#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q12483	uniprotkb:P47142	intact:EBI-30277|uniprotkb:D6W410|ensemblfungi:YPL002C	intact:EBI-25595|uniprotkb:D6VWS1|ensemblfungi:YJR102C	psi-mi:snf8_yeast(display_long)|uniprotkb:Vacuolar protein-sorting-associated protein 22(gene name synonym)|uniprotkb:SNF8(gene name)|psi-mi:SNF8(display_short)|uniprotkb:ESCRT-II complex subunit VPS22(gene name synonym)|uniprotkb:VPS22(gene name synonym)|uniprotkb:YPL002C(locus name)	psi-mi:vps25_yeast(display_long)|uniprotkb:YJR102C(locus name)|uniprotkb:J1957(orf name)|uniprotkb:VPS25(gene name)|psi-mi:VPS25(display_short)|uniprotkb:VPT25(gene name synonym)|uniprotkb:ESCRT-II complex subunit VPS25(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hierro et al. (2004)	pubmed:15329733	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1040027|rcsb pdb:1U5T	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015323.1|sgd:S000005923|dip:DIP-1745N|mint:Q12483|ensemblfungi:YPL002C(gene)|ensemblfungi:YPL002C_mRNA(transcript)|go:"GO:0000433"(carbon catabolite repression of transcription from RNA polymerase II promoter by glucose)|go:"GO:0000814"(ESCRT II complex)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1904669"(ATP export)|interpro:IPR016689(ESCRT-2 complex, Snf8)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040608|rcsb pdb:1U5T|rcsb pdb:1W7P|reactome:R-SCE-917729	refseq:NP_012636.1|sgd:S000003863|mint:P47142|dip:DIP-4446N|ensemblfungi:YJR102C(gene)|ensemblfungi:YJR102C_mRNA(transcript)|go:"GO:0000433"(carbon catabolite repression of transcription from RNA polymerase II promoter by glucose)|go:"GO:0000814"(ESCRT II complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1904669"(ATP export)|interpro:IPR008570(ESCRT-II complex, vps25 subunit)|interpro:IPR014041(ESCRT-II complex, vps25 subunit, N-terminal winged helix)|interpro:IPR036388|interpro:IPR036390|rcsb pdb:1U5T|rcsb pdb:1W7P|rcsb pdb:1XB4|reactome:R-SCE-917729	-	crc64:212C74F086A0325E	crc64:6A4545A8BC772CA2	assembly:tetrameric, multimeric|3d-r-factors:working 77.400%, free 71.100%|3d-resolution:3.6A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:id37iKOY9XSalOC/tvdEFWDvlvg559292	rogid:LlNZVpWKYsWsgu0FcP2sL10lYHc559292	intact-crc:54A3785739D1323C|rigid:wvsz6rEvHiBPfjuz8yE4EX4YhfI	false	sufficient binding region:1-233	sufficient binding region:1-202	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12483	uniprotkb:Q06696	intact:EBI-30277|uniprotkb:D6W410|ensemblfungi:YPL002C	intact:EBI-36540|uniprotkb:D6VZ53|ensemblfungi:YLR417W	psi-mi:snf8_yeast(display_long)|uniprotkb:Vacuolar protein-sorting-associated protein 22(gene name synonym)|uniprotkb:SNF8(gene name)|psi-mi:SNF8(display_short)|uniprotkb:ESCRT-II complex subunit VPS22(gene name synonym)|uniprotkb:VPS22(gene name synonym)|uniprotkb:YPL002C(locus name)	psi-mi:vps36_yeast(display_long)|uniprotkb:VPS36(gene name)|psi-mi:VPS36(display_short)|uniprotkb:GRD12(gene name synonym)|uniprotkb:VAC3(gene name synonym)|uniprotkb:VPL11(gene name synonym)|uniprotkb:YLR417W(locus name)|uniprotkb:ESCRT-II complex subunit VPS36(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hierro et al. (2004)	pubmed:15329733	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1040027|rcsb pdb:1U5T	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015323.1|sgd:S000005923|dip:DIP-1745N|mint:Q12483|ensemblfungi:YPL002C(gene)|ensemblfungi:YPL002C_mRNA(transcript)|go:"GO:0000433"(carbon catabolite repression of transcription from RNA polymerase II promoter by glucose)|go:"GO:0000814"(ESCRT II complex)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:1904669"(ATP export)|interpro:IPR016689(ESCRT-2 complex, Snf8)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040608|rcsb pdb:1U5T|rcsb pdb:1W7P|reactome:R-SCE-917729	sgd:S000004409|refseq:NP_013521.3|mint:Q06696|dip:DIP-1744N|ensemblfungi:YLR417W(gene)|ensemblfungi:YLR417W_mRNA(transcript)|go:"GO:0000433"(carbon catabolite repression of transcription from RNA polymerase II promoter by glucose)|go:"GO:0000814"(ESCRT II complex)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0016236"(macroautophagy)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032258"(cytoplasm to vacuole transport by the Cvt pathway)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0046872"(metal ion binding)|go:"GO:1904669"(ATP export)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR021648|interpro:IPR031558|interpro:IPR036388|interpro:IPR036390|interpro:IPR036443|interpro:IPR037855|interpro:IPR040608|rcsb pdb:1U5T|rcsb pdb:1W7P|rcsb pdb:2CAY|rcsb pdb:2J9U|reactome:R-SCE-917729	-	crc64:212C74F086A0325E	crc64:60DDD4EA3A620409	assembly:tetrameric, multimeric|3d-r-factors:working 77.400%, free 71.100%|3d-resolution:3.6A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:id37iKOY9XSalOC/tvdEFWDvlvg559292	rogid:0JxE/Mkfz7lf9e9Nd28YlrH3c8o559292	intact-crc:54A3785739D1323C|rigid:wvsz6rEvHiBPfjuz8yE4EX4YhfI	false	sufficient binding region:1-233	sufficient binding region:396-564	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)