#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21146	uniprotkb:P62871	intact:EBI-1036401|ensembl:ENSBTAP00000050806	intact:EBI-357141|ensembl:ENSBTAP00000000259|ensembl:ENSBTAP00000042481|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:Q3MHF1	psi-mi:arbk1_bovin(display_long)|uniprotkb:GRK2(gene name)|psi-mi:GRK2(display_short)|uniprotkb:ADRBK1(gene name synonym)|uniprotkb:G-protein-coupled receptor kinase 2(gene name synonym)	psi-mi:gbb1_bovin(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Lodowski et al. (2003)	pubmed:12764189	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1036439|rcsb pdb:1OMW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777135.1|ensembl:ENSBTAG00000005832(gene)|ensembl:ENSBTAT00000055962(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|go:"GO:1903566"(positive regulation of protein localization to cilium)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:1OMW|rcsb pdb:1YM7|rcsb pdb:2BCJ|rcsb pdb:3PSC|rcsb pdb:3PVU|rcsb pdb:3PVW|rcsb pdb:3UZS|rcsb pdb:3UZT|rcsb pdb:5HE0|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKM|dip:DIP-37856N	ensembl:ENSBTAG00000000215(gene)|ensembl:ENSBTAT00000000259(transcript)|ensembl:ENSBTAT00000045065(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62871|rcsb pdb:1A0R|rcsb pdb:1B9X|rcsb pdb:1B9Y|rcsb pdb:1GG2|rcsb pdb:1GOT|rcsb pdb:1GP2|rcsb pdb:1OMW|rcsb pdb:1TBG|rcsb pdb:1XHM|rcsb pdb:2BCJ|rcsb pdb:2TRC|rcsb pdb:3AH8|rcsb pdb:3CIK|rcsb pdb:3KRW|rcsb pdb:3KRX|rcsb pdb:3PSC|rcsb pdb:3PVU|rcsb pdb:3PVW|rcsb pdb:3UZS|rcsb pdb:3V5W|rcsb pdb:4MK0|rcsb pdb:5KDO|rcsb pdb:5WG3|rcsb pdb:5WG4|rcsb pdb:5WG5|rcsb pdb:6B20|rcsb pdb:6C2Y|rcsb pdb:6OY9|rcsb pdb:6OYA|rcsb pdb:6PCV|rcsb pdb:6QNO|rcsb pdb:6U7C|rcsb pdb:7BZ2|rcsb pdb:7D68|rcsb pdb:7DHI|rcsb pdb:7DHR|rcsb pdb:7JJO|rcsb pdb:7O7F|refseq:NP_786971.2|dip:DIP-29227N|refseq:XP_010811610.1|refseq:XP_005217074.1	-	-	-	assembly:trimeric, multimeric|3d-r-factors:working 79.800%, free 74.800%|3d-resolution:2.5A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:TV0K9Zn5mqxFoLZmgbrxWr7ksNE9913	rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9913	intact-crc:AA3A9F6F4D93164F|rigid:YkRWGF+nTxNQvoNavGOdnlDSPVg	false	sufficient binding region:1-689	sufficient binding region:2-340	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21146	uniprotkb:P63212	intact:EBI-1036401|ensembl:ENSBTAP00000050806	intact:EBI-1036424|uniprotkb:P16874|uniprotkb:Q2KI31|uniprotkb:Q61013|uniprotkb:Q9TS47|ensembl:ENSBTAP00000003959	psi-mi:arbk1_bovin(display_long)|uniprotkb:GRK2(gene name)|psi-mi:GRK2(display_short)|uniprotkb:ADRBK1(gene name synonym)|uniprotkb:G-protein-coupled receptor kinase 2(gene name synonym)	psi-mi:gbg2_bovin(display_long)|uniprotkb:GNG2(gene name)|psi-mi:GNG2(display_short)|uniprotkb:G gamma-I(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Lodowski et al. (2003)	pubmed:12764189	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1036439|rcsb pdb:1OMW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777135.1|ensembl:ENSBTAG00000005832(gene)|ensembl:ENSBTAT00000055962(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|go:"GO:1903566"(positive regulation of protein localization to cilium)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|rcsb pdb:1OMW|rcsb pdb:1YM7|rcsb pdb:2BCJ|rcsb pdb:3PSC|rcsb pdb:3PVU|rcsb pdb:3PVW|rcsb pdb:3UZS|rcsb pdb:3UZT|rcsb pdb:5HE0|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKM|dip:DIP-37856N	refseq:NP_776497.1|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071870"(cellular response to catecholamine stimulus)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|rcsb pdb:1GG2|rcsb pdb:1GP2|rcsb pdb:1OMW|rcsb pdb:1XHM|rcsb pdb:2BCJ|rcsb pdb:3AH8|rcsb pdb:3CIK|rcsb pdb:3KRW|rcsb pdb:3KRX|rcsb pdb:3SN6|rcsb pdb:3UZS|rcsb pdb:3V5W|rcsb pdb:4MK0|rcsb pdb:4PNK|rcsb pdb:5TDH|rcsb pdb:5VAI|rcsb pdb:5WG3|rcsb pdb:5WG4|rcsb pdb:5WG5|rcsb pdb:6C2Y|rcsb pdb:6CMO|rcsb pdb:6LPB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|rcsb pdb:6PCV|rcsb pdb:6U7C|rcsb pdb:7BW0|rcsb pdb:7BZ2|rcsb pdb:7CZ5|rcsb pdb:7D3S|rcsb pdb:7D68|rcsb pdb:7DHI|rcsb pdb:7DHR|rcsb pdb:7JJO|rcsb pdb:3PSC|rcsb pdb:3PVU|rcsb pdb:3PVW|rcsb pdb:7LJC|rcsb pdb:7LJD|reactome:R-BTA-392170|reactome:R-BTA-416476|reactome:R-BTA-418594|reactome:R-BTA-418597|reactome:R-BTA-428930|reactome:R-BTA-456926|reactome:R-BTA-6814122|reactome:R-BTA-392451|ensembl:ENSBTAG00000003043(gene)|ensembl:ENSBTAT00000003959(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|refseq:XP_005211711.1|refseq:XP_010807541.1|dip:DIP-586N	-	-	-	assembly:trimeric, multimeric|3d-r-factors:working 79.800%, free 74.800%|3d-resolution:2.5A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:TV0K9Zn5mqxFoLZmgbrxWr7ksNE9913	rogid:8asTjDtSU6sCPSMwcXMbV340Rt49913	intact-crc:AA3A9F6F4D93164F|rigid:YkRWGF+nTxNQvoNavGOdnlDSPVg	false	sufficient binding region:1-689	sufficient binding region:2-67	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)