#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15831	uniprotkb:Q7RTN6	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-1109114|uniprotkb:Q5JPI2|uniprotkb:Q7Z4K9|uniprotkb:Q8NC31|uniprotkb:Q8NCF1|uniprotkb:Q9H272|ensembl:ENSP00000336655|uniprotkb:B4DDE3|uniprotkb:B4DW17|uniprotkb:J3KTC9	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:straa_human(display_long)|uniprotkb:STRADA(gene name)|psi-mi:STRADA(display_short)|uniprotkb:Serologically defined breast cancer antigen NY-BR-96(gene name synonym)|uniprotkb:STRAD(gene name synonym)|uniprotkb:LYK5(gene name synonym)|uniprotkb:STE20-related adapter protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Baas et al. (2003)	pubmed:12805220|imex:IM-19902	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1109128|imex:IM-19902-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_001003786.1|refseq:NP_001003787.1|refseq:NP_001003788.1|refseq:NP_001159441.1|refseq:NP_001159442.1|refseq:NP_699166.2|interpro:IPR011009(Protein kinase-like)|rcsb pdb:1UPK|rcsb pdb:2WTK|rcsb pdb:3GNI|reactome:R-HSA-380972|interpro:IPR000719(Protein kinase, core)|ensembl:ENSG00000266173(gene)|ensembl:ENST00000336174(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0019900"(kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|refseq:XP_005257856.1|dip:DIP-35775N	-	-	-	comment:"Kinase dead (Asp176Tyr) STK11 (Q15831) used as bait."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/10/10	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:WoEj2CkvNp1pV4Hx5asrQMddP5w9606	intact-crc:132DAF6AE7FE26B4|rigid:oofDZLxtsL8tRYx2BLQxZhIxTTY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15831	uniprotkb:Q7RTN6	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-1109114|uniprotkb:Q5JPI2|uniprotkb:Q7Z4K9|uniprotkb:Q8NC31|uniprotkb:Q8NCF1|uniprotkb:Q9H272|ensembl:ENSP00000336655|uniprotkb:B4DDE3|uniprotkb:B4DW17|uniprotkb:J3KTC9	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:straa_human(display_long)|uniprotkb:STRADA(gene name)|psi-mi:STRADA(display_short)|uniprotkb:Serologically defined breast cancer antigen NY-BR-96(gene name synonym)|uniprotkb:STRAD(gene name synonym)|uniprotkb:LYK5(gene name synonym)|uniprotkb:STE20-related adapter protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Baas et al. (2003)	pubmed:12805220|imex:IM-19902	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1109139|imex:IM-19902-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_001003786.1|refseq:NP_001003787.1|refseq:NP_001003788.1|refseq:NP_001159441.1|refseq:NP_001159442.1|refseq:NP_699166.2|interpro:IPR011009(Protein kinase-like)|rcsb pdb:1UPK|rcsb pdb:2WTK|rcsb pdb:3GNI|reactome:R-HSA-380972|interpro:IPR000719(Protein kinase, core)|ensembl:ENSG00000266173(gene)|ensembl:ENST00000336174(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0019900"(kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|refseq:XP_005257856.1|dip:DIP-35775N	-	-	-	figure legend:2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/10/10	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:WoEj2CkvNp1pV4Hx5asrQMddP5w9606	intact-crc:50F7CA805A08F52D|rigid:oofDZLxtsL8tRYx2BLQxZhIxTTY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:D4AE59	uniprotkb:Q7TNZ6	intact:EBI-1109147|ensembl:ENSRNOP00000057414|uniprotkb:D4A179|uniprotkb:A0A0H2UI02	intact:EBI-1109197|uniprotkb:Q66HD4	psi-mi:stk11_rat(display_long)|uniprotkb:Lkb1(gene name synonym)|uniprotkb:Liver kinase B1 homolog(gene name synonym)|uniprotkb:Stk11(gene name)|psi-mi:Stk11(display_short)	psi-mi:straa_rat(display_long)|uniprotkb:Strada(gene name)|psi-mi:Strada(display_short)|uniprotkb:Strad(gene name synonym)|uniprotkb:Lyk5(gene name synonym)|uniprotkb:STE20-related adapter protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Baas et al. (2003)	pubmed:12805220|imex:IM-19902	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1109237|imex:IM-19902-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000014287(gene)|ensembl:ENSRNOT00000060683(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|rgd:1308653|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033762"(response to glucagon)|go:"GO:0033993"(response to lipid)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0051645"(Golgi localization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|reactome:R-RNO-380972|reactome:R-RNO-6804756|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|refseq:XP_006240972.1|refseq:NP_001101539.1|refseq:XP_008763318.1	rgd:727905|refseq:NP_877972.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0019900"(kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044877"(protein-containing complex binding)|reactome:R-RNO-380972	-	-	-	figure legend:2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-rat-2)|taxid:10116(Rat R2 embryo cells)	-	2006/10/10	2021/02/11	rogid:y/RqMwopJ1UX0BeZkmrUiqRZ5x010116	rogid:GllwCaWcShWWXiZF23uho5Z+H+Q10116	intact-crc:712D40BE96097160|rigid:laXgoEP83FCspy+6KoIoHvx5Mb8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15831	uniprotkb:Q7RTN6	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-1109114|uniprotkb:Q5JPI2|uniprotkb:Q7Z4K9|uniprotkb:Q8NC31|uniprotkb:Q8NCF1|uniprotkb:Q9H272|ensembl:ENSP00000336655|uniprotkb:B4DDE3|uniprotkb:B4DW17|uniprotkb:J3KTC9	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:straa_human(display_long)|uniprotkb:STRADA(gene name)|psi-mi:STRADA(display_short)|uniprotkb:Serologically defined breast cancer antigen NY-BR-96(gene name synonym)|uniprotkb:STRAD(gene name synonym)|uniprotkb:LYK5(gene name synonym)|uniprotkb:STE20-related adapter protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Baas et al. (2003)	pubmed:12805220|imex:IM-19902	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1109276|imex:IM-19902-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_001003786.1|refseq:NP_001003787.1|refseq:NP_001003788.1|refseq:NP_001159441.1|refseq:NP_001159442.1|refseq:NP_699166.2|interpro:IPR011009(Protein kinase-like)|rcsb pdb:1UPK|rcsb pdb:2WTK|rcsb pdb:3GNI|reactome:R-HSA-380972|interpro:IPR000719(Protein kinase, core)|ensembl:ENSG00000266173(gene)|ensembl:ENST00000336174(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0019900"(kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|refseq:XP_005257856.1|dip:DIP-35775N	-	-	-	figure legend:2B & 2C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/10/10	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:WoEj2CkvNp1pV4Hx5asrQMddP5w9606	intact-crc:8F0146CEFF27CC99|rigid:oofDZLxtsL8tRYx2BLQxZhIxTTY	false	glutathione s tranferase tag:?-?|necessary binding region:319-343	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15831	uniprotkb:Q7RTN6	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-1109114|uniprotkb:Q5JPI2|uniprotkb:Q7Z4K9|uniprotkb:Q8NC31|uniprotkb:Q8NCF1|uniprotkb:Q9H272|ensembl:ENSP00000336655|uniprotkb:B4DDE3|uniprotkb:B4DW17|uniprotkb:J3KTC9	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:straa_human(display_long)|uniprotkb:STRADA(gene name)|psi-mi:STRADA(display_short)|uniprotkb:Serologically defined breast cancer antigen NY-BR-96(gene name synonym)|uniprotkb:STRAD(gene name synonym)|uniprotkb:LYK5(gene name synonym)|uniprotkb:STE20-related adapter protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Baas et al. (2003)	pubmed:12805220|imex:IM-19902	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1109318|imex:IM-19902-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_001003786.1|refseq:NP_001003787.1|refseq:NP_001003788.1|refseq:NP_001159441.1|refseq:NP_001159442.1|refseq:NP_699166.2|interpro:IPR011009(Protein kinase-like)|rcsb pdb:1UPK|rcsb pdb:2WTK|rcsb pdb:3GNI|reactome:R-HSA-380972|interpro:IPR000719(Protein kinase, core)|ensembl:ENSG00000266173(gene)|ensembl:ENST00000336174(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0019900"(kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|refseq:XP_005257856.1|dip:DIP-35775N	-	-	-	figure legend:3A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/10/10	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:WoEj2CkvNp1pV4Hx5asrQMddP5w9606	intact-crc:41B2FE3C3E846D18|rigid:oofDZLxtsL8tRYx2BLQxZhIxTTY	false	necessary binding region:303-306|myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15831	-	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	-	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Baas et al. (2003)	pubmed:12805220|imex:IM-19902	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1109418|imex:IM-19902-6	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	-	go:"GO:0046777"(protein autophosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:3A & 3B|resulting-ptm:"Autophosphorylation of STK11 (Q15831). Subsequent mapping by mass spectrometry showed this to me at Thr-185 and Thr-402."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/10	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	-	intact-crc:54CA1D799B7EA21B	false	myc tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	-
uniprotkb:Q7RTN6	uniprotkb:Q15831	intact:EBI-1109114|uniprotkb:Q5JPI2|uniprotkb:Q7Z4K9|uniprotkb:Q8NC31|uniprotkb:Q8NCF1|uniprotkb:Q9H272|ensembl:ENSP00000336655|uniprotkb:B4DDE3|uniprotkb:B4DW17|uniprotkb:J3KTC9	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:straa_human(display_long)|uniprotkb:STRADA(gene name)|psi-mi:STRADA(display_short)|uniprotkb:Serologically defined breast cancer antigen NY-BR-96(gene name synonym)|uniprotkb:STRAD(gene name synonym)|uniprotkb:LYK5(gene name synonym)|uniprotkb:STE20-related adapter protein(gene name synonym)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Baas et al. (2003)	pubmed:12805220|imex:IM-19902	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1109451|imex:IM-19902-7	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003786.1|refseq:NP_001003787.1|refseq:NP_001003788.1|refseq:NP_001159441.1|refseq:NP_001159442.1|refseq:NP_699166.2|interpro:IPR011009(Protein kinase-like)|rcsb pdb:1UPK|rcsb pdb:2WTK|rcsb pdb:3GNI|reactome:R-HSA-380972|interpro:IPR000719(Protein kinase, core)|ensembl:ENSG00000266173(gene)|ensembl:ENST00000336174(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0019900"(kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|refseq:XP_005257856.1|dip:DIP-35775N	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:3A & 3B|resulting-ptm:"Phosphorylation of STARD (Q7RTN6). Subsequent mapping of phosphorylation sites by mass spectrometry (Fig. 6A) were shown to be Thr-329 and Thr-419."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/10	2014/10/16	rogid:WoEj2CkvNp1pV4Hx5asrQMddP5w9606	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:229DAFAE692F25EB|rigid:oofDZLxtsL8tRYx2BLQxZhIxTTY	false	flag tag:?-?	necessary binding region:303-306|myc tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7RTN6	uniprotkb:Q15831	intact:EBI-1109114|uniprotkb:Q5JPI2|uniprotkb:Q7Z4K9|uniprotkb:Q8NC31|uniprotkb:Q8NCF1|uniprotkb:Q9H272|ensembl:ENSP00000336655|uniprotkb:B4DDE3|uniprotkb:B4DW17|uniprotkb:J3KTC9	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	psi-mi:straa_human(display_long)|uniprotkb:STRADA(gene name)|psi-mi:STRADA(display_short)|uniprotkb:Serologically defined breast cancer antigen NY-BR-96(gene name synonym)|uniprotkb:STRAD(gene name synonym)|uniprotkb:LYK5(gene name synonym)|uniprotkb:STE20-related adapter protein(gene name synonym)	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Baas et al. (2003)	pubmed:12805220|imex:IM-19902	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1109485|imex:IM-19902-8	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003786.1|refseq:NP_001003787.1|refseq:NP_001003788.1|refseq:NP_001159441.1|refseq:NP_001159442.1|refseq:NP_699166.2|interpro:IPR011009(Protein kinase-like)|rcsb pdb:1UPK|rcsb pdb:2WTK|rcsb pdb:3GNI|reactome:R-HSA-380972|interpro:IPR000719(Protein kinase, core)|ensembl:ENSG00000266173(gene)|ensembl:ENST00000336174(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0019900"(kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|refseq:XP_005257856.1|dip:DIP-35775N	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:3D|resulting-ptm:"Phosphorylation of STRAD (Q7RTN6)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/10	2014/10/16	rogid:WoEj2CkvNp1pV4Hx5asrQMddP5w9606	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	intact-crc:6795E48334812563|rigid:oofDZLxtsL8tRYx2BLQxZhIxTTY	false	flag tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15831	-	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	-	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Baas et al. (2003)	pubmed:12805220|imex:IM-19902	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1109764|imex:IM-19902-9	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	-	go:"GO:0046777"(protein autophosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:4A|stimulant:"STRAD (Q7RTN6)"|resulting-ptm:"Autophosphorylation of STK11 (Q15381)"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/10/10	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	-	intact-crc:B59038FEE94B7F29	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	-
uniprotkb:Q15831	uniprotkb:Q7RTN6	intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7	intact:EBI-1109114|uniprotkb:Q5JPI2|uniprotkb:Q7Z4K9|uniprotkb:Q8NC31|uniprotkb:Q8NCF1|uniprotkb:Q9H272|ensembl:ENSP00000336655|uniprotkb:B4DDE3|uniprotkb:B4DW17|uniprotkb:J3KTC9	psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym)	psi-mi:straa_human(display_long)|uniprotkb:STRADA(gene name)|psi-mi:STRADA(display_short)|uniprotkb:Serologically defined breast cancer antigen NY-BR-96(gene name synonym)|uniprotkb:STRAD(gene name synonym)|uniprotkb:LYK5(gene name synonym)|uniprotkb:STE20-related adapter protein(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Baas et al. (2003)	pubmed:12805220|imex:IM-19902	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1109785|imex:IM-19902-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N	refseq:NP_001003786.1|refseq:NP_001003787.1|refseq:NP_001003788.1|refseq:NP_001159441.1|refseq:NP_001159442.1|refseq:NP_699166.2|interpro:IPR011009(Protein kinase-like)|rcsb pdb:1UPK|rcsb pdb:2WTK|rcsb pdb:3GNI|reactome:R-HSA-380972|interpro:IPR000719(Protein kinase, core)|ensembl:ENSG00000266173(gene)|ensembl:ENST00000336174(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0019900"(kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|refseq:XP_005257856.1|dip:DIP-35775N	go:"GO:0046827"(positive regulation of protein export from nucleus)	-	-	figure legend:3A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/10/10	2014/10/16	rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606	rogid:WoEj2CkvNp1pV4Hx5asrQMddP5w9606	intact-crc:AA6A37CA270EB33F|rigid:oofDZLxtsL8tRYx2BLQxZhIxTTY	false	myc tag:?-?|necessary binding region:303-306	flag tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)