#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P00734	uniprotkb:P07204	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	intact:EBI-941422|uniprotkb:Q8IV29|uniprotkb:Q9UC32|ensembl:ENSP00000366307	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:trbm_human(display_long)|uniprotkb:THBD(gene name)|psi-mi:THBD(display_short)|uniprotkb:THRM(gene name synonym)|uniprotkb:Fetomodulin(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Baerga-Ortiz et al. (2004)	pubmed:14691232|imex:IM-20080	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941421|imex:IM-20080-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	refseq:NP_000352.1|ensembl:ENSG00000178726(gene)|ensembl:ENST00000377103(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0051918"(negative regulation of fibrinolysis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015149(Thrombomodulin-like, EGF-like)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR016316(Complement component C1q/Thrombomodulin)|interpro:IPR018097|interpro:IPR026823|rcsb pdb:1ADX|rcsb pdb:1DQB|rcsb pdb:1DX5|rcsb pdb:1EGT|rcsb pdb:1FGD|rcsb pdb:1FGE|rcsb pdb:1HLT|rcsb pdb:1TMR|rcsb pdb:1ZAQ|rcsb pdb:2ADX|rcsb pdb:3GIS|rcsb pdb:5TO3|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	comment:Thrombin is activated before use, however since activated thrombin involves describing two cleavage groups forming a complex, I have left it as parent protein plus a comment.|comment:"Thrombin purified from plasma barium citrate eluate, activated by PPACK (Phe-Pro-Arg-chloromethylketone) and repurified before use."|figure legend:2b, 5 and Table 1|kinetics:Association rate constant ka = 2.0 x 10 exp7 M-1sec-1|kinetics:Dissociation rate constant kd = 0.037 sec-1|comment:Run conditions 298 K and 150 mM NaCl.|comment:The favorable entropy of the thrombin�TM interaction seems to be derived from electrostatic steering and a contribution from solvent release, the thrombin�TM interaction showed no significant trend in lnKD over the temperature range studied.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	rogid:6plk9lmL2aEGHQfdwj/wXLkAocg9606	intact-crc:D4F66D92E8907518|rigid:L00222Y3y1eh/RDomOlMrNprSKY	false	-	sufficient binding region:362-484(IPR006210)|biotin tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-941456	uniprotkb:P00734	-	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	psi-mi:anti-thrombin_mus_pe(display_short)|psi-mi:EBI-941456(display_long)	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Baerga-Ortiz et al. (2004)	pubmed:14691232|imex:IM-20080	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941479|imex:IM-20080-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Mouse monoclonal antibody raised against human thrombin	-	comment:"Thrombin purified from plasma barium citrate eluate, activated by PPACK (Phe-Pro-Arg-chloromethylketone) and repurified before use."|figure legend:2b|kinetics:Association rate constant ka = 6.40 x 10exp5 M-1sec-1|kinetics:Dissociation rate constant kd = 0.001 sec-1|comment:Run conditions of 298 K and 150 mM NaCl.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	-	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	intact-crc:C0DF1F95A2DB1610	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00734	uniprotkb:P07204	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	intact:EBI-941422|uniprotkb:Q8IV29|uniprotkb:Q9UC32|ensembl:ENSP00000366307	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:trbm_human(display_long)|uniprotkb:THBD(gene name)|psi-mi:THBD(display_short)|uniprotkb:THRM(gene name synonym)|uniprotkb:Fetomodulin(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Baerga-Ortiz et al. (2004)	pubmed:14691232|imex:IM-20080	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941543|imex:IM-20080-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	refseq:NP_000352.1|ensembl:ENSG00000178726(gene)|ensembl:ENST00000377103(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0051918"(negative regulation of fibrinolysis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015149(Thrombomodulin-like, EGF-like)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR016316(Complement component C1q/Thrombomodulin)|interpro:IPR018097|interpro:IPR026823|rcsb pdb:1ADX|rcsb pdb:1DQB|rcsb pdb:1DX5|rcsb pdb:1EGT|rcsb pdb:1FGD|rcsb pdb:1FGE|rcsb pdb:1HLT|rcsb pdb:1TMR|rcsb pdb:1ZAQ|rcsb pdb:2ADX|rcsb pdb:3GIS|rcsb pdb:5TO3|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	comment:"Thrombin purified from plasma barium citrate eluate, activated by PPACK (Phe-Pro-Arg-chloromethylketone) and repurified before use."|figure legend:2b, 5 and Table 1|kinetics:Association rate constant ka = 7.82 x 10 exp6 M-1sec-1|kinetics:Dissociation rate constant kd = 0.028 sec-1|comment:Run conditions 279 K and 150 mM NaCl.|comment:The favorable entropy of the thrombin�TM interaction seems to be derived from electrostatic steering and a contribution from solvent release, the thrombin�TM interaction showed no significant trend in lnKD over the temperature range studied.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	rogid:6plk9lmL2aEGHQfdwj/wXLkAocg9606	intact-crc:CAC9B47E2F0B8E32|rigid:L00222Y3y1eh/RDomOlMrNprSKY	false	-	sufficient binding region:362-484|biotin tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07204	uniprotkb:P00734	intact:EBI-941422|uniprotkb:Q8IV29|uniprotkb:Q9UC32|ensembl:ENSP00000366307	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	psi-mi:trbm_human(display_long)|uniprotkb:THBD(gene name)|psi-mi:THBD(display_short)|uniprotkb:THRM(gene name synonym)|uniprotkb:Fetomodulin(gene name synonym)	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Baerga-Ortiz et al. (2004)	pubmed:14691232|imex:IM-20080	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941558|imex:IM-20080-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000352.1|ensembl:ENSG00000178726(gene)|ensembl:ENST00000377103(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0051918"(negative regulation of fibrinolysis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015149(Thrombomodulin-like, EGF-like)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR016316(Complement component C1q/Thrombomodulin)|interpro:IPR018097|interpro:IPR026823|rcsb pdb:1ADX|rcsb pdb:1DQB|rcsb pdb:1DX5|rcsb pdb:1EGT|rcsb pdb:1FGD|rcsb pdb:1FGE|rcsb pdb:1HLT|rcsb pdb:1TMR|rcsb pdb:1ZAQ|rcsb pdb:2ADX|rcsb pdb:3GIS|rcsb pdb:5TO3|reactome:R-HSA-140875|reactome:R-HSA-202733	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	-	-	-	comment:"Thrombin purified from plasma barium citrate eluate, activated by PPACK (Phe-Pro-Arg-chloromethylketone) and repurified before use."|figure legend:2b, 5 and Table 1|kinetics:Association rate constant ka = 3.78 x 10 exp7 M-1sec-1|kinetics:Dissociation rate constant kd = 0.072 sec-1|comment:Run conditions 293 K and 150 mM NaCl.|comment:The favorable entropy of the thrombin�TM interaction seems to be derived from electrostatic steering and a contribution from solvent release, the thrombin�TM interaction showed no significant trend in lnKD over the temperature range studied.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:6plk9lmL2aEGHQfdwj/wXLkAocg9606	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	intact-crc:A36542D3E5754A1F|rigid:L00222Y3y1eh/RDomOlMrNprSKY	false	biotin tag:n-n|sufficient binding region:362-484	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00734	uniprotkb:P07204	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	intact:EBI-941422|uniprotkb:Q8IV29|uniprotkb:Q9UC32|ensembl:ENSP00000366307	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:trbm_human(display_long)|uniprotkb:THBD(gene name)|psi-mi:THBD(display_short)|uniprotkb:THRM(gene name synonym)|uniprotkb:Fetomodulin(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Baerga-Ortiz et al. (2004)	pubmed:14691232|imex:IM-20080	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941573|imex:IM-20080-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	refseq:NP_000352.1|ensembl:ENSG00000178726(gene)|ensembl:ENST00000377103(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007565"(female pregnancy)|go:"GO:0007596"(blood coagulation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0051918"(negative regulation of fibrinolysis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015149(Thrombomodulin-like, EGF-like)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR016316(Complement component C1q/Thrombomodulin)|interpro:IPR018097|interpro:IPR026823|rcsb pdb:1ADX|rcsb pdb:1DQB|rcsb pdb:1DX5|rcsb pdb:1EGT|rcsb pdb:1FGD|rcsb pdb:1FGE|rcsb pdb:1HLT|rcsb pdb:1TMR|rcsb pdb:1ZAQ|rcsb pdb:2ADX|rcsb pdb:3GIS|rcsb pdb:5TO3|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	comment:"Thrombin purified from plasma barium citrate eluate, activated by PPACK (Phe-Pro-Arg-chloromethylketone) and repurified before use."|figure legend:2b, 5 and Table 1|kinetics:Association rate constant ka = 2.89 x 10 exp7 M-1sec-1|kinetics:Dissociation rate constant kd = 0.055 sec-1|comment:Run conditions 313 K and 150 mM NaCl.|comment:The favorable entropy of the thrombin�TM interaction seems to be derived from electrostatic steering and a contribution from solvent release, the thrombin�TM interaction showed no significant trend in lnKD over the temperature range studied.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	rogid:6plk9lmL2aEGHQfdwj/wXLkAocg9606	intact-crc:32B5EA0C02B94244|rigid:L00222Y3y1eh/RDomOlMrNprSKY	false	-	sufficient binding region:362-484|biotin tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00734	intact:EBI-941456	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	-	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:anti-thrombin_mus_pe(display_short)|psi-mi:EBI-941456(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Baerga-Ortiz et al. (2004)	pubmed:14691232|imex:IM-20080	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941586|imex:IM-20080-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	-	-	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Mouse monoclonal antibody raised against human thrombin	comment:"Thrombin purified from plasma barium citrate eluate, activated by PPACK (Phe-Pro-Arg-chloromethylketone) and repurified before use."|figure legend:2b, 4, 5a, Table 1|kinetics:Association rate constant ka = 4.22 x 10exp5 M-1sec-1|kinetics:Dissociation rate constant kd = 0.00009 sec-1|comment:Run conditions of 279 K and 150 mM NaCl.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	-	intact-crc:2EA2B0B339A4272E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-941456	uniprotkb:P00734	-	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	psi-mi:anti-thrombin_mus_pe(display_short)|psi-mi:EBI-941456(display_long)	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Baerga-Ortiz et al. (2004)	pubmed:14691232|imex:IM-20080	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941594|imex:IM-20080-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Mouse monoclonal antibody raised against human thrombin	-	comment:"Thrombin purified from plasma barium citrate eluate, activated by PPACK (Phe-Pro-Arg-chloromethylketone) and repurified before use."|figure legend:2b, 4, 5a, Table 1|kinetics:Association rate constant ka = 1.13 x 10exp5 M-1sec-1|kinetics:Dissociation rate constant kd = 0.00005 sec-1|comment:Run conditions of 288 K and 150 mM NaCl.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	-	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	intact-crc:077298983356686A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-941456	uniprotkb:P00734	-	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	psi-mi:anti-thrombin_mus_pe(display_short)|psi-mi:EBI-941456(display_long)	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Baerga-Ortiz et al. (2004)	pubmed:14691232|imex:IM-20080	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941604|imex:IM-20080-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Mouse monoclonal antibody raised against human thrombin	-	comment:"Thrombin purified from plasma barium citrate eluate, activated by PPACK (Phe-Pro-Arg-chloromethylketone) and repurified before use."|figure legend:2b, 4, 5a, Table 1|kinetics:Association rate constant ka = 4.34 x 10exp5 M-1sec-1|kinetics:Dissociation rate constant kd = 0.00035 sec-1|comment:Run conditions of 293 K and 150 mM NaCl.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	-	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	intact-crc:629C5D9B600ABAB0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00734	intact:EBI-941456	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	-	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:anti-thrombin_mus_pe(display_short)|psi-mi:EBI-941456(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Baerga-Ortiz et al. (2004)	pubmed:14691232|imex:IM-20080	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941620|imex:IM-20080-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	-	-	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Mouse monoclonal antibody raised against human thrombin	comment:"Thrombin purified from plasma barium citrate eluate, activated by PPACK (Phe-Pro-Arg-chloromethylketone) and repurified before use."|figure legend:2b, 4, 5a, Table 1|kinetics:Association rate constant ka = 9.24 x 10exp5 M-1sec-1|kinetics:Dissociation rate constant kd = 0.00168 sec-1|comment:Run conditions of 303 K and 150 mM NaCl.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	-	intact-crc:A70190F8D18CB7AF	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-941456	uniprotkb:P00734	-	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	psi-mi:anti-thrombin_mus_pe(display_short)|psi-mi:EBI-941456(display_long)	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Baerga-Ortiz et al. (2004)	pubmed:14691232|imex:IM-20080	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941630|imex:IM-20080-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Mouse monoclonal antibody raised against human thrombin	-	comment:"Thrombin purified from plasma barium citrate eluate, activated by PPACK (Phe-Pro-Arg-chloromethylketone) and repurified before use."|figure legend:2b, 4, 5a, Table 1|kinetics:Association rate constant ka = 9.33 x 10exp5 M-1sec-1|kinetics:Dissociation rate constant kd = 0.002 sec-1|comment:Run conditions of 310 K and 150 mM NaCl.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	-	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	intact-crc:578B125761B7195F	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-941456	uniprotkb:P00734	-	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	psi-mi:anti-thrombin_mus_pe(display_short)|psi-mi:EBI-941456(display_long)	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Baerga-Ortiz et al. (2004)	pubmed:14691232|imex:IM-20080	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941640|imex:IM-20080-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Mouse monoclonal antibody raised against human thrombin	-	comment:"Thrombin purified from plasma barium citrate eluate, activated by PPACK (Phe-Pro-Arg-chloromethylketone) and repurified before use."|figure legend:2b, 4, 5a, Table 1|kinetics:Association rate constant ka = 1.06 x 10exp6 M-1sec-1|kinetics:Dissociation rate constant kd = 0.00195 sec-1|comment:Run conditions of 313 K and 150 mM NaCl.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	-	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	intact-crc:C187ABD4F92DC51D	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-941456	uniprotkb:P00734	-	intact:EBI-297094|ensembl:ENSP00000308541|uniprotkb:B2R7F7|uniprotkb:B4E1A7|uniprotkb:Q4QZ40|uniprotkb:Q53H04|uniprotkb:Q53H06|uniprotkb:Q7Z7P3|uniprotkb:Q9UCA1|uniprotkb:Q69EZ7	psi-mi:anti-thrombin_mus_pe(display_short)|psi-mi:EBI-941456(display_long)	psi-mi:thrb_human(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Baerga-Ortiz et al. (2004)	pubmed:14691232|imex:IM-20080	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941519|imex:IM-20080-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:1BTH|rcsb pdb:1C1U|rcsb pdb:1C1V|rcsb pdb:1C1W|rcsb pdb:1C4U|rcsb pdb:1C4V|rcsb pdb:1C4Y|rcsb pdb:1C5L|rcsb pdb:1C5N|rcsb pdb:1C5O|rcsb pdb:1CA8|rcsb pdb:1D3D|rcsb pdb:1D3P|rcsb pdb:1D3Q|rcsb pdb:1D3T|rcsb pdb:1D4P|rcsb pdb:1D6W|rcsb pdb:1BMN|rcsb pdb:1D9I|rcsb pdb:1DE7|rcsb pdb:1DIT|rcsb pdb:1DM4|rcsb pdb:1DOJ|rcsb pdb:1DWB|rcsb pdb:1DWC|rcsb pdb:1DWD|rcsb pdb:1LHF|rcsb pdb:1LHG|rcsb pdb:1MH0|rcsb pdb:1MU6|rcsb pdb:1MU8|rcsb pdb:1MUE|rcsb pdb:1NM6|rcsb pdb:1NO9|rcsb pdb:1NRN|rcsb pdb:1NRO|rcsb pdb:1NRP|rcsb pdb:1NRQ|rcsb pdb:1NRR|rcsb pdb:1NRS|rcsb pdb:1DWE|rcsb pdb:1NT1|rcsb pdb:1NU7|rcsb pdb:1NU9|rcsb pdb:1KTT|rcsb pdb:1LHC|rcsb pdb:1NY2|rcsb pdb:1NZQ|rcsb pdb:1LHD|rcsb pdb:1O0D|rcsb pdb:1O2G|rcsb pdb:1LHE|rcsb pdb:1O5G|rcsb pdb:1OOK|rcsb pdb:1OYT|rcsb pdb:1P8V|rcsb pdb:1PPB|rcsb pdb:1HAG|rcsb pdb:1HAH|rcsb pdb:1DX5|rcsb pdb:1E0F|rcsb pdb:1EB1|rcsb pdb:1HAI|rcsb pdb:1HAO|rcsb pdb:1EOJ|rcsb pdb:1EOL|rcsb pdb:1FPC|rcsb pdb:1FPH|rcsb pdb:1HAP|rcsb pdb:1HBT|rcsb pdb:1G30|rcsb pdb:1G32|rcsb pdb:1G37|rcsb pdb:1GHV|rcsb pdb:1HDT|rcsb pdb:1HGT|rcsb pdb:1GHW|rcsb pdb:1GHX|rcsb pdb:1GHY|rcsb pdb:1GJ4|rcsb pdb:1GJ5|rcsb pdb:1HLT|rcsb pdb:1HUT|rcsb pdb:1HXE|rcsb pdb:1HXF|rcsb pdb:1IHS|rcsb pdb:1IHT|rcsb pdb:1H8D|rcsb pdb:1H8I|rcsb pdb:1JMO|rcsb pdb:1JOU|rcsb pdb:1JWT|rcsb pdb:1K21|rcsb pdb:1K22|rcsb pdb:1KTS|ensembl:ENST00000311907(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|ensembl:ENSG00000180210(gene)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0072562"(blood microparticle)|go:"GO:0042730"(fibrinolysis)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|rcsb pdb:1A3B|rcsb pdb:1A3E|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|rcsb pdb:1A46|rcsb pdb:1A4W|interpro:IPR018056|rcsb pdb:1A5G|rcsb pdb:1A61|rcsb pdb:1ABI|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|rcsb pdb:1ABJ|rcsb pdb:1AD8|interpro:IPR035972|rcsb pdb:1AE8|rcsb pdb:1AFE|rcsb pdb:1AHT|rcsb pdb:1AI8|rcsb pdb:1AIX|rcsb pdb:1AWF|rcsb pdb:1AWH|rcsb pdb:1AY6|interpro:IPR037111|rcsb pdb:1B5G|rcsb pdb:1B7X|rcsb pdb:1BA8|rcsb pdb:1BB0|rcsb pdb:1BCU|interpro:IPR038178|rcsb pdb:1BHX|interpro:IPR043504|mint:P00734|rcsb pdb:1BMM|rcsb pdb:1A2C|rcsb pdb:2ZI2|rcsb pdb:2ZIQ|rcsb pdb:2ZNK|rcsb pdb:2ZO3|rcsb pdb:3B23|rcsb pdb:2ZHW|rcsb pdb:3B9F|rcsb pdb:3BEF|rcsb pdb:3BEI|rcsb pdb:3BF6|rcsb pdb:3BIU|rcsb pdb:3BIV|rcsb pdb:3BV9|rcsb pdb:3C1K|rcsb pdb:3C27|rcsb pdb:3D49|rcsb pdb:3DA9|rcsb pdb:3DD2|rcsb pdb:3DHK|rcsb pdb:3DT0|rcsb pdb:3DUX|rcsb pdb:3E6P|rcsb pdb:3EE0|rcsb pdb:3EGK|rcsb pdb:3EQ0|rcsb pdb:3F68|rcsb pdb:3GIC|rcsb pdb:3GIS|rcsb pdb:3HAT|rcsb pdb:3HKJ|rcsb pdb:3HTC|rcsb pdb:3JZ1|rcsb pdb:3JZ2|rcsb pdb:3K65|rcsb pdb:3LDX|rcsb pdb:3LU9|rcsb pdb:3NXP|rcsb pdb:3P17|rcsb pdb:3P6Z|rcsb pdb:3P70|rcsb pdb:3PMH|rcsb pdb:3PO1|rcsb pdb:3QDZ|rcsb pdb:3QGN|rcsb pdb:3QLP|rcsb pdb:3QTO|rcsb pdb:3QTV|rcsb pdb:3QWC|rcsb pdb:3QX5|rcsb pdb:1QBV|rcsb pdb:1QHR|rcsb pdb:1QJ1|rcsb pdb:1QJ6|rcsb pdb:1TB6|rcsb pdb:1QJ7|rcsb pdb:1QUR|rcsb pdb:1RD3|rcsb pdb:1TBZ|rcsb pdb:1RIW|rcsb pdb:1THP|rcsb pdb:1THR|rcsb pdb:1THS|rcsb pdb:1SB1|rcsb pdb:1SFQ|rcsb pdb:1SG8|rcsb pdb:1SGI|rcsb pdb:1SHH|rcsb pdb:1TMB|rcsb pdb:1SL3|rcsb pdb:1SR5|rcsb pdb:1T4U|rcsb pdb:1T4V|rcsb pdb:1TA2|rcsb pdb:1TMT|rcsb pdb:1TMU|rcsb pdb:1TOM|rcsb pdb:1TQ0|rcsb pdb:1TQ7|rcsb pdb:1TWX|rcsb pdb:1UMA|rcsb pdb:1UVS|rcsb pdb:1VR1|rcsb pdb:1VZQ|rcsb pdb:1W7G|rcsb pdb:1WAY|rcsb pdb:1WBG|rcsb pdb:1XM1|rcsb pdb:1XMN|rcsb pdb:1YPE|rcsb pdb:1YPG|rcsb pdb:1YPJ|rcsb pdb:1YPK|rcsb pdb:1YPL|rcsb pdb:1TA6|rcsb pdb:1YPM|rcsb pdb:1Z71|rcsb pdb:2AFQ|rcsb pdb:2ANK|rcsb pdb:2ANM|rcsb pdb:2B5T|rcsb pdb:2BDY|rcsb pdb:2BVR|rcsb pdb:2BVS|rcsb pdb:2BVX|rcsb pdb:2BXT|rcsb pdb:2BXU|rcsb pdb:2C8W|rcsb pdb:2C8X|rcsb pdb:2C8Y|rcsb pdb:2C8Z|rcsb pdb:2C90|rcsb pdb:2C93|rcsb pdb:2CF8|rcsb pdb:2CF9|rcsb pdb:1Z8I|rcsb pdb:2CN0|rcsb pdb:2FEQ|rcsb pdb:1Z8J|rcsb pdb:1ZGI|rcsb pdb:1ZGV|rcsb pdb:1ZRB|rcsb pdb:2A0Q|rcsb pdb:2A2X|rcsb pdb:2FES|rcsb pdb:2GDE|rcsb pdb:2GP9|rcsb pdb:2A45|rcsb pdb:2H9T|rcsb pdb:2HGT|rcsb pdb:2HNT|rcsb pdb:2HPP|rcsb pdb:2HPQ|rcsb pdb:2HWL|rcsb pdb:3RLW|rcsb pdb:3RLY|rcsb pdb:3RM0|rcsb pdb:3R3G|rcsb pdb:3RM2|rcsb pdb:3RML|rcsb pdb:3RMM|rcsb pdb:3RMN|rcsb pdb:3RMO|rcsb pdb:3S7H|rcsb pdb:3S7K|rcsb pdb:3SHA|rcsb pdb:3SHC|rcsb pdb:3SI3|rcsb pdb:3SI4|rcsb pdb:3SQE|rcsb pdb:3SQH|rcsb pdb:3SV2|rcsb pdb:3T5F|rcsb pdb:3TU7|rcsb pdb:3U69|rcsb pdb:3U8O|rcsb pdb:3U8R|rcsb pdb:3U8T|rcsb pdb:3U98|rcsb pdb:3U9A|rcsb pdb:3UTU|rcsb pdb:3UWJ|rcsb pdb:3VXE|rcsb pdb:3VXF|rcsb pdb:4AX9|rcsb pdb:4AYV|rcsb pdb:4AYY|rcsb pdb:4AZ2|rcsb pdb:4BAH|rcsb pdb:4BAK|rcsb pdb:4BAM|rcsb pdb:4BAN|rcsb pdb:4BAO|rcsb pdb:4BAQ|rcsb pdb:4BOH|rcsb pdb:4CH2|rcsb pdb:4CH8|rcsb pdb:4DIH|rcsb pdb:4DII|rcsb pdb:4DT7|rcsb pdb:4DY7|rcsb pdb:4E05|rcsb pdb:4E7R|rcsb pdb:4H6S|rcsb pdb:4H6T|rcsb pdb:4HFP|rcsb pdb:4HTC|rcsb pdb:4HZH|rcsb pdb:4I7Y|rcsb pdb:4LOY|rcsb pdb:4LXB|rcsb pdb:4LZ1|rcsb pdb:4LZ4|rcsb pdb:4MLF|rcsb pdb:4NZQ|rcsb pdb:4O03|rcsb pdb:4RKJ|rcsb pdb:4RKO|rcsb pdb:4RN6|rcsb pdb:4THN|rcsb pdb:4UD9|rcsb pdb:4UDW|rcsb pdb:4UE7|rcsb pdb:4UEH|rcsb pdb:4UFD|rcsb pdb:4UFE|rcsb pdb:4UFF|rcsb pdb:4UFG|rcsb pdb:4YES|rcsb pdb:5A2M|rcsb pdb:5AF9|rcsb pdb:4E06|rcsb pdb:5AFY|rcsb pdb:5AHG|rcsb pdb:5CMX|rcsb pdb:5DO4|rcsb pdb:5E8E|rcsb pdb:5EDK|rcsb pdb:5EDM|rcsb pdb:5EW1|rcsb pdb:5EW2|rcsb pdb:5GDS|rcsb pdb:5GIM|rcsb pdb:5JDU|rcsb pdb:5JFD|rcsb pdb:5JZY|rcsb pdb:5L6N|rcsb pdb:5MJT|rcsb pdb:5MLS|rcsb pdb:5MM6|rcsb pdb:5NHU|rcsb pdb:5TO3|rcsb pdb:5Z5W|rcsb pdb:5Z5X|rcsb pdb:6BJR|rcsb pdb:6C2W|rcsb pdb:6EO6|rcsb pdb:6EO7|rcsb pdb:6EO8|rcsb pdb:6EO9|rcsb pdb:6V5T|rcsb pdb:7KME|rcsb pdb:8KME|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|reactome:R-HSA-202733|reactome:R-HSA-375276|reactome:R-HSA-381426|reactome:R-HSA-416476|rcsb pdb:5AFZ|rcsb pdb:2JH5|rcsb pdb:2JH6|rcsb pdb:2OD3|rcsb pdb:2PGB|rcsb pdb:2PGQ|rcsb pdb:2PKS|rcsb pdb:2PW8|rcsb pdb:2R2M|rcsb pdb:2THF|rcsb pdb:2UUF|rcsb pdb:2UUJ|rcsb pdb:2UUK|rcsb pdb:2V3H|rcsb pdb:2V3O|rcsb pdb:2ZC9|rcsb pdb:2ZDA|rcsb pdb:2ZDV|rcsb pdb:2ZF0|rcsb pdb:2ZFF|rcsb pdb:2ZFP|rcsb pdb:2ZFQ|rcsb pdb:2ZFR|rcsb pdb:2ZG0|rcsb pdb:2JH0|rcsb pdb:2ZGB|rcsb pdb:2ZGX|rcsb pdb:2ZHE|rcsb pdb:2ZHF|rcsb pdb:2ZHQ|reactome:R-HSA-76009|reactome:R-HSA-9657688|reactome:R-HSA-9672391|reactome:R-HSA-977606|reactome:R-HSA-456926|refseq:NP_000497.1|refseq:NP_001298186.1|dip:DIP-6115N	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Mouse monoclonal antibody raised against human thrombin	-	comment:"Thrombin purified from plasma barium citrate eluate, activated by PPACK (Phe-Pro-Arg-chloromethylketone) and repurified before use."|figure legend:3A and 3B|kinetics:{Delta}Hobs = -8.2 � 0.9 kcal per mole of thrombin|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	-	rogid:f6OQ6v3WbFpxr7N6GhfZOHjSsTQ9606	intact-crc:2A3E1587D0D4B679	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)