#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q09463	uniprotkb:P49023	intact:EBI-963421|ensemblmetazoa:C16C10.7a.1	intact:EBI-702209|uniprotkb:O14970|uniprotkb:O14971|uniprotkb:O60360|uniprotkb:B2RAI3|uniprotkb:Q5HYA4|uniprotkb:B7ZMB4|ensembl:ENSP00000228307	psi-mi:rnf5_caeel(display_long)|uniprotkb:rnf-5(gene name)|psi-mi:rnf-5(display_short)|uniprotkb:RING finger protein 5(gene name synonym)|uniprotkb:C16C10.7(orf name)	psi-mi:paxi_human(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Didier et al. (2003)	pubmed:12861019|imex:IM-20096	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-963427|imex:IM-20096-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:C16C10.7a.1(transcript)|ensemblmetazoa:WBGene00004381(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0018996"(molting cycle, collagen and cuticulin-based cuticle)|go:"GO:0030054"(cell junction)|go:"GO:0040039"(inductive cell migration)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0055120"(striated muscle dense body)|refseq:NP_497830.1|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|wormbase:C16C10.7a|reactome:R-CEL-382556	refseq:NP_001074324.1|refseq:NP_002850.2|refseq:NP_079433.3|refseq:NP_001230685.1|refseq:XP_016875232.1|dip:DIP-33851N|ensembl:ENSG00000089159(gene)|ensembl:ENST00000228307(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49023|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2K2R|rcsb pdb:2O9V|rcsb pdb:2VZD|rcsb pdb:2VZG|rcsb pdb:2VZI|rcsb pdb:3GM1|rcsb pdb:3PY7|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3U3F|rcsb pdb:4EDN|rcsb pdb:4R32|rcsb pdb:4XGZ|rcsb pdb:4XH2|rcsb pdb:5UWH|rcsb pdb:6IUI|rcsb pdb:6PW8|rcsb pdb:6U4M|rcsb pdb:6U4N|reactome:R-HSA-180292|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-446343|reactome:R-HSA-446388|reactome:R-HSA-8849471	-	-	-	figure legend:2A|comment:"Transfected C-elegans RNF5 with a 17aa deletion (not further specified) and RNF5 with a cys26ala mutation have also be shown to interact."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/07/07	2014/10/16	rogid:4XjMiPCdHn5mYmth6qGKheEqwZM6239	rogid:H8osAQRrVydLfDL97uSSA6Mf6ME9606	intact-crc:CA84CE9DC7F46F91|rigid:U7INjsyU9AkjK7JesZqJjYIx+4o	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49023	uniprotkb:Q99942	intact:EBI-702209|uniprotkb:O14970|uniprotkb:O14971|uniprotkb:O60360|uniprotkb:B2RAI3|uniprotkb:Q5HYA4|uniprotkb:B7ZMB4|ensembl:ENSP00000228307	intact:EBI-348482|ensembl:ENSP00000364235|ensembl:ENSP00000387879|ensembl:ENSP00000388795|ensembl:ENSP00000401172|ensembl:ENSP00000413131|ensembl:ENSP00000415127|ensembl:ENSP00000415784|uniprotkb:A2BFI6|uniprotkb:Q0VDB7|uniprotkb:Q9UMQ2|uniprotkb:B2R4K3	psi-mi:paxi_human(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short)	psi-mi:rnf5_human(display_long)|uniprotkb:RNF5(gene name)|psi-mi:RNF5(display_short)|uniprotkb:G16(gene name synonym)|uniprotkb:RING finger protein 5(gene name synonym)|uniprotkb:Protein G16(gene name synonym)|uniprotkb:NG2(gene name synonym)|uniprotkb:RMA1(gene name synonym)|uniprotkb:Ram1 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Didier et al. (2003)	pubmed:12861019|imex:IM-20096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-963436|imex:IM-20096-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074324.1|refseq:NP_002850.2|refseq:NP_079433.3|refseq:NP_001230685.1|refseq:XP_016875232.1|dip:DIP-33851N|ensembl:ENSG00000089159(gene)|ensembl:ENST00000228307(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49023|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2K2R|rcsb pdb:2O9V|rcsb pdb:2VZD|rcsb pdb:2VZG|rcsb pdb:2VZI|rcsb pdb:3GM1|rcsb pdb:3PY7|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3U3F|rcsb pdb:4EDN|rcsb pdb:4R32|rcsb pdb:4XGZ|rcsb pdb:4XH2|rcsb pdb:5UWH|rcsb pdb:6IUI|rcsb pdb:6PW8|rcsb pdb:6U4M|rcsb pdb:6U4N|reactome:R-HSA-180292|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-446343|reactome:R-HSA-446388|reactome:R-HSA-8849471	refseq:NP_008844.1|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|ensembl:ENST00000456167(transcript)|ensembl:ENSG00000183574(gene)|ensembl:ENSG00000204308(gene)|ensembl:ENSG00000223767(gene)|ensembl:ENSG00000225452(gene)|ensembl:ENSG00000227277(gene)|ensembl:ENSG00000228405(gene)|ensembl:ENSG00000228907(gene)|ensembl:ENST00000375094(transcript)|ensembl:ENST00000413786(transcript)|ensembl:ENST00000432616(transcript)|ensembl:ENST00000445885(transcript)|ensembl:ENST00000449794(transcript)|ensembl:ENST00000453473(transcript)|go:"GO:0055085"(transmembrane transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-382556|reactome:R-HSA-5678895|reactome:R-HSA-901032|go:"GO:0044877"(protein-containing complex binding)|dip:DIP-29268N	-	-	-	figure legend:2B and C|comment:293T cells have been transfected with human RNF5.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/07/07	2014/10/16	rogid:H8osAQRrVydLfDL97uSSA6Mf6ME9606	rogid:eHlCD+xbWmpzFdhVn6OC5MPqeNE9606	intact-crc:0F42FE3AC6CA0ACD|rigid:lwdNu7l2aFH9lgw7skKtWINXTQE	false	-	binding-associated region:1-164|mutation increasing interaction:30-30,27-27|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99942	uniprotkb:P49023	intact:EBI-348482|ensembl:ENSP00000364235|ensembl:ENSP00000387879|ensembl:ENSP00000388795|ensembl:ENSP00000401172|ensembl:ENSP00000413131|ensembl:ENSP00000415127|ensembl:ENSP00000415784|uniprotkb:A2BFI6|uniprotkb:Q0VDB7|uniprotkb:Q9UMQ2|uniprotkb:B2R4K3	intact:EBI-702209|uniprotkb:O14970|uniprotkb:O14971|uniprotkb:O60360|uniprotkb:B2RAI3|uniprotkb:Q5HYA4|uniprotkb:B7ZMB4|ensembl:ENSP00000228307	psi-mi:rnf5_human(display_long)|uniprotkb:RNF5(gene name)|psi-mi:RNF5(display_short)|uniprotkb:G16(gene name synonym)|uniprotkb:RING finger protein 5(gene name synonym)|uniprotkb:Protein G16(gene name synonym)|uniprotkb:NG2(gene name synonym)|uniprotkb:RMA1(gene name synonym)|uniprotkb:Ram1 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF5(gene name synonym)	psi-mi:paxi_human(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Didier et al. (2003)	pubmed:12861019|imex:IM-20096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-963447|imex:IM-20096-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008844.1|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|ensembl:ENST00000456167(transcript)|ensembl:ENSG00000183574(gene)|ensembl:ENSG00000204308(gene)|ensembl:ENSG00000223767(gene)|ensembl:ENSG00000225452(gene)|ensembl:ENSG00000227277(gene)|ensembl:ENSG00000228405(gene)|ensembl:ENSG00000228907(gene)|ensembl:ENST00000375094(transcript)|ensembl:ENST00000413786(transcript)|ensembl:ENST00000432616(transcript)|ensembl:ENST00000445885(transcript)|ensembl:ENST00000449794(transcript)|ensembl:ENST00000453473(transcript)|go:"GO:0055085"(transmembrane transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-382556|reactome:R-HSA-5678895|reactome:R-HSA-901032|go:"GO:0044877"(protein-containing complex binding)|dip:DIP-29268N	refseq:NP_001074324.1|refseq:NP_002850.2|refseq:NP_079433.3|refseq:NP_001230685.1|refseq:XP_016875232.1|dip:DIP-33851N|ensembl:ENSG00000089159(gene)|ensembl:ENST00000228307(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49023|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2K2R|rcsb pdb:2O9V|rcsb pdb:2VZD|rcsb pdb:2VZG|rcsb pdb:2VZI|rcsb pdb:3GM1|rcsb pdb:3PY7|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3U3F|rcsb pdb:4EDN|rcsb pdb:4R32|rcsb pdb:4XGZ|rcsb pdb:4XH2|rcsb pdb:5UWH|rcsb pdb:6IUI|rcsb pdb:6PW8|rcsb pdb:6U4M|rcsb pdb:6U4N|reactome:R-HSA-180292|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-446343|reactome:R-HSA-446388|reactome:R-HSA-8849471	-	-	-	figure legend:2D|comment:Endogeneous protein was coimmunoprecipitated.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/07/07	2014/10/16	rogid:eHlCD+xbWmpzFdhVn6OC5MPqeNE9606	rogid:H8osAQRrVydLfDL97uSSA6Mf6ME9606	intact-crc:E9BB81D15AD99F37|rigid:lwdNu7l2aFH9lgw7skKtWINXTQE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99942	uniprotkb:P49023	intact:EBI-348482|ensembl:ENSP00000364235|ensembl:ENSP00000387879|ensembl:ENSP00000388795|ensembl:ENSP00000401172|ensembl:ENSP00000413131|ensembl:ENSP00000415127|ensembl:ENSP00000415784|uniprotkb:A2BFI6|uniprotkb:Q0VDB7|uniprotkb:Q9UMQ2|uniprotkb:B2R4K3	intact:EBI-702209|uniprotkb:O14970|uniprotkb:O14971|uniprotkb:O60360|uniprotkb:B2RAI3|uniprotkb:Q5HYA4|uniprotkb:B7ZMB4|ensembl:ENSP00000228307	psi-mi:rnf5_human(display_long)|uniprotkb:RNF5(gene name)|psi-mi:RNF5(display_short)|uniprotkb:G16(gene name synonym)|uniprotkb:RING finger protein 5(gene name synonym)|uniprotkb:Protein G16(gene name synonym)|uniprotkb:NG2(gene name synonym)|uniprotkb:RMA1(gene name synonym)|uniprotkb:Ram1 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF5(gene name synonym)	psi-mi:paxi_human(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Didier et al. (2003)	pubmed:12861019|imex:IM-20096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-963454|imex:IM-20096-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008844.1|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|ensembl:ENST00000456167(transcript)|ensembl:ENSG00000183574(gene)|ensembl:ENSG00000204308(gene)|ensembl:ENSG00000223767(gene)|ensembl:ENSG00000225452(gene)|ensembl:ENSG00000227277(gene)|ensembl:ENSG00000228405(gene)|ensembl:ENSG00000228907(gene)|ensembl:ENST00000375094(transcript)|ensembl:ENST00000413786(transcript)|ensembl:ENST00000432616(transcript)|ensembl:ENST00000445885(transcript)|ensembl:ENST00000449794(transcript)|ensembl:ENST00000453473(transcript)|go:"GO:0055085"(transmembrane transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-382556|reactome:R-HSA-5678895|reactome:R-HSA-901032|go:"GO:0044877"(protein-containing complex binding)|dip:DIP-29268N	refseq:NP_001074324.1|refseq:NP_002850.2|refseq:NP_079433.3|refseq:NP_001230685.1|refseq:XP_016875232.1|dip:DIP-33851N|ensembl:ENSG00000089159(gene)|ensembl:ENST00000228307(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49023|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2K2R|rcsb pdb:2O9V|rcsb pdb:2VZD|rcsb pdb:2VZG|rcsb pdb:2VZI|rcsb pdb:3GM1|rcsb pdb:3PY7|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3U3F|rcsb pdb:4EDN|rcsb pdb:4R32|rcsb pdb:4XGZ|rcsb pdb:4XH2|rcsb pdb:5UWH|rcsb pdb:6IUI|rcsb pdb:6PW8|rcsb pdb:6U4M|rcsb pdb:6U4N|reactome:R-HSA-180292|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-446343|reactome:R-HSA-446388|reactome:R-HSA-8849471	-	-	-	figure legend:2D|comment:Endogeneous protein was coimmunoprecipitated.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/07/07	2014/10/16	rogid:eHlCD+xbWmpzFdhVn6OC5MPqeNE9606	rogid:H8osAQRrVydLfDL97uSSA6Mf6ME9606	intact-crc:157DC123B76B9BDA|rigid:lwdNu7l2aFH9lgw7skKtWINXTQE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99942	uniprotkb:P49023	intact:EBI-348482|ensembl:ENSP00000364235|ensembl:ENSP00000387879|ensembl:ENSP00000388795|ensembl:ENSP00000401172|ensembl:ENSP00000413131|ensembl:ENSP00000415127|ensembl:ENSP00000415784|uniprotkb:A2BFI6|uniprotkb:Q0VDB7|uniprotkb:Q9UMQ2|uniprotkb:B2R4K3	intact:EBI-702209|uniprotkb:O14970|uniprotkb:O14971|uniprotkb:O60360|uniprotkb:B2RAI3|uniprotkb:Q5HYA4|uniprotkb:B7ZMB4|ensembl:ENSP00000228307	psi-mi:rnf5_human(display_long)|uniprotkb:RNF5(gene name)|psi-mi:RNF5(display_short)|uniprotkb:G16(gene name synonym)|uniprotkb:RING finger protein 5(gene name synonym)|uniprotkb:Protein G16(gene name synonym)|uniprotkb:NG2(gene name synonym)|uniprotkb:RMA1(gene name synonym)|uniprotkb:Ram1 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF5(gene name synonym)	psi-mi:paxi_human(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Didier et al. (2003)	pubmed:12861019|imex:IM-20096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-963460|imex:IM-20096-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008844.1|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|ensembl:ENST00000456167(transcript)|ensembl:ENSG00000183574(gene)|ensembl:ENSG00000204308(gene)|ensembl:ENSG00000223767(gene)|ensembl:ENSG00000225452(gene)|ensembl:ENSG00000227277(gene)|ensembl:ENSG00000228405(gene)|ensembl:ENSG00000228907(gene)|ensembl:ENST00000375094(transcript)|ensembl:ENST00000413786(transcript)|ensembl:ENST00000432616(transcript)|ensembl:ENST00000445885(transcript)|ensembl:ENST00000449794(transcript)|ensembl:ENST00000453473(transcript)|go:"GO:0055085"(transmembrane transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-382556|reactome:R-HSA-5678895|reactome:R-HSA-901032|go:"GO:0044877"(protein-containing complex binding)|dip:DIP-29268N	refseq:NP_001074324.1|refseq:NP_002850.2|refseq:NP_079433.3|refseq:NP_001230685.1|refseq:XP_016875232.1|dip:DIP-33851N|ensembl:ENSG00000089159(gene)|ensembl:ENST00000228307(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49023|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2K2R|rcsb pdb:2O9V|rcsb pdb:2VZD|rcsb pdb:2VZG|rcsb pdb:2VZI|rcsb pdb:3GM1|rcsb pdb:3PY7|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3U3F|rcsb pdb:4EDN|rcsb pdb:4R32|rcsb pdb:4XGZ|rcsb pdb:4XH2|rcsb pdb:5UWH|rcsb pdb:6IUI|rcsb pdb:6PW8|rcsb pdb:6U4M|rcsb pdb:6U4N|reactome:R-HSA-180292|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-446343|reactome:R-HSA-446388|reactome:R-HSA-8849471	-	-	-	figure legend:2E|comment:293T cells have been transfected with human RNF5 and with PAXN deletion constructs.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/07/07	2014/10/16	rogid:eHlCD+xbWmpzFdhVn6OC5MPqeNE9606	rogid:H8osAQRrVydLfDL97uSSA6Mf6ME9606	intact-crc:077066036FCDC690|rigid:lwdNu7l2aFH9lgw7skKtWINXTQE	false	flag tag:?-?	ha tag:?-?|binding-associated region:1-355	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49023	uniprotkb:Q99942	intact:EBI-702209|uniprotkb:O14970|uniprotkb:O14971|uniprotkb:O60360|uniprotkb:B2RAI3|uniprotkb:Q5HYA4|uniprotkb:B7ZMB4|ensembl:ENSP00000228307	intact:EBI-348482|ensembl:ENSP00000364235|ensembl:ENSP00000387879|ensembl:ENSP00000388795|ensembl:ENSP00000401172|ensembl:ENSP00000413131|ensembl:ENSP00000415127|ensembl:ENSP00000415784|uniprotkb:A2BFI6|uniprotkb:Q0VDB7|uniprotkb:Q9UMQ2|uniprotkb:B2R4K3	psi-mi:paxi_human(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short)	psi-mi:rnf5_human(display_long)|uniprotkb:RNF5(gene name)|psi-mi:RNF5(display_short)|uniprotkb:G16(gene name synonym)|uniprotkb:RING finger protein 5(gene name synonym)|uniprotkb:Protein G16(gene name synonym)|uniprotkb:NG2(gene name synonym)|uniprotkb:RMA1(gene name synonym)|uniprotkb:Ram1 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Didier et al. (2003)	pubmed:12861019|imex:IM-20096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-963485|imex:IM-20096-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074324.1|refseq:NP_002850.2|refseq:NP_079433.3|refseq:NP_001230685.1|refseq:XP_016875232.1|dip:DIP-33851N|ensembl:ENSG00000089159(gene)|ensembl:ENST00000228307(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49023|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2K2R|rcsb pdb:2O9V|rcsb pdb:2VZD|rcsb pdb:2VZG|rcsb pdb:2VZI|rcsb pdb:3GM1|rcsb pdb:3PY7|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3U3F|rcsb pdb:4EDN|rcsb pdb:4R32|rcsb pdb:4XGZ|rcsb pdb:4XH2|rcsb pdb:5UWH|rcsb pdb:6IUI|rcsb pdb:6PW8|rcsb pdb:6U4M|rcsb pdb:6U4N|reactome:R-HSA-180292|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-446343|reactome:R-HSA-446388|reactome:R-HSA-8849471	refseq:NP_008844.1|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|ensembl:ENST00000456167(transcript)|ensembl:ENSG00000183574(gene)|ensembl:ENSG00000204308(gene)|ensembl:ENSG00000223767(gene)|ensembl:ENSG00000225452(gene)|ensembl:ENSG00000227277(gene)|ensembl:ENSG00000228405(gene)|ensembl:ENSG00000228907(gene)|ensembl:ENST00000375094(transcript)|ensembl:ENST00000413786(transcript)|ensembl:ENST00000432616(transcript)|ensembl:ENST00000445885(transcript)|ensembl:ENST00000449794(transcript)|ensembl:ENST00000453473(transcript)|go:"GO:0055085"(transmembrane transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-382556|reactome:R-HSA-5678895|reactome:R-HSA-901032|go:"GO:0044877"(protein-containing complex binding)|dip:DIP-29268N	-	-	-	figure legend:2F|comment:Weak association only.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/07	2014/10/16	rogid:H8osAQRrVydLfDL97uSSA6Mf6ME9606	rogid:eHlCD+xbWmpzFdhVn6OC5MPqeNE9606	intact-crc:D591087600611072|rigid:lwdNu7l2aFH9lgw7skKtWINXTQE	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q09463	uniprotkb:P49023	intact:EBI-963421|ensemblmetazoa:C16C10.7a.1	intact:EBI-702209|uniprotkb:O14970|uniprotkb:O14971|uniprotkb:O60360|uniprotkb:B2RAI3|uniprotkb:Q5HYA4|uniprotkb:B7ZMB4|ensembl:ENSP00000228307	psi-mi:rnf5_caeel(display_long)|uniprotkb:rnf-5(gene name)|psi-mi:rnf-5(display_short)|uniprotkb:RING finger protein 5(gene name synonym)|uniprotkb:C16C10.7(orf name)	psi-mi:paxi_human(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short)	psi-mi:"MI:0096"(pull down)	Didier et al. (2003)	pubmed:12861019|imex:IM-20096	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-963496|imex:IM-20096-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:C16C10.7a.1(transcript)|ensemblmetazoa:WBGene00004381(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0018996"(molting cycle, collagen and cuticulin-based cuticle)|go:"GO:0030054"(cell junction)|go:"GO:0040039"(inductive cell migration)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0055120"(striated muscle dense body)|refseq:NP_497830.1|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|wormbase:C16C10.7a|reactome:R-CEL-382556	refseq:NP_001074324.1|refseq:NP_002850.2|refseq:NP_079433.3|refseq:NP_001230685.1|refseq:XP_016875232.1|dip:DIP-33851N|ensembl:ENSG00000089159(gene)|ensembl:ENST00000228307(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49023|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2K2R|rcsb pdb:2O9V|rcsb pdb:2VZD|rcsb pdb:2VZG|rcsb pdb:2VZI|rcsb pdb:3GM1|rcsb pdb:3PY7|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3U3F|rcsb pdb:4EDN|rcsb pdb:4R32|rcsb pdb:4XGZ|rcsb pdb:4XH2|rcsb pdb:5UWH|rcsb pdb:6IUI|rcsb pdb:6PW8|rcsb pdb:6U4M|rcsb pdb:6U4N|reactome:R-HSA-180292|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-446343|reactome:R-HSA-446388|reactome:R-HSA-8849471	-	-	-	figure legend:2F|comment:Weak association only.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/07	2014/10/16	rogid:4XjMiPCdHn5mYmth6qGKheEqwZM6239	rogid:H8osAQRrVydLfDL97uSSA6Mf6ME9606	intact-crc:CE84BCFF8A715601|rigid:U7INjsyU9AkjK7JesZqJjYIx+4o	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99942	uniprotkb:P49023	intact:EBI-348482|ensembl:ENSP00000364235|ensembl:ENSP00000387879|ensembl:ENSP00000388795|ensembl:ENSP00000401172|ensembl:ENSP00000413131|ensembl:ENSP00000415127|ensembl:ENSP00000415784|uniprotkb:A2BFI6|uniprotkb:Q0VDB7|uniprotkb:Q9UMQ2|uniprotkb:B2R4K3	intact:EBI-702209|uniprotkb:O14970|uniprotkb:O14971|uniprotkb:O60360|uniprotkb:B2RAI3|uniprotkb:Q5HYA4|uniprotkb:B7ZMB4|ensembl:ENSP00000228307	psi-mi:rnf5_human(display_long)|uniprotkb:RNF5(gene name)|psi-mi:RNF5(display_short)|uniprotkb:G16(gene name synonym)|uniprotkb:RING finger protein 5(gene name synonym)|uniprotkb:Protein G16(gene name synonym)|uniprotkb:NG2(gene name synonym)|uniprotkb:RMA1(gene name synonym)|uniprotkb:Ram1 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF5(gene name synonym)	psi-mi:paxi_human(display_long)|uniprotkb:PXN(gene name)|psi-mi:PXN(display_short)	psi-mi:"MI:0096"(pull down)	Didier et al. (2003)	pubmed:12861019|imex:IM-20096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-963509|imex:IM-20096-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008844.1|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|ensembl:ENST00000456167(transcript)|ensembl:ENSG00000183574(gene)|ensembl:ENSG00000204308(gene)|ensembl:ENSG00000223767(gene)|ensembl:ENSG00000225452(gene)|ensembl:ENSG00000227277(gene)|ensembl:ENSG00000228405(gene)|ensembl:ENSG00000228907(gene)|ensembl:ENST00000375094(transcript)|ensembl:ENST00000413786(transcript)|ensembl:ENST00000432616(transcript)|ensembl:ENST00000445885(transcript)|ensembl:ENST00000449794(transcript)|ensembl:ENST00000453473(transcript)|go:"GO:0055085"(transmembrane transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-382556|reactome:R-HSA-5678895|reactome:R-HSA-901032|go:"GO:0044877"(protein-containing complex binding)|dip:DIP-29268N	refseq:NP_001074324.1|refseq:NP_002850.2|refseq:NP_079433.3|refseq:NP_001230685.1|refseq:XP_016875232.1|dip:DIP-33851N|ensembl:ENSG00000089159(gene)|ensembl:ENST00000228307(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR001904(Paxillin)|mint:P49023|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:1OW6|rcsb pdb:1OW7|rcsb pdb:1OW8|rcsb pdb:2K2R|rcsb pdb:2O9V|rcsb pdb:2VZD|rcsb pdb:2VZG|rcsb pdb:2VZI|rcsb pdb:3GM1|rcsb pdb:3PY7|rcsb pdb:3RQE|rcsb pdb:3RQF|rcsb pdb:3RQG|rcsb pdb:3U3F|rcsb pdb:4EDN|rcsb pdb:4R32|rcsb pdb:4XGZ|rcsb pdb:4XH2|rcsb pdb:5UWH|rcsb pdb:6IUI|rcsb pdb:6PW8|rcsb pdb:6U4M|rcsb pdb:6U4N|reactome:R-HSA-180292|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-446343|reactome:R-HSA-446388|reactome:R-HSA-8849471	-	-	-	figure legend:2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/07/07	2014/10/16	rogid:eHlCD+xbWmpzFdhVn6OC5MPqeNE9606	rogid:H8osAQRrVydLfDL97uSSA6Mf6ME9606	intact-crc:0A5CB4F8060DEA18|rigid:lwdNu7l2aFH9lgw7skKtWINXTQE	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)