#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q79PF4	uniprotkb:Q06904	intact:EBI-592287|uniprotkb:Q31NX3|uniprotkb:Q9Z3H2|ensemblbacteria:ABB57246	intact:EBI-626872|ensemblbacteria:ABB58144|uniprotkb:Q31LC5	psi-mi:kaic_syne7(display_long)|uniprotkb:see0011(orf name)|uniprotkb:kaiC(gene name)|psi-mi:kaiC(display_short)|uniprotkb:Synpcc7942_1216(locus name)	psi-mi:sasa_syne7(display_long)|uniprotkb:Synechococcus adaptive sensor protein A(gene name synonym)|uniprotkb:sasA(gene name)|psi-mi:sasA(display_short)|uniprotkb:sarS(gene name synonym)|uniprotkb:Synpcc7942_2114(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kageyama et al. (2003)	pubmed:12441347|imex:IM-19529	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-904759|imex:IM-19529-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_011242648.1|dip:DIP-33330N|ensemblbacteria:ABB57246(transcript)|ensemblbacteria:Synpcc7942_1216(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0070297"(regulation of phosphorelay signal transduction system)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR010624(Circadian clock protein KaiC)|interpro:IPR013503(Circadian clock, KaiC)|interpro:IPR014774(Circadian clock protein KaiC, central region)|interpro:IPR027417|interpro:IPR030665|rcsb pdb:1TF7|rcsb pdb:1U9I|rcsb pdb:2GBL|rcsb pdb:3DVL|rcsb pdb:3JZM|rcsb pdb:3K09|rcsb pdb:3K0A|rcsb pdb:3K0C|rcsb pdb:3K0E|rcsb pdb:3K0F|rcsb pdb:3S1A|rcsb pdb:4DUG|rcsb pdb:4IJM|rcsb pdb:4TL6|rcsb pdb:4TL7|rcsb pdb:4TL8|rcsb pdb:4TL9|rcsb pdb:4TLA|rcsb pdb:4TLB|rcsb pdb:4TLC|rcsb pdb:4TLD|rcsb pdb:4TLE|rcsb pdb:5C5E|rcsb pdb:5N8Y|rcsb pdb:5YZ8	interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR011649(KaiB)|interpro:IPR023527|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR005467(Signal transduction histidine kinase, core)|rcsb pdb:1T4Y|rcsb pdb:1T4Z|ensemblbacteria:ABB58144(transcript)|ensemblbacteria:Synpcc7942_2114(gene)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007623"(circadian rhythm)|refseq:WP_011378322.1|interpro:IPR036097|interpro:IPR036249|interpro:IPR036890	-	-	-	comment:"KaiA, KaiB, and SasA bound to KaiC more abundantly during subjective night in continuous light conditions (LL). The level of SasA interacting with KaiC is more abundant between 12�16 hours in LL whereas the levels of KaiA and KaiB interacting with KaiC  peaks at hours 20�24 in LL."|complex-properties:Immunoprecipitation assay with anti-KaiC antiserum performed using KaiC-containing fractions after the gel filtration assay further confirm that the Kai proteins and SasA interact to form 400�670-kDa protein complexes in a circadian fashion.|dataset:Cyanobacteria - Interaction dataset based on Cyanobacteria proteins and related species|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	-	2006/01/18	2014/10/16	rogid:Gu0/UHx7QliYil8+UXQAq28uuQg1140	rogid:XkraHzuOvWWi+nEHlmlr8ao2JAQ1140	intact-crc:CB94DB15C365B0C0|rigid:bXRUEXoK1m5gO7l5m1IlZPXsSIU	false	mutation decreasing interaction:52-52	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q79PF4	uniprotkb:Q79PF5	intact:EBI-592287|uniprotkb:Q31NX3|uniprotkb:Q9Z3H2|ensemblbacteria:ABB57246	intact:EBI-619150|ensemblbacteria:ABB57247|uniprotkb:Q31NX2|uniprotkb:Q9Z3H3	psi-mi:kaic_syne7(display_long)|uniprotkb:see0011(orf name)|uniprotkb:kaiC(gene name)|psi-mi:kaiC(display_short)|uniprotkb:Synpcc7942_1216(locus name)	psi-mi:kaib_syne7(display_long)|uniprotkb:kaiB(gene name)|psi-mi:kaiB(display_short)|uniprotkb:see0010(orf name)|uniprotkb:Synpcc7942_1217(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kageyama et al. (2003)	pubmed:12441347|imex:IM-19529	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-904759|imex:IM-19529-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_011242648.1|dip:DIP-33330N|ensemblbacteria:ABB57246(transcript)|ensemblbacteria:Synpcc7942_1216(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0070297"(regulation of phosphorelay signal transduction system)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR010624(Circadian clock protein KaiC)|interpro:IPR013503(Circadian clock, KaiC)|interpro:IPR014774(Circadian clock protein KaiC, central region)|interpro:IPR027417|interpro:IPR030665|rcsb pdb:1TF7|rcsb pdb:1U9I|rcsb pdb:2GBL|rcsb pdb:3DVL|rcsb pdb:3JZM|rcsb pdb:3K09|rcsb pdb:3K0A|rcsb pdb:3K0C|rcsb pdb:3K0E|rcsb pdb:3K0F|rcsb pdb:3S1A|rcsb pdb:4DUG|rcsb pdb:4IJM|rcsb pdb:4TL6|rcsb pdb:4TL7|rcsb pdb:4TL8|rcsb pdb:4TL9|rcsb pdb:4TLA|rcsb pdb:4TLB|rcsb pdb:4TLC|rcsb pdb:4TLD|rcsb pdb:4TLE|rcsb pdb:5C5E|rcsb pdb:5N8Y|rcsb pdb:5YZ8	go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|interpro:IPR011649(KaiB)|interpro:IPR013474(Circadian clock protein KaiB)|interpro:IPR036249|interpro:IPR039022|rcsb pdb:4KSO|rcsb pdb:5N8Y|ensemblbacteria:ABB57247(transcript)|ensemblbacteria:Synpcc7942_1217(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|refseq:WP_011242647.1|dip:DIP-33331N	-	-	-	comment:"KaiA, KaiB, and SasA bound to KaiC more abundantly during subjective night in continuous light conditions (LL). The level of SasA interacting with KaiC is more abundant between 12�16 hours in LL whereas the levels of KaiA and KaiB interacting with KaiC  peaks at hours 20�24 in LL."|complex-properties:Immunoprecipitation assay with anti-KaiC antiserum performed using KaiC-containing fractions after the gel filtration assay further confirm that the Kai proteins and SasA interact to form 400�670-kDa protein complexes in a circadian fashion.|dataset:Cyanobacteria - Interaction dataset based on Cyanobacteria proteins and related species|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	-	2006/01/18	2014/10/16	rogid:Gu0/UHx7QliYil8+UXQAq28uuQg1140	rogid:wRRxnoTHBFDLszzILsCOoPOzS2w1140	intact-crc:CB94DB15C365B0C0|rigid:bXRUEXoK1m5gO7l5m1IlZPXsSIU	false	mutation decreasing interaction:52-52	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q79PF4	uniprotkb:Q79PF6	intact:EBI-592287|uniprotkb:Q31NX3|uniprotkb:Q9Z3H2|ensemblbacteria:ABB57246	intact:EBI-592281|uniprotkb:Q31NX1|uniprotkb:Q9Z3H4|ensemblbacteria:ABB57248	psi-mi:kaic_syne7(display_long)|uniprotkb:see0011(orf name)|uniprotkb:kaiC(gene name)|psi-mi:kaiC(display_short)|uniprotkb:Synpcc7942_1216(locus name)	psi-mi:kaia_syne7(display_long)|uniprotkb:see0009(orf name)|uniprotkb:kaiA(gene name)|psi-mi:kaiA(display_short)|uniprotkb:Synpcc7942_1218(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kageyama et al. (2003)	pubmed:12441347|imex:IM-19529	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-904759|imex:IM-19529-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_011242648.1|dip:DIP-33330N|ensemblbacteria:ABB57246(transcript)|ensemblbacteria:Synpcc7942_1216(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0070297"(regulation of phosphorelay signal transduction system)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR010624(Circadian clock protein KaiC)|interpro:IPR013503(Circadian clock, KaiC)|interpro:IPR014774(Circadian clock protein KaiC, central region)|interpro:IPR027417|interpro:IPR030665|rcsb pdb:1TF7|rcsb pdb:1U9I|rcsb pdb:2GBL|rcsb pdb:3DVL|rcsb pdb:3JZM|rcsb pdb:3K09|rcsb pdb:3K0A|rcsb pdb:3K0C|rcsb pdb:3K0E|rcsb pdb:3K0F|rcsb pdb:3S1A|rcsb pdb:4DUG|rcsb pdb:4IJM|rcsb pdb:4TL6|rcsb pdb:4TL7|rcsb pdb:4TL8|rcsb pdb:4TL9|rcsb pdb:4TLA|rcsb pdb:4TLB|rcsb pdb:4TLC|rcsb pdb:4TLD|rcsb pdb:4TLE|rcsb pdb:5C5E|rcsb pdb:5N8Y|rcsb pdb:5YZ8	refseq:WP_011377921.1|dip:DIP-33329N|ensemblbacteria:ABB57248(transcript)|ensemblbacteria:Synpcc7942_1218(gene)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|interpro:IPR011006(CheY-like)|interpro:IPR011648(KaiA)|interpro:IPR017944|interpro:IPR020844|interpro:IPR020856|rcsb pdb:1M2E|rcsb pdb:1M2F|rcsb pdb:1R8J|rcsb pdb:4G86|rcsb pdb:5C5E|rcsb pdb:5N8Y	-	-	-	comment:"KaiA, KaiB, and SasA bound to KaiC more abundantly during subjective night in continuous light conditions (LL). The level of SasA interacting with KaiC is more abundant between 12�16 hours in LL whereas the levels of KaiA and KaiB interacting with KaiC  peaks at hours 20�24 in LL."|complex-properties:Immunoprecipitation assay with anti-KaiC antiserum performed using KaiC-containing fractions after the gel filtration assay further confirm that the Kai proteins and SasA interact to form 400�670-kDa protein complexes in a circadian fashion.|dataset:Cyanobacteria - Interaction dataset based on Cyanobacteria proteins and related species|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	-	2006/01/18	2014/10/16	rogid:Gu0/UHx7QliYil8+UXQAq28uuQg1140	rogid:STO0VFooBIZrPJfGkR/89dQUZHU1140	intact-crc:CB94DB15C365B0C0|rigid:bXRUEXoK1m5gO7l5m1IlZPXsSIU	false	mutation decreasing interaction:52-52	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q79PF6	uniprotkb:Q79PF5	intact:EBI-592281|uniprotkb:Q31NX1|uniprotkb:Q9Z3H4|ensemblbacteria:ABB57248	intact:EBI-619150|ensemblbacteria:ABB57247|uniprotkb:Q31NX2|uniprotkb:Q9Z3H3	psi-mi:kaia_syne7(display_long)|uniprotkb:see0009(orf name)|uniprotkb:kaiA(gene name)|psi-mi:kaiA(display_short)|uniprotkb:Synpcc7942_1218(locus name)	psi-mi:kaib_syne7(display_long)|uniprotkb:kaiB(gene name)|psi-mi:kaiB(display_short)|uniprotkb:see0010(orf name)|uniprotkb:Synpcc7942_1217(locus name)	psi-mi:"MI:0071"(molecular sieving)	Kageyama et al. (2003)	pubmed:12441347|imex:IM-19529	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-904776|imex:IM-19529-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_011377921.1|dip:DIP-33329N|ensemblbacteria:ABB57248(transcript)|ensemblbacteria:Synpcc7942_1218(gene)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|interpro:IPR011006(CheY-like)|interpro:IPR011648(KaiA)|interpro:IPR017944|interpro:IPR020844|interpro:IPR020856|rcsb pdb:1M2E|rcsb pdb:1M2F|rcsb pdb:1R8J|rcsb pdb:4G86|rcsb pdb:5C5E|rcsb pdb:5N8Y	go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|interpro:IPR011649(KaiB)|interpro:IPR013474(Circadian clock protein KaiB)|interpro:IPR036249|interpro:IPR039022|rcsb pdb:4KSO|rcsb pdb:5N8Y|ensemblbacteria:ABB57247(transcript)|ensemblbacteria:Synpcc7942_1217(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|refseq:WP_011242647.1|dip:DIP-33331N	go:"GO:0042752"(regulation of circadian rhythm)	-	-	comment:"Under Light-Dark conditions (LD) all four clock-related proteins are co-fractionated during the night (ZT16 to ZT22) in 400-600kDa portions, whereas they separated into different fractions during the daytime, especially at ZT 10. Similarly in continous light conditions (LL) clock-related proteins occur as a 400-600kDa complex during sujective night (LL16 to LL22) whereas they separate in different fraction during subjective day."|complex-properties:KaiA, KaiB, KaiC and SasA depleted strains have no circadian rythms and fail to form the 400-600KDa complex observed in the wild strain.|stimulant:The night. KaiC forms protein complexes of around 350kDa during the subjective day and 400-600kDa during the subjective night due to night specific-interaction with KaiA and KaiB.|comment:Kai proteins and SasA form heteromultimeric protein complex dynamically in a circadian fashion forming the circadian protein complexes.|dataset:Cyanobacteria - Interaction dataset based on Cyanobacteria proteins and related species|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	-	2006/01/18	2014/10/16	rogid:STO0VFooBIZrPJfGkR/89dQUZHU1140	rogid:wRRxnoTHBFDLszzILsCOoPOzS2w1140	intact-crc:100FC83BDF48F5D9|rigid:bXRUEXoK1m5gO7l5m1IlZPXsSIU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q79PF6	uniprotkb:Q79PF4	intact:EBI-592281|uniprotkb:Q31NX1|uniprotkb:Q9Z3H4|ensemblbacteria:ABB57248	intact:EBI-592287|uniprotkb:Q31NX3|uniprotkb:Q9Z3H2|ensemblbacteria:ABB57246	psi-mi:kaia_syne7(display_long)|uniprotkb:see0009(orf name)|uniprotkb:kaiA(gene name)|psi-mi:kaiA(display_short)|uniprotkb:Synpcc7942_1218(locus name)	psi-mi:kaic_syne7(display_long)|uniprotkb:see0011(orf name)|uniprotkb:kaiC(gene name)|psi-mi:kaiC(display_short)|uniprotkb:Synpcc7942_1216(locus name)	psi-mi:"MI:0071"(molecular sieving)	Kageyama et al. (2003)	pubmed:12441347|imex:IM-19529	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-904776|imex:IM-19529-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_011377921.1|dip:DIP-33329N|ensemblbacteria:ABB57248(transcript)|ensemblbacteria:Synpcc7942_1218(gene)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|interpro:IPR011006(CheY-like)|interpro:IPR011648(KaiA)|interpro:IPR017944|interpro:IPR020844|interpro:IPR020856|rcsb pdb:1M2E|rcsb pdb:1M2F|rcsb pdb:1R8J|rcsb pdb:4G86|rcsb pdb:5C5E|rcsb pdb:5N8Y	refseq:WP_011242648.1|dip:DIP-33330N|ensemblbacteria:ABB57246(transcript)|ensemblbacteria:Synpcc7942_1216(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0070297"(regulation of phosphorelay signal transduction system)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR010624(Circadian clock protein KaiC)|interpro:IPR013503(Circadian clock, KaiC)|interpro:IPR014774(Circadian clock protein KaiC, central region)|interpro:IPR027417|interpro:IPR030665|rcsb pdb:1TF7|rcsb pdb:1U9I|rcsb pdb:2GBL|rcsb pdb:3DVL|rcsb pdb:3JZM|rcsb pdb:3K09|rcsb pdb:3K0A|rcsb pdb:3K0C|rcsb pdb:3K0E|rcsb pdb:3K0F|rcsb pdb:3S1A|rcsb pdb:4DUG|rcsb pdb:4IJM|rcsb pdb:4TL6|rcsb pdb:4TL7|rcsb pdb:4TL8|rcsb pdb:4TL9|rcsb pdb:4TLA|rcsb pdb:4TLB|rcsb pdb:4TLC|rcsb pdb:4TLD|rcsb pdb:4TLE|rcsb pdb:5C5E|rcsb pdb:5N8Y|rcsb pdb:5YZ8	go:"GO:0042752"(regulation of circadian rhythm)	-	-	comment:"Under Light-Dark conditions (LD) all four clock-related proteins are co-fractionated during the night (ZT16 to ZT22) in 400-600kDa portions, whereas they separated into different fractions during the daytime, especially at ZT 10. Similarly in continous light conditions (LL) clock-related proteins occur as a 400-600kDa complex during sujective night (LL16 to LL22) whereas they separate in different fraction during subjective day."|complex-properties:KaiA, KaiB, KaiC and SasA depleted strains have no circadian rythms and fail to form the 400-600KDa complex observed in the wild strain.|stimulant:The night. KaiC forms protein complexes of around 350kDa during the subjective day and 400-600kDa during the subjective night due to night specific-interaction with KaiA and KaiB.|comment:Kai proteins and SasA form heteromultimeric protein complex dynamically in a circadian fashion forming the circadian protein complexes.|dataset:Cyanobacteria - Interaction dataset based on Cyanobacteria proteins and related species|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	-	2006/01/18	2014/10/16	rogid:STO0VFooBIZrPJfGkR/89dQUZHU1140	rogid:Gu0/UHx7QliYil8+UXQAq28uuQg1140	intact-crc:100FC83BDF48F5D9|rigid:bXRUEXoK1m5gO7l5m1IlZPXsSIU	false	-	mutation disrupting interaction:52-52	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q79PF6	uniprotkb:Q06904	intact:EBI-592281|uniprotkb:Q31NX1|uniprotkb:Q9Z3H4|ensemblbacteria:ABB57248	intact:EBI-626872|ensemblbacteria:ABB58144|uniprotkb:Q31LC5	psi-mi:kaia_syne7(display_long)|uniprotkb:see0009(orf name)|uniprotkb:kaiA(gene name)|psi-mi:kaiA(display_short)|uniprotkb:Synpcc7942_1218(locus name)	psi-mi:sasa_syne7(display_long)|uniprotkb:Synechococcus adaptive sensor protein A(gene name synonym)|uniprotkb:sasA(gene name)|psi-mi:sasA(display_short)|uniprotkb:sarS(gene name synonym)|uniprotkb:Synpcc7942_2114(locus name)	psi-mi:"MI:0071"(molecular sieving)	Kageyama et al. (2003)	pubmed:12441347|imex:IM-19529	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-904776|imex:IM-19529-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_011377921.1|dip:DIP-33329N|ensemblbacteria:ABB57248(transcript)|ensemblbacteria:Synpcc7942_1218(gene)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|interpro:IPR011006(CheY-like)|interpro:IPR011648(KaiA)|interpro:IPR017944|interpro:IPR020844|interpro:IPR020856|rcsb pdb:1M2E|rcsb pdb:1M2F|rcsb pdb:1R8J|rcsb pdb:4G86|rcsb pdb:5C5E|rcsb pdb:5N8Y	interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR011649(KaiB)|interpro:IPR023527|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR005467(Signal transduction histidine kinase, core)|rcsb pdb:1T4Y|rcsb pdb:1T4Z|ensemblbacteria:ABB58144(transcript)|ensemblbacteria:Synpcc7942_2114(gene)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007623"(circadian rhythm)|refseq:WP_011378322.1|interpro:IPR036097|interpro:IPR036249|interpro:IPR036890	go:"GO:0042752"(regulation of circadian rhythm)	-	-	comment:"Under Light-Dark conditions (LD) all four clock-related proteins are co-fractionated during the night (ZT16 to ZT22) in 400-600kDa portions, whereas they separated into different fractions during the daytime, especially at ZT 10. Similarly in continous light conditions (LL) clock-related proteins occur as a 400-600kDa complex during sujective night (LL16 to LL22) whereas they separate in different fraction during subjective day."|complex-properties:KaiA, KaiB, KaiC and SasA depleted strains have no circadian rythms and fail to form the 400-600KDa complex observed in the wild strain.|stimulant:The night. KaiC forms protein complexes of around 350kDa during the subjective day and 400-600kDa during the subjective night due to night specific-interaction with KaiA and KaiB.|comment:Kai proteins and SasA form heteromultimeric protein complex dynamically in a circadian fashion forming the circadian protein complexes.|dataset:Cyanobacteria - Interaction dataset based on Cyanobacteria proteins and related species|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:1140(syne7)|taxid:1140("Synechococcus elongatus (strain PCC 7942)")	-	2006/01/18	2014/10/16	rogid:STO0VFooBIZrPJfGkR/89dQUZHU1140	rogid:XkraHzuOvWWi+nEHlmlr8ao2JAQ1140	intact-crc:100FC83BDF48F5D9|rigid:bXRUEXoK1m5gO7l5m1IlZPXsSIU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)