#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16649	uniprotkb:Q12214	intact:EBI-19654|uniprotkb:P17995|uniprotkb:P18323|uniprotkb:D6VR85|ensemblfungi:YCR084C	intact:EBI-8471|uniprotkb:D6W472|ensemblfungi:YPR068C	psi-mi:tup1_yeast(display_long)|uniprotkb:TUP1(gene name)|psi-mi:TUP1(display_short)|uniprotkb:AAR1(gene name synonym)|uniprotkb:AER2(gene name synonym)|uniprotkb:AMM1(gene name synonym)|uniprotkb:CYC9(gene name synonym)|uniprotkb:FLK1(gene name synonym)|uniprotkb:SFL2(gene name synonym)|uniprotkb:UMR7(gene name synonym)|uniprotkb:YCR084C(locus name)|uniprotkb:YCR84C(orf name)|uniprotkb:Glucose repression regulatory protein TUP1(gene name synonym)|uniprotkb:Flocculation suppressor protein(gene name synonym)|uniprotkb:Repressor AER2(gene name synonym)	psi-mi:hos1_yeast(display_long)|uniprotkb:YP9499.23C(orf name)|uniprotkb:YPR068C(locus name)|uniprotkb:HOS1(gene name)|psi-mi:HOS1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Davie et al. (2003)	pubmed:14525981|imex:IM-19904	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1111102|imex:IM-19904-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010007.1|sgd:S000000680|ensemblfungi:YCR084C(gene)|ensemblfungi:YCR084C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000433"(carbon catabolite repression of transcription from RNA polymerase II promoter by glucose)|go:"GO:0001198"(negative regulation of mating-type specific transcription from RNA polymerase II promoter)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060256"(regulation of flocculation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:1900192"(positive regulation of single-species biofilm formation)|go:"GO:2000217"(regulation of invasive growth in response to glucose limitation)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR013890(Transcriptional repressor Tup1,  N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1ERJ|rcsb pdb:3VP8|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|rcsb pdb:3VP9|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043486"(histone exchange)|dip:DIP-512N|mint:P16649	refseq:NP_015393.1|sgd:S000006272|dip:DIP-7974N|ensemblfungi:YPR068C(gene)|ensemblfungi:YPR068C_mRNA(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR023696|interpro:IPR023801	-	crc64:444104AAD63CB944	crc64:5DCFF35D8F6AC87D	figure legend:1B|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/10/23	2014/10/16	rogid:luwCf4aC9uWc9C8Vt2etbCoLcU8559292	rogid:51A8VCXiJNqUYGQpNxjycMGXuQ4559292	intact-crc:592B10AC523FF815|rigid:HY6Mgvz2nlxnc4ORXooEze+ACo4	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14922	uniprotkb:Q12214	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	intact:EBI-8471|uniprotkb:D6W472|ensemblfungi:YPR068C	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:hos1_yeast(display_long)|uniprotkb:YP9499.23C(orf name)|uniprotkb:YPR068C(locus name)|uniprotkb:HOS1(gene name)|psi-mi:HOS1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Davie et al. (2003)	pubmed:14525981|imex:IM-19904	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1111109|imex:IM-19904-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	refseq:NP_015393.1|sgd:S000006272|dip:DIP-7974N|ensemblfungi:YPR068C(gene)|ensemblfungi:YPR068C_mRNA(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR023696|interpro:IPR023801	-	crc64:FC2D0D0C1B181207	crc64:5DCFF35D8F6AC87D	figure legend:1B|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/10/23	2014/10/16	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	rogid:51A8VCXiJNqUYGQpNxjycMGXuQ4559292	intact-crc:684E36D43823D970|rigid:f+sKWyA+FJFTMks0/O09P4CA2UQ	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14922	uniprotkb:P53096	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	intact:EBI-8475|uniprotkb:D6VTW0|ensemblfungi:YGL194C	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:hos2_yeast(display_long)|uniprotkb:G1330(orf name)|uniprotkb:YGL194C(locus name)|uniprotkb:HOS2(gene name)|psi-mi:HOS2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Davie et al. (2003)	pubmed:14525981|imex:IM-19904	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1111122|imex:IM-19904-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	refseq:NP_011321.1|sgd:S000003162|dip:DIP-6828N|ensemblfungi:YGL194C(gene)|ensemblfungi:YGL194C_mRNA(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034967"(Set3 complex)|go:"GO:0045129"(NAD-independent histone deacetylase activity)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070210"(Rpd3L-Expanded complex)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138	-	crc64:FC2D0D0C1B181207	-	figure legend:1C and 2C|comment:Interaction is independent of TUP1 as it was also demonstrated in a TUP1-deleted strain.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/10/23	2014/10/16	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	rogid:BrN7mkwCPoteiuLh77zOHBumwbY559292	intact-crc:180462E977C09069|rigid:e46NyKLW31V9HDreCBbtuNFaTEo	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14922	uniprotkb:P16649	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	intact:EBI-19654|uniprotkb:P17995|uniprotkb:P18323|uniprotkb:D6VR85|ensemblfungi:YCR084C	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:tup1_yeast(display_long)|uniprotkb:TUP1(gene name)|psi-mi:TUP1(display_short)|uniprotkb:AAR1(gene name synonym)|uniprotkb:AER2(gene name synonym)|uniprotkb:AMM1(gene name synonym)|uniprotkb:CYC9(gene name synonym)|uniprotkb:FLK1(gene name synonym)|uniprotkb:SFL2(gene name synonym)|uniprotkb:UMR7(gene name synonym)|uniprotkb:YCR084C(locus name)|uniprotkb:YCR84C(orf name)|uniprotkb:Glucose repression regulatory protein TUP1(gene name synonym)|uniprotkb:Flocculation suppressor protein(gene name synonym)|uniprotkb:Repressor AER2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Davie et al. (2003)	pubmed:14525981|imex:IM-19904	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1111129|imex:IM-19904-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	refseq:NP_010007.1|sgd:S000000680|ensemblfungi:YCR084C(gene)|ensemblfungi:YCR084C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000433"(carbon catabolite repression of transcription from RNA polymerase II promoter by glucose)|go:"GO:0001198"(negative regulation of mating-type specific transcription from RNA polymerase II promoter)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060256"(regulation of flocculation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:1900192"(positive regulation of single-species biofilm formation)|go:"GO:2000217"(regulation of invasive growth in response to glucose limitation)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR013890(Transcriptional repressor Tup1,  N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1ERJ|rcsb pdb:3VP8|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|rcsb pdb:3VP9|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043486"(histone exchange)|dip:DIP-512N|mint:P16649	-	crc64:FC2D0D0C1B181207	crc64:444104AAD63CB944	figure legend:1C|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/10/23	2014/10/16	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	rogid:luwCf4aC9uWc9C8Vt2etbCoLcU8559292	intact-crc:DF3FD8EA75F268F4|rigid:U+IAUnZoQMFI5dEq7lEl52gpCUk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14922	uniprotkb:P32561	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	intact:EBI-15864|uniprotkb:D6W0L7|ensemblfungi:YNL330C	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:rpd3_yeast(display_long)|uniprotkb:RPD3(gene name)|psi-mi:RPD3(display_short)|uniprotkb:SDI2(gene name synonym)|uniprotkb:YNL330C(locus name)|uniprotkb:N0305(orf name)|uniprotkb:MOF6(gene name synonym)|uniprotkb:REC3(gene name synonym)|uniprotkb:SDS6(gene name synonym)|uniprotkb:Transcriptional regulatory protein RPD3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Davie et al. (2003)	pubmed:14525981|imex:IM-19904	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1111133|imex:IM-19904-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	ensemblfungi:YNL330C(gene)|ensemblfungi:YNL330C_mRNA(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000117"(regulation of transcription involved in G2/M transition of mitotic cell cycle)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031939"(obsolete negative regulation of chromatin silencing at telomere)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032221"(Rpd3S/Clr6-CII complex)|go:"GO:0033698"(Rpd3L complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045128"(negative regulation of reciprocal meiotic recombination)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051038"(negative regulation of transcription involved in meiotic cell cycle)|go:"GO:0061186"(negative regulation of silent mating-type cassette heterochromatin assembly)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|go:"GO:0070210"(Rpd3L-Expanded complex)|go:"GO:0070211"(Snt2C complex)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0070550"(rDNA condensation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-SCE-3214815|reactome:R-SCE-4551638|reactome:R-SCE-9018519|go:"GO:0070822"(Sin3-type complex)|go:"GO:0070932"(histone H3 deacetylation)|refseq:NP_014069.1|sgd:S000005274|dip:DIP-681N|mint:P32561	-	crc64:FC2D0D0C1B181207	crc64:34FFD72A7E7425DB	comment:Interaction is independent of TUP1 as it was also demonstrated in a TUP1-deleted strain.|figure legend:2A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/10/23	2014/10/16	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	rogid:GQ1xB56fpHiVV03yhoPADv04fl0559292	intact-crc:C88AC3A76D086AEF|rigid:Z9sutU8RqT+QRXg9bPMHot1mbes	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16649	uniprotkb:P32561	intact:EBI-19654|uniprotkb:P17995|uniprotkb:P18323|uniprotkb:D6VR85|ensemblfungi:YCR084C	intact:EBI-15864|uniprotkb:D6W0L7|ensemblfungi:YNL330C	psi-mi:tup1_yeast(display_long)|uniprotkb:TUP1(gene name)|psi-mi:TUP1(display_short)|uniprotkb:AAR1(gene name synonym)|uniprotkb:AER2(gene name synonym)|uniprotkb:AMM1(gene name synonym)|uniprotkb:CYC9(gene name synonym)|uniprotkb:FLK1(gene name synonym)|uniprotkb:SFL2(gene name synonym)|uniprotkb:UMR7(gene name synonym)|uniprotkb:YCR084C(locus name)|uniprotkb:YCR84C(orf name)|uniprotkb:Glucose repression regulatory protein TUP1(gene name synonym)|uniprotkb:Flocculation suppressor protein(gene name synonym)|uniprotkb:Repressor AER2(gene name synonym)	psi-mi:rpd3_yeast(display_long)|uniprotkb:RPD3(gene name)|psi-mi:RPD3(display_short)|uniprotkb:SDI2(gene name synonym)|uniprotkb:YNL330C(locus name)|uniprotkb:N0305(orf name)|uniprotkb:MOF6(gene name synonym)|uniprotkb:REC3(gene name synonym)|uniprotkb:SDS6(gene name synonym)|uniprotkb:Transcriptional regulatory protein RPD3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Davie et al. (2003)	pubmed:14525981|imex:IM-19904	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1111142|imex:IM-19904-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010007.1|sgd:S000000680|ensemblfungi:YCR084C(gene)|ensemblfungi:YCR084C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000433"(carbon catabolite repression of transcription from RNA polymerase II promoter by glucose)|go:"GO:0001198"(negative regulation of mating-type specific transcription from RNA polymerase II promoter)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060256"(regulation of flocculation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:1900192"(positive regulation of single-species biofilm formation)|go:"GO:2000217"(regulation of invasive growth in response to glucose limitation)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR013890(Transcriptional repressor Tup1,  N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1ERJ|rcsb pdb:3VP8|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|rcsb pdb:3VP9|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043486"(histone exchange)|dip:DIP-512N|mint:P16649	ensemblfungi:YNL330C(gene)|ensemblfungi:YNL330C_mRNA(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000117"(regulation of transcription involved in G2/M transition of mitotic cell cycle)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031939"(obsolete negative regulation of chromatin silencing at telomere)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032221"(Rpd3S/Clr6-CII complex)|go:"GO:0033698"(Rpd3L complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045128"(negative regulation of reciprocal meiotic recombination)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051038"(negative regulation of transcription involved in meiotic cell cycle)|go:"GO:0061186"(negative regulation of silent mating-type cassette heterochromatin assembly)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|go:"GO:0070210"(Rpd3L-Expanded complex)|go:"GO:0070211"(Snt2C complex)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0070550"(rDNA condensation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-SCE-3214815|reactome:R-SCE-4551638|reactome:R-SCE-9018519|go:"GO:0070822"(Sin3-type complex)|go:"GO:0070932"(histone H3 deacetylation)|refseq:NP_014069.1|sgd:S000005274|dip:DIP-681N|mint:P32561	-	crc64:444104AAD63CB944	crc64:34FFD72A7E7425DB	comment:A weak interaction was also demonstrated in a CYC8-deleted strain.|figure legend:2B|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/10/23	2014/10/16	rogid:luwCf4aC9uWc9C8Vt2etbCoLcU8559292	rogid:GQ1xB56fpHiVV03yhoPADv04fl0559292	intact-crc:68940A9321DBD3EB|rigid:ro64BAm6EP1mfofXn73QHO6PelU	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32561	uniprotkb:P14922	intact:EBI-15864|uniprotkb:D6W0L7|ensemblfungi:YNL330C	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	psi-mi:rpd3_yeast(display_long)|uniprotkb:RPD3(gene name)|psi-mi:RPD3(display_short)|uniprotkb:SDI2(gene name synonym)|uniprotkb:YNL330C(locus name)|uniprotkb:N0305(orf name)|uniprotkb:MOF6(gene name synonym)|uniprotkb:REC3(gene name synonym)|uniprotkb:SDS6(gene name synonym)|uniprotkb:Transcriptional regulatory protein RPD3(gene name synonym)	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Davie et al. (2003)	pubmed:14525981|imex:IM-19904	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1111155|imex:IM-19904-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YNL330C(gene)|ensemblfungi:YNL330C_mRNA(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000117"(regulation of transcription involved in G2/M transition of mitotic cell cycle)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031939"(obsolete negative regulation of chromatin silencing at telomere)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032221"(Rpd3S/Clr6-CII complex)|go:"GO:0033698"(Rpd3L complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045128"(negative regulation of reciprocal meiotic recombination)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051038"(negative regulation of transcription involved in meiotic cell cycle)|go:"GO:0061186"(negative regulation of silent mating-type cassette heterochromatin assembly)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|go:"GO:0070210"(Rpd3L-Expanded complex)|go:"GO:0070211"(Snt2C complex)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0070550"(rDNA condensation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-SCE-3214815|reactome:R-SCE-4551638|reactome:R-SCE-9018519|go:"GO:0070822"(Sin3-type complex)|go:"GO:0070932"(histone H3 deacetylation)|refseq:NP_014069.1|sgd:S000005274|dip:DIP-681N|mint:P32561	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	-	crc64:34FFD72A7E7425DB	crc64:FC2D0D0C1B181207	figure legend:3|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:GQ1xB56fpHiVV03yhoPADv04fl0559292	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	intact-crc:3C831F09CFCC1E3F|rigid:Z9sutU8RqT+QRXg9bPMHot1mbes	false	-	binding-associated region:?-?,1-398|binding-associated region:1-398	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14922	uniprotkb:P32561	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	intact:EBI-15864|uniprotkb:D6W0L7|ensemblfungi:YNL330C	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:rpd3_yeast(display_long)|uniprotkb:RPD3(gene name)|psi-mi:RPD3(display_short)|uniprotkb:SDI2(gene name synonym)|uniprotkb:YNL330C(locus name)|uniprotkb:N0305(orf name)|uniprotkb:MOF6(gene name synonym)|uniprotkb:REC3(gene name synonym)|uniprotkb:SDS6(gene name synonym)|uniprotkb:Transcriptional regulatory protein RPD3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Davie et al. (2003)	pubmed:14525981|imex:IM-19904	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1111162|imex:IM-19904-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	ensemblfungi:YNL330C(gene)|ensemblfungi:YNL330C_mRNA(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000117"(regulation of transcription involved in G2/M transition of mitotic cell cycle)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031939"(obsolete negative regulation of chromatin silencing at telomere)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032221"(Rpd3S/Clr6-CII complex)|go:"GO:0033698"(Rpd3L complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045128"(negative regulation of reciprocal meiotic recombination)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051038"(negative regulation of transcription involved in meiotic cell cycle)|go:"GO:0061186"(negative regulation of silent mating-type cassette heterochromatin assembly)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|go:"GO:0070210"(Rpd3L-Expanded complex)|go:"GO:0070211"(Snt2C complex)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0070550"(rDNA condensation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-SCE-3214815|reactome:R-SCE-4551638|reactome:R-SCE-9018519|go:"GO:0070822"(Sin3-type complex)|go:"GO:0070932"(histone H3 deacetylation)|refseq:NP_014069.1|sgd:S000005274|dip:DIP-681N|mint:P32561	-	crc64:FC2D0D0C1B181207	crc64:34FFD72A7E7425DB	figure legend:3|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	rogid:GQ1xB56fpHiVV03yhoPADv04fl0559292	intact-crc:A15DDDFE6FC25C22|rigid:Z9sutU8RqT+QRXg9bPMHot1mbes	false	glutathione s tranferase tag:?-?|binding-associated region:1-398	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32561	uniprotkb:P14922	intact:EBI-15864|uniprotkb:D6W0L7|ensemblfungi:YNL330C	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	psi-mi:rpd3_yeast(display_long)|uniprotkb:RPD3(gene name)|psi-mi:RPD3(display_short)|uniprotkb:SDI2(gene name synonym)|uniprotkb:YNL330C(locus name)|uniprotkb:N0305(orf name)|uniprotkb:MOF6(gene name synonym)|uniprotkb:REC3(gene name synonym)|uniprotkb:SDS6(gene name synonym)|uniprotkb:Transcriptional regulatory protein RPD3(gene name synonym)	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Davie et al. (2003)	pubmed:14525981|imex:IM-19904	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1111175|imex:IM-19904-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YNL330C(gene)|ensemblfungi:YNL330C_mRNA(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000117"(regulation of transcription involved in G2/M transition of mitotic cell cycle)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031939"(obsolete negative regulation of chromatin silencing at telomere)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032221"(Rpd3S/Clr6-CII complex)|go:"GO:0033698"(Rpd3L complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045128"(negative regulation of reciprocal meiotic recombination)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051038"(negative regulation of transcription involved in meiotic cell cycle)|go:"GO:0061186"(negative regulation of silent mating-type cassette heterochromatin assembly)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|go:"GO:0070210"(Rpd3L-Expanded complex)|go:"GO:0070211"(Snt2C complex)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0070550"(rDNA condensation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-SCE-3214815|reactome:R-SCE-4551638|reactome:R-SCE-9018519|go:"GO:0070822"(Sin3-type complex)|go:"GO:0070932"(histone H3 deacetylation)|refseq:NP_014069.1|sgd:S000005274|dip:DIP-681N|mint:P32561	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	-	crc64:34FFD72A7E7425DB	crc64:FC2D0D0C1B181207	figure legend:3|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/23	2014/10/16	rogid:GQ1xB56fpHiVV03yhoPADv04fl0559292	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	intact-crc:709558CA1F57DBA5|rigid:Z9sutU8RqT+QRXg9bPMHot1mbes	false	ha tag:?-?	binding-associated region:428-966	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32561	uniprotkb:P14922	intact:EBI-15864|uniprotkb:D6W0L7|ensemblfungi:YNL330C	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	psi-mi:rpd3_yeast(display_long)|uniprotkb:RPD3(gene name)|psi-mi:RPD3(display_short)|uniprotkb:SDI2(gene name synonym)|uniprotkb:YNL330C(locus name)|uniprotkb:N0305(orf name)|uniprotkb:MOF6(gene name synonym)|uniprotkb:REC3(gene name synonym)|uniprotkb:SDS6(gene name synonym)|uniprotkb:Transcriptional regulatory protein RPD3(gene name synonym)	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Davie et al. (2003)	pubmed:14525981|imex:IM-19904	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1111190|imex:IM-19904-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YNL330C(gene)|ensemblfungi:YNL330C_mRNA(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000117"(regulation of transcription involved in G2/M transition of mitotic cell cycle)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031939"(obsolete negative regulation of chromatin silencing at telomere)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032221"(Rpd3S/Clr6-CII complex)|go:"GO:0033698"(Rpd3L complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034503"(protein localization to nucleolar rDNA repeats)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045128"(negative regulation of reciprocal meiotic recombination)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051038"(negative regulation of transcription involved in meiotic cell cycle)|go:"GO:0061186"(negative regulation of silent mating-type cassette heterochromatin assembly)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|go:"GO:0070210"(Rpd3L-Expanded complex)|go:"GO:0070211"(Snt2C complex)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0070550"(rDNA condensation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-SCE-3214815|reactome:R-SCE-4551638|reactome:R-SCE-9018519|go:"GO:0070822"(Sin3-type complex)|go:"GO:0070932"(histone H3 deacetylation)|refseq:NP_014069.1|sgd:S000005274|dip:DIP-681N|mint:P32561	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	-	crc64:34FFD72A7E7425DB	crc64:FC2D0D0C1B181207	figure legend:5|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/10/23	2014/10/16	rogid:GQ1xB56fpHiVV03yhoPADv04fl0559292	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	intact-crc:0C670DBBBCCD78C3|rigid:Z9sutU8RqT+QRXg9bPMHot1mbes	false	ha tag:?-?	v5 tag:c-c|binding-associated region:46-398	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P53096	uniprotkb:P14922	intact:EBI-8475|uniprotkb:D6VTW0|ensemblfungi:YGL194C	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	psi-mi:hos2_yeast(display_long)|uniprotkb:G1330(orf name)|uniprotkb:YGL194C(locus name)|uniprotkb:HOS2(gene name)|psi-mi:HOS2(display_short)	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Davie et al. (2003)	pubmed:14525981|imex:IM-19904	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1111200|imex:IM-19904-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011321.1|sgd:S000003162|dip:DIP-6828N|ensemblfungi:YGL194C(gene)|ensemblfungi:YGL194C_mRNA(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034967"(Set3 complex)|go:"GO:0045129"(NAD-independent histone deacetylase activity)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070210"(Rpd3L-Expanded complex)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	-	-	crc64:FC2D0D0C1B181207	figure legend:5|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/10/23	2014/10/16	rogid:BrN7mkwCPoteiuLh77zOHBumwbY559292	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	intact-crc:E968F02A6DE29A16|rigid:e46NyKLW31V9HDreCBbtuNFaTEo	false	ha tag:?-?	binding-associated region:79-300|v5 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)