#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q07688	uniprotkb:P39928	intact:EBI-34423|uniprotkb:D6VRC1|ensemblfungi:YDL235C	intact:EBI-17357|uniprotkb:D6VVE0|ensemblfungi:YIL147C	psi-mi:ypd1_yeast(display_long)|uniprotkb:YPD1(gene name)|psi-mi:YPD1(display_short)|uniprotkb:Histidine-containing phosphotransfer protein YPD1(gene name synonym)|uniprotkb:Tyrosine phosphatase-dependent protein 1(gene name synonym)|uniprotkb:D0790(orf name)|uniprotkb:YDL235C(locus name)	psi-mi:sln1_yeast(display_long)|uniprotkb:YIL147C(locus name)|uniprotkb:SLN1(gene name)|psi-mi:SLN1(display_short)|uniprotkb:YPD2(gene name synonym)|uniprotkb:Osmolarity two-component system protein SLN1(gene name synonym)|uniprotkb:Tyrosine phosphatase-dependent protein 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Xu et al. (2003)	pubmed:14656441	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1037541|rcsb pdb:1OXB	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010046.1|sgd:S000002394|mint:Q07688|dip:DIP-5899N|ensemblfungi:YDL235C(gene)|ensemblfungi:YDL235C_mRNA(transcript)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007234"(osmosensory signaling via phosphorelay pathway)|go:"GO:0009927"(histidine phosphotransfer kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016772"(transferase activity, transferring phosphorus-containing groups)|go:"GO:0043424"(protein histidine kinase binding)|interpro:IPR008207("Signal transduction histidine kinase, phosphotransfer (Hpt) region")|interpro:IPR036641|rcsb pdb:1C02|rcsb pdb:1C03|rcsb pdb:1OXB|rcsb pdb:1OXK|rcsb pdb:1QSP|rcsb pdb:2R25|rcsb pdb:5KBX|rcsb pdb:6M7W	refseq:NP_012119.1|sgd:S000001409|ensemblfungi:YIL147C(gene)|ensemblfungi:YIL147C_mRNA(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007234"(osmosensory signaling via phosphorelay pathway)|go:"GO:0009927"(histidine phosphotransfer kinase activity)|go:"GO:0018106"(peptidyl-histidine phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071944"(cell periphery)|interpro:IPR001789(Signal transduction response regulator, receiver region)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003660(Signal transduction histidine kinase, HAMP region)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR011006(CheY-like)|interpro:IPR036097|interpro:IPR036890|rcsb pdb:1OXB|rcsb pdb:1OXK|rcsb pdb:2R25|dip:DIP-2939N|mint:P39928	-	crc64:4B923E621C57783D	crc64:45FFE24A8165486B	assembly:dimeric, multimeric|3d-r-factors:working 78.600%, free 73.400%|3d-resolution:2.3A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:YN/TB6a79rhT0M1R09pLAyj/Xac559292	rogid:9MmMp/opdyg0Fiu8CY+eTEylx0Q559292	intact-crc:B27CA2E2E8F1B50C|rigid:mTIszi5ne6nccr/4ddGf5ercUt4	false	sufficient binding region:2-167	sufficient binding region:1087-1220	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39928	uniprotkb:Q07688	intact:EBI-17357|uniprotkb:D6VVE0|ensemblfungi:YIL147C	intact:EBI-34423|uniprotkb:D6VRC1|ensemblfungi:YDL235C	psi-mi:sln1_yeast(display_long)|uniprotkb:YIL147C(locus name)|uniprotkb:SLN1(gene name)|psi-mi:SLN1(display_short)|uniprotkb:YPD2(gene name synonym)|uniprotkb:Osmolarity two-component system protein SLN1(gene name synonym)|uniprotkb:Tyrosine phosphatase-dependent protein 2(gene name synonym)	psi-mi:ypd1_yeast(display_long)|uniprotkb:YPD1(gene name)|psi-mi:YPD1(display_short)|uniprotkb:Histidine-containing phosphotransfer protein YPD1(gene name synonym)|uniprotkb:Tyrosine phosphatase-dependent protein 1(gene name synonym)|uniprotkb:D0790(orf name)|uniprotkb:YDL235C(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Xu et al. (2003)	pubmed:14656441	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1037552|rcsb pdb:1OXK	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012119.1|sgd:S000001409|ensemblfungi:YIL147C(gene)|ensemblfungi:YIL147C_mRNA(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007234"(osmosensory signaling via phosphorelay pathway)|go:"GO:0009927"(histidine phosphotransfer kinase activity)|go:"GO:0018106"(peptidyl-histidine phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071944"(cell periphery)|interpro:IPR001789(Signal transduction response regulator, receiver region)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003660(Signal transduction histidine kinase, HAMP region)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR011006(CheY-like)|interpro:IPR036097|interpro:IPR036890|rcsb pdb:1OXB|rcsb pdb:1OXK|rcsb pdb:2R25|dip:DIP-2939N|mint:P39928	refseq:NP_010046.1|sgd:S000002394|mint:Q07688|dip:DIP-5899N|ensemblfungi:YDL235C(gene)|ensemblfungi:YDL235C_mRNA(transcript)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007234"(osmosensory signaling via phosphorelay pathway)|go:"GO:0009927"(histidine phosphotransfer kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016772"(transferase activity, transferring phosphorus-containing groups)|go:"GO:0043424"(protein histidine kinase binding)|interpro:IPR008207("Signal transduction histidine kinase, phosphotransfer (Hpt) region")|interpro:IPR036641|rcsb pdb:1C02|rcsb pdb:1C03|rcsb pdb:1OXB|rcsb pdb:1OXK|rcsb pdb:1QSP|rcsb pdb:2R25|rcsb pdb:5KBX|rcsb pdb:6M7W	-	crc64:45FFE24A8165486B	crc64:4B923E621C57783D	assembly:dimeric, multimeric|3d-r-factors:working 76.400%, free 74.200%|3d-resolution:2.1A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:9MmMp/opdyg0Fiu8CY+eTEylx0Q559292	rogid:YN/TB6a79rhT0M1R09pLAyj/Xac559292	intact-crc:620A286E245ACF9C|rigid:mTIszi5ne6nccr/4ddGf5ercUt4	false	sufficient binding region:1087-1220	sufficient binding region:2-167	6	6	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)