#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P91682	uniprotkb:O16844	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jia et al. (2003)	pubmed:14597665	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1151155	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N	intact:EBI-872934(intact-secondary)	-	-	figure legend:5B	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2006/10/31	2014/10/16	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227	intact-crc:E8FE9F639D7AB491|rigid:HPAFIeiGMXSxqgpGEAztj5GRnVo	false	necessary binding region:555-1036|myc tag:n-n	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P91682	uniprotkb:P23647	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jia et al. (2003)	pubmed:14597665	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1151155	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N	intact:EBI-872934(intact-secondary)	-	-	figure legend:5B	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2006/10/31	2014/10/16	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227	intact-crc:E8FE9F639D7AB491|rigid:HPAFIeiGMXSxqgpGEAztj5GRnVo	false	necessary binding region:555-1036|myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P91682	uniprotkb:O16844	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jia et al. (2003)	pubmed:14597665	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1151206	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N	intact:EBI-872934(intact-secondary)	-	-	figure legend:5C	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2006/10/31	2014/10/16	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227	intact-crc:5AB1A3BCCE5012DD|rigid:HPAFIeiGMXSxqgpGEAztj5GRnVo	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P91682	uniprotkb:P23647	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jia et al. (2003)	pubmed:14597665	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1151206	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N	intact:EBI-872934(intact-secondary)	-	-	figure legend:5C	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2006/10/31	2014/10/16	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227	intact-crc:5AB1A3BCCE5012DD|rigid:HPAFIeiGMXSxqgpGEAztj5GRnVo	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P91682	uniprotkb:P23647	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jia et al. (2003)	pubmed:14597665	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1151237	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N	-	-	-	figure legend:5E|comment:"Myr-Smo AA 556-730 pulled down diminishing levels of Cos2/Fu as compared to  Myr-Smo AA625-818, which appeared to bind Cos2/Fu with affinity similar to that of Myr-SmoCT (AA 556-1036)"	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2006/10/31	2014/10/16	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227	intact-crc:B56F85CF5A5EF554|rigid:HPAFIeiGMXSxqgpGEAztj5GRnVo	false	fusion protein:n-n|flag tag:n-n|sufficient binding region:556-730	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P91682	uniprotkb:O16844	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jia et al. (2003)	pubmed:14597665	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1151237	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N	-	-	-	figure legend:5E|comment:"Myr-Smo AA 556-730 pulled down diminishing levels of Cos2/Fu as compared to  Myr-Smo AA625-818, which appeared to bind Cos2/Fu with affinity similar to that of Myr-SmoCT (AA 556-1036)"	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2006/10/31	2014/10/16	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227	intact-crc:B56F85CF5A5EF554|rigid:HPAFIeiGMXSxqgpGEAztj5GRnVo	false	fusion protein:n-n|flag tag:n-n|sufficient binding region:556-730	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O16844	uniprotkb:P91682	intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jia et al. (2003)	pubmed:14597665	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1151310	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	-	-	-	figure legend:5F	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2006/10/31	2014/10/16	rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	intact-crc:2B23633721CB54DE|rigid:MLEovjBqI9I/n7xwkXo0D0HYF+0	false	ha tag:?-?|sufficient binding region:990-1201|sufficient binding region:?-?	myc tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P91682	uniprotkb:O16844	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-102069|intact:EBI-868718|intact:EBI-1151174|intact:EBI-497208|uniprotkb:A1Z6X4|uniprotkb:B5RIP3|uniprotkb:Q6AWI9|uniprotkb:Q8IH04|ensemblmetazoa:FBpp0088087|ensemblmetazoa:FBpp0307854	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:cos_drome(display_long)|uniprotkb:cos(gene name)|psi-mi:cos(display_short)|uniprotkb:cos2(gene name synonym)|uniprotkb:costal-2(gene name synonym)|uniprotkb:Kinesin-like protein costal2(gene name synonym)|uniprotkb:CG1708(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jia et al. (2003)	pubmed:14597665	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1151228	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	refseq:NP_477092.1|flybase:FBgn0000352|ensemblmetazoa:FBgn0000352(gene)|ensemblmetazoa:FBtr0089015(transcript)|ensemblmetazoa:FBtr0336916(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005119"(smoothened binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_001260765.1|dip:DIP-22550N	-	-	-	figure legend:5D	taxid:7227(drome-wing disc)|taxid:7227(Drosophila melanogaster wing disc)	-	2006/10/31	2014/10/16	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:6k5Ur6D1FPXovKN/UUjCoqKajQk7227	intact-crc:8D09E2F647A106AD|rigid:HPAFIeiGMXSxqgpGEAztj5GRnVo	false	myc tag:n-n|necessary binding region:555-1036	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P91682	uniprotkb:P23647	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jia et al. (2003)	pubmed:14597665	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1151228	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N	-	-	-	figure legend:5D	taxid:7227(drome-wing disc)|taxid:7227(Drosophila melanogaster wing disc)	-	2006/10/31	2014/10/16	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227	intact-crc:8D09E2F647A106AD|rigid:HPAFIeiGMXSxqgpGEAztj5GRnVo	false	myc tag:n-n|necessary binding region:555-1036	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)