#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P20701	uniprotkb:P05362	intact:EBI-961214|ensembl:ENSP00000349252|uniprotkb:O43746|uniprotkb:Q45H73|uniprotkb:Q9UBC8|intact:EBI-3962403|uniprotkb:Q96HB1	intact:EBI-1035358|uniprotkb:Q96B50|uniprotkb:Q5NKV7|uniprotkb:B2R6M3|ensembl:ENSP00000264832	psi-mi:ital_human(display_long)|uniprotkb:ITGAL(gene name)|psi-mi:ITGAL(display_short)|uniprotkb:CD11A(gene name synonym)|uniprotkb:Leukocyte adhesion glycoprotein LFA-1 alpha chain(gene name synonym)|uniprotkb:Leukocyte function-associated molecule 1 alpha chain(gene name synonym)|uniprotkb:CD11 antigen-like family member A(gene name synonym)	psi-mi:icam1_human(display_long)|uniprotkb:ICAM1(gene name)|psi-mi:ICAM1(display_short)|uniprotkb:Major group rhinovirus receptor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Shimaoka et al. (2003)	pubmed:12526797	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1035376|rcsb pdb:1MQ8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002200.2|ensembl:ENSG00000005844(gene)|ensembl:ENST00000356798(transcript)|go:"GO:0002291"(T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035683"(memory T cell extravasation)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|rcsb pdb:1CQP|rcsb pdb:1DGQ|rcsb pdb:1IJ4|rcsb pdb:1LFA|rcsb pdb:1MJN|rcsb pdb:1MQ8|rcsb pdb:1MQ9|rcsb pdb:1MQA|rcsb pdb:1RD4|rcsb pdb:1T0P|rcsb pdb:1XDD|rcsb pdb:1XDG|rcsb pdb:1XUO|rcsb pdb:1ZON|rcsb pdb:1ZOO|rcsb pdb:1ZOP|rcsb pdb:2ICA|rcsb pdb:2K8O|rcsb pdb:2M3E|rcsb pdb:2O7N|rcsb pdb:3BN3|rcsb pdb:3BQM|rcsb pdb:3BQN|rcsb pdb:3E2M|rcsb pdb:3EOA|rcsb pdb:3EOB|rcsb pdb:3F74|rcsb pdb:3HI6|rcsb pdb:3F78|rcsb pdb:3M6F|rcsb pdb:3TCX|rcsb pdb:4IXD|rcsb pdb:5E6R|rcsb pdb:5E6S|rcsb pdb:5E6U|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6798695|reactome:R-HSA-8949275|refseq:NP_001107852.1|dip:DIP-623N	refseq:NP_000192.2|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0072683"(T cell extravasation)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003988(Intercellular adhesion molecule)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P05362|rcsb pdb:1D3E|rcsb pdb:1D3I|rcsb pdb:1D3L|rcsb pdb:1IAM|rcsb pdb:1IC1|rcsb pdb:1IJ4|rcsb pdb:1MQ8|rcsb pdb:1P53|rcsb pdb:1Z7Z|rcsb pdb:2OZ4|rcsb pdb:3TCX|rcsb pdb:5MZA|rcsb pdb:6EIT|rcsb pdb:6S8U|rcsb pdb:7BG7|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-877300|ensembl:ENSG00000090339(gene)|ensembl:ENST00000264832(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001910"(regulation of leukocyte mediated cytotoxicity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002291"(T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0002457"(T cell antigen processing and presentation)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007569"(cell aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010477"(response to sulfur dioxide)|go:"GO:0016020"(membrane)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032868"(response to insulin)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0043200"(response to amino acid)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044406"(adhesion of symbiont to host)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046688"(response to copper ion)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051926"(negative regulation of calcium ion transport)|dip:DIP-36658N	-	-	-	assembly:tetrameric, multimeric|3d-r-factors:working 73.600%, free 68.700%|3d-resolution:3.3A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:JeiBJZbkw8mtrE7WrFlkepPiAOY9606	rogid:eGWJdcEXTjCbhV12bVI/7RhPN8w9606	intact-crc:BB7D16F34B2495DE|rigid:McIiA4PFHwIYLQdoTkSsJM0eSpQ	false	sufficient binding region:155-331	sufficient binding region:28-318	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)