#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P43276 uniprotkb:P13297 intact:EBI-903960|uniprotkb:Q9CRM8|ensembl:ENSMUSP00000079356 intact:EBI-903969|uniprotkb:Q91W75|uniprotkb:Q9ERF6|ensembl:ENSMUSP00000058354 psi-mi:h15_mouse(display_long)|uniprotkb:H1-5(gene name)|psi-mi:H1-5(display_short)|uniprotkb:H1 VAR.5(gene name synonym)|uniprotkb:H1b(gene name synonym)|uniprotkb:H1f5(gene name synonym)|uniprotkb:Hist1h1b(gene name synonym) psi-mi:msx1_mouse(display_long)|uniprotkb:Msx1(gene name)|psi-mi:Msx1(display_short)|uniprotkb:Hox7(gene name synonym)|uniprotkb:Hox7.1(gene name synonym)|uniprotkb:Msh homeobox 1-like protein(gene name synonym)|uniprotkb:Homeobox protein Hox-7(gene name synonym)|uniprotkb:Hox-7.1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lee et al. (2004) pubmed:15192231|imex:IM-19849 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-903982|imex:IM-19849-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_064418.1|ensembl:ENSMUSG00000058773(gene)|ensembl:ENSMUST00000080511(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0007517"(muscle organ development)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P43276|reactome:R-MMU-140342|reactome:R-MMU-2559584 refseq:NP_034965.2|ensembl:ENSMUSG00000048450(gene)|ensembl:ENSMUST00000063116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002039"(p53 binding)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035880"(embryonic nail plate morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0090427"(activation of meiosis)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001055"(positive regulation of mesenchymal cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:1IG7 go:"GO:0007517"(muscle organ development) - - expression level:P43276 endogenous|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast) - 2006/03/14 2014/10/16 rogid:XG7QIbZHXPP+4PO4OY4XdcBAZlc10090 rogid:IhoTzyWDHT9qyxeKcResnWl7TxY10090 intact-crc:264DEF81AADC71CC|rigid:Ne7A5yxoPHXLMFJJM2HvsF862x8 false - flag tag:?-?|necessary binding region:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P13297 uniprotkb:P43276 intact:EBI-903969|uniprotkb:Q91W75|uniprotkb:Q9ERF6|ensembl:ENSMUSP00000058354 intact:EBI-903960|uniprotkb:Q9CRM8|ensembl:ENSMUSP00000079356 psi-mi:msx1_mouse(display_long)|uniprotkb:Msx1(gene name)|psi-mi:Msx1(display_short)|uniprotkb:Hox7(gene name synonym)|uniprotkb:Hox7.1(gene name synonym)|uniprotkb:Msh homeobox 1-like protein(gene name synonym)|uniprotkb:Homeobox protein Hox-7(gene name synonym)|uniprotkb:Hox-7.1(gene name synonym) psi-mi:h15_mouse(display_long)|uniprotkb:H1-5(gene name)|psi-mi:H1-5(display_short)|uniprotkb:H1 VAR.5(gene name synonym)|uniprotkb:H1b(gene name synonym)|uniprotkb:H1f5(gene name synonym)|uniprotkb:Hist1h1b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lee et al. (2004) pubmed:15192231|imex:IM-19849 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-904000|imex:IM-19849-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034965.2|ensembl:ENSMUSG00000048450(gene)|ensembl:ENSMUST00000063116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002039"(p53 binding)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035880"(embryonic nail plate morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0090427"(activation of meiosis)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001055"(positive regulation of mesenchymal cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:1IG7 refseq:NP_064418.1|ensembl:ENSMUSG00000058773(gene)|ensembl:ENSMUST00000080511(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0007517"(muscle organ development)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P43276|reactome:R-MMU-140342|reactome:R-MMU-2559584 go:"GO:0007517"(muscle organ development) - - comment:"Some amount of V5 tagged H1A (P43275) was also observed."|comment:"This interaction was also observed when H1b was n-terminally V5 tagged (fig S1)"|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast) - 2006/03/14 2014/10/16 rogid:IhoTzyWDHT9qyxeKcResnWl7TxY10090 rogid:XG7QIbZHXPP+4PO4OY4XdcBAZlc10090 intact-crc:D56E4AE183C434FF|rigid:Ne7A5yxoPHXLMFJJM2HvsF862x8 false flag tag:?-? myc tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P43276 uniprotkb:P13297 intact:EBI-903960|uniprotkb:Q9CRM8|ensembl:ENSMUSP00000079356 intact:EBI-903969|uniprotkb:Q91W75|uniprotkb:Q9ERF6|ensembl:ENSMUSP00000058354 psi-mi:h15_mouse(display_long)|uniprotkb:H1-5(gene name)|psi-mi:H1-5(display_short)|uniprotkb:H1 VAR.5(gene name synonym)|uniprotkb:H1b(gene name synonym)|uniprotkb:H1f5(gene name synonym)|uniprotkb:Hist1h1b(gene name synonym) psi-mi:msx1_mouse(display_long)|uniprotkb:Msx1(gene name)|psi-mi:Msx1(display_short)|uniprotkb:Hox7(gene name synonym)|uniprotkb:Hox7.1(gene name synonym)|uniprotkb:Msh homeobox 1-like protein(gene name synonym)|uniprotkb:Homeobox protein Hox-7(gene name synonym)|uniprotkb:Hox-7.1(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2004) pubmed:15192231|imex:IM-19849 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-904029|imex:IM-19849-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_064418.1|ensembl:ENSMUSG00000058773(gene)|ensembl:ENSMUST00000080511(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0007517"(muscle organ development)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0030261"(chromosome condensation)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031936"(obsolete negative regulation of chromatin silencing)|go:"GO:0045910"(negative regulation of DNA recombination)|interpro:IPR005818(Histone H1/H5)|interpro:IPR005819(Histone H5)|interpro:IPR036388|interpro:IPR036390|mint:P43276|reactome:R-MMU-140342|reactome:R-MMU-2559584 refseq:NP_034965.2|ensembl:ENSMUSG00000048450(gene)|ensembl:ENSMUST00000063116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002039"(p53 binding)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035880"(embryonic nail plate morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042481"(regulation of odontogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0090427"(activation of meiosis)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001055"(positive regulation of mesenchymal cell apoptotic process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:1IG7 - - - sample process:P43276 purified|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/03/14 2014/10/16 rogid:XG7QIbZHXPP+4PO4OY4XdcBAZlc10090 rogid:IhoTzyWDHT9qyxeKcResnWl7TxY10090 intact-crc:83380D0B87978514|rigid:Ne7A5yxoPHXLMFJJM2HvsF862x8 false - maltose binding protein tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)