#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7TSE9	uniprotkb:Q08201	intact:EBI-930005|uniprotkb:Q5D1N3|uniprotkb:Q5D1N4|uniprotkb:Q7TSE7|uniprotkb:Q7TSE8	intact:EBI-929988|uniprotkb:Q78E07	psi-mi:hax1_rat(display_long)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:mdr3_rat(display_long)|uniprotkb:Pgp3(gene name synonym)|uniprotkb:Pgy2(gene name synonym)|uniprotkb:Abcb4(gene name)|psi-mi:Abcb4(display_short)|uniprotkb:Mdr2(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 4(gene name synonym)|uniprotkb:P-glycoprotein 2(gene name synonym)|uniprotkb:P-glycoprotein 3(gene name synonym)|uniprotkb:Multidrug resistance protein 2(gene name synonym)|uniprotkb:Multidrug resistance protein 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Ortiz et al. (2004)	imex:IM-14463|pubmed:15159385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-930001|imex:IM-14463-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017248(HS1-associating, X-1)|rgd:727960|refseq:NP_853658.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)	rgd:620248|refseq:NP_036822.1|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR027417|interpro:IPR030275|interpro:IPR036640|interpro:IPR039421|reactome:R-RNO-382556|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032782"(bile acid secretion)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090555"(phosphatidylethanolamine flippase activity)|go:"GO:0099038"(ceramide floppase activity)|go:"GO:1901557"(response to fenofibrate)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:2001140"(positive regulation of phospholipid transport)	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/04/24	2014/10/16	rogid:6d8i4PF7ohyfm/GGfsn5YPioT1Y10116	rogid:4wNwfyHY7IIHYFR9bHpFIqYT8xE10116	intact-crc:C80F8C2CE889768B|rigid:Kx15Q4qtBqcN4B6FO5UZxebdzWM	false	-	sufficient binding region:620-698	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q08201	uniprotkb:Q7TSE9	intact:EBI-929988|uniprotkb:Q78E07	intact:EBI-930005|uniprotkb:Q5D1N3|uniprotkb:Q5D1N4|uniprotkb:Q7TSE7|uniprotkb:Q7TSE8	psi-mi:mdr3_rat(display_long)|uniprotkb:Pgp3(gene name synonym)|uniprotkb:Pgy2(gene name synonym)|uniprotkb:Abcb4(gene name)|psi-mi:Abcb4(display_short)|uniprotkb:Mdr2(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 4(gene name synonym)|uniprotkb:P-glycoprotein 2(gene name synonym)|uniprotkb:P-glycoprotein 3(gene name synonym)|uniprotkb:Multidrug resistance protein 2(gene name synonym)|uniprotkb:Multidrug resistance protein 3(gene name synonym)	psi-mi:hax1_rat(display_long)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Ortiz et al. (2004)	imex:IM-14463|pubmed:15159385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-930027|imex:IM-14463-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620248|refseq:NP_036822.1|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR027417|interpro:IPR030275|interpro:IPR036640|interpro:IPR039421|reactome:R-RNO-382556|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032782"(bile acid secretion)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090555"(phosphatidylethanolamine flippase activity)|go:"GO:0099038"(ceramide floppase activity)|go:"GO:1901557"(response to fenofibrate)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:2001140"(positive regulation of phospholipid transport)	interpro:IPR017248(HS1-associating, X-1)|rgd:727960|refseq:NP_853658.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/04/24	2014/10/16	rogid:4wNwfyHY7IIHYFR9bHpFIqYT8xE10116	rogid:6d8i4PF7ohyfm/GGfsn5YPioT1Y10116	intact-crc:F61B868CA59B3D36|rigid:Kx15Q4qtBqcN4B6FO5UZxebdzWM	false	sufficient binding region:622-656|necessary binding region:622-645	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O70127	uniprotkb:Q7TSE9	intact:EBI-930036	intact:EBI-930005|uniprotkb:Q5D1N3|uniprotkb:Q5D1N4|uniprotkb:Q7TSE7|uniprotkb:Q7TSE8	psi-mi:abcbb_rat(display_long)|uniprotkb:Abcb11(gene name)|psi-mi:Abcb11(display_short)|uniprotkb:Bsep(gene name synonym)|uniprotkb:Spgp(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 11(gene name synonym)|uniprotkb:Sister of P-glycoprotein(gene name synonym)	psi-mi:hax1_rat(display_long)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Ortiz et al. (2004)	imex:IM-14463|pubmed:15159385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-930049|imex:IM-14463-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:619930|refseq:NP_113948.1|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR030278|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|reactome:R-RNO-159418|reactome:R-RNO-193368|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015126"(canalicular bile acid transmembrane transporter activity)|go:"GO:0015144"(carbohydrate transmembrane transporter activity)|go:"GO:0015432"(ABC-type bile acid transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0015722"(canalicular bile acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017144"|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043627"(response to estrogen)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0046618"(xenobiotic export)|go:"GO:0046691"(intracellular canaliculus)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:0120189"(positive regulation of bile acid secretion)|go:"GO:1904251"(regulation of bile acid metabolic process)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)	interpro:IPR017248(HS1-associating, X-1)|rgd:727960|refseq:NP_853658.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/04/24	2014/10/16	rogid:CcB8zd8iM+EBun9D4DF29nmQi4k10116	rogid:6d8i4PF7ohyfm/GGfsn5YPioT1Y10116	intact-crc:F570CED48D9D4FDC|rigid:XFpLamu8MK2rie7cAXxe9RpEB58	false	sufficient binding region:651-670	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7TSE9	uniprotkb:Q6PSM0	intact:EBI-930005|uniprotkb:Q5D1N3|uniprotkb:Q5D1N4|uniprotkb:Q7TSE7|uniprotkb:Q7TSE8	intact:EBI-930055	psi-mi:hax1_rat(display_long)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:q6psm0_rat(display_long)|uniprotkb:Mdr1a(gene name)|psi-mi:Mdr1a(display_short)	psi-mi:"MI:0018"(two hybrid)	Ortiz et al. (2004)	imex:IM-14463|pubmed:15159385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-930069|imex:IM-14463-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017248(HS1-associating, X-1)|rgd:727960|refseq:NP_853658.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)	interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|interpro:IPR030258|go:"GO:0005524"(ATP binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/04/24	2014/10/16	rogid:6d8i4PF7ohyfm/GGfsn5YPioT1Y10116	rogid:iLhsK43mexgKjbdX/7vF3m1nG/010116	intact-crc:0D300D92E90AF220|rigid:zEkh0jfWZP4zM9KKQKDk/lf7/38	false	-	sufficient binding region:611-704	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7TSE9	uniprotkb:Q08201	intact:EBI-930005|uniprotkb:Q5D1N3|uniprotkb:Q5D1N4|uniprotkb:Q7TSE7|uniprotkb:Q7TSE8	intact:EBI-929988|uniprotkb:Q78E07	psi-mi:hax1_rat(display_long)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:mdr3_rat(display_long)|uniprotkb:Pgp3(gene name synonym)|uniprotkb:Pgy2(gene name synonym)|uniprotkb:Abcb4(gene name)|psi-mi:Abcb4(display_short)|uniprotkb:Mdr2(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 4(gene name synonym)|uniprotkb:P-glycoprotein 2(gene name synonym)|uniprotkb:P-glycoprotein 3(gene name synonym)|uniprotkb:Multidrug resistance protein 2(gene name synonym)|uniprotkb:Multidrug resistance protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ortiz et al. (2004)	imex:IM-14463|pubmed:15159385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-930082|imex:IM-14463-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017248(HS1-associating, X-1)|rgd:727960|refseq:NP_853658.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)	rgd:620248|refseq:NP_036822.1|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR027417|interpro:IPR030275|interpro:IPR036640|interpro:IPR039421|reactome:R-RNO-382556|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032782"(bile acid secretion)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061092"(positive regulation of phospholipid translocation)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090555"(phosphatidylethanolamine flippase activity)|go:"GO:0099038"(ceramide floppase activity)|go:"GO:1901557"(response to fenofibrate)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:2001140"(positive regulation of phospholipid transport)	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/04/24	2014/10/16	rogid:6d8i4PF7ohyfm/GGfsn5YPioT1Y10116	rogid:4wNwfyHY7IIHYFR9bHpFIqYT8xE10116	intact-crc:E10C377B526AA49D|rigid:Kx15Q4qtBqcN4B6FO5UZxebdzWM	false	-	sufficient binding region:620-698|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O70127	uniprotkb:Q7TSE9	intact:EBI-930036	intact:EBI-930005|uniprotkb:Q5D1N3|uniprotkb:Q5D1N4|uniprotkb:Q7TSE7|uniprotkb:Q7TSE8	psi-mi:abcbb_rat(display_long)|uniprotkb:Abcb11(gene name)|psi-mi:Abcb11(display_short)|uniprotkb:Bsep(gene name synonym)|uniprotkb:Spgp(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 11(gene name synonym)|uniprotkb:Sister of P-glycoprotein(gene name synonym)	psi-mi:hax1_rat(display_long)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ortiz et al. (2004)	imex:IM-14463|pubmed:15159385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-930089|imex:IM-14463-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:619930|refseq:NP_113948.1|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR030278|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|reactome:R-RNO-159418|reactome:R-RNO-193368|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015126"(canalicular bile acid transmembrane transporter activity)|go:"GO:0015144"(carbohydrate transmembrane transporter activity)|go:"GO:0015432"(ABC-type bile acid transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0015722"(canalicular bile acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017144"|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043627"(response to estrogen)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0046618"(xenobiotic export)|go:"GO:0046691"(intracellular canaliculus)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:0120189"(positive regulation of bile acid secretion)|go:"GO:1904251"(regulation of bile acid metabolic process)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)	interpro:IPR017248(HS1-associating, X-1)|rgd:727960|refseq:NP_853658.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/04/24	2014/10/16	rogid:CcB8zd8iM+EBun9D4DF29nmQi4k10116	rogid:6d8i4PF7ohyfm/GGfsn5YPioT1Y10116	intact-crc:7CABD9CECAAE32B3|rigid:XFpLamu8MK2rie7cAXxe9RpEB58	false	sufficient binding region:651-741|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O70127	uniprotkb:Q7TSE9	intact:EBI-930036	intact:EBI-930005|uniprotkb:Q5D1N3|uniprotkb:Q5D1N4|uniprotkb:Q7TSE7|uniprotkb:Q7TSE8	psi-mi:abcbb_rat(display_long)|uniprotkb:Abcb11(gene name)|psi-mi:Abcb11(display_short)|uniprotkb:Bsep(gene name synonym)|uniprotkb:Spgp(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 11(gene name synonym)|uniprotkb:Sister of P-glycoprotein(gene name synonym)	psi-mi:hax1_rat(display_long)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ortiz et al. (2004)	imex:IM-14463|pubmed:15159385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-930201|imex:IM-14463-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:619930|refseq:NP_113948.1|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR030278|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|reactome:R-RNO-159418|reactome:R-RNO-193368|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015126"(canalicular bile acid transmembrane transporter activity)|go:"GO:0015144"(carbohydrate transmembrane transporter activity)|go:"GO:0015432"(ABC-type bile acid transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0015722"(canalicular bile acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017144"|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043627"(response to estrogen)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0046618"(xenobiotic export)|go:"GO:0046691"(intracellular canaliculus)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:0120189"(positive regulation of bile acid secretion)|go:"GO:1904251"(regulation of bile acid metabolic process)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)	interpro:IPR017248(HS1-associating, X-1)|rgd:727960|refseq:NP_853658.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)	psi-mi:"MI:0469"(intact)	-	-	sample process:overexpressed. Q7TSE9. O70127.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/04/24	2014/10/16	rogid:CcB8zd8iM+EBun9D4DF29nmQi4k10116	rogid:6d8i4PF7ohyfm/GGfsn5YPioT1Y10116	intact-crc:926FDF8A9743746B|rigid:XFpLamu8MK2rie7cAXxe9RpEB58	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00165	uniprotkb:O70127	intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002	intact:EBI-930036	psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:abcbb_rat(display_long)|uniprotkb:Abcb11(gene name)|psi-mi:Abcb11(display_short)|uniprotkb:Bsep(gene name synonym)|uniprotkb:Spgp(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 11(gene name synonym)|uniprotkb:Sister of P-glycoprotein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ortiz et al. (2004)	imex:IM-14463|pubmed:15159385	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-930216|imex:IM-14463-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165	rgd:619930|refseq:NP_113948.1|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR030278|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|reactome:R-RNO-159418|reactome:R-RNO-193368|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015126"(canalicular bile acid transmembrane transporter activity)|go:"GO:0015144"(carbohydrate transmembrane transporter activity)|go:"GO:0015432"(ABC-type bile acid transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0015722"(canalicular bile acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017144"|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043627"(response to estrogen)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0046618"(xenobiotic export)|go:"GO:0046691"(intracellular canaliculus)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:0120189"(positive regulation of bile acid secretion)|go:"GO:1904251"(regulation of bile acid metabolic process)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)	psi-mi:"MI:0469"(intact)	-	-	sample process:overexpressed. O70127.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/04/24	2014/10/16	rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606	rogid:CcB8zd8iM+EBun9D4DF29nmQi4k10116	intact-crc:D1C8A80ED342F20C|rigid:2lzYQz7OLvAeG+3huicD7F6sFq0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00165	uniprotkb:Q6PSM0	intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002	intact:EBI-930055	psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:q6psm0_rat(display_long)|uniprotkb:Mdr1a(gene name)|psi-mi:Mdr1a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ortiz et al. (2004)	imex:IM-14463|pubmed:15159385	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-930234|imex:IM-14463-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165	interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|interpro:IPR030258|go:"GO:0005524"(ATP binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)	psi-mi:"MI:0469"(intact)	-	-	sample process:over-expressed. Q6PSM0.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/04/24	2014/10/16	rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606	rogid:iLhsK43mexgKjbdX/7vF3m1nG/010116	intact-crc:151EEAD9780957CD|rigid:aEqy/KmYcwqyM4/0zvs7X1d0WBs	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q7TSE9	uniprotkb:O70127	intact:EBI-930005|uniprotkb:Q5D1N3|uniprotkb:Q5D1N4|uniprotkb:Q7TSE7|uniprotkb:Q7TSE8	intact:EBI-930036	psi-mi:hax1_rat(display_long)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:abcbb_rat(display_long)|uniprotkb:Abcb11(gene name)|psi-mi:Abcb11(display_short)|uniprotkb:Bsep(gene name synonym)|uniprotkb:Spgp(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 11(gene name synonym)|uniprotkb:Sister of P-glycoprotein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ortiz et al. (2004)	imex:IM-14463|pubmed:15159385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-930372|imex:IM-14463-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017248(HS1-associating, X-1)|rgd:727960|refseq:NP_853658.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)	rgd:619930|refseq:NP_113948.1|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR030278|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|reactome:R-RNO-159418|reactome:R-RNO-193368|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015126"(canalicular bile acid transmembrane transporter activity)|go:"GO:0015144"(carbohydrate transmembrane transporter activity)|go:"GO:0015432"(ABC-type bile acid transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0015722"(canalicular bile acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017144"|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043627"(response to estrogen)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0046618"(xenobiotic export)|go:"GO:0046691"(intracellular canaliculus)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:0120189"(positive regulation of bile acid secretion)|go:"GO:1904251"(regulation of bile acid metabolic process)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2006/04/24	2014/10/16	rogid:6d8i4PF7ohyfm/GGfsn5YPioT1Y10116	rogid:CcB8zd8iM+EBun9D4DF29nmQi4k10116	intact-crc:A954C10AD2C3961F|rigid:XFpLamu8MK2rie7cAXxe9RpEB58	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PSM0	uniprotkb:Q7TSE9	intact:EBI-930055	intact:EBI-930005|uniprotkb:Q5D1N3|uniprotkb:Q5D1N4|uniprotkb:Q7TSE7|uniprotkb:Q7TSE8	psi-mi:q6psm0_rat(display_long)|uniprotkb:Mdr1a(gene name)|psi-mi:Mdr1a(display_short)	psi-mi:hax1_rat(display_long)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ortiz et al. (2004)	imex:IM-14463|pubmed:15159385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-930375|imex:IM-14463-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|interpro:IPR030258|go:"GO:0005524"(ATP binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)	interpro:IPR017248(HS1-associating, X-1)|rgd:727960|refseq:NP_853658.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)	psi-mi:"MI:0469"(intact)	-	-	caution:The antibody used recognize both MDR1 and MDR2. Both MDR1a and MDR2 were shown to bind rat HAX-1 in vitro.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2006/04/24	2014/10/16	rogid:iLhsK43mexgKjbdX/7vF3m1nG/010116	rogid:6d8i4PF7ohyfm/GGfsn5YPioT1Y10116	intact-crc:F3CB14AC6E78B566|rigid:zEkh0jfWZP4zM9KKQKDk/lf7/38	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70420	uniprotkb:Q7TSE9	intact:EBI-922114	intact:EBI-930005|uniprotkb:Q5D1N3|uniprotkb:Q5D1N4|uniprotkb:Q7TSE7|uniprotkb:Q7TSE8	psi-mi:o70420_rat(display_long)	psi-mi:hax1_rat(display_long)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ortiz et al. (2004)	imex:IM-14463|pubmed:15159385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-930391|imex:IM-14463-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR015503(Cortactin)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR001452(Src homology-3)|go:"GO:0030041"(actin filament polymerization)|interpro:IPR035716|interpro:IPR036028	interpro:IPR017248(HS1-associating, X-1)|rgd:727960|refseq:NP_853658.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)	psi-mi:"MI:0469"(intact)	-	-	caution:The antibody my not be specific to an isofom of cortactin.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2006/04/24	2014/10/16	rogid:fE1JcV1/JO4SJ4mKSga4mth6cZY10116	rogid:6d8i4PF7ohyfm/GGfsn5YPioT1Y10116	intact-crc:46ACBC581567D615|rigid:eByZr2bHI1Q5tXS7B6HnSgikSnY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70127	uniprotkb:Q7TSE9	intact:EBI-930036	intact:EBI-930005|uniprotkb:Q5D1N3|uniprotkb:Q5D1N4|uniprotkb:Q7TSE7|uniprotkb:Q7TSE8	psi-mi:abcbb_rat(display_long)|uniprotkb:Abcb11(gene name)|psi-mi:Abcb11(display_short)|uniprotkb:Bsep(gene name synonym)|uniprotkb:Spgp(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 11(gene name synonym)|uniprotkb:Sister of P-glycoprotein(gene name synonym)	psi-mi:hax1_rat(display_long)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Ortiz et al. (2004)	imex:IM-14463|pubmed:15159385	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-930357|imex:IM-14463-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:619930|refseq:NP_113948.1|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR030278|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|reactome:R-RNO-159418|reactome:R-RNO-193368|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006855"(xenobiotic transmembrane transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008559"(ABC-type xenobiotic transporter activity)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015126"(canalicular bile acid transmembrane transporter activity)|go:"GO:0015144"(carbohydrate transmembrane transporter activity)|go:"GO:0015432"(ABC-type bile acid transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0015722"(canalicular bile acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017144"|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043627"(response to estrogen)|go:"GO:0045177"(apical part of cell)|go:"GO:0045471"(response to ethanol)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0046618"(xenobiotic export)|go:"GO:0046691"(intracellular canaliculus)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:0120189"(positive regulation of bile acid secretion)|go:"GO:1904251"(regulation of bile acid metabolic process)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)	interpro:IPR017248(HS1-associating, X-1)|rgd:727960|refseq:NP_853658.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)	go:"GO:0016324"(apical plasma membrane)	-	-	sample process:overexpressed. Q7TSE9. O70127.|comment:One to 2 days after confluency, cells showed differentiation of apical and lateral membranes. HAX-1 partially co-localized with BSEP-EYFP in the apical membrane; however, most HAX-1 was located immediately below the apical domain, where it partially localized with BSEP-EYFP. In polarized columnar cells, 4-5 days after confluency, BSEP-EYFP was mostly restricted to the apical membrane where it co-localized with HAX-1|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/04/24	2014/10/16	rogid:CcB8zd8iM+EBun9D4DF29nmQi4k10116	rogid:6d8i4PF7ohyfm/GGfsn5YPioT1Y10116	intact-crc:8548F8522A6E1B58|rigid:XFpLamu8MK2rie7cAXxe9RpEB58	false	yellow fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)