#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9Y169 uniprotkb:Q9V730 intact:EBI-142791|uniprotkb:A4UZJ2|ensemblmetazoa:FBpp0099953 intact:EBI-166374|uniprotkb:O76796|uniprotkb:Q5BI21|ensemblmetazoa:FBpp0086624|ensemblmetazoa:FBpp0305367 psi-mi:ext2_drome(display_long)|uniprotkb:sotv(gene name)|psi-mi:sotv(display_short)|uniprotkb:Ext2(gene name synonym)|uniprotkb:Protein sister of tout-velu(gene name synonym)|uniprotkb:CG33038(orf name) psi-mi:ext1_drome(display_long)|uniprotkb:ttv(gene name)|psi-mi:ttv(display_short)|uniprotkb:CG10117(orf name)|uniprotkb:DEXT1(gene name synonym)|uniprotkb:Protein tout-velu(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Han et al. (2004) pubmed:14998928 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1151000 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_725536.1|flybase:FBgn0029175|ensemblmetazoa:FBgn0029175(gene)|ensemblmetazoa:FBtr0100513(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0015012"(heparan sulfate proteoglycan biosynthetic process)|go:"GO:0015014"(heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0030206"(chondroitin sulfate biosynthetic process)|go:"GO:0030210"(heparin biosynthetic process)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050508"(glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity)|go:"GO:0050509"(N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR004263(Exostosin-like)|interpro:IPR015338(EXTL2, alpha-1,4-N-acetylhexosaminyltransferase)|interpro:IPR027673|interpro:IPR029044|interpro:IPR040911|reactome:R-DME-2022928 refseq:NP_477231.1|refseq:NP_001260971.1|flybase:FBgn0265974|go:"GO:0008354"(germ cell migration)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0030210"(heparin biosynthetic process)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050508"(glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity)|go:"GO:0050509"(N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR004263(Exostosin-like)|interpro:IPR015338(EXTL2, alpha-1,4-N-acetylhexosaminyltransferase)|interpro:IPR029044|interpro:IPR040911|reactome:R-DME-2022928|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015012"(heparan sulfate proteoglycan biosynthetic process)|go:"GO:0015014"(heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process)|go:"GO:0015020"(glucuronosyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|ensemblmetazoa:FBgn0265974(gene)|ensemblmetazoa:FBtr0087495(transcript)|ensemblmetazoa:FBtr0333164(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0007411"(axon guidance) - - - figure legend:7A|comment:Interaction between Ttv and Sotv was not observed when cellular lysates from individually transfected cells were mixed and immunoprecipitated, this indicated that in vivo presence of both proteins was necessary from the interaction. taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2006/10/31 2014/10/16 rogid:pZBxzF0ipSgQ4iwtZ51x/Cll6VA7227 rogid:LLDB50D8Px9RR08s0w5lPPSZKoA7227 intact-crc:8DC5EDCB701EC040|rigid:ig3ZYiS+7bXRejHtBCkYNljx2MI false v5 tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9V730 uniprotkb:Q9Y169 intact:EBI-166374|uniprotkb:O76796|uniprotkb:Q5BI21|ensemblmetazoa:FBpp0086624|ensemblmetazoa:FBpp0305367 intact:EBI-142791|uniprotkb:A4UZJ2|ensemblmetazoa:FBpp0099953 psi-mi:ext1_drome(display_long)|uniprotkb:ttv(gene name)|psi-mi:ttv(display_short)|uniprotkb:CG10117(orf name)|uniprotkb:DEXT1(gene name synonym)|uniprotkb:Protein tout-velu(gene name synonym) psi-mi:ext2_drome(display_long)|uniprotkb:sotv(gene name)|psi-mi:sotv(display_short)|uniprotkb:Ext2(gene name synonym)|uniprotkb:Protein sister of tout-velu(gene name synonym)|uniprotkb:CG33038(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Han et al. (2004) pubmed:14998928 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1151021 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477231.1|refseq:NP_001260971.1|flybase:FBgn0265974|go:"GO:0008354"(germ cell migration)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0030210"(heparin biosynthetic process)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050508"(glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity)|go:"GO:0050509"(N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR004263(Exostosin-like)|interpro:IPR015338(EXTL2, alpha-1,4-N-acetylhexosaminyltransferase)|interpro:IPR029044|interpro:IPR040911|reactome:R-DME-2022928|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015012"(heparan sulfate proteoglycan biosynthetic process)|go:"GO:0015014"(heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process)|go:"GO:0015020"(glucuronosyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|ensemblmetazoa:FBgn0265974(gene)|ensemblmetazoa:FBtr0087495(transcript)|ensemblmetazoa:FBtr0333164(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0007411"(axon guidance) refseq:NP_725536.1|flybase:FBgn0029175|ensemblmetazoa:FBgn0029175(gene)|ensemblmetazoa:FBtr0100513(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0015012"(heparan sulfate proteoglycan biosynthetic process)|go:"GO:0015014"(heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0030206"(chondroitin sulfate biosynthetic process)|go:"GO:0030210"(heparin biosynthetic process)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050508"(glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity)|go:"GO:0050509"(N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR004263(Exostosin-like)|interpro:IPR015338(EXTL2, alpha-1,4-N-acetylhexosaminyltransferase)|interpro:IPR027673|interpro:IPR029044|interpro:IPR040911|reactome:R-DME-2022928 - - - figure legend:7A|comment:Interaction between Ttv and Sotv was not observed when cellular lysates from individually transfected cells were mixed and immunoprecipitated, this indicated that in vivo presence of both proteins was necessary fro the interaction. taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2006/10/31 2014/10/16 rogid:LLDB50D8Px9RR08s0w5lPPSZKoA7227 rogid:pZBxzF0ipSgQ4iwtZ51x/Cll6VA7227 intact-crc:3467515EE323B4E1|rigid:ig3ZYiS+7bXRejHtBCkYNljx2MI false myc tag:?-? v5 tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9V730 uniprotkb:Q9Y169 intact:EBI-166374|uniprotkb:O76796|uniprotkb:Q5BI21|ensemblmetazoa:FBpp0086624|ensemblmetazoa:FBpp0305367 intact:EBI-142791|uniprotkb:A4UZJ2|ensemblmetazoa:FBpp0099953 psi-mi:ext1_drome(display_long)|uniprotkb:ttv(gene name)|psi-mi:ttv(display_short)|uniprotkb:CG10117(orf name)|uniprotkb:DEXT1(gene name synonym)|uniprotkb:Protein tout-velu(gene name synonym) psi-mi:ext2_drome(display_long)|uniprotkb:sotv(gene name)|psi-mi:sotv(display_short)|uniprotkb:Ext2(gene name synonym)|uniprotkb:Protein sister of tout-velu(gene name synonym)|uniprotkb:CG33038(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Han et al. (2004) pubmed:14998928 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-1151049 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477231.1|refseq:NP_001260971.1|flybase:FBgn0265974|go:"GO:0008354"(germ cell migration)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0030210"(heparin biosynthetic process)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050508"(glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity)|go:"GO:0050509"(N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR004263(Exostosin-like)|interpro:IPR015338(EXTL2, alpha-1,4-N-acetylhexosaminyltransferase)|interpro:IPR029044|interpro:IPR040911|reactome:R-DME-2022928|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015012"(heparan sulfate proteoglycan biosynthetic process)|go:"GO:0015014"(heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process)|go:"GO:0015020"(glucuronosyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|ensemblmetazoa:FBgn0265974(gene)|ensemblmetazoa:FBtr0087495(transcript)|ensemblmetazoa:FBtr0333164(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0007411"(axon guidance) refseq:NP_725536.1|flybase:FBgn0029175|ensemblmetazoa:FBgn0029175(gene)|ensemblmetazoa:FBtr0100513(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0015012"(heparan sulfate proteoglycan biosynthetic process)|go:"GO:0015014"(heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0030206"(chondroitin sulfate biosynthetic process)|go:"GO:0030210"(heparin biosynthetic process)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050508"(glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity)|go:"GO:0050509"(N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR004263(Exostosin-like)|interpro:IPR015338(EXTL2, alpha-1,4-N-acetylhexosaminyltransferase)|interpro:IPR027673|interpro:IPR029044|interpro:IPR040911|reactome:R-DME-2022928 - - - figure legend:7F taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2006/10/31 2014/10/16 rogid:LLDB50D8Px9RR08s0w5lPPSZKoA7227 rogid:pZBxzF0ipSgQ4iwtZ51x/Cll6VA7227 intact-crc:CFA71CE74AC62CE5|rigid:ig3ZYiS+7bXRejHtBCkYNljx2MI false myc tag:?-? v5 tag:?-? - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:Q9V730 uniprotkb:O02393 intact:EBI-166374|uniprotkb:O76796|uniprotkb:Q5BI21|ensemblmetazoa:FBpp0086624|ensemblmetazoa:FBpp0305367 intact:EBI-1167014 psi-mi:ext1_drome(display_long)|uniprotkb:ttv(gene name)|psi-mi:ttv(display_short)|uniprotkb:CG10117(orf name)|uniprotkb:DEXT1(gene name synonym)|uniprotkb:Protein tout-velu(gene name synonym) psi-mi:o02393_drome(display_long)|uniprotkb:Cnx99A(gene name)|psi-mi:Cnx99A(display_short)|uniprotkb:CG11958(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Han et al. (2004) pubmed:14998928 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-1167031 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477231.1|refseq:NP_001260971.1|flybase:FBgn0265974|go:"GO:0008354"(germ cell migration)|go:"GO:0016757"(glycosyltransferase activity)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0030210"(heparin biosynthetic process)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050508"(glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity)|go:"GO:0050509"(N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR004263(Exostosin-like)|interpro:IPR015338(EXTL2, alpha-1,4-N-acetylhexosaminyltransferase)|interpro:IPR029044|interpro:IPR040911|reactome:R-DME-2022928|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015012"(heparan sulfate proteoglycan biosynthetic process)|go:"GO:0015014"(heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process)|go:"GO:0015020"(glucuronosyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|ensemblmetazoa:FBgn0265974(gene)|ensemblmetazoa:FBtr0087495(transcript)|ensemblmetazoa:FBtr0333164(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0007411"(axon guidance) flybase:FBgn0015622|go:"GO:0005509"(calcium ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124 go:"GO:0005783"(endoplasmic reticulum) - - figure legend:7E|comment:ER marker Calnexin was used. taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells) - 2006/10/31 2014/10/16 rogid:LLDB50D8Px9RR08s0w5lPPSZKoA7227 rogid:zDFGszvkjBq0WWWgJbz+emYDA547227 intact-crc:642D8246AE4CE562|rigid:WgCE3sF3OTX40cBRSpr4sfQTJNU false myc tag:?-? - - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining)