#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P01876 uniprotkb:P24071 intact:EBI-727651|ensembl:ENSP00000374989|ensembl:ENSP00000488021 intact:EBI-1036488|uniprotkb:Q13603|uniprotkb:Q13604|uniprotkb:Q15727|uniprotkb:Q15728|uniprotkb:Q92590|uniprotkb:Q1AJL7|uniprotkb:Q1AJL8|uniprotkb:Q1AJL9|uniprotkb:Q53X38|uniprotkb:Q92587|uniprotkb:Q92588|uniprotkb:Q92592|uniprotkb:Q92593|uniprotkb:Q9UEK0|uniprotkb:Q53X39|ensembl:ENSP00000347714|ensembl:ENSP00000478465|ensembl:ENSP00000479738|ensembl:ENSP00000481195|ensembl:ENSP00000481502|ensembl:ENSP00000482334|ensembl:ENSP00000482623|ensembl:ENSP00000482807|ensembl:ENSP00000483099|ensembl:ENSP00000491490|ensembl:ENSP00000492230|ensembl:ENSP00000492442|ensembl:ENSP00000492447|ensembl:ENSP00000492529|ensembl:ENSP00000492762 psi-mi:igha1_human(display_long)|uniprotkb:IGHA1(gene name)|psi-mi:IGHA1(display_short)|uniprotkb:Ig alpha-1 chain C region(gene name synonym)|uniprotkb:Ig alpha-1 chain C region BUR(gene name synonym)|uniprotkb:Ig alpha-1 chain C region TRO(gene name synonym) psi-mi:fcar_human(display_long)|uniprotkb:FCAR(gene name)|psi-mi:FCAR(display_short)|uniprotkb:CD89(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Herr et al. (2003) pubmed:12768205 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1036536|rcsb pdb:1OW0 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000211895(gene)|ensembl:ENSG00000282633(gene)|ensembl:ENST00000390547(transcript)|ensembl:ENST00000633714(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003094"(glomerular filtration)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0071748"(monomeric IgA immunoglobulin complex)|go:"GO:0071751"(secretory IgA immunoglobulin complex)|go:"GO:0071752"(secretory dimeric IgA immunoglobulin complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IGA|rcsb pdb:1OW0|rcsb pdb:2ESG|rcsb pdb:2QEJ|rcsb pdb:3CHN|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6UE7|rcsb pdb:6XJA|reactome:R-HSA-202733|reactome:R-HSA-2168880|go:"GO:0070062"(extracellular exosome) refseq:NP_001991.1|refseq:NP_579803.1|refseq:NP_579805.1|refseq:NP_579806.1|refseq:NP_579807.1|refseq:NP_579808.1|refseq:NP_579811.1|refseq:NP_579812.1|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1903209"(positive regulation of oxidative stress-induced cell death)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1OVZ|rcsb pdb:1OW0|rcsb pdb:1UCT|reactome:R-HSA-6798695|ensembl:ENSG00000186431(gene)|ensembl:ENSG00000273738(gene)|ensembl:ENSG00000274580(gene)|ensembl:ENSG00000275136(gene)|ensembl:ENSG00000275269(gene)|ensembl:ENSG00000275564(gene)|ensembl:ENSG00000275970(gene)|ensembl:ENSG00000276858(gene)|ensembl:ENSG00000276985(gene)|ensembl:ENSG00000283750(gene)|ensembl:ENSG00000283953(gene)|ensembl:ENSG00000284004(gene)|ensembl:ENSG00000284061(gene)|ensembl:ENSG00000284245(gene)|ensembl:ENST00000355524(transcript)|ensembl:ENST00000613199(transcript)|ensembl:ENST00000614226(transcript)|ensembl:ENST00000615829(transcript)|ensembl:ENST00000619385(transcript)|ensembl:ENST00000621702(transcript)|ensembl:ENST00000622157(transcript)|ensembl:ENST00000622737(transcript)|ensembl:ENST00000638212(transcript)|ensembl:ENST00000639402(transcript)|ensembl:ENST00000640025(transcript)|ensembl:ENST00000640239(transcript)|ensembl:ENST00000640405(transcript)|ensembl:ENST00000640582(transcript)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0019766"(IgA receptor activity)|go:"GO:0019862"(IgA binding)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0035579"(specific granule membrane)|go:"GO:0038093"(Fc receptor signaling pathway)|go:"GO:0042119"(neutrophil activation)|go:"GO:0070821"(tertiary granule membrane)|ensembl:ENST00000620801(transcript) - - - assembly:tetrameric, multimeric|3d-r-factors:working 74.800%, free 71.600%|3d-resolution:3.1A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:Mystbtg9uttxFXl//LGdoM32po09606 rogid:ycl94oh6X+RBbqjJyhU44bOz+d89606 intact-crc:02E1D38AB291C5C8|rigid:E19K4hKaZqmebaGei6q8QcYvCmA false sufficient binding region:123-335 sufficient binding region:22-216 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)