#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q14181	uniprotkb:P09884	intact:EBI-712752|ensembl:ENSP00000265465|uniprotkb:Q9BPV3|uniprotkb:B4DNB4	intact:EBI-850026|uniprotkb:Q86UQ7|intact:EBI-28966824|ensembl:ENSP00000368349	psi-mi:dpoa2_human(display_long)|uniprotkb:DNA polymerase alpha 70 kDa subunit(gene name synonym)|uniprotkb:POLA2(gene name)|psi-mi:POLA2(display_short)	psi-mi:dpola_human(display_long)|uniprotkb:POLA1(gene name)|psi-mi:POLA1(display_short)|uniprotkb:POLA(gene name synonym)|uniprotkb:DNA polymerase alpha catalytic subunit p180(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Ott et al. (2002)	pubmed:12138179	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-850066	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-69183|reactome:R-HSA-69166|reactome:R-HSA-9710421|ensembl:ENSG00000014138(gene)|ensembl:ENST00000265465(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR013627(DNA polymerase alpha, subunit B N-terminal)|interpro:IPR016722(DNA polymerase alpha, subunit B)|interpro:IPR043034|rcsb pdb:2KEB|rcsb pdb:4E2I|rcsb pdb:4Y97|rcsb pdb:5EXR|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|refseq:NP_002680.2	ensembl:ENSP00000368349|refseq:NP_058633.2|ensembl:ENSG00000101868(gene)|ensembl:ENST00000379059(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017076"(purine nucleotide binding)|go:"GO:0019103"(pyrimidine nucleotide binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR015088(Zinc finger, DNA-directed DNA polymerase, family B, alpha)|interpro:IPR017964|interpro:IPR024647|interpro:IPR036397|interpro:IPR038256|interpro:IPR042087|interpro:IPR043502|mint:P09884|rcsb pdb:1K0P|rcsb pdb:1K18|rcsb pdb:1N5G|rcsb pdb:4Q5V|rcsb pdb:4QCL|rcsb pdb:4Y97|rcsb pdb:5EXR|rcsb pdb:5IUD|rcsb pdb:6AS7|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-9710421	go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0006270"(DNA replication initiation)	-	-	comment:Small amounts of the proteolytic cleavage products of POLA were also observed in the complex.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/10	2014/10/16	rogid:cPvK8qerkbSbnl1+TAIlBqTuEFU9606	rogid:X/oe9TEoaNUf5UPtWEXunsFtRZg9606	intact-crc:2384A6C302CFFF71|rigid:IEtNlxk4p9U8xHMjLJrrAIl92yE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14181	uniprotkb:P49642	intact:EBI-712752|ensembl:ENSP00000265465|uniprotkb:Q9BPV3|uniprotkb:B4DNB4	intact:EBI-726050|ensembl:ENSP00000350491	psi-mi:dpoa2_human(display_long)|uniprotkb:DNA polymerase alpha 70 kDa subunit(gene name synonym)|uniprotkb:POLA2(gene name)|psi-mi:POLA2(display_short)	psi-mi:pri1_human(display_long)|uniprotkb:DNA primase 49 kDa subunit(gene name synonym)|uniprotkb:PRIM1(gene name)|psi-mi:PRIM1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Ott et al. (2002)	pubmed:12138179	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-850066	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-69183|reactome:R-HSA-69166|reactome:R-HSA-9710421|ensembl:ENSG00000014138(gene)|ensembl:ENST00000265465(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR013627(DNA polymerase alpha, subunit B N-terminal)|interpro:IPR016722(DNA polymerase alpha, subunit B)|interpro:IPR043034|rcsb pdb:2KEB|rcsb pdb:4E2I|rcsb pdb:4Y97|rcsb pdb:5EXR|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|refseq:NP_002680.2	ensembl:ENSG00000198056(gene)|interpro:IPR014052(DNA primase, small subunit, eukaryotic and archaeal)|refseq:NP_000937.1|rcsb pdb:4BPU|rcsb pdb:4BPW|ensembl:ENST00000338193(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003896"(DNA primase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0032553"(ribonucleotide binding)|rcsb pdb:4BPX|rcsb pdb:4LIK|interpro:IPR002755(DNA primase, small subunit)|rcsb pdb:4LIL|rcsb pdb:4MHQ|rcsb pdb:4RR2|rcsb pdb:5EXR|rcsb pdb:6R4S|rcsb pdb:6R4T|rcsb pdb:6R4U|rcsb pdb:6R5D|rcsb pdb:6R5E|rcsb pdb:6RB4|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-9710421	go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0006270"(DNA replication initiation)	-	-	comment:Small amounts of the proteolytic cleavage products of POLA were also observed in the complex.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/10	2014/10/16	rogid:cPvK8qerkbSbnl1+TAIlBqTuEFU9606	rogid:bgNj0hjvHPliBXVfkZmg7v0N/uw9606	intact-crc:2384A6C302CFFF71|rigid:IEtNlxk4p9U8xHMjLJrrAIl92yE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14181	uniprotkb:P49643	intact:EBI-712752|ensembl:ENSP00000265465|uniprotkb:Q9BPV3|uniprotkb:B4DNB4	intact:EBI-850004|uniprotkb:Q53FJ8|uniprotkb:Q6P1Q7|uniprotkb:Q8WVL2|uniprotkb:Q9H413|ensembl:ENSP00000484105	psi-mi:dpoa2_human(display_long)|uniprotkb:DNA polymerase alpha 70 kDa subunit(gene name synonym)|uniprotkb:POLA2(gene name)|psi-mi:POLA2(display_short)	psi-mi:pri2_human(display_long)|uniprotkb:DNA primase 58 kDa subunit(gene name synonym)|uniprotkb:PRIM2(gene name)|psi-mi:PRIM2(display_short)|uniprotkb:PRIM2A(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Ott et al. (2002)	pubmed:12138179	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-850066	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-69183|reactome:R-HSA-69166|reactome:R-HSA-9710421|ensembl:ENSG00000014138(gene)|ensembl:ENST00000265465(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR013627(DNA polymerase alpha, subunit B N-terminal)|interpro:IPR016722(DNA polymerase alpha, subunit B)|interpro:IPR043034|rcsb pdb:2KEB|rcsb pdb:4E2I|rcsb pdb:4Y97|rcsb pdb:5EXR|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|refseq:NP_002680.2	refseq:NP_001269416.1|refseq:NP_001269417.1|refseq:NP_000938.2|dip:DIP-36438N|ensembl:ENSG00000146143(gene)|ensembl:ENST00000615550(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071667"(DNA/RNA hybrid binding)|interpro:IPR007238(DNA primase, large subunit, eukaryotic/archaeal)|interpro:IPR016558(DNA primase, large subunit, eukaryotic)|mint:P49643|rcsb pdb:3L9Q|rcsb pdb:3Q36|rcsb pdb:4BPU|rcsb pdb:4BPW|rcsb pdb:4BPX|rcsb pdb:4RR2|rcsb pdb:5DQO|rcsb pdb:5EXR|rcsb pdb:5F0Q|rcsb pdb:5F0S|rcsb pdb:5I7M|rcsb pdb:6DHW|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-9710421	go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0006270"(DNA replication initiation)	-	-	comment:Small amounts of the proteolytic cleavage products of POLA were also observed in the complex.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/10	2014/10/16	rogid:cPvK8qerkbSbnl1+TAIlBqTuEFU9606	rogid:WL5i+CvK52C93/3X4a3MFQvD0JQ9606	intact-crc:2384A6C302CFFF71|rigid:IEtNlxk4p9U8xHMjLJrrAIl92yE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09884	uniprotkb:P49642	intact:EBI-850026|uniprotkb:Q86UQ7|intact:EBI-28966824|ensembl:ENSP00000368349	intact:EBI-726050|ensembl:ENSP00000350491	psi-mi:dpola_human(display_long)|uniprotkb:POLA1(gene name)|psi-mi:POLA1(display_short)|uniprotkb:POLA(gene name synonym)|uniprotkb:DNA polymerase alpha catalytic subunit p180(gene name synonym)	psi-mi:pri1_human(display_long)|uniprotkb:DNA primase 49 kDa subunit(gene name synonym)|uniprotkb:PRIM1(gene name)|psi-mi:PRIM1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Ott et al. (2002)	pubmed:12138179	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-850113	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000368349|refseq:NP_058633.2|ensembl:ENSG00000101868(gene)|ensembl:ENST00000379059(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017076"(purine nucleotide binding)|go:"GO:0019103"(pyrimidine nucleotide binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR015088(Zinc finger, DNA-directed DNA polymerase, family B, alpha)|interpro:IPR017964|interpro:IPR024647|interpro:IPR036397|interpro:IPR038256|interpro:IPR042087|interpro:IPR043502|mint:P09884|rcsb pdb:1K0P|rcsb pdb:1K18|rcsb pdb:1N5G|rcsb pdb:4Q5V|rcsb pdb:4QCL|rcsb pdb:4Y97|rcsb pdb:5EXR|rcsb pdb:5IUD|rcsb pdb:6AS7|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-9710421	ensembl:ENSG00000198056(gene)|interpro:IPR014052(DNA primase, small subunit, eukaryotic and archaeal)|refseq:NP_000937.1|rcsb pdb:4BPU|rcsb pdb:4BPW|ensembl:ENST00000338193(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003896"(DNA primase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0032553"(ribonucleotide binding)|rcsb pdb:4BPX|rcsb pdb:4LIK|interpro:IPR002755(DNA primase, small subunit)|rcsb pdb:4LIL|rcsb pdb:4MHQ|rcsb pdb:4RR2|rcsb pdb:5EXR|rcsb pdb:6R4S|rcsb pdb:6R4T|rcsb pdb:6R4U|rcsb pdb:6R5D|rcsb pdb:6R5E|rcsb pdb:6RB4|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-9710421	go:"GO:0006270"(DNA replication initiation)	-	-	comment:Small amounts of the proteolytic cleavage products of POLA were also observed in the complex.|comment:The trimer, purified in the absence of POLA2, exhibits lower specific activity that that of the tetramer in both a polymerase and a primase assay.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/10	2014/10/16	rogid:X/oe9TEoaNUf5UPtWEXunsFtRZg9606	rogid:bgNj0hjvHPliBXVfkZmg7v0N/uw9606	intact-crc:55D158131E4B1195|rigid:VS+2YeUuv/gaAk211VBR/nhSBi0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09884	uniprotkb:P49643	intact:EBI-850026|uniprotkb:Q86UQ7|intact:EBI-28966824|ensembl:ENSP00000368349	intact:EBI-850004|uniprotkb:Q53FJ8|uniprotkb:Q6P1Q7|uniprotkb:Q8WVL2|uniprotkb:Q9H413|ensembl:ENSP00000484105	psi-mi:dpola_human(display_long)|uniprotkb:POLA1(gene name)|psi-mi:POLA1(display_short)|uniprotkb:POLA(gene name synonym)|uniprotkb:DNA polymerase alpha catalytic subunit p180(gene name synonym)	psi-mi:pri2_human(display_long)|uniprotkb:DNA primase 58 kDa subunit(gene name synonym)|uniprotkb:PRIM2(gene name)|psi-mi:PRIM2(display_short)|uniprotkb:PRIM2A(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Ott et al. (2002)	pubmed:12138179	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-850113	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000368349|refseq:NP_058633.2|ensembl:ENSG00000101868(gene)|ensembl:ENST00000379059(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017076"(purine nucleotide binding)|go:"GO:0019103"(pyrimidine nucleotide binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR015088(Zinc finger, DNA-directed DNA polymerase, family B, alpha)|interpro:IPR017964|interpro:IPR024647|interpro:IPR036397|interpro:IPR038256|interpro:IPR042087|interpro:IPR043502|mint:P09884|rcsb pdb:1K0P|rcsb pdb:1K18|rcsb pdb:1N5G|rcsb pdb:4Q5V|rcsb pdb:4QCL|rcsb pdb:4Y97|rcsb pdb:5EXR|rcsb pdb:5IUD|rcsb pdb:6AS7|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-9710421	refseq:NP_001269416.1|refseq:NP_001269417.1|refseq:NP_000938.2|dip:DIP-36438N|ensembl:ENSG00000146143(gene)|ensembl:ENST00000615550(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071667"(DNA/RNA hybrid binding)|interpro:IPR007238(DNA primase, large subunit, eukaryotic/archaeal)|interpro:IPR016558(DNA primase, large subunit, eukaryotic)|mint:P49643|rcsb pdb:3L9Q|rcsb pdb:3Q36|rcsb pdb:4BPU|rcsb pdb:4BPW|rcsb pdb:4BPX|rcsb pdb:4RR2|rcsb pdb:5DQO|rcsb pdb:5EXR|rcsb pdb:5F0Q|rcsb pdb:5F0S|rcsb pdb:5I7M|rcsb pdb:6DHW|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-9710421	go:"GO:0006270"(DNA replication initiation)	-	-	comment:Small amounts of the proteolytic cleavage products of POLA were also observed in the complex.|comment:The trimer, purified in the absence of POLA2, exhibits lower specific activity that that of the tetramer in both a polymerase and a primase assay.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/02/10	2014/10/16	rogid:X/oe9TEoaNUf5UPtWEXunsFtRZg9606	rogid:WL5i+CvK52C93/3X4a3MFQvD0JQ9606	intact-crc:55D158131E4B1195|rigid:VS+2YeUuv/gaAk211VBR/nhSBi0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)