#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13253	uniprotkb:P18075	intact:EBI-1035205|ensembl:ENSP00000328181	intact:EBI-1035195|uniprotkb:Q9H512|uniprotkb:Q9NTQ7|ensembl:ENSP00000379204	psi-mi:nogg_human(display_long)|uniprotkb:NOG(gene name)|psi-mi:NOG(display_short)	psi-mi:bmp7_human(display_long)|uniprotkb:BMP7(gene name)|psi-mi:BMP7(display_short)|uniprotkb:OP1(gene name synonym)|uniprotkb:Osteogenic protein 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Groppe et al. (2002)	pubmed:12478285	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1035219|rcsb pdb:1M4U	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005441.1|ensembl:ENSG00000183691(gene)|ensembl:ENST00000332822(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001839"(neural plate morphogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007399"(nervous system development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019955"(cytokine binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021533"(cell differentiation in hindbrain)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042060"(wound healing)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060173"(limb development)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060302"(negative regulation of cytokine activity)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060513"(prostatic bud formation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0060825"(fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0061053"(somite development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090193"(positive regulation of glomerulus development)|go:"GO:1905006"(negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:2000313"(regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR008717(Noggin)|interpro:IPR029034|mint:Q13253|rcsb pdb:1M4U|reactome:R-HSA-201451	refseq:NP_001710.1|ensembl:ENSG00000101144(gene)|ensembl:ENST00000395863(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001823"(mesonephros development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007411"(axon guidance)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030902"(hindbrain development)|go:"GO:0031982"(vesicle)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043401"(steroid hormone mediated signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060686"(negative regulation of prostatic bud formation)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072040"(negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900106"(positive regulation of hyaluranon cable assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1905069"(allantois development)|go:"GO:1905312"(positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P18075|rcsb pdb:1BMP|rcsb pdb:1LX5|rcsb pdb:1LXI|rcsb pdb:1M4U|reactome:R-HSA-2129379|dip:DIP-5800N	-	-	-	assembly:tetrameric, multimeric|3d-r-factors:working 75.900%, free 72.700%|3d-resolution:2.42A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:y87SXdQNC1QEsDmhf0xe7db+rdQ9606	rogid:mERrodas0KrwJ+jn0hpU6NnR6PI9606	intact-crc:F1A6CC2738A91BFA|rigid:jN0wpfR9BSsqHYOQqU/LvRsQzYY	false	sufficient binding region:28-232	sufficient binding region:293-431	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)