#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P24482	uniprotkb:P27344	intact:EBI-6071|uniprotkb:Q06622|uniprotkb:D6W4H6|ensemblfungi:YPR175W	intact:EBI-6076|uniprotkb:D6VQS3|ensemblfungi:YBR278W	psi-mi:dpb2_yeast(display_long)|uniprotkb:DPB2(gene name)|psi-mi:DPB2(display_short)|uniprotkb:YPR175W(locus name)|uniprotkb:P9705.7(orf name)|uniprotkb:DNA polymerase II subunit 2(gene name synonym)	psi-mi:dpb3_yeast(display_long)|uniprotkb:DPB3(gene name)|psi-mi:DPB3(display_short)|uniprotkb:YBR278W(locus name)|uniprotkb:YBR2015(orf name)|uniprotkb:DNA polymerase II subunit C(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Chilkova et al. (2003)	pubmed:12571237|imex:IM-27293	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-866653|imex:IM-27293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015501.2|sgd:S000006379|dip:DIP-2533N|mint:P24482|ensemblfungi:YPR175W(gene)|ensemblfungi:YPR175W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0045005"(DNA-dependent DNA replication maintenance of fidelity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR016266(DNA polymerase epsilon, subunit B)|rcsb pdb:6HV8|rcsb pdb:6HV9|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	refseq:NP_009837.1|sgd:S000000482|dip:DIP-4803N|mint:P27344|ensemblfungi:YBR278W(gene)|ensemblfungi:YBR278W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0008623"(CHRAC)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|interpro:IPR009072(Histone-fold)|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	go:"GO:0008622"(epsilon DNA polymerase complex)	crc64:0936E3FC90552788	crc64:288913917D49C7F9	comment:Stokes radius of the complex was estimated to be 74.5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/27	2014/10/16	rogid:jKBQrq2Ly8tCccOCiAcF1nfO87I559292	rogid:vWWMmgZ4w7G1VF2V2TDY8cZpKas559292	intact-crc:18DC9C5502E49938|rigid:HagyRfqlPzWLyiCMlbzEmxcHxfQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24482	uniprotkb:Q04603	intact:EBI-6071|uniprotkb:Q06622|uniprotkb:D6W4H6|ensemblfungi:YPR175W	intact:EBI-29938|uniprotkb:D6VSA7|ensemblfungi:YDR121W	psi-mi:dpb2_yeast(display_long)|uniprotkb:DPB2(gene name)|psi-mi:DPB2(display_short)|uniprotkb:YPR175W(locus name)|uniprotkb:P9705.7(orf name)|uniprotkb:DNA polymerase II subunit 2(gene name synonym)	psi-mi:dpb4_yeast(display_long)|uniprotkb:DPB4(gene name)|psi-mi:DPB4(display_short)|uniprotkb:DNA polymerase II subunit D(gene name synonym)|uniprotkb:YDR121W(locus name)	psi-mi:"MI:0071"(molecular sieving)	Chilkova et al. (2003)	pubmed:12571237|imex:IM-27293	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-866653|imex:IM-27293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015501.2|sgd:S000006379|dip:DIP-2533N|mint:P24482|ensemblfungi:YPR175W(gene)|ensemblfungi:YPR175W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0045005"(DNA-dependent DNA replication maintenance of fidelity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR016266(DNA polymerase epsilon, subunit B)|rcsb pdb:6HV8|rcsb pdb:6HV9|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	sgd:S000002528|refseq:NP_010406.3|dip:DIP-4621N|mint:Q04603|ensemblfungi:YDR121W(gene)|ensemblfungi:YDR121W_mRNA(transcript)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0008623"(CHRAC)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0043044"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|interpro:IPR009072(Histone-fold)|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	go:"GO:0008622"(epsilon DNA polymerase complex)	crc64:0936E3FC90552788	-	comment:Stokes radius of the complex was estimated to be 74.5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/27	2014/10/16	rogid:jKBQrq2Ly8tCccOCiAcF1nfO87I559292	rogid:vEA21+6hLP2O4eSSuKA49lbi0E0559292	intact-crc:18DC9C5502E49938|rigid:HagyRfqlPzWLyiCMlbzEmxcHxfQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24482	uniprotkb:P21951	intact:EBI-6071|uniprotkb:Q06622|uniprotkb:D6W4H6|ensemblfungi:YPR175W	intact:EBI-6140|uniprotkb:D6W0T1|ensemblfungi:YNL262W	psi-mi:dpb2_yeast(display_long)|uniprotkb:DPB2(gene name)|psi-mi:DPB2(display_short)|uniprotkb:YPR175W(locus name)|uniprotkb:P9705.7(orf name)|uniprotkb:DNA polymerase II subunit 2(gene name synonym)	psi-mi:dpoe_yeast(display_long)|uniprotkb:POL2(gene name)|psi-mi:POL2(display_short)|uniprotkb:DUN2(gene name synonym)|uniprotkb:YNL262W(locus name)|uniprotkb:N0825(orf name)|uniprotkb:DNA polymerase II subunit A(gene name synonym)|uniprotkb:3'-5' exodeoxyribonuclease(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Chilkova et al. (2003)	pubmed:12571237|imex:IM-27293	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-866653|imex:IM-27293-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015501.2|sgd:S000006379|dip:DIP-2533N|mint:P24482|ensemblfungi:YPR175W(gene)|ensemblfungi:YPR175W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0045005"(DNA-dependent DNA replication maintenance of fidelity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR016266(DNA polymerase epsilon, subunit B)|rcsb pdb:6HV8|rcsb pdb:6HV9|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	refseq:NP_014137.1|sgd:S000005206|dip:DIP-2532N|mint:P21951|ensemblfungi:YNL262W(gene)|ensemblfungi:YNL262W_mRNA(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005657"(replication fork)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006284"(base-excision repair)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008310"(single-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032183"(SUMO binding)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035822"(gene conversion)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013697(Region of unknown function DUF1744)|interpro:IPR029703|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:4M8O|rcsb pdb:4PTF|rcsb pdb:5OKI|rcsb pdb:6FWK|rcsb pdb:6G0A|rcsb pdb:6H1V|rcsb pdb:6HV8|rcsb pdb:6HV9|rcsb pdb:6I8A|rcsb pdb:6QIB|rcsb pdb:6S1C|rcsb pdb:6S2E|rcsb pdb:6S2F|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	go:"GO:0008622"(epsilon DNA polymerase complex)	crc64:0936E3FC90552788	crc64:CBCDDE2AB147D65B	comment:Stokes radius of the complex was estimated to be 74.5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/27	2014/10/16	rogid:jKBQrq2Ly8tCccOCiAcF1nfO87I559292	rogid:2OXq7Xt5TAcYf7QLOpKzpol96sE559292	intact-crc:18DC9C5502E49938|rigid:HagyRfqlPzWLyiCMlbzEmxcHxfQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24482	uniprotkb:P27344	intact:EBI-6071|uniprotkb:Q06622|uniprotkb:D6W4H6|ensemblfungi:YPR175W	intact:EBI-6076|uniprotkb:D6VQS3|ensemblfungi:YBR278W	psi-mi:dpb2_yeast(display_long)|uniprotkb:DPB2(gene name)|psi-mi:DPB2(display_short)|uniprotkb:YPR175W(locus name)|uniprotkb:P9705.7(orf name)|uniprotkb:DNA polymerase II subunit 2(gene name synonym)	psi-mi:dpb3_yeast(display_long)|uniprotkb:DPB3(gene name)|psi-mi:DPB3(display_short)|uniprotkb:YBR278W(locus name)|uniprotkb:YBR2015(orf name)|uniprotkb:DNA polymerase II subunit C(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Chilkova et al. (2003)	pubmed:12571237|imex:IM-27293	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-866669|imex:IM-27293-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015501.2|sgd:S000006379|dip:DIP-2533N|mint:P24482|ensemblfungi:YPR175W(gene)|ensemblfungi:YPR175W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0045005"(DNA-dependent DNA replication maintenance of fidelity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR016266(DNA polymerase epsilon, subunit B)|rcsb pdb:6HV8|rcsb pdb:6HV9|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	refseq:NP_009837.1|sgd:S000000482|dip:DIP-4803N|mint:P27344|ensemblfungi:YBR278W(gene)|ensemblfungi:YBR278W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0008623"(CHRAC)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|interpro:IPR009072(Histone-fold)|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	go:"GO:0008622"(epsilon DNA polymerase complex)	crc64:0936E3FC90552788	crc64:288913917D49C7F9	comment:The sedimentation coefficient for Pol epsilon  was determined to be 11.9 S. Calculated molecular mass = 371 kDa.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/27	2014/10/16	rogid:jKBQrq2Ly8tCccOCiAcF1nfO87I559292	rogid:vWWMmgZ4w7G1VF2V2TDY8cZpKas559292	intact-crc:618C0EC1910A4568|rigid:HagyRfqlPzWLyiCMlbzEmxcHxfQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24482	uniprotkb:Q04603	intact:EBI-6071|uniprotkb:Q06622|uniprotkb:D6W4H6|ensemblfungi:YPR175W	intact:EBI-29938|uniprotkb:D6VSA7|ensemblfungi:YDR121W	psi-mi:dpb2_yeast(display_long)|uniprotkb:DPB2(gene name)|psi-mi:DPB2(display_short)|uniprotkb:YPR175W(locus name)|uniprotkb:P9705.7(orf name)|uniprotkb:DNA polymerase II subunit 2(gene name synonym)	psi-mi:dpb4_yeast(display_long)|uniprotkb:DPB4(gene name)|psi-mi:DPB4(display_short)|uniprotkb:DNA polymerase II subunit D(gene name synonym)|uniprotkb:YDR121W(locus name)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Chilkova et al. (2003)	pubmed:12571237|imex:IM-27293	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-866669|imex:IM-27293-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015501.2|sgd:S000006379|dip:DIP-2533N|mint:P24482|ensemblfungi:YPR175W(gene)|ensemblfungi:YPR175W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0045005"(DNA-dependent DNA replication maintenance of fidelity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR016266(DNA polymerase epsilon, subunit B)|rcsb pdb:6HV8|rcsb pdb:6HV9|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	sgd:S000002528|refseq:NP_010406.3|dip:DIP-4621N|mint:Q04603|ensemblfungi:YDR121W(gene)|ensemblfungi:YDR121W_mRNA(transcript)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0008623"(CHRAC)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0043044"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|interpro:IPR009072(Histone-fold)|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	go:"GO:0008622"(epsilon DNA polymerase complex)	crc64:0936E3FC90552788	-	comment:The sedimentation coefficient for Pol epsilon  was determined to be 11.9 S. Calculated molecular mass = 371 kDa.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/27	2014/10/16	rogid:jKBQrq2Ly8tCccOCiAcF1nfO87I559292	rogid:vEA21+6hLP2O4eSSuKA49lbi0E0559292	intact-crc:618C0EC1910A4568|rigid:HagyRfqlPzWLyiCMlbzEmxcHxfQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24482	uniprotkb:P21951	intact:EBI-6071|uniprotkb:Q06622|uniprotkb:D6W4H6|ensemblfungi:YPR175W	intact:EBI-6140|uniprotkb:D6W0T1|ensemblfungi:YNL262W	psi-mi:dpb2_yeast(display_long)|uniprotkb:DPB2(gene name)|psi-mi:DPB2(display_short)|uniprotkb:YPR175W(locus name)|uniprotkb:P9705.7(orf name)|uniprotkb:DNA polymerase II subunit 2(gene name synonym)	psi-mi:dpoe_yeast(display_long)|uniprotkb:POL2(gene name)|psi-mi:POL2(display_short)|uniprotkb:DUN2(gene name synonym)|uniprotkb:YNL262W(locus name)|uniprotkb:N0825(orf name)|uniprotkb:DNA polymerase II subunit A(gene name synonym)|uniprotkb:3'-5' exodeoxyribonuclease(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Chilkova et al. (2003)	pubmed:12571237|imex:IM-27293	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-866669|imex:IM-27293-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015501.2|sgd:S000006379|dip:DIP-2533N|mint:P24482|ensemblfungi:YPR175W(gene)|ensemblfungi:YPR175W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0045005"(DNA-dependent DNA replication maintenance of fidelity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR016266(DNA polymerase epsilon, subunit B)|rcsb pdb:6HV8|rcsb pdb:6HV9|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	refseq:NP_014137.1|sgd:S000005206|dip:DIP-2532N|mint:P21951|ensemblfungi:YNL262W(gene)|ensemblfungi:YNL262W_mRNA(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005657"(replication fork)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006284"(base-excision repair)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008310"(single-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032183"(SUMO binding)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035822"(gene conversion)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013697(Region of unknown function DUF1744)|interpro:IPR029703|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:4M8O|rcsb pdb:4PTF|rcsb pdb:5OKI|rcsb pdb:6FWK|rcsb pdb:6G0A|rcsb pdb:6H1V|rcsb pdb:6HV8|rcsb pdb:6HV9|rcsb pdb:6I8A|rcsb pdb:6QIB|rcsb pdb:6S1C|rcsb pdb:6S2E|rcsb pdb:6S2F|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	go:"GO:0008622"(epsilon DNA polymerase complex)	crc64:0936E3FC90552788	crc64:CBCDDE2AB147D65B	comment:The sedimentation coefficient for Pol epsilon  was determined to be 11.9 S. Calculated molecular mass = 371 kDa.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/27	2014/10/16	rogid:jKBQrq2Ly8tCccOCiAcF1nfO87I559292	rogid:2OXq7Xt5TAcYf7QLOpKzpol96sE559292	intact-crc:618C0EC1910A4568|rigid:HagyRfqlPzWLyiCMlbzEmxcHxfQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24482	uniprotkb:P27344	intact:EBI-6071|uniprotkb:Q06622|uniprotkb:D6W4H6|ensemblfungi:YPR175W	intact:EBI-6076|uniprotkb:D6VQS3|ensemblfungi:YBR278W	psi-mi:dpb2_yeast(display_long)|uniprotkb:DPB2(gene name)|psi-mi:DPB2(display_short)|uniprotkb:YPR175W(locus name)|uniprotkb:P9705.7(orf name)|uniprotkb:DNA polymerase II subunit 2(gene name synonym)	psi-mi:dpb3_yeast(display_long)|uniprotkb:DPB3(gene name)|psi-mi:DPB3(display_short)|uniprotkb:YBR278W(locus name)|uniprotkb:YBR2015(orf name)|uniprotkb:DNA polymerase II subunit C(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Chilkova et al. (2003)	pubmed:12571237|imex:IM-27293	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-866682|imex:IM-27293-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015501.2|sgd:S000006379|dip:DIP-2533N|mint:P24482|ensemblfungi:YPR175W(gene)|ensemblfungi:YPR175W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0045005"(DNA-dependent DNA replication maintenance of fidelity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR016266(DNA polymerase epsilon, subunit B)|rcsb pdb:6HV8|rcsb pdb:6HV9|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	refseq:NP_009837.1|sgd:S000000482|dip:DIP-4803N|mint:P27344|ensemblfungi:YBR278W(gene)|ensemblfungi:YBR278W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0008623"(CHRAC)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|interpro:IPR009072(Histone-fold)|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	go:"GO:0008622"(epsilon DNA polymerase complex)	crc64:0936E3FC90552788	crc64:288913917D49C7F9	comment:The molecular mass of Pol epsilon  w= 366 kDa under these conditions. A comparison with the predicted distribution of a monomeric versus a dimeric assembly showed that Pol epsilon  was present as a monomer in the solution under all conditions investigated|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/27	2014/10/16	rogid:jKBQrq2Ly8tCccOCiAcF1nfO87I559292	rogid:vWWMmgZ4w7G1VF2V2TDY8cZpKas559292	intact-crc:A404B80AD7F2421E|rigid:HagyRfqlPzWLyiCMlbzEmxcHxfQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24482	uniprotkb:Q04603	intact:EBI-6071|uniprotkb:Q06622|uniprotkb:D6W4H6|ensemblfungi:YPR175W	intact:EBI-29938|uniprotkb:D6VSA7|ensemblfungi:YDR121W	psi-mi:dpb2_yeast(display_long)|uniprotkb:DPB2(gene name)|psi-mi:DPB2(display_short)|uniprotkb:YPR175W(locus name)|uniprotkb:P9705.7(orf name)|uniprotkb:DNA polymerase II subunit 2(gene name synonym)	psi-mi:dpb4_yeast(display_long)|uniprotkb:DPB4(gene name)|psi-mi:DPB4(display_short)|uniprotkb:DNA polymerase II subunit D(gene name synonym)|uniprotkb:YDR121W(locus name)	psi-mi:"MI:0027"(cosedimentation)	Chilkova et al. (2003)	pubmed:12571237|imex:IM-27293	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-866682|imex:IM-27293-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015501.2|sgd:S000006379|dip:DIP-2533N|mint:P24482|ensemblfungi:YPR175W(gene)|ensemblfungi:YPR175W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0045005"(DNA-dependent DNA replication maintenance of fidelity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR016266(DNA polymerase epsilon, subunit B)|rcsb pdb:6HV8|rcsb pdb:6HV9|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	sgd:S000002528|refseq:NP_010406.3|dip:DIP-4621N|mint:Q04603|ensemblfungi:YDR121W(gene)|ensemblfungi:YDR121W_mRNA(transcript)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0008623"(CHRAC)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0043044"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|interpro:IPR009072(Histone-fold)|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	go:"GO:0008622"(epsilon DNA polymerase complex)	crc64:0936E3FC90552788	-	comment:The molecular mass of Pol epsilon  w= 366 kDa under these conditions. A comparison with the predicted distribution of a monomeric versus a dimeric assembly showed that Pol epsilon  was present as a monomer in the solution under all conditions investigated|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/27	2014/10/16	rogid:jKBQrq2Ly8tCccOCiAcF1nfO87I559292	rogid:vEA21+6hLP2O4eSSuKA49lbi0E0559292	intact-crc:A404B80AD7F2421E|rigid:HagyRfqlPzWLyiCMlbzEmxcHxfQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24482	uniprotkb:P21951	intact:EBI-6071|uniprotkb:Q06622|uniprotkb:D6W4H6|ensemblfungi:YPR175W	intact:EBI-6140|uniprotkb:D6W0T1|ensemblfungi:YNL262W	psi-mi:dpb2_yeast(display_long)|uniprotkb:DPB2(gene name)|psi-mi:DPB2(display_short)|uniprotkb:YPR175W(locus name)|uniprotkb:P9705.7(orf name)|uniprotkb:DNA polymerase II subunit 2(gene name synonym)	psi-mi:dpoe_yeast(display_long)|uniprotkb:POL2(gene name)|psi-mi:POL2(display_short)|uniprotkb:DUN2(gene name synonym)|uniprotkb:YNL262W(locus name)|uniprotkb:N0825(orf name)|uniprotkb:DNA polymerase II subunit A(gene name synonym)|uniprotkb:3'-5' exodeoxyribonuclease(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Chilkova et al. (2003)	pubmed:12571237|imex:IM-27293	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-866682|imex:IM-27293-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015501.2|sgd:S000006379|dip:DIP-2533N|mint:P24482|ensemblfungi:YPR175W(gene)|ensemblfungi:YPR175W_mRNA(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007049"(cell cycle)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0045005"(DNA-dependent DNA replication maintenance of fidelity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR016266(DNA polymerase epsilon, subunit B)|rcsb pdb:6HV8|rcsb pdb:6HV9|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	refseq:NP_014137.1|sgd:S000005206|dip:DIP-2532N|mint:P21951|ensemblfungi:YNL262W(gene)|ensemblfungi:YNL262W_mRNA(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005657"(replication fork)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006284"(base-excision repair)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008310"(single-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032183"(SUMO binding)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035822"(gene conversion)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0070868"(obsolete heterochromatin organization involved in chromatin silencing)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013697(Region of unknown function DUF1744)|interpro:IPR029703|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:4M8O|rcsb pdb:4PTF|rcsb pdb:5OKI|rcsb pdb:6FWK|rcsb pdb:6G0A|rcsb pdb:6H1V|rcsb pdb:6HV8|rcsb pdb:6HV9|rcsb pdb:6I8A|rcsb pdb:6QIB|rcsb pdb:6S1C|rcsb pdb:6S2E|rcsb pdb:6S2F|rcsb pdb:6WJV|reactome:R-SCE-5656169|reactome:R-SCE-6782135|reactome:R-SCE-68952|reactome:R-SCE-68962	go:"GO:0008622"(epsilon DNA polymerase complex)	crc64:0936E3FC90552788	crc64:CBCDDE2AB147D65B	comment:The molecular mass of Pol epsilon  w= 366 kDa under these conditions. A comparison with the predicted distribution of a monomeric versus a dimeric assembly showed that Pol epsilon  was present as a monomer in the solution under all conditions investigated|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/02/27	2014/10/16	rogid:jKBQrq2Ly8tCccOCiAcF1nfO87I559292	rogid:2OXq7Xt5TAcYf7QLOpKzpol96sE559292	intact-crc:A404B80AD7F2421E|rigid:HagyRfqlPzWLyiCMlbzEmxcHxfQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)