyTNl60TnWsInE false binding-associated region:257-422(MINT-1895449) binding-associated region:2950-3511(IPR009065)|glutathione s tranferase tag:?-?(MINT-1895446) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q13402 uniprotkb:Q80VW5 intact:EBI-7417855|uniprotkb:Q13321|uniprotkb:Q92822|intact:MINT-1895479|uniprotkb:Q14785|uniprotkb:Q92821|uniprotkb:F8VUN5|uniprotkb:P78427|uniprotkb:B9A011|ensembl:ENSP00000386331 intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4 psi-mi:myo7a_human(display_long)|uniprotkb:MYO7A(gene name)|psi-mi:MYO7A(display_short)|uniprotkb:USH1B(gene name synonym) psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym) psi-mi:"MI:0096"(pull down) Delprat et al. (2005) pubmed:15590698|mint:MINT-5217399 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7417923|mint:MINT-1895458 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000251.3|refseq:NP_001120652.1|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042470"(melanosome)|go:"GO:0042490"(mechanoreceptor differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0050957"(equilibrioception)|go:"GO:0051015"(actin filament binding)|go:"GO:0051904"(pigment granule transport)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0120044"(stereocilium base)|go:"GO:1990435"(upper tip-link density)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR029071|interpro:IPR035963|interpro:IPR036028|interpro:IPR036106|interpro:IPR036961|go:"GO:0034613"(cellular protein localization)|interpro:IPR038185|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005902"(microvillus)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007423"(sensory organ development)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030507"(spectrin binding)|go:"GO:0031477"(myosin VII complex)|go:"GO:0031982"(vesicle)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000137474(gene)|ensembl:ENST00000409709(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001845"(phagolysosome assembly)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|interpro:IPR041794|mint:Q13402|rcsb pdb:5MV9|reactome:R-HSA-2453902|reactome:R-HSA-9662360|reactome:R-HSA-9662361|interpro:IPR041793|mint:MINT-1895467(identity) refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N|mint:MINT-1895459(identity) - comment:mint|function:Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. In retina, myosin VIIa might play a role in trafficking of ribbon-synaptic vesicle complexes and renewal of the outer photoreceptors disks. In inner ear, it might maintain the rigidity of stereocilia during the dynamic movements of the bundle. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity|function:"Defects in MYO7A are the cause of Usher syndrome type 1B (USH1B) [MIM:276900]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness"|function:"Defects in MYO7A are the cause of non-syndromic sensorineural deafness autosomal recessive type 2 (DFNB2) [MIM:600060]; also called neurosensory non-syndromic recessive deafness 2 (NSRD2). DFNB2 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information{EC15,EC16}"|function:"Defects in MYO7A are the cause of non-syndromic sensorineural deafness autosomal dominant type 11 (DFNA11) [MIM:601317]"|comment:"Stoichiometry: 1.0" function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"|comment:"Stoichiometry: 1.0" figure legend:F3D|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/04 2014/10/16 rogid:OwxpV+yOnwipkRuEY1IAUY3i2/w9606 rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090 intact-crc:6A91427D95366E45|rigid:nGmwQ4Km0AFMocERuZpbHNVYV7A false binding-associated region:?-?(MINT-1895474) glutathione s tranferase tag:?-?(MINT-1895564) 1 1 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8C031 uniprotkb:Q80VW5 intact:EBI-7417983|uniprotkb:Q505E5|uniprotkb:Q8BGH8|intact:MINT-1895606|ensembl:ENSMUSP00000125218|ensembl:ENSMUSP00000130984|ensembl:ENSMUSP00000131795 intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4 psi-mi:lrc4c_mouse(display_long)|uniprotkb:Lrrc4c(gene name)|psi-mi:Lrrc4c(display_short)|uniprotkb:Ngl1(gene name synonym)|uniprotkb:Netrin-G1 ligand(gene name synonym) psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym) psi-mi:"MI:0096"(pull down) Delprat et al. (2005) pubmed:15590698|mint:MINT-5217399 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7417978|mint:MINT-1895666 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_848840.3|refseq:XP_017173628.1|refseq:XP_017173629.1|refseq:XP_006499542.1|ensembl:ENSMUSG00000050587(gene)|ensembl:ENSMUST00000059049(transcript)|ensembl:ENSMUST00000135431(transcript)|ensembl:ENSMUST00000162807(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026878|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q8C031|go:"GO:0016020"(membrane)|refseq:NP_001276671.1|refseq:NP_001276672.1|refseq:NP_001276673.1|dip:DIP-42049N|mint:MINT-1895673(identity) refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N|mint:MINT-1895667(identity) - comment:mint|function:May promote neurite outgrowth of developing thalamic neurons|comment:"Stoichiometry: 1.0" function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"|comment:"Stoichiometry: 1.0" figure legend:F4C|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/04 2014/10/16 rogid:8TBYGYy46jts2gGhDFxMciu+zJc10090 rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090 intact-crc:86A23A004EA0D5E7|rigid:C65+1RFNS9DYUmwDXRrLwQqob+8 false glutathione s tranferase tag:?-?(MINT-1895686) binding-associated region:141-220(MINT-1895689) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q80VW5 uniprotkb:Q80VW5 intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4 intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4 psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym) psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym) psi-mi:"MI:0096"(pull down) Delprat et al. (2005) pubmed:15590698|mint:MINT-5217399 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7417944|mint:MINT-1895567 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N|mint:MINT-1895568(identity) refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N|mint:MINT-1895575(identity) - function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"|comment:"Stoichiometry: 1.0" function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"|comment:"Stoichiometry: 1.0" figure legend:F3E|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/04 2014/10/16 rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090 rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090 intact-crc:76B4753F69D5166F|rigid:32VUU7ocs5PKVlBhftDHWjzbJHw false glutathione s tranferase tag:?-?(MINT-1895573) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8C031 uniprotkb:Q80VW5 intact:EBI-7417983|uniprotkb:Q505E5|uniprotkb:Q8BGH8|intact:MINT-1895606|ensembl:ENSMUSP00000125218|ensembl:ENSMUSP00000130984|ensembl:ENSMUSP00000131795 intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4 psi-mi:lrc4c_mouse(display_long)|uniprotkb:Lrrc4c(gene name)|psi-mi:Lrrc4c(display_short)|uniprotkb:Ngl1(gene name synonym)|uniprotkb:Netrin-G1 ligand(gene name synonym) psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym) psi-mi:"MI:0096"(pull down) Delprat et al. (2005) pubmed:15590698|mint:MINT-5217399 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7418027|mint:MINT-1895693 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_848840.3|refseq:XP_017173628.1|refseq:XP_017173629.1|refseq:XP_006499542.1|ensembl:ENSMUSG00000050587(gene)|ensembl:ENSMUST00000059049(transcript)|ensembl:ENSMUST00000135431(transcript)|ensembl:ENSMUST00000162807(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026878|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q8C031|go:"GO:0016020"(membrane)|refseq:NP_001276671.1|refseq:NP_001276672.1|refseq:NP_001276673.1|dip:DIP-42049N|mint:MINT-1895702(identity) refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N|mint:MINT-1895694(identity) - comment:mint|function:May promote neurite outgrowth of developing thalamic neurons|comment:"Stoichiometry: 1.0" function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"|comment:"Stoichiometry: 1.0" figure legend:F4C|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/04 2014/10/16 rogid:8TBYGYy46jts2gGhDFxMciu+zJc10090 rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090 intact-crc:79A8B3FEED1F026F|rigid:C65+1RFNS9DYUmwDXRrLwQqob+8 false glutathione s tranferase tag:?-?(MINT-1895707) binding-associated region:280-358(MINT-1895695) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8C031 uniprotkb:Q8C031 intact:EBI-7417983|uniprotkb:Q505E5|uniprotkb:Q8BGH8|intact:MINT-1895606|ensembl:ENSMUSP00000125218|ensembl:ENSMUSP00000130984|ensembl:ENSMUSP00000131795 intact:EBI-7417983|uniprotkb:Q505E5|uniprotkb:Q8BGH8|intact:MINT-1895606|ensembl:ENSMUSP00000125218|ensembl:ENSMUSP00000130984|ensembl:ENSMUSP00000131795 psi-mi:lrc4c_mouse(display_long)|uniprotkb:Lrrc4c(gene name)|psi-mi:Lrrc4c(display_short)|uniprotkb:Ngl1(gene name synonym)|uniprotkb:Netrin-G1 ligand(gene name synonym) psi-mi:lrc4c_mouse(display_long)|uniprotkb:Lrrc4c(gene name)|psi-mi:Lrrc4c(display_short)|uniprotkb:Ngl1(gene name synonym)|uniprotkb:Netrin-G1 ligand(gene name synonym) psi-mi:"MI:0096"(pull down) Delprat et al. (2005) pubmed:15590698|mint:MINT-5217399 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7418046|mint:MINT-1895711 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_848840.3|refseq:XP_017173628.1|refseq:XP_017173629.1|refseq:XP_006499542.1|ensembl:ENSMUSG00000050587(gene)|ensembl:ENSMUST00000059049(transcript)|ensembl:ENSMUST00000135431(transcript)|ensembl:ENSMUST00000162807(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026878|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q8C031|go:"GO:0016020"(membrane)|refseq:NP_001276671.1|refseq:NP_001276672.1|refseq:NP_001276673.1|dip:DIP-42049N|mint:MINT-1895720(identity) refseq:NP_848840.3|refseq:XP_017173628.1|refseq:XP_017173629.1|refseq:XP_006499542.1|ensembl:ENSMUSG00000050587(gene)|ensembl:ENSMUST00000059049(transcript)|ensembl:ENSMUST00000135431(transcript)|ensembl:ENSMUST00000162807(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026878|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q8C031|go:"GO:0016020"(membrane)|refseq:NP_001276671.1|refseq:NP_001276672.1|refseq:NP_001276673.1|dip:DIP-42049N|mint:MINT-1895712(identity) - comment:mint|function:May promote neurite outgrowth of developing thalamic neurons|comment:"Stoichiometry: 1.0" comment:mint|function:May promote neurite outgrowth of developing thalamic neurons|comment:"Stoichiometry: 1.0" figure legend:F4D|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/05/04 2014/10/16 rogid:8TBYGYy46jts2gGhDFxMciu+zJc10090 rogid:8TBYGYy46jts2gGhDFxMciu+zJc10090 intact-crc:2005693D60D55303|rigid:TH2Wu/lLpef/hwqJs5Dozlz7LM8 false glutathione s tranferase tag:?-?(MINT-1895721) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8C031 uniprotkb:Q80VW5 intact:EBI-7417983|uniprotkb:Q505E5|uniprotkb:Q8BGH8|intact:MINT-1895606|ensembl:ENSMUSP00000125218|ensembl:ENSMUSP00000130984|ensembl:ENSMUSP00000131795 intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4 psi-mi:lrc4c_mouse(display_long)|uniprotkb:Lrrc4c(gene name)|psi-mi:Lrrc4c(display_short)|uniprotkb:Ngl1(gene name synonym)|uniprotkb:Netrin-G1 ligand(gene name synonym) psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym) psi-mi:"MI:0018"(two hybrid) Delprat et al. (2005) pubmed:15590698|mint:MINT-5217399 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7418107|mint:MINT-1895592 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_848840.3|refseq:XP_017173628.1|refseq:XP_017173629.1|refseq:XP_006499542.1|ensembl:ENSMUSG00000050587(gene)|ensembl:ENSMUST00000059049(transcript)|ensembl:ENSMUST00000135431(transcript)|ensembl:ENSMUST00000162807(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026878|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q8C031|go:"GO:0016020"(membrane)|refseq:NP_001276671.1|refseq:NP_001276672.1|refseq:NP_001276673.1|dip:DIP-42049N|mint:MINT-1895593(identity) refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N|mint:MINT-1895598(identity) - comment:mint|function:May promote neurite outgrowth of developing thalamic neurons|comment:"Stoichiometry: 1.0" function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"|comment:"Stoichiometry: 1.0" figure legend:NFA|comment:homomint|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/05/04 2014/10/16 rogid:8TBYGYy46jts2gGhDFxMciu+zJc10090 rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090 intact-crc:C4C0D2D0CB7D3294|rigid:C65+1RFNS9DYUmwDXRrLwQqob+8 false tag:?-?(MINT-1895628) binding-associated region:1-422(MINT-1895633)|tag:?-?(MINT-1895603) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8C031 uniprotkb:Q80VW5 intact:EBI-7417983|uniprotkb:Q505E5|uniprotkb:Q8BGH8|intact:MINT-1895606|ensembl:ENSMUSP00000125218|ensembl:ENSMUSP00000130984|ensembl:ENSMUSP00000131795 intact:EBI-7417603|ensembl:ENSMUSP00000081557|uniprotkb:A2AGD2|uniprotkb:Q80TC2|intact:MINT-1895268|uniprotkb:Q5MLF5|uniprotkb:Q5MLF8|uniprotkb:Q5MLF2|uniprotkb:Q3TZC8|uniprotkb:I6MML6|uniprotkb:Q5MLF1|uniprotkb:Q5MLF3|uniprotkb:Q80VW4|uniprotkb:Q5MLF6|uniprotkb:Q5MLF9|uniprotkb:Q5MLF7|uniprotkb:I6MML7|uniprotkb:Q5MLF4 psi-mi:lrc4c_mouse(display_long)|uniprotkb:Lrrc4c(gene name)|psi-mi:Lrrc4c(display_short)|uniprotkb:Ngl1(gene name synonym)|uniprotkb:Netrin-G1 ligand(gene name synonym) psi-mi:whrn_mouse(display_long)|uniprotkb:Whrn(gene name)|psi-mi:Whrn(display_short)|uniprotkb:Dfnb31(gene name synonym)|uniprotkb:Kiaa1526(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Delprat et al. (2005) pubmed:15590698|mint:MINT-5217399 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7418138|mint:MINT-1895640 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_848840.3|refseq:XP_017173628.1|refseq:XP_017173629.1|refseq:XP_006499542.1|ensembl:ENSMUSG00000050587(gene)|ensembl:ENSMUST00000059049(transcript)|ensembl:ENSMUST00000135431(transcript)|ensembl:ENSMUST00000162807(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR026878|interpro:IPR026906|interpro:IPR032675|interpro:IPR036179|mint:Q8C031|go:"GO:0016020"(membrane)|refseq:NP_001276671.1|refseq:NP_001276672.1|refseq:NP_001276673.1|dip:DIP-42049N|mint:MINT-1895652(identity) refseq:XP_017175899.1|ensembl:ENSMUSG00000039137(gene)|ensembl:ENSMUST00000084510(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002141"(stereocilia ankle link)|go:"GO:0002142"(stereocilia ankle link complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0030426"(growth cone)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032426"(stereocilium tip)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044303"(axon collateral)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0050953"(sensory perception of light stimulus)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990075"(periciliary membrane compartment)|go:"GO:1990227"(paranodal junction maintenance)|go:"GO:1990696"(USH2 complex)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR033028|interpro:IPR036034|mint:Q80VW5|rcsb pdb:6FDD|rcsb pdb:6FDE|rcsb pdb:6Y38|rcsb pdb:6Y9N|rcsb pdb:6Y9O|rcsb pdb:6Y9P|rcsb pdb:6Y9Q|refseq:NP_082916.1|refseq:NP_001008792.1|refseq:NP_001263300.1|refseq:NP_001008791.1|refseq:NP_001008793.1|dip:DIP-42047N|mint:MINT-1895641(identity) - comment:mint|function:May promote neurite outgrowth of developing thalamic neurons|comment:"Stoichiometry: 1.0" function:Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear|comment:mint|function:"Defects in Whrn are the cause of the phenotype whirler (wi). Mutants are characterized by deafness due to malformation of the cochlear inner and outer hair cells and by circling behavior. Stereocilia are shorter and wider than in wild-type animals and there is a decrease in the number of actin filaments in inner and outer hair cells. The number of outer hair cell stereocilia is reduced with increased spacing between them"|comment:"Stoichiometry: 1.0" figure legend:F4A|comment:homomint|comment:mint taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells") - 2006/05/04 2014/10/16 rogid:8TBYGYy46jts2gGhDFxMciu+zJc10090 rogid:6N5se4ijefLU6c1zlQobN/Hi8N810090 intact-crc:623B70B66CC001A6|rigid:C65+1RFNS9DYUmwDXRrLwQqob+8 false - - 1 1 psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0708"(monoclonal antibody immunostaining)