#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q60598	uniprotkb:Q8K1I7	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kinley et al. (2003)	pubmed:12620186|imex:IM-19872|mint:MINT-5216188	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-915405|imex:IM-19872-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N	refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/04/04	2014/10/16	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090	intact-crc:095F1DFA8C903D9C|rigid:iXBd5bLa99XoI33U6k3juyMdTMc	false	sufficient binding region:?-?(IPR001452)	sufficient binding region:138-207	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43516	uniprotkb:Q60598	intact:EBI-346356|uniprotkb:Q15220|uniprotkb:Q6MZU9|uniprotkb:Q9BU37|uniprotkb:Q9UNP1|uniprotkb:Q53TA9|uniprotkb:B8ZZM1|uniprotkb:D3DPE4|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENSP00000503603	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:wipf1_human(display_long)|uniprotkb:WIPF1(gene name)|psi-mi:WIPF1(display_short)|uniprotkb:WIP(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Protein PRPL-2(gene name synonym)|uniprotkb:WASPIP(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kinley et al. (2003)	pubmed:12620186|imex:IM-19872|mint:MINT-5216188	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-915418|imex:IM-19872-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070737.1|refseq:NP_003378.3|refseq:XP_011510082.1|ensembl:ENST00000272746|ensembl:ENSP00000272746|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENST00000409891|ensembl:ENSP00000386431|ensembl:ENSP00000503603|dip:DIP-17015N|ensembl:ENSG00000115935(gene)|ensembl:ENST00000359761(transcript)|ensembl:ENST00000392546(transcript)|ensembl:ENST00000392547(transcript)|ensembl:ENST00000679041(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:O43516|rcsb pdb:2A41|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9664422	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/04/04	2014/10/16	rogid:8qaxT2n0EXIVTi08xHsryCSSt9k9606	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:6FA74106AB80723C|rigid:ClkvKZpibGGSPGioPOp7CNKx+Ao	false	flag tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:325..325-546..546(IPR001452)|mutation disrupting interaction:526-526	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16333	uniprotkb:O43516	intact:EBI-389883|uniprotkb:B7Z751|ensembl:ENSP00000288986|ensembl:ENSP00000417273|intact:EBI-3448658|uniprotkb:D3DNE3	intact:EBI-346356|uniprotkb:Q15220|uniprotkb:Q6MZU9|uniprotkb:Q9BU37|uniprotkb:Q9UNP1|uniprotkb:Q53TA9|uniprotkb:B8ZZM1|uniprotkb:D3DPE4|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENSP00000503603	psi-mi:nck1_human(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:wipf1_human(display_long)|uniprotkb:WIPF1(gene name)|psi-mi:WIPF1(display_short)|uniprotkb:WIP(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Protein PRPL-2(gene name synonym)|uniprotkb:WASPIP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kinley et al. (2003)	pubmed:12620186|imex:IM-19872|mint:MINT-5216188	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-919803|imex:IM-19872-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278928.1|ensembl:ENSG00000158092(gene)|ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007172"(signal complex assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|refseq:NP_001177725.1|refseq:NP_006144.1|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|mint:P16333|rcsb pdb:2CI8|rcsb pdb:2CI9|rcsb pdb:2CUB|rcsb pdb:2JS0|rcsb pdb:2JS2|rcsb pdb:2JW4|rcsb pdb:5QU1|rcsb pdb:5QU2|rcsb pdb:5QU3|rcsb pdb:5QU4|rcsb pdb:5QU5|rcsb pdb:5QU6|rcsb pdb:5QU7|rcsb pdb:5QU8|rcsb pdb:5QUA|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-373753|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9664422|reactome:R-HSA-983695|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|dip:DIP-639N	refseq:NP_001070737.1|refseq:NP_003378.3|refseq:XP_011510082.1|ensembl:ENST00000272746|ensembl:ENSP00000272746|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENST00000409891|ensembl:ENSP00000386431|ensembl:ENSP00000503603|dip:DIP-17015N|ensembl:ENSG00000115935(gene)|ensembl:ENST00000359761(transcript)|ensembl:ENST00000392546(transcript)|ensembl:ENST00000392547(transcript)|ensembl:ENST00000679041(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:O43516|rcsb pdb:2A41|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9664422	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/04/04	2014/10/16	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	rogid:8qaxT2n0EXIVTi08xHsryCSSt9k9606	intact-crc:E2B9D8E70F746D1E|rigid:2JVd6cgBMPCGTZJAe5ztey+JV74	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60598	uniprotkb:O43516	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	intact:EBI-346356|uniprotkb:Q15220|uniprotkb:Q6MZU9|uniprotkb:Q9BU37|uniprotkb:Q9UNP1|uniprotkb:Q53TA9|uniprotkb:B8ZZM1|uniprotkb:D3DPE4|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENSP00000503603	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:wipf1_human(display_long)|uniprotkb:WIPF1(gene name)|psi-mi:WIPF1(display_short)|uniprotkb:WIP(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Protein PRPL-2(gene name synonym)|uniprotkb:WASPIP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kinley et al. (2003)	pubmed:12620186|imex:IM-19872|mint:MINT-5216188	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921690|imex:IM-19872-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N	refseq:NP_001070737.1|refseq:NP_003378.3|refseq:XP_011510082.1|ensembl:ENST00000272746|ensembl:ENSP00000272746|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENST00000409891|ensembl:ENSP00000386431|ensembl:ENSP00000503603|dip:DIP-17015N|ensembl:ENSG00000115935(gene)|ensembl:ENST00000359761(transcript)|ensembl:ENST00000392546(transcript)|ensembl:ENST00000392547(transcript)|ensembl:ENST00000679041(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:O43516|rcsb pdb:2A41|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9664422	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/04/04	2014/10/16	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	rogid:8qaxT2n0EXIVTi08xHsryCSSt9k9606	intact-crc:45CF0813E1BCC8FE|rigid:ClkvKZpibGGSPGioPOp7CNKx+Ao	false	sufficient binding region:325..325-546..546|mutation disrupting interaction:526-526|glutathione s tranferase tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43516	uniprotkb:P16333	intact:EBI-346356|uniprotkb:Q15220|uniprotkb:Q6MZU9|uniprotkb:Q9BU37|uniprotkb:Q9UNP1|uniprotkb:Q53TA9|uniprotkb:B8ZZM1|uniprotkb:D3DPE4|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENSP00000503603	intact:EBI-389883|uniprotkb:B7Z751|ensembl:ENSP00000288986|ensembl:ENSP00000417273|intact:EBI-3448658|uniprotkb:D3DNE3	psi-mi:wipf1_human(display_long)|uniprotkb:WIPF1(gene name)|psi-mi:WIPF1(display_short)|uniprotkb:WIP(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Protein PRPL-2(gene name synonym)|uniprotkb:WASPIP(gene name synonym)	psi-mi:nck1_human(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kinley et al. (2003)	pubmed:12620186|imex:IM-19872|mint:MINT-5216188	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921702|imex:IM-19872-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070737.1|refseq:NP_003378.3|refseq:XP_011510082.1|ensembl:ENST00000272746|ensembl:ENSP00000272746|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENST00000409891|ensembl:ENSP00000386431|ensembl:ENSP00000503603|dip:DIP-17015N|ensembl:ENSG00000115935(gene)|ensembl:ENST00000359761(transcript)|ensembl:ENST00000392546(transcript)|ensembl:ENST00000392547(transcript)|ensembl:ENST00000679041(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:O43516|rcsb pdb:2A41|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9664422	refseq:NP_001278928.1|ensembl:ENSG00000158092(gene)|ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007172"(signal complex assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|refseq:NP_001177725.1|refseq:NP_006144.1|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|mint:P16333|rcsb pdb:2CI8|rcsb pdb:2CI9|rcsb pdb:2CUB|rcsb pdb:2JS0|rcsb pdb:2JS2|rcsb pdb:2JW4|rcsb pdb:5QU1|rcsb pdb:5QU2|rcsb pdb:5QU3|rcsb pdb:5QU4|rcsb pdb:5QU5|rcsb pdb:5QU6|rcsb pdb:5QU7|rcsb pdb:5QU8|rcsb pdb:5QUA|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-373753|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9664422|reactome:R-HSA-983695|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|dip:DIP-639N	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/04/04	2014/10/16	rogid:8qaxT2n0EXIVTi08xHsryCSSt9k9606	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	intact-crc:77DEF8CF865C93F0|rigid:2JVd6cgBMPCGTZJAe5ztey+JV74	false	his tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60598	uniprotkb:O43516	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	intact:EBI-346356|uniprotkb:Q15220|uniprotkb:Q6MZU9|uniprotkb:Q9BU37|uniprotkb:Q9UNP1|uniprotkb:Q53TA9|uniprotkb:B8ZZM1|uniprotkb:D3DPE4|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENSP00000503603	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:wipf1_human(display_long)|uniprotkb:WIPF1(gene name)|psi-mi:WIPF1(display_short)|uniprotkb:WIP(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Protein PRPL-2(gene name synonym)|uniprotkb:WASPIP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kinley et al. (2003)	pubmed:12620186|imex:IM-19872|mint:MINT-5216188	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921975|imex:IM-19872-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N	refseq:NP_001070737.1|refseq:NP_003378.3|refseq:XP_011510082.1|ensembl:ENST00000272746|ensembl:ENSP00000272746|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENST00000409891|ensembl:ENSP00000386431|ensembl:ENSP00000503603|dip:DIP-17015N|ensembl:ENSG00000115935(gene)|ensembl:ENST00000359761(transcript)|ensembl:ENST00000392546(transcript)|ensembl:ENST00000392547(transcript)|ensembl:ENST00000679041(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:O43516|rcsb pdb:2A41|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9664422	-	-	-	comment:The Kd was estimated by adding different amount of GST-cortactin to a fixed amount of WIP and plotting the amount of bound proteins.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/04/04	2014/10/16	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	rogid:8qaxT2n0EXIVTi08xHsryCSSt9k9606	intact-crc:C9707B335A097037|rigid:ClkvKZpibGGSPGioPOp7CNKx+Ao	false	glutathione s tranferase tag:?-?|mutation disrupting interaction:526-526	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14247	uniprotkb:O43516	intact:EBI-351886|intact:EBI-3959948|ensembl:ENSP00000301843|ensembl:ENSP00000500756|uniprotkb:Q8N707|uniprotkb:Q96H99	intact:EBI-346356|uniprotkb:Q15220|uniprotkb:Q6MZU9|uniprotkb:Q9BU37|uniprotkb:Q9UNP1|uniprotkb:Q53TA9|uniprotkb:B8ZZM1|uniprotkb:D3DPE4|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENSP00000503603	psi-mi:src8_human(display_long)|uniprotkb:CTTN(gene name)|psi-mi:CTTN(display_short)|uniprotkb:EMS1(gene name synonym)|uniprotkb:Amplaxin(gene name synonym)|uniprotkb:Oncogene EMS1(gene name synonym)	psi-mi:wipf1_human(display_long)|uniprotkb:WIPF1(gene name)|psi-mi:WIPF1(display_short)|uniprotkb:WIP(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Protein PRPL-2(gene name synonym)|uniprotkb:WASPIP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kinley et al. (2003)	pubmed:12620186|imex:IM-19872|mint:MINT-5216188	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-921997|imex:IM-19872-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005222.2|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|mint:Q14247|rcsb pdb:1X69|rcsb pdb:2D1X|reactome:R-HSA-5627123|reactome:R-HSA-8856828|ensembl:ENSG00000085733(gene)|ensembl:ENSG00000288401(gene)|ensembl:ENST00000301843(transcript)|ensembl:ENST00000671805(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|refseq:NP_001171669.1|refseq:NP_612632.1|dip:DIP-33190N	refseq:NP_001070737.1|refseq:NP_003378.3|refseq:XP_011510082.1|ensembl:ENST00000272746|ensembl:ENSP00000272746|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENST00000409891|ensembl:ENSP00000386431|ensembl:ENSP00000503603|dip:DIP-17015N|ensembl:ENSG00000115935(gene)|ensembl:ENST00000359761(transcript)|ensembl:ENST00000392546(transcript)|ensembl:ENST00000392547(transcript)|ensembl:ENST00000679041(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:O43516|rcsb pdb:2A41|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9664422	-	-	-	sample process:over-expressed level. O43516|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/04/04	2014/10/16	rogid:uzhAnL5Fu9Mgg9/LWeNiaYIwNVU9606	rogid:8qaxT2n0EXIVTi08xHsryCSSt9k9606	intact-crc:554C2DB15B008C44|rigid:DdAg8yda7h+5a02+/DrLK9trXiY	false	-	flag tag:?-?|sufficient binding region:112-503|necessary binding region:112-170	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70420	uniprotkb:O43516	intact:EBI-922114	intact:EBI-346356|uniprotkb:Q15220|uniprotkb:Q6MZU9|uniprotkb:Q9BU37|uniprotkb:Q9UNP1|uniprotkb:Q53TA9|uniprotkb:B8ZZM1|uniprotkb:D3DPE4|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENSP00000503603	psi-mi:o70420_rat(display_long)	psi-mi:wipf1_human(display_long)|uniprotkb:WIPF1(gene name)|psi-mi:WIPF1(display_short)|uniprotkb:WIP(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Protein PRPL-2(gene name synonym)|uniprotkb:WASPIP(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Kinley et al. (2003)	pubmed:12620186|imex:IM-19872|mint:MINT-5216188	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-922123|imex:IM-19872-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR015503(Cortactin)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR001452(Src homology-3)|go:"GO:0030041"(actin filament polymerization)|interpro:IPR035716|interpro:IPR036028	refseq:NP_001070737.1|refseq:NP_003378.3|refseq:XP_011510082.1|ensembl:ENST00000272746|ensembl:ENSP00000272746|ensembl:ENSP00000352802|ensembl:ENSP00000376329|ensembl:ENSP00000376330|ensembl:ENST00000409891|ensembl:ENSP00000386431|ensembl:ENSP00000503603|dip:DIP-17015N|ensembl:ENSG00000115935(gene)|ensembl:ENST00000359761(transcript)|ensembl:ENST00000392546(transcript)|ensembl:ENST00000392547(transcript)|ensembl:ENST00000679041(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:O43516|rcsb pdb:2A41|reactome:R-HSA-2029482|reactome:R-HSA-5663213|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9664422	-	-	-	sample process:over-expressed level. O43516|caution:FLAG-WIP fragment 237-503 and FLAG-WIP delta 110-170 did not colocalize with cortactin.|comment:WIP and cortactin associate at the cell periphery and the cortactin binding region of WIP seems to be required for efficient cortical localization.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-ref52)|taxid:10116(Rattus norvegicus embryonic fibroblast cells)	-	2006/04/04	2014/10/16	rogid:fE1JcV1/JO4SJ4mKSga4mth6cZY10116	rogid:8qaxT2n0EXIVTi08xHsryCSSt9k9606	intact-crc:25C163A47E582E2B|rigid:v1YiKW6ghkosZQI66bpUDOP45pU	false	-	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)