#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P40879	uniprotkb:Q15599	intact:EBI-8542350|intact:MINT-1787198|ensembl:ENSP00000345873	intact:EBI-1149760|uniprotkb:O00272|uniprotkb:O00556|uniprotkb:Q3KQY7|uniprotkb:D3DU84|uniprotkb:D3DU85|uniprotkb:H3BSV6|ensembl:ENSP00000408005|intact:EBI-15579694	psi-mi:s26a3_human(display_long)|uniprotkb:SLC26A3(gene name)|psi-mi:SLC26A3(display_short)|uniprotkb:DRA(gene name synonym)|uniprotkb:Down-regulated in adenoma(gene name synonym)|uniprotkb:Solute carrier family 26 member 3(gene name synonym)	psi-mi:nhrf2_human(display_long)|uniprotkb:SLC9A3R2(gene name)|psi-mi:SLC9A3R2(display_short)|uniprotkb:NHERF2(gene name synonym)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lamprecht et al. (2002)	mint:MINT-5215811|pubmed:12369822	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8542345|mint:MINT-1787222	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011514169.1|refseq:NP_000102.1|ensembl:ENSG00000091138(gene)|ensembl:ENST00000340010(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006820"(anion transport)|go:"GO:0007588"(excretion)|go:"GO:0008271"(secondary active sulfate transmembrane transporter activity)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019531"(oxalate transmembrane transporter activity)|go:"GO:0031526"(brush border membrane)|go:"GO:0048240"(sperm capacitation)|go:"GO:0051454"(intracellular pH elevation)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097225"(sperm midpiece)|interpro:IPR001902(Sulphate anion transporter)|interpro:IPR002645(Sulphate transporter/antisigma-factor antagonist STAS)|interpro:IPR011547(Sulphate transporter)|interpro:IPR018045|interpro:IPR030321|interpro:IPR036513|reactome:R-HSA-427601|reactome:R-HSA-5619085|mint:MINT-1787224(identity)	refseq:NP_001123484.1|refseq:NP_004776.3|refseq:NP_001239002.1|ensembl:ENSG00000065054(gene)|ensembl:ENST00000424542(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031197|interpro:IPR036034|mint:Q15599|rcsb pdb:2D11|rcsb pdb:2HE4|rcsb pdb:2OCS|rcsb pdb:4P0C|go:"GO:0042802"(identical protein binding)|dip:DIP-29093N|mint:MINT-1787223(identity)	-	comment:mint|function:Chloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption|function:"Defects in SLC26A3 are the cause of congenital chloride diarrhea (CLD) [MIM:214700]. CLD is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/20	2014/10/16	rogid:MBIcF6FGDHPM9Y4NWkDAi9FghXI9606	rogid:BRqFx6BigKEZV84KUdfvppEXg+s9606	intact-crc:2EEFED2257C0D38B|rigid:EObauHIaEvYEwC+xt1z6rENf6lk	false	biotin tag:n-n(MINT-1787229)|mutation disrupting interaction:761-764(MINT-1787239)|binding-associated region:567-764(MINT-1787236)	binding-associated region:1-141(MINT-1787246)|his tag:n-n(MINT-1787504)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40879	uniprotkb:Q15599	intact:EBI-8542350|intact:MINT-1787198|ensembl:ENSP00000345873	intact:EBI-1149760|uniprotkb:O00272|uniprotkb:O00556|uniprotkb:Q3KQY7|uniprotkb:D3DU84|uniprotkb:D3DU85|uniprotkb:H3BSV6|ensembl:ENSP00000408005|intact:EBI-15579694	psi-mi:s26a3_human(display_long)|uniprotkb:SLC26A3(gene name)|psi-mi:SLC26A3(display_short)|uniprotkb:DRA(gene name synonym)|uniprotkb:Down-regulated in adenoma(gene name synonym)|uniprotkb:Solute carrier family 26 member 3(gene name synonym)	psi-mi:nhrf2_human(display_long)|uniprotkb:SLC9A3R2(gene name)|psi-mi:SLC9A3R2(display_short)|uniprotkb:NHERF2(gene name synonym)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lamprecht et al. (2002)	mint:MINT-5215811|pubmed:12369822	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8542415|mint:MINT-1787249	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011514169.1|refseq:NP_000102.1|ensembl:ENSG00000091138(gene)|ensembl:ENST00000340010(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006820"(anion transport)|go:"GO:0007588"(excretion)|go:"GO:0008271"(secondary active sulfate transmembrane transporter activity)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019531"(oxalate transmembrane transporter activity)|go:"GO:0031526"(brush border membrane)|go:"GO:0048240"(sperm capacitation)|go:"GO:0051454"(intracellular pH elevation)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097225"(sperm midpiece)|interpro:IPR001902(Sulphate anion transporter)|interpro:IPR002645(Sulphate transporter/antisigma-factor antagonist STAS)|interpro:IPR011547(Sulphate transporter)|interpro:IPR018045|interpro:IPR030321|interpro:IPR036513|reactome:R-HSA-427601|reactome:R-HSA-5619085|mint:MINT-1787257(identity)	refseq:NP_001123484.1|refseq:NP_004776.3|refseq:NP_001239002.1|ensembl:ENSG00000065054(gene)|ensembl:ENST00000424542(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031197|interpro:IPR036034|mint:Q15599|rcsb pdb:2D11|rcsb pdb:2HE4|rcsb pdb:2OCS|rcsb pdb:4P0C|go:"GO:0042802"(identical protein binding)|dip:DIP-29093N|mint:MINT-1787250(identity)	-	comment:mint|function:Chloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption|function:"Defects in SLC26A3 are the cause of congenital chloride diarrhea (CLD) [MIM:214700]. CLD is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/20	2014/10/16	rogid:MBIcF6FGDHPM9Y4NWkDAi9FghXI9606	rogid:BRqFx6BigKEZV84KUdfvppEXg+s9606	intact-crc:47377617B989D0DC|rigid:EObauHIaEvYEwC+xt1z6rENf6lk	false	biotin tag:?-?(MINT-1787267)|mutation disrupting interaction:761-764(MINT-1792177)|binding-associated region:744-764(MINT-1787260)	his tag:?-?(MINT-1787506)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P13569	uniprotkb:Q15599	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	intact:EBI-1149760|uniprotkb:O00272|uniprotkb:O00556|uniprotkb:Q3KQY7|uniprotkb:D3DU84|uniprotkb:D3DU85|uniprotkb:H3BSV6|ensembl:ENSP00000408005|intact:EBI-15579694	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:nhrf2_human(display_long)|uniprotkb:SLC9A3R2(gene name)|psi-mi:SLC9A3R2(display_short)|uniprotkb:NHERF2(gene name synonym)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lamprecht et al. (2002)	mint:MINT-5215811|pubmed:12369822	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8542481|mint:MINT-1787274	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N|mint:MINT-1787280(identity)	refseq:NP_001123484.1|refseq:NP_004776.3|refseq:NP_001239002.1|ensembl:ENSG00000065054(gene)|ensembl:ENST00000424542(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031197|interpro:IPR036034|mint:Q15599|rcsb pdb:2D11|rcsb pdb:2HE4|rcsb pdb:2OCS|rcsb pdb:4P0C|go:"GO:0042802"(identical protein binding)|dip:DIP-29093N|mint:MINT-1787275(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/20	2014/10/16	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	rogid:BRqFx6BigKEZV84KUdfvppEXg+s9606	intact-crc:0F3D93BBB7110D75|rigid:K1nYWKKZgH+FurluaRxHy3BhqQ4	false	mutation disrupting interaction:1477-1480(MINT-1792203)|biotin tag:?-?(MINT-1787287)|binding-associated region:1460-1480(MINT-1787281)	his tag:?-?(MINT-1787508)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40879	uniprotkb:Q15599	intact:EBI-8542350|intact:MINT-1787198|ensembl:ENSP00000345873	intact:EBI-1149760|uniprotkb:O00272|uniprotkb:O00556|uniprotkb:Q3KQY7|uniprotkb:D3DU84|uniprotkb:D3DU85|uniprotkb:H3BSV6|ensembl:ENSP00000408005|intact:EBI-15579694	psi-mi:s26a3_human(display_long)|uniprotkb:SLC26A3(gene name)|psi-mi:SLC26A3(display_short)|uniprotkb:DRA(gene name synonym)|uniprotkb:Down-regulated in adenoma(gene name synonym)|uniprotkb:Solute carrier family 26 member 3(gene name synonym)	psi-mi:nhrf2_human(display_long)|uniprotkb:SLC9A3R2(gene name)|psi-mi:SLC9A3R2(display_short)|uniprotkb:NHERF2(gene name synonym)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lamprecht et al. (2002)	mint:MINT-5215811|pubmed:12369822	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8542530|mint:MINT-1792121	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011514169.1|refseq:NP_000102.1|ensembl:ENSG00000091138(gene)|ensembl:ENST00000340010(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006820"(anion transport)|go:"GO:0007588"(excretion)|go:"GO:0008271"(secondary active sulfate transmembrane transporter activity)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019531"(oxalate transmembrane transporter activity)|go:"GO:0031526"(brush border membrane)|go:"GO:0048240"(sperm capacitation)|go:"GO:0051454"(intracellular pH elevation)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097225"(sperm midpiece)|interpro:IPR001902(Sulphate anion transporter)|interpro:IPR002645(Sulphate transporter/antisigma-factor antagonist STAS)|interpro:IPR011547(Sulphate transporter)|interpro:IPR018045|interpro:IPR030321|interpro:IPR036513|reactome:R-HSA-427601|reactome:R-HSA-5619085|mint:MINT-1792122(identity)	refseq:NP_001123484.1|refseq:NP_004776.3|refseq:NP_001239002.1|ensembl:ENSG00000065054(gene)|ensembl:ENST00000424542(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031197|interpro:IPR036034|mint:Q15599|rcsb pdb:2D11|rcsb pdb:2HE4|rcsb pdb:2OCS|rcsb pdb:4P0C|go:"GO:0042802"(identical protein binding)|dip:DIP-29093N|mint:MINT-1792134(identity)	-	comment:mint|function:Chloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption|function:"Defects in SLC26A3 are the cause of congenital chloride diarrhea (CLD) [MIM:214700]. CLD is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/20	2014/10/16	rogid:MBIcF6FGDHPM9Y4NWkDAi9FghXI9606	rogid:BRqFx6BigKEZV84KUdfvppEXg+s9606	intact-crc:D0FCBECE3B227562|rigid:EObauHIaEvYEwC+xt1z6rENf6lk	false	biotin tag:n-n(MINT-1792132)|mutation disrupting interaction:761-764(MINT-1792123)|binding-associated region:567-764(MINT-1792125)	his tag:n-n(MINT-1792142)|binding-associated region:130-311(MINT-1792135)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40879	uniprotkb:Q15599	intact:EBI-8542350|intact:MINT-1787198|ensembl:ENSP00000345873	intact:EBI-1149760|uniprotkb:O00272|uniprotkb:O00556|uniprotkb:Q3KQY7|uniprotkb:D3DU84|uniprotkb:D3DU85|uniprotkb:H3BSV6|ensembl:ENSP00000408005|intact:EBI-15579694	psi-mi:s26a3_human(display_long)|uniprotkb:SLC26A3(gene name)|psi-mi:SLC26A3(display_short)|uniprotkb:DRA(gene name synonym)|uniprotkb:Down-regulated in adenoma(gene name synonym)|uniprotkb:Solute carrier family 26 member 3(gene name synonym)	psi-mi:nhrf2_human(display_long)|uniprotkb:SLC9A3R2(gene name)|psi-mi:SLC9A3R2(display_short)|uniprotkb:NHERF2(gene name synonym)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Lamprecht et al. (2002)	mint:MINT-5215811|pubmed:12369822	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8542665|mint:MINT-1787327	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011514169.1|refseq:NP_000102.1|ensembl:ENSG00000091138(gene)|ensembl:ENST00000340010(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006820"(anion transport)|go:"GO:0007588"(excretion)|go:"GO:0008271"(secondary active sulfate transmembrane transporter activity)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019531"(oxalate transmembrane transporter activity)|go:"GO:0031526"(brush border membrane)|go:"GO:0048240"(sperm capacitation)|go:"GO:0051454"(intracellular pH elevation)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097225"(sperm midpiece)|interpro:IPR001902(Sulphate anion transporter)|interpro:IPR002645(Sulphate transporter/antisigma-factor antagonist STAS)|interpro:IPR011547(Sulphate transporter)|interpro:IPR018045|interpro:IPR030321|interpro:IPR036513|reactome:R-HSA-427601|reactome:R-HSA-5619085|mint:MINT-1787338(identity)	refseq:NP_001123484.1|refseq:NP_004776.3|refseq:NP_001239002.1|ensembl:ENSG00000065054(gene)|ensembl:ENST00000424542(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031197|interpro:IPR036034|mint:Q15599|rcsb pdb:2D11|rcsb pdb:2HE4|rcsb pdb:2OCS|rcsb pdb:4P0C|go:"GO:0042802"(identical protein binding)|dip:DIP-29093N|mint:MINT-1787328(identity)	-	comment:mint|function:Chloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption|function:"Defects in SLC26A3 are the cause of congenital chloride diarrhea (CLD) [MIM:214700]. CLD is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|kinetics:kd 1269 nanomolar|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/20	2014/10/16	rogid:MBIcF6FGDHPM9Y4NWkDAi9FghXI9606	rogid:BRqFx6BigKEZV84KUdfvppEXg+s9606	intact-crc:D620078F6CEC336A|rigid:EObauHIaEvYEwC+xt1z6rENf6lk	false	biotin tag:?-?(MINT-1787355)|binding-associated region:744-764(MINT-1787361)	his tag:?-?(MINT-1787336)|binding-associated region:130-311(MINT-1787329)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40879	uniprotkb:Q15599	intact:EBI-8542350|intact:MINT-1787198|ensembl:ENSP00000345873	intact:EBI-1149760|uniprotkb:O00272|uniprotkb:O00556|uniprotkb:Q3KQY7|uniprotkb:D3DU84|uniprotkb:D3DU85|uniprotkb:H3BSV6|ensembl:ENSP00000408005|intact:EBI-15579694	psi-mi:s26a3_human(display_long)|uniprotkb:SLC26A3(gene name)|psi-mi:SLC26A3(display_short)|uniprotkb:DRA(gene name synonym)|uniprotkb:Down-regulated in adenoma(gene name synonym)|uniprotkb:Solute carrier family 26 member 3(gene name synonym)	psi-mi:nhrf2_human(display_long)|uniprotkb:SLC9A3R2(gene name)|psi-mi:SLC9A3R2(display_short)|uniprotkb:NHERF2(gene name synonym)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Lamprecht et al. (2002)	mint:MINT-5215811|pubmed:12369822	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8542631|mint:MINT-1787290	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011514169.1|refseq:NP_000102.1|ensembl:ENSG00000091138(gene)|ensembl:ENST00000340010(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006820"(anion transport)|go:"GO:0007588"(excretion)|go:"GO:0008271"(secondary active sulfate transmembrane transporter activity)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019531"(oxalate transmembrane transporter activity)|go:"GO:0031526"(brush border membrane)|go:"GO:0048240"(sperm capacitation)|go:"GO:0051454"(intracellular pH elevation)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097225"(sperm midpiece)|interpro:IPR001902(Sulphate anion transporter)|interpro:IPR002645(Sulphate transporter/antisigma-factor antagonist STAS)|interpro:IPR011547(Sulphate transporter)|interpro:IPR018045|interpro:IPR030321|interpro:IPR036513|reactome:R-HSA-427601|reactome:R-HSA-5619085|mint:MINT-1787291(identity)	refseq:NP_001123484.1|refseq:NP_004776.3|refseq:NP_001239002.1|ensembl:ENSG00000065054(gene)|ensembl:ENST00000424542(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031197|interpro:IPR036034|mint:Q15599|rcsb pdb:2D11|rcsb pdb:2HE4|rcsb pdb:2OCS|rcsb pdb:4P0C|go:"GO:0042802"(identical protein binding)|dip:DIP-29093N|mint:MINT-1787300(identity)	-	comment:mint|function:Chloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption|function:"Defects in SLC26A3 are the cause of congenital chloride diarrhea (CLD) [MIM:214700]. CLD is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/20	2014/10/16	rogid:MBIcF6FGDHPM9Y4NWkDAi9FghXI9606	rogid:BRqFx6BigKEZV84KUdfvppEXg+s9606	intact-crc:DB3B6B75570BE913|rigid:EObauHIaEvYEwC+xt1z6rENf6lk	false	mutation disrupting interaction:761-764(MINT-1787308)|mutation disrupting interaction:764-764(MINT-1787318)|biotin tag:?-?(MINT-1787298)|binding-associated region:745-764(MINT-1792237)	his tag:n-n(MINT-1787321)|binding-associated region:130-311(MINT-1787323)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P13569	uniprotkb:Q15599	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	intact:EBI-1149760|uniprotkb:O00272|uniprotkb:O00556|uniprotkb:Q3KQY7|uniprotkb:D3DU84|uniprotkb:D3DU85|uniprotkb:H3BSV6|ensembl:ENSP00000408005|intact:EBI-15579694	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:nhrf2_human(display_long)|uniprotkb:SLC9A3R2(gene name)|psi-mi:SLC9A3R2(display_short)|uniprotkb:NHERF2(gene name synonym)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Lamprecht et al. (2002)	mint:MINT-5215811|pubmed:12369822	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8542719|mint:MINT-1787402	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N|mint:MINT-1787403(identity)	refseq:NP_001123484.1|refseq:NP_004776.3|refseq:NP_001239002.1|ensembl:ENSG00000065054(gene)|ensembl:ENST00000424542(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031197|interpro:IPR036034|mint:Q15599|rcsb pdb:2D11|rcsb pdb:2HE4|rcsb pdb:2OCS|rcsb pdb:4P0C|go:"GO:0042802"(identical protein binding)|dip:DIP-29093N|mint:MINT-1787412(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|kinetics:kd 1371,1 nanomolar|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/20	2014/10/16	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	rogid:BRqFx6BigKEZV84KUdfvppEXg+s9606	intact-crc:DFD3B616115A4071|rigid:K1nYWKKZgH+FurluaRxHy3BhqQ4	false	binding-associated region:1460-1480(MINT-1787404)|biotin tag:?-?(MINT-1787410)	binding-associated region:1-141(MINT-1787419)|his tag:?-?(MINT-1787413)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P13569	uniprotkb:Q15599	intact:EBI-349854|uniprotkb:Q20BG8|uniprotkb:Q20BH2|uniprotkb:Q2I0A1|uniprotkb:Q2I102|ensembl:ENSP00000003084	intact:EBI-1149760|uniprotkb:O00272|uniprotkb:O00556|uniprotkb:Q3KQY7|uniprotkb:D3DU84|uniprotkb:D3DU85|uniprotkb:H3BSV6|ensembl:ENSP00000408005|intact:EBI-15579694	psi-mi:cftr_human(display_long)|uniprotkb:CFTR(gene name)|psi-mi:CFTR(display_short)|uniprotkb:ABCC7(gene name synonym)|uniprotkb:cAMP-dependent chloride channel(gene name synonym)|uniprotkb:ATP-binding cassette sub-family C member 7(gene name synonym)|uniprotkb:Channel conductance-controlling ATPase(gene name synonym)	psi-mi:nhrf2_human(display_long)|uniprotkb:SLC9A3R2(gene name)|psi-mi:SLC9A3R2(display_short)|uniprotkb:NHERF2(gene name synonym)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Lamprecht et al. (2002)	mint:MINT-5215811|pubmed:12369822	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8542692|mint:MINT-1787368	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000483.3|reactome:R-HSA-8856828|reactome:R-HSA-9013406|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|ensembl:ENSG00000001626(gene)|ensembl:ENST00000003084(transcript)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005260"(intracellularly ATP-gated chloride channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0106138"(Sec61 translocon complex binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902161"(positive regulation of cyclic nucleotide-gated ion channel activity)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902943"(positive regulation of voltage-gated chloride channel activity)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR009147(Cystic fibrosis transmembrane conductance regulator)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR025837|interpro:IPR027417|interpro:IPR036640|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043225"(ATPase-coupled inorganic anion transmembrane transporter activity)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051454"(intracellular pH elevation)|rcsb pdb:6O1V|rcsb pdb:6O2P|rcsb pdb:6UK1|rcsb pdb:6WBS|reactome:R-HSA-382556|reactome:R-HSA-5627083|reactome:R-HSA-5678895|reactome:R-HSA-5689880|mint:P13569|rcsb pdb:1NBD|rcsb pdb:1XMI|rcsb pdb:1XMJ|rcsb pdb:2BBO|rcsb pdb:2BBS|rcsb pdb:2BBT|rcsb pdb:2LOB|rcsb pdb:2PZE|rcsb pdb:2PZF|rcsb pdb:2PZG|rcsb pdb:3GD7|rcsb pdb:3ISW|rcsb pdb:4WZ6|rcsb pdb:5D2D|rcsb pdb:5D3E|rcsb pdb:5D3F|rcsb pdb:5TF7|rcsb pdb:5TF8|rcsb pdb:5TFA|rcsb pdb:5TFB|rcsb pdb:5TFC|rcsb pdb:5TFD|rcsb pdb:5TFF|rcsb pdb:5TFG|rcsb pdb:5TFI|rcsb pdb:5TFJ|rcsb pdb:5TGK|rcsb pdb:5UAK|rcsb pdb:6GJQ|rcsb pdb:6GJS|rcsb pdb:6GJU|rcsb pdb:6GK4|rcsb pdb:6GKD|rcsb pdb:6HEP|rcsb pdb:6MSM|reactome:R-HSA-8856825|dip:DIP-32788N|mint:MINT-1787369(identity)	refseq:NP_001123484.1|refseq:NP_004776.3|refseq:NP_001239002.1|ensembl:ENSG00000065054(gene)|ensembl:ENST00000424542(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031197|interpro:IPR036034|mint:Q15599|rcsb pdb:2D11|rcsb pdb:2HE4|rcsb pdb:2OCS|rcsb pdb:4P0C|go:"GO:0042802"(identical protein binding)|dip:DIP-29093N|mint:MINT-1787378(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F5|kinetics:kd 252,1 nanomolar|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/20	2014/10/16	rogid:iuEu3sctRkxQlQYP4BVxV/u4DaA9606	rogid:BRqFx6BigKEZV84KUdfvppEXg+s9606	intact-crc:F904B2EF058D1B04|rigid:K1nYWKKZgH+FurluaRxHy3BhqQ4	false	binding-associated region:1460-1480(MINT-1787370)|biotin tag:?-?(MINT-1787376)	binding-associated region:130-311(MINT-1787379)|his tag:?-?(MINT-1787386)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)