#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P27348	uniprotkb:P23945	intact:EBI-359854|uniprotkb:Q567U5|uniprotkb:Q5TZU8|uniprotkb:Q9UP48|uniprotkb:D6W4Z5|ensembl:ENSP00000238081|ensembl:ENSP00000371267	intact:EBI-848239|uniprotkb:Q4QRJ3|uniprotkb:Q16225|intact:EBI-848267|uniprotkb:A8K947|uniprotkb:Q4ZFZ2|uniprotkb:Q53RW2|uniprotkb:Q05AH0|uniprotkb:G5CBS7|uniprotkb:G5E967|uniprotkb:J3KQ00|uniprotkb:A0A0A0MSC5|ensembl:ENSP00000306780	psi-mi:1433t_human(display_long)|uniprotkb:YWHAQ(gene name)|psi-mi:YWHAQ(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)|uniprotkb:14-3-3 protein T-cell(gene name synonym)|uniprotkb:Protein HS1(gene name synonym)	psi-mi:fshr_human(display_long)|uniprotkb:Follitropin receptor(gene name synonym)|uniprotkb:FSHR(gene name)|psi-mi:FSHR(display_short)|uniprotkb:LGR1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Cohen et al. (2004)	pubmed:15196694|imex:IM-20075|mint:MINT-5217056	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-848264|imex:IM-20075-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006817.1|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P27348|rcsb pdb:2BTP|rcsb pdb:5IQP|rcsb pdb:6BCR|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6KZG|rcsb pdb:6KZH|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9614399|ensembl:ENSG00000134308(gene)|ensembl:ENST00000238081(transcript)|ensembl:ENST00000381844(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|dip:DIP-27584N	refseq:NP_000136.2|refseq:NP_852111.2|dip:DIP-35605N|ensembl:ENSG00000170820(gene)|ensembl:ENST00000304421(transcript)|go:"GO:0004963"(follicle-stimulating hormone receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007292"(female gamete generation)|go:"GO:0008406"(gonad development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR002131(Glycoprotein hormone receptor)|interpro:IPR002272(Follicle-stimulating hormone receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR024635|interpro:IPR026906|rcsb pdb:1XUN|rcsb pdb:1XWD|rcsb pdb:4AY9|rcsb pdb:4MQW|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821	-	-	-	sample process:P27348 cDNA library|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/06	2014/10/16	rogid:3I07h/wy8qcwUJqvO1RA76qnW5U9606	rogid:/X+tlZ4lvnJkOx2ze67Y3IzCUcw9606	intact-crc:4E07A3398BE503E2|rigid:phc1Lq04Qizaa/bsj9bdfwtcsPI	false	sufficient binding region:50-245	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P23945	uniprotkb:P27348	intact:EBI-848239|uniprotkb:Q4QRJ3|uniprotkb:Q16225|intact:EBI-848267|uniprotkb:A8K947|uniprotkb:Q4ZFZ2|uniprotkb:Q53RW2|uniprotkb:Q05AH0|uniprotkb:G5CBS7|uniprotkb:G5E967|uniprotkb:J3KQ00|uniprotkb:A0A0A0MSC5|ensembl:ENSP00000306780	intact:EBI-359854|uniprotkb:Q567U5|uniprotkb:Q5TZU8|uniprotkb:Q9UP48|uniprotkb:D6W4Z5|ensembl:ENSP00000238081|ensembl:ENSP00000371267	psi-mi:fshr_human(display_long)|uniprotkb:Follitropin receptor(gene name synonym)|uniprotkb:FSHR(gene name)|psi-mi:FSHR(display_short)|uniprotkb:LGR1(gene name synonym)	psi-mi:1433t_human(display_long)|uniprotkb:YWHAQ(gene name)|psi-mi:YWHAQ(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)|uniprotkb:14-3-3 protein T-cell(gene name synonym)|uniprotkb:Protein HS1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Cohen et al. (2004)	pubmed:15196694|imex:IM-20075|mint:MINT-5217056	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-848290|imex:IM-20075-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000136.2|refseq:NP_852111.2|dip:DIP-35605N|ensembl:ENSG00000170820(gene)|ensembl:ENST00000304421(transcript)|go:"GO:0004963"(follicle-stimulating hormone receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007292"(female gamete generation)|go:"GO:0008406"(gonad development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR002131(Glycoprotein hormone receptor)|interpro:IPR002272(Follicle-stimulating hormone receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR024635|interpro:IPR026906|rcsb pdb:1XUN|rcsb pdb:1XWD|rcsb pdb:4AY9|rcsb pdb:4MQW|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:NP_006817.1|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P27348|rcsb pdb:2BTP|rcsb pdb:5IQP|rcsb pdb:6BCR|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6KZG|rcsb pdb:6KZH|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9614399|ensembl:ENSG00000134308(gene)|ensembl:ENST00000238081(transcript)|ensembl:ENST00000381844(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|dip:DIP-27584N	-	-	-	caution:The interaction is weak and the construct with both intracellular loops L1 and L2 of human FSHR joined by a glycyl-seryl linker has greater interaction signal with 14-3-3 tau.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/06	2014/10/16	rogid:/X+tlZ4lvnJkOx2ze67Y3IzCUcw9606	rogid:3I07h/wy8qcwUJqvO1RA76qnW5U9606	intact-crc:971BEB881AE14366|rigid:phc1Lq04Qizaa/bsj9bdfwtcsPI	false	sufficient binding region:458-498	sufficient binding region:50-245	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23945	uniprotkb:P27348	intact:EBI-848239|uniprotkb:Q4QRJ3|uniprotkb:Q16225|intact:EBI-848267|uniprotkb:A8K947|uniprotkb:Q4ZFZ2|uniprotkb:Q53RW2|uniprotkb:Q05AH0|uniprotkb:G5CBS7|uniprotkb:G5E967|uniprotkb:J3KQ00|uniprotkb:A0A0A0MSC5|ensembl:ENSP00000306780	intact:EBI-359854|uniprotkb:Q567U5|uniprotkb:Q5TZU8|uniprotkb:Q9UP48|uniprotkb:D6W4Z5|ensembl:ENSP00000238081|ensembl:ENSP00000371267	psi-mi:fshr_human(display_long)|uniprotkb:Follitropin receptor(gene name synonym)|uniprotkb:FSHR(gene name)|psi-mi:FSHR(display_short)|uniprotkb:LGR1(gene name synonym)	psi-mi:1433t_human(display_long)|uniprotkb:YWHAQ(gene name)|psi-mi:YWHAQ(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)|uniprotkb:14-3-3 protein T-cell(gene name synonym)|uniprotkb:Protein HS1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cohen et al. (2004)	pubmed:15196694|imex:IM-20075|mint:MINT-5217056	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-848323|imex:IM-20075-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000136.2|refseq:NP_852111.2|dip:DIP-35605N|ensembl:ENSG00000170820(gene)|ensembl:ENST00000304421(transcript)|go:"GO:0004963"(follicle-stimulating hormone receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007292"(female gamete generation)|go:"GO:0008406"(gonad development)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR002131(Glycoprotein hormone receptor)|interpro:IPR002272(Follicle-stimulating hormone receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR024635|interpro:IPR026906|rcsb pdb:1XUN|rcsb pdb:1XWD|rcsb pdb:4AY9|rcsb pdb:4MQW|reactome:R-HSA-375281|reactome:R-HSA-418555|reactome:R-HSA-9660821	refseq:NP_006817.1|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P27348|rcsb pdb:2BTP|rcsb pdb:5IQP|rcsb pdb:6BCR|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6KZG|rcsb pdb:6KZH|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9614399|ensembl:ENSG00000134308(gene)|ensembl:ENST00000238081(transcript)|ensembl:ENST00000381844(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|dip:DIP-27584N	-	-	-	agonist:"Addition of follitropin (FSH) to cells induces interaction."|comment:"stable transfection of FSHR (P23945)"|expression level:P27348 over-expressed|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/02/06	2014/10/16	rogid:/X+tlZ4lvnJkOx2ze67Y3IzCUcw9606	rogid:3I07h/wy8qcwUJqvO1RA76qnW5U9606	intact-crc:00A1FD9CB074EBFF|rigid:phc1Lq04Qizaa/bsj9bdfwtcsPI	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)