#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02930	uniprotkb:P0AE06	intact:EBI-875614|uniprotkb:Q2M9G5|ensemblbacteria:AAC76071|ensemblbacteria:BAE77091	intact:EBI-875601|uniprotkb:P31223|uniprotkb:Q2MBW4|ensemblbacteria:AAC73565|ensemblbacteria:BAE76242	psi-mi:tolc_ecoli(display_long)|uniprotkb:tolC(gene name)|psi-mi:tolC(display_short)|uniprotkb:mtcB(gene name synonym)|uniprotkb:mukA(gene name synonym)|uniprotkb:refI(gene name synonym)|uniprotkb:Multidrug efflux pump subunit TolC(gene name synonym)|uniprotkb:Outer membrane factor TolC(gene name synonym)|uniprotkb:colE1-i(gene name synonym)|uniprotkb:toc(gene name synonym)|uniprotkb:weeA(gene name synonym)|uniprotkb:JW5503(locus name)|uniprotkb:b3035(locus name)	psi-mi:acra_ecoli(display_long)|uniprotkb:acrA(gene name)|psi-mi:acrA(display_short)|uniprotkb:lir(gene name synonym)|uniprotkb:mtcA(gene name synonym)|uniprotkb:b0463(locus name)|uniprotkb:JW0452(locus name)|uniprotkb:AcrAB-TolC multidrug efflux pump subunit AcrA(gene name synonym)|uniprotkb:Acridine resistance protein A(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husain et al. (2004)	pubmed:15576805	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-875610	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417507.2|refseq:WP_000735278.1|dip:DIP-11007N|ensemblbacteria:AAC76071(transcript)|ensemblbacteria:b3035(gene)|ensemblbacteria:BAE77091(gene)|ensemblbacteria:BAE77091(transcript)|go:"GO:0005216"(ion channel activity)|go:"GO:0009279"(cell outer membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015288"(porin activity)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042930"(enterobactin transport)|go:"GO:0045203"(integral component of cell outer membrane)|go:"GO:0046677"(response to antibiotic)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:1990196"(MacAB-TolC complex)|go:"GO:1990281"(efflux pump complex)|interpro:IPR003423(Outer membrane efflux protein)|interpro:IPR010130(Type I secretion outer membrane protein, TolC)|rcsb pdb:1EK9|rcsb pdb:1TQQ|rcsb pdb:2VDD|rcsb pdb:2VDE|rcsb pdb:2WMZ|rcsb pdb:2XMN|rcsb pdb:5NG5|rcsb pdb:5NIK|rcsb pdb:5NIL|rcsb pdb:5O66|rcsb pdb:5V5S|rcsb pdb:6WXH|rcsb pdb:6WXI	refseq:NP_414996.1|refseq:WP_001295324.1|dip:DIP-29039N|ensemblbacteria:AAC73565(transcript)|ensemblbacteria:b0463(gene)|ensemblbacteria:BAE76242(gene)|ensemblbacteria:BAE76242(transcript)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0046677"(response to antibiotic)|go:"GO:1990281"(efflux pump complex)|interpro:IPR006143(Secretion protein HlyD)|interpro:IPR032317|interpro:IPR043602|rcsb pdb:2F1M|rcsb pdb:5NG5|rcsb pdb:5O66|rcsb pdb:5V5S	-	-	crc64:5B81DD5BC2B0A077	comment:"The absence of DSP cross-linker did not affect the  binding or elution of AcrA-His, but TolC was no longer detectable  in the elution fractions. TolC cross-linked with AcrA-His regardless of whether the cultures were preincubated with the antibiotic ("|complex-properties:These experiments showed that TolCAcrA complexes exist even when cells are not challenged by the addition of a substrate of the TolC-AcrAB efflux pump.	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2006/03/02	2014/10/16	rogid:67LQDsYiAt6tDwigzlhM3Pp5+JA83333	rogid:SAeFuPoeyyXFuBiQN5ZAQH5f5W883333	intact-crc:AD340806DBB8E1B4|rigid:2rDXo6oI3/mEDZ0gCWyje8bDnb8	false	-	his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)