#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H6X2-2	uniprotkb:P13423	intact:EBI-905659|ensembl:ENSP00000386494	intact:EBI-456868|uniprotkb:Q937W2|uniprotkb:Q937W3|uniprotkb:Q9F5R7|uniprotkb:Q9KH69|uniprotkb:Q9RQU2|ensemblbacteria:AAT28905	psi-mi:q9h6x2-2(display_long)|uniprotkb:ANTXR1(gene name)|psi-mi:ANTXR1(display_short)|uniprotkb:ATR(gene name synonym)|uniprotkb:TEM8(gene name synonym)|uniprotkb:Tumor endothelial marker 8(gene name synonym)	psi-mi:pag_bacan(display_long)|uniprotkb:PA-83(gene name synonym)|uniprotkb:Anthrax toxins translocating protein(gene name synonym)|uniprotkb:pagA(gene name)|psi-mi:pagA(display_short)|uniprotkb:pag(gene name synonym)|uniprotkb:pXO1-110(locus name)|uniprotkb:BXA0164(locus name)|uniprotkb:GBAA_pXO1_0164(locus name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Bradley et al. (2003)	pubmed:14507921|imex:IM-19859	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1392(bacan)|taxid:1392(Bacillus anthracis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-905641|imex:IM-19859-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-905643(antr1_human)|ensembl:ENSG00000169604(gene)|ensembl:ENST00000409349(transcript)	refseq:NP_052806.1|refseq:WP_000746488.1|ensemblbacteria:AAT28905(transcript)|ensemblbacteria:GBAA_pXO1_0164(gene)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0015267"(channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044533"(positive regulation of apoptotic process in another organism)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051844"(translocation of peptides or proteins into symbiont)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090729"(toxin activity)|interpro:IPR003896(Bacterial exotoxin B)|interpro:IPR011658(PA14)|interpro:IPR027439|refseq:WP_000746487.1|refseq:WP_000746486.1|dip:DIP-29841N|mint:P13423|rcsb pdb:3Q8B|rcsb pdb:3Q8C|rcsb pdb:3Q8E|rcsb pdb:3Q8F|rcsb pdb:3TEW|rcsb pdb:3TEX|rcsb pdb:3TEY|rcsb pdb:3TEZ|rcsb pdb:4EE2|rcsb pdb:4H2A|rcsb pdb:4NAM|rcsb pdb:5FR3|rcsb pdb:6PSN|rcsb pdb:6UJI|rcsb pdb:6UZB|rcsb pdb:6UZD|rcsb pdb:6UZE|rcsb pdb:6VRA|rcsb pdb:3Q8A|rcsb pdb:6WJJ|rcsb pdb:6ZXJ|interpro:IPR027441|interpro:IPR035088|interpro:IPR035331|interpro:IPR037149|interpro:IPR037524|rcsb pdb:1ACC|rcsb pdb:1T6B|rcsb pdb:1TX5|rcsb pdb:1TZN|rcsb pdb:1TZO|rcsb pdb:1V36|rcsb pdb:3ETB|rcsb pdb:3INO|rcsb pdb:3J9C|rcsb pdb:3KWV|rcsb pdb:3MHZ|rcsb pdb:6ZXL|rcsb pdb:7O85|reactome:R-HSA-5210891|rcsb pdb:6ZXK	-	-	-	stimulant:Binding of PA to ATR-mycHis is supported by Mn2+ or less efficiently by Mg2+, whereas Ca2+ is not able to support toxin-receptor binding.|sample process:Q9H6X2-2 purified|sample process:P13423 purified|comment:"The ATR(glu50ala) mutation is predicted to disrupt metal coordination and  mutation of the MIDAS threonine (thr118ala) is predicted to lock the I domain into a closed conformation. Both mutations are shown to strongly affect the binding pr Atr with toxin althought they do not affect the folding of Atr."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/16	2014/10/16	rogid:Zf4W6+r4NcIRwEQGEnaj5oENeak9606	rogid:xLr/ydN4I0qJ46G/8A3JfZqAbyE1392	intact-crc:50205AC2F09EC37C|rigid:rJlXbb8vAe8N9vUnlWL8YDiwJNQ	false	myc tag:?-?|his tag:?-?|binding-associated region:1-229|mutation decreasing interaction:50-50|mutation decreasing interaction:118-118	binding-associated region:30-764	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13423	uniprotkb:Q9H6X2-2	intact:EBI-456868|uniprotkb:Q937W2|uniprotkb:Q937W3|uniprotkb:Q9F5R7|uniprotkb:Q9KH69|uniprotkb:Q9RQU2|ensemblbacteria:AAT28905	intact:EBI-905659|ensembl:ENSP00000386494	psi-mi:pag_bacan(display_long)|uniprotkb:PA-83(gene name synonym)|uniprotkb:Anthrax toxins translocating protein(gene name synonym)|uniprotkb:pagA(gene name)|psi-mi:pagA(display_short)|uniprotkb:pag(gene name synonym)|uniprotkb:pXO1-110(locus name)|uniprotkb:BXA0164(locus name)|uniprotkb:GBAA_pXO1_0164(locus name)	psi-mi:q9h6x2-2(display_long)|uniprotkb:ANTXR1(gene name)|psi-mi:ANTXR1(display_short)|uniprotkb:ATR(gene name synonym)|uniprotkb:TEM8(gene name synonym)|uniprotkb:Tumor endothelial marker 8(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Bradley et al. (2003)	pubmed:14507921|imex:IM-19859	taxid:1392(bacan)|taxid:1392(Bacillus anthracis)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-905739|imex:IM-19859-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_052806.1|refseq:WP_000746488.1|ensemblbacteria:AAT28905(transcript)|ensemblbacteria:GBAA_pXO1_0164(gene)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0015267"(channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044533"(positive regulation of apoptotic process in another organism)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051844"(translocation of peptides or proteins into symbiont)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090729"(toxin activity)|interpro:IPR003896(Bacterial exotoxin B)|interpro:IPR011658(PA14)|interpro:IPR027439|refseq:WP_000746487.1|refseq:WP_000746486.1|dip:DIP-29841N|mint:P13423|rcsb pdb:3Q8B|rcsb pdb:3Q8C|rcsb pdb:3Q8E|rcsb pdb:3Q8F|rcsb pdb:3TEW|rcsb pdb:3TEX|rcsb pdb:3TEY|rcsb pdb:3TEZ|rcsb pdb:4EE2|rcsb pdb:4H2A|rcsb pdb:4NAM|rcsb pdb:5FR3|rcsb pdb:6PSN|rcsb pdb:6UJI|rcsb pdb:6UZB|rcsb pdb:6UZD|rcsb pdb:6UZE|rcsb pdb:6VRA|rcsb pdb:3Q8A|rcsb pdb:6WJJ|rcsb pdb:6ZXJ|interpro:IPR027441|interpro:IPR035088|interpro:IPR035331|interpro:IPR037149|interpro:IPR037524|rcsb pdb:1ACC|rcsb pdb:1T6B|rcsb pdb:1TX5|rcsb pdb:1TZN|rcsb pdb:1TZO|rcsb pdb:1V36|rcsb pdb:3ETB|rcsb pdb:3INO|rcsb pdb:3J9C|rcsb pdb:3KWV|rcsb pdb:3MHZ|rcsb pdb:6ZXL|rcsb pdb:7O85|reactome:R-HSA-5210891|rcsb pdb:6ZXK	intact:EBI-905643(antr1_human)|ensembl:ENSG00000169604(gene)|ensembl:ENST00000409349(transcript)	go:"GO:0009986"(cell surface)	-	-	sample process:P13423 purified|comment:"The ATR(glu50ala) mutants show no complex formation on the facs analysis and confer full resistance to the toxin to the CHO cells. In the other hand the threonine (thr118ala) mutants have a limited interacting ability with the anthrax toxin and only confer a mild resistance during a cell killing assay."|sample process:Q9H6X2-2 living cell|caution:Although not specified in the paper it is likely that PagA construct include only the aminoacid range 30-764.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/16	2014/10/16	rogid:xLr/ydN4I0qJ46G/8A3JfZqAbyE1392	rogid:Zf4W6+r4NcIRwEQGEnaj5oENeak9606	intact-crc:1446E6E1D95431E0|rigid:rJlXbb8vAe8N9vUnlWL8YDiwJNQ	false	-	green fluorescent protein tag:?-?|binding-associated region:1-229|mutation decreasing interaction:50-50|mutation decreasing interaction:118-118	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H6X2-2	uniprotkb:P13423	intact:EBI-905659|ensembl:ENSP00000386494	intact:EBI-456868|uniprotkb:Q937W2|uniprotkb:Q937W3|uniprotkb:Q9F5R7|uniprotkb:Q9KH69|uniprotkb:Q9RQU2|ensemblbacteria:AAT28905	psi-mi:q9h6x2-2(display_long)|uniprotkb:ANTXR1(gene name)|psi-mi:ANTXR1(display_short)|uniprotkb:ATR(gene name synonym)|uniprotkb:TEM8(gene name synonym)|uniprotkb:Tumor endothelial marker 8(gene name synonym)	psi-mi:pag_bacan(display_long)|uniprotkb:PA-83(gene name synonym)|uniprotkb:Anthrax toxins translocating protein(gene name synonym)|uniprotkb:pagA(gene name)|psi-mi:pagA(display_short)|uniprotkb:pag(gene name synonym)|uniprotkb:pXO1-110(locus name)|uniprotkb:BXA0164(locus name)|uniprotkb:GBAA_pXO1_0164(locus name)	psi-mi:"MI:0096"(pull down)	Bradley et al. (2003)	pubmed:14507921|imex:IM-19859	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1392(bacan)|taxid:1392(Bacillus anthracis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-905790|imex:IM-19859-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-905643(antr1_human)|ensembl:ENSG00000169604(gene)|ensembl:ENST00000409349(transcript)	refseq:NP_052806.1|refseq:WP_000746488.1|ensemblbacteria:AAT28905(transcript)|ensemblbacteria:GBAA_pXO1_0164(gene)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0015267"(channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044533"(positive regulation of apoptotic process in another organism)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051844"(translocation of peptides or proteins into symbiont)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090729"(toxin activity)|interpro:IPR003896(Bacterial exotoxin B)|interpro:IPR011658(PA14)|interpro:IPR027439|refseq:WP_000746487.1|refseq:WP_000746486.1|dip:DIP-29841N|mint:P13423|rcsb pdb:3Q8B|rcsb pdb:3Q8C|rcsb pdb:3Q8E|rcsb pdb:3Q8F|rcsb pdb:3TEW|rcsb pdb:3TEX|rcsb pdb:3TEY|rcsb pdb:3TEZ|rcsb pdb:4EE2|rcsb pdb:4H2A|rcsb pdb:4NAM|rcsb pdb:5FR3|rcsb pdb:6PSN|rcsb pdb:6UJI|rcsb pdb:6UZB|rcsb pdb:6UZD|rcsb pdb:6UZE|rcsb pdb:6VRA|rcsb pdb:3Q8A|rcsb pdb:6WJJ|rcsb pdb:6ZXJ|interpro:IPR027441|interpro:IPR035088|interpro:IPR035331|interpro:IPR037149|interpro:IPR037524|rcsb pdb:1ACC|rcsb pdb:1T6B|rcsb pdb:1TX5|rcsb pdb:1TZN|rcsb pdb:1TZO|rcsb pdb:1V36|rcsb pdb:3ETB|rcsb pdb:3INO|rcsb pdb:3J9C|rcsb pdb:3KWV|rcsb pdb:3MHZ|rcsb pdb:6ZXL|rcsb pdb:7O85|reactome:R-HSA-5210891|rcsb pdb:6ZXK	-	-	-	sample process:P13423 purified|sample process:Q9H6X2-2 purified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/16	2014/10/16	rogid:Zf4W6+r4NcIRwEQGEnaj5oENeak9606	rogid:xLr/ydN4I0qJ46G/8A3JfZqAbyE1392	intact-crc:3AC350B692D81F64|rigid:rJlXbb8vAe8N9vUnlWL8YDiwJNQ	false	myc tag:?-?|binding-associated region:1-229|his tag:?-?	binding-associated region:625-764|mutation decreasing interaction:712-712|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)