#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01909	uniprotkb:P01920	intact:EBI-713389|uniprotkb:O19630|uniprotkb:Q30101|uniprotkb:Q9UM31|ensembl:ENSP00000339398|ensembl:ENSP00000364087|ensembl:ENSP00000372738|ensembl:ENSP00000382583|ensembl:ENSP00000382586|ensembl:ENSP00000387892|ensembl:ENSP00000413237|ensembl:ENSP00000378767|intact:EBI-1038000|uniprotkb:Q06751|uniprotkb:Q29994|uniprotkb:Q30086|uniprotkb:Q5Y7D5|uniprotkb:O19706|uniprotkb:P01907|uniprotkb:P04225|uniprotkb:P04226|uniprotkb:P79553|uniprotkb:Q29876|uniprotkb:Q2Q6Y6|uniprotkb:Q2Q6Y7|uniprotkb:Q2Q6Y8|uniprotkb:Q2WCM3|uniprotkb:Q30064|uniprotkb:Q30067|uniprotkb:Q30068|uniprotkb:Q30070|uniprotkb:Q30071|uniprotkb:Q30072|uniprotkb:Q30073|uniprotkb:Q6ICU6|uniprotkb:Q6PR46|uniprotkb:Q6QDB1|uniprotkb:Q860W2|uniprotkb:Q860W4|uniprotkb:Q9BD37|uniprotkb:Q9TPM3|uniprotkb:Q5Y7F5|uniprotkb:P01908|uniprotkb:P05536	intact:EBI-1038012|uniprotkb:O19713|uniprotkb:O78223|uniprotkb:Q29966|uniprotkb:Q30082|uniprotkb:Q30089|uniprotkb:Q30095|uniprotkb:P01917|uniprotkb:P01918|uniprotkb:P01919|uniprotkb:P05537|uniprotkb:P79482|uniprotkb:P79526|uniprotkb:B7VU69|uniprotkb:C0MQ34|uniprotkb:O98034|uniprotkb:O98201|uniprotkb:C0MQ35|uniprotkb:C8ZL52|uniprotkb:C8ZLJ8|uniprotkb:C8ZLJ9|uniprotkb:C9DRQ3|uniprotkb:O19708|uniprotkb:O19724|uniprotkb:O62861|uniprotkb:O78046|uniprotkb:O78221|uniprotkb:A1KR27|uniprotkb:A2RPH3|uniprotkb:A4Q9R4|uniprotkb:B5BLN7|uniprotkb:A4USG2|uniprotkb:A4USG5|uniprotkb:A6N8I7|uniprotkb:A9YQA0|uniprotkb:B0S7Y7|uniprotkb:B1A0K6|uniprotkb:B1GXI3|uniprotkb:B3VLT3|uniprotkb:P03992|uniprotkb:Q8SNB4|uniprotkb:Q8SND1|uniprotkb:Q8SP70|uniprotkb:Q8WMA3|uniprotkb:Q9BD17|uniprotkb:Q9MYH2|uniprotkb:Q9TPA9|uniprotkb:Q9XRY6|uniprotkb:Q9XRY7|uniprotkb:Q9XRZ2|uniprotkb:P79544|uniprotkb:P79551|uniprotkb:Q08GC8|uniprotkb:Q09035|uniprotkb:Q0E4V9|uniprotkb:Q1M312|uniprotkb:Q29731|uniprotkb:Q29877|uniprotkb:Q29884|uniprotkb:Q29915|uniprotkb:Q2P9N3|uniprotkb:Q2QK85|uniprotkb:Q30061|uniprotkb:Q30075|uniprotkb:Q30076|uniprotkb:Q30080|uniprotkb:Q30081|uniprotkb:Q30083|uniprotkb:Q30084|uniprotkb:Q31633|uniprotkb:Q38I47|uniprotkb:Q45UE3|uniprotkb:Q4QZB5|uniprotkb:Q53I44|uniprotkb:Q564J6|uniprotkb:Q5G841|uniprotkb:Q5ISH1|uniprotkb:Q5ISH3|uniprotkb:Q5W1E1|uniprotkb:Q5Y7G8|uniprotkb:Q643R4|uniprotkb:Q6B9X1|uniprotkb:Q70VH8|uniprotkb:Q7YP69|uniprotkb:Q8HWH0|uniprotkb:Q8MH58|ensembl:ENSP00000396539|ensembl:ENSP00000402865|ensembl:ENSP00000410107|ensembl:ENSP00000410330|ensembl:ENSP00000414079|ensembl:ENSP00000382038	psi-mi:dqa1_human(display_long)|uniprotkb:DC-alpha(gene name synonym)|uniprotkb:HLA-DCA(gene name synonym)|uniprotkb:DC-1 alpha chain(gene name synonym)|uniprotkb:MHC class II DQA1(gene name synonym)|uniprotkb:HLA-DQA1(gene name)|psi-mi:HLA-DQA1(display_short)	psi-mi:dqb1_human(display_long)|uniprotkb:HLA-DQB1(gene name)|psi-mi:HLA-DQB1(display_short)|uniprotkb:HLA-DQB(gene name synonym)|uniprotkb:MHC class II antigen DQB1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Siebold et al. (2004)	pubmed:14769912	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1038032|rcsb pdb:1UVQ	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002113.2|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1JK8|rcsb pdb:1NBN|rcsb pdb:1S9V|rcsb pdb:1UVQ|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|rcsb pdb:5KSA|rcsb pdb:5KSB|rcsb pdb:5KSU|rcsb pdb:5KSV|rcsb pdb:6MFF|rcsb pdb:6MFG|rcsb pdb:6U3M|rcsb pdb:6U3N|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|ensembl:ENSG00000196735(gene)|ensembl:ENSG00000206305(gene)|ensembl:ENSG00000232062(gene)|ensembl:ENST00000343139(transcript)|ensembl:ENST00000374949(transcript)|ensembl:ENST00000383251(transcript)|ensembl:ENST00000395363(transcript)|ensembl:ENST00000399675(transcript)|ensembl:ENST00000399678(transcript)|ensembl:ENST00000418023(transcript)|ensembl:ENST00000444296(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex)	refseq:NP_002114.3|refseq:NP_001230891.1|ensembl:ENSG00000225824(gene)|ensembl:ENST00000399088(transcript)|ensembl:ENST00000413089(transcript)|ensembl:ENST00000416192(transcript)|ensembl:ENSG00000231286(gene)|ensembl:ENST00000419914(transcript)|ensembl:ENST00000422950(transcript)|ensembl:ENST00000424806(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|ensembl:ENSG00000233209(gene)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1JK8|rcsb pdb:1NBN|rcsb pdb:1S9V|rcsb pdb:1UVQ|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300	-	-	-	assembly:trimeric, multimeric|3d-r-factors:working 81.100%, free 79.500%|3d-resolution:1.8A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:cU5mVu+BL26LvdsGgq5F64+4Wm09606	rogid:aHNr7nDJWr7CrSHrZqsv9VVTFyc9606	intact-crc:6CFBDC45C5A40318|rigid:OR2SHWIPbU4mzCrRt/P8cOr4R88	false	sufficient binding region:24-219	sufficient binding region:35-230	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01909	uniprotkb:O43612	intact:EBI-713389|uniprotkb:O19630|uniprotkb:Q30101|uniprotkb:Q9UM31|ensembl:ENSP00000339398|ensembl:ENSP00000364087|ensembl:ENSP00000372738|ensembl:ENSP00000382583|ensembl:ENSP00000382586|ensembl:ENSP00000387892|ensembl:ENSP00000413237|ensembl:ENSP00000378767|intact:EBI-1038000|uniprotkb:Q06751|uniprotkb:Q29994|uniprotkb:Q30086|uniprotkb:Q5Y7D5|uniprotkb:O19706|uniprotkb:P01907|uniprotkb:P04225|uniprotkb:P04226|uniprotkb:P79553|uniprotkb:Q29876|uniprotkb:Q2Q6Y6|uniprotkb:Q2Q6Y7|uniprotkb:Q2Q6Y8|uniprotkb:Q2WCM3|uniprotkb:Q30064|uniprotkb:Q30067|uniprotkb:Q30068|uniprotkb:Q30070|uniprotkb:Q30071|uniprotkb:Q30072|uniprotkb:Q30073|uniprotkb:Q6ICU6|uniprotkb:Q6PR46|uniprotkb:Q6QDB1|uniprotkb:Q860W2|uniprotkb:Q860W4|uniprotkb:Q9BD37|uniprotkb:Q9TPM3|uniprotkb:Q5Y7F5|uniprotkb:P01908|uniprotkb:P05536	intact:EBI-1037990|ensembl:ENSP00000293330	psi-mi:dqa1_human(display_long)|uniprotkb:DC-alpha(gene name synonym)|uniprotkb:HLA-DCA(gene name synonym)|uniprotkb:DC-1 alpha chain(gene name synonym)|uniprotkb:MHC class II DQA1(gene name synonym)|uniprotkb:HLA-DQA1(gene name)|psi-mi:HLA-DQA1(display_short)	psi-mi:orex_human(display_long)|uniprotkb:HCRT(gene name)|psi-mi:HCRT(display_short)|uniprotkb:OX(gene name synonym)|uniprotkb:PPORX(gene name synonym)|uniprotkb:PPOX(gene name synonym)|uniprotkb:Hypocretin(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Siebold et al. (2004)	pubmed:14769912	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1038032|rcsb pdb:1UVQ	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002113.2|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1JK8|rcsb pdb:1NBN|rcsb pdb:1S9V|rcsb pdb:1UVQ|rcsb pdb:2NNA|rcsb pdb:4GG6|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|rcsb pdb:5KSA|rcsb pdb:5KSB|rcsb pdb:5KSU|rcsb pdb:5KSV|rcsb pdb:6MFF|rcsb pdb:6MFG|rcsb pdb:6U3M|rcsb pdb:6U3N|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|ensembl:ENSG00000196735(gene)|ensembl:ENSG00000206305(gene)|ensembl:ENSG00000232062(gene)|ensembl:ENST00000343139(transcript)|ensembl:ENST00000374949(transcript)|ensembl:ENST00000383251(transcript)|ensembl:ENST00000395363(transcript)|ensembl:ENST00000399675(transcript)|ensembl:ENST00000399678(transcript)|ensembl:ENST00000418023(transcript)|ensembl:ENST00000444296(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010008"(endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042613"(MHC class II protein complex)	refseq:NP_001515.1|ensembl:ENSG00000161610(gene)|ensembl:ENST00000293330(transcript)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0030141"(secretory granule)|go:"GO:0030431"(sleep)|go:"GO:0031771"(type 1 hypocretin receptor binding)|go:"GO:0031772"(type 2 hypocretin receptor binding)|go:"GO:0042594"(response to starvation)|go:"GO:0042755"(eating behavior)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051970"(negative regulation of transmission of nerve impulse)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR001704(Prepro-orexin)|rcsb pdb:1CQ0|rcsb pdb:1R02|rcsb pdb:1UVQ|rcsb pdb:1WSO|rcsb pdb:7L1U|reactome:R-HSA-389397|reactome:R-HSA-416476	-	-	-	assembly:trimeric, multimeric|3d-r-factors:working 81.100%, free 79.500%|3d-resolution:1.8A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:cU5mVu+BL26LvdsGgq5F64+4Wm09606	rogid:m5DbrFqj577JZWIMDWH/N9iql2E9606	intact-crc:6CFBDC45C5A40318|rigid:OR2SHWIPbU4mzCrRt/P8cOr4R88	false	sufficient binding region:24-219	sufficient binding region:1-13	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)