#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P40189	uniprotkb:P15018	intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04	intact:EBI-1037189|uniprotkb:Q52LZ2|uniprotkb:B2RCW7|ensembl:ENSP00000249075|uniprotkb:B5MC23	psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym)	psi-mi:lif_human(display_long)|uniprotkb:LIF(gene name)|psi-mi:LIF(display_short)|uniprotkb:HILDA(gene name synonym)|uniprotkb:Differentiation-stimulating factor(gene name synonym)|uniprotkb:Melanoma-derived LPL inhibitor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Boulanger et al. (2003)	pubmed:14527405	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1037207|rcsb pdb:1PVH	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N	refseq:NP_002300.1|refseq:NP_001244064.1|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072108"(positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901676"(positive regulation of histone H3-K27 acetylation)|go:"GO:1903025"(regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR001581(LIF/OSM)|interpro:IPR003624(Leukemia inhibitory factor)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019827|rcsb pdb:1EMR|rcsb pdb:1PVH|rcsb pdb:2Q7N|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-6788467|ensembl:ENSG00000128342(gene)|ensembl:ENST00000249075(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005146"(leukemia inhibitory factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007275"(multicellular organism development)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0007566"(embryo implantation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060426"(lung vasculature development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0060707"(trophoblast giant cell differentiation)|dip:DIP-5769N	-	-	-	assembly:dimeric, multimeric|3d-r-factors:working 75.200%, free 71.100%|3d-resolution:2.5A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606	rogid:2d7GyGfcJX8JuAWYA3ZIcmwzTbY9606	intact-crc:950CAC3F1BDC5DD8|rigid:cU3+K8RHQJLxPwnVnQvmVlanUI0	false	sufficient binding region:123-323	sufficient binding region:34-202	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)