#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:B2RXS4 uniprotkb:Q68FM7 intact:EBI-8496724|intact:MINT-1853052|uniprotkb:Q3UH76|ensembl:ENSMUSP00000051731|ensembl:ENSMUSP00000104955 intact:EBI-2365869|ensembl:ENSMUSP00000039900 psi-mi:plxb2_mouse(display_long)|uniprotkb:Plxnb2(gene name)|psi-mi:Plxnb2(display_short) psi-mi:q68fm7_mouse(display_long)|uniprotkb:Arhgef11(gene name)|psi-mi:Arhgef11(display_short) psi-mi:"MI:0018"(two hybrid) Swiercz et al. (2002) pubmed:12123608|mint:MINT-5215559 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8496720|mint:MINT-1791169 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271435.1|refseq:XP_011243751.1|refseq:XP_011243752.1|refseq:XP_011243753.1|refseq:NP_001152993.1|refseq:NP_620088.2|refseq:XP_006520475.1|refseq:XP_006520476.1|ensembl:ENSMUSG00000036606(gene)|ensembl:ENSMUST00000060808(transcript)|ensembl:ENSMUST00000109331(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|rcsb pdb:5E6P|mint:MINT-1791170(identity) refseq:NP_001003912.1|ensembl:ENSMUSG00000041977(gene)|ensembl:ENSMUST00000039476(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR032919|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037803|interpro:IPR037889|interpro:IPR041020|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|mint:MINT-1791171(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:NFA|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/03/28 2014/10/16 rogid:gbcsG7EzU6t15hxiDlvEzOYHy3o10090 rogid:HfOmxaqJCdDnhnAT3fWk9t8MPMs10090 intact-crc:1C900F37BE3CD924|rigid:EVtW1x14UF7ZOqkgcMfsZIhzA0I false binding-associated region:1648-1842(MINT-1791220)|tag:?-?(MINT-1791213) binding-associated region:43-133(MINT-1791183)|tag:?-?(MINT-1791176) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q68FM7 uniprotkb:Q8CJH3 intact:EBI-2365869|ensembl:ENSMUSP00000039900 intact:EBI-2637650|uniprotkb:E9QKS4|uniprotkb:Q6ZQC3|uniprotkb:Q80ZZ1|ensembl:ENSMUSP00000071966 psi-mi:q68fm7_mouse(display_long)|uniprotkb:Arhgef11(gene name)|psi-mi:Arhgef11(display_short) psi-mi:plxb1_mouse(display_long)|uniprotkb:Plxnb1(gene name)|psi-mi:Plxnb1(display_short)|uniprotkb:Kiaa0407(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Swiercz et al. (2002) pubmed:12123608|mint:MINT-5215559 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8496804|mint:MINT-1791223 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001003912.1|ensembl:ENSMUSG00000041977(gene)|ensembl:ENSMUST00000039476(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR032919|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037803|interpro:IPR037889|interpro:IPR041020|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|mint:MINT-1791234(identity) refseq:NP_766363.2|refseq:XP_006512138.1|refseq:XP_006512139.1|refseq:XP_006512140.1|refseq:XP_006512141.1|refseq:XP_006512142.1|refseq:XP_006512143.1|ensembl:ENSMUSG00000053646(gene)|ensembl:ENSMUST00000072093(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|mint:Q8CJH3|reactome:R-MMU-416482|reactome:R-MMU-416550|reactome:R-MMU-416572|mint:MINT-1791224(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:homomint|comment:mint taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2006/03/28 2014/10/16 rogid:HfOmxaqJCdDnhnAT3fWk9t8MPMs10090 rogid:3owlCeP7yhTsrYoSASDOYA8mWzc10090 intact-crc:F455EEFF8E852CEE|rigid:YXc5gbcVzDS01+VEYbbfMQE54F8 false binding-associated region:43-133(MINT-1791235)|flag tag:n-n(MINT-1791243) ha tag:?-?(MINT-1791232)|binding-associated region:1925-2119(MINT-1791225) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:B2RXS4 uniprotkb:Q68FM7 intact:EBI-8496724|intact:MINT-1853052|uniprotkb:Q3UH76|ensembl:ENSMUSP00000051731|ensembl:ENSMUSP00000104955 intact:EBI-2365869|ensembl:ENSMUSP00000039900 psi-mi:plxb2_mouse(display_long)|uniprotkb:Plxnb2(gene name)|psi-mi:Plxnb2(display_short) psi-mi:q68fm7_mouse(display_long)|uniprotkb:Arhgef11(gene name)|psi-mi:Arhgef11(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Swiercz et al. (2002) pubmed:12123608|mint:MINT-5215559 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8496873|mint:MINT-1791251 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271435.1|refseq:XP_011243751.1|refseq:XP_011243752.1|refseq:XP_011243753.1|refseq:NP_001152993.1|refseq:NP_620088.2|refseq:XP_006520475.1|refseq:XP_006520476.1|ensembl:ENSMUSG00000036606(gene)|ensembl:ENSMUST00000060808(transcript)|ensembl:ENSMUST00000109331(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|rcsb pdb:5E6P|mint:MINT-1791252(identity) refseq:NP_001003912.1|ensembl:ENSMUSG00000041977(gene)|ensembl:ENSMUST00000039476(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR032919|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037803|interpro:IPR037889|interpro:IPR041020|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|mint:MINT-1791262(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:mint taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2006/03/28 2014/10/16 rogid:gbcsG7EzU6t15hxiDlvEzOYHy3o10090 rogid:HfOmxaqJCdDnhnAT3fWk9t8MPMs10090 intact-crc:566E4EC2E2C59AA4|rigid:EVtW1x14UF7ZOqkgcMfsZIhzA0I false binding-associated region:1648-1842(MINT-1791253)|ha tag:?-?(MINT-1791260) binding-associated region:43-133(MINT-1791263)|flag tag:n-n(MINT-1791271) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9QY40 uniprotkb:Q68FM7 intact:EBI-6271317|ensembl:ENSMUSP00000002079|uniprotkb:A2AFF9|uniprotkb:Q80TH8 intact:EBI-2365869|ensembl:ENSMUSP00000039900 psi-mi:plxb3_mouse(display_long)|uniprotkb:Plxnb3(gene name)|psi-mi:Plxnb3(display_short)|uniprotkb:Kiaa1206(gene name synonym)|uniprotkb:Plexin-6(gene name synonym)|uniprotkb:Plxn6(gene name synonym) psi-mi:q68fm7_mouse(display_long)|uniprotkb:Arhgef11(gene name)|psi-mi:Arhgef11(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Swiercz et al. (2002) pubmed:12123608|mint:MINT-5215559 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8496932|mint:MINT-1791297 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031385(gene)|ensembl:ENSMUST00000002079(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|reactome:R-MMU-416700|refseq:NP_062533.2|refseq:XP_006527842.1|refseq:XP_006527843.1|mint:MINT-1791298(identity) refseq:NP_001003912.1|ensembl:ENSMUSG00000041977(gene)|ensembl:ENSMUST00000039476(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR032919|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037803|interpro:IPR037889|interpro:IPR041020|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|mint:MINT-1791308(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1B|comment:homomint|comment:mint taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2006/03/28 2014/10/16 rogid:MK43LzW7I/npR6b9TedY4YbLQ2w10090 rogid:HfOmxaqJCdDnhnAT3fWk9t8MPMs10090 intact-crc:4837B2E47A57B864|rigid:/g4uioeKri0JpCpiM2N4kWoXET8 false binding-associated region:1708-1902(MINT-1791299)|ha tag:?-?(MINT-1791306) flag tag:n-n(MINT-1791309)|binding-associated region:43-133(MINT-1791316) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8CJH3 uniprotkb:Q68FM7 intact:EBI-2637650|uniprotkb:E9QKS4|uniprotkb:Q6ZQC3|uniprotkb:Q80ZZ1|ensembl:ENSMUSP00000071966 intact:EBI-2365869|ensembl:ENSMUSP00000039900 psi-mi:plxb1_mouse(display_long)|uniprotkb:Plxnb1(gene name)|psi-mi:Plxnb1(display_short)|uniprotkb:Kiaa0407(gene name synonym) psi-mi:q68fm7_mouse(display_long)|uniprotkb:Arhgef11(gene name)|psi-mi:Arhgef11(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Swiercz et al. (2002) pubmed:12123608|mint:MINT-5215559 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8496980|mint:MINT-1791403 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766363.2|refseq:XP_006512138.1|refseq:XP_006512139.1|refseq:XP_006512140.1|refseq:XP_006512141.1|refseq:XP_006512142.1|refseq:XP_006512143.1|ensembl:ENSMUSG00000053646(gene)|ensembl:ENSMUST00000072093(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|mint:Q8CJH3|reactome:R-MMU-416482|reactome:R-MMU-416550|reactome:R-MMU-416572|mint:MINT-1791410(identity) refseq:NP_001003912.1|ensembl:ENSMUSG00000041977(gene)|ensembl:ENSMUST00000039476(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR032919|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037803|interpro:IPR037889|interpro:IPR041020|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|mint:MINT-1791404(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3A|comment:homomint|comment:mint taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2006/03/28 2014/10/16 rogid:3owlCeP7yhTsrYoSASDOYA8mWzc10090 rogid:HfOmxaqJCdDnhnAT3fWk9t8MPMs10090 intact-crc:C2421ECFB0586F00|rigid:YXc5gbcVzDS01+VEYbbfMQE54F8 false tag:?-?(MINT-1791423) flag tag:?-?(MINT-1791420)|binding-associated region:43-123(MINT-1791426) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q68FM7 uniprotkb:Q8CJH3 intact:EBI-2365869|ensembl:ENSMUSP00000039900 intact:EBI-2637650|uniprotkb:E9QKS4|uniprotkb:Q6ZQC3|uniprotkb:Q80ZZ1|ensembl:ENSMUSP00000071966 psi-mi:q68fm7_mouse(display_long)|uniprotkb:Arhgef11(gene name)|psi-mi:Arhgef11(display_short) psi-mi:plxb1_mouse(display_long)|uniprotkb:Plxnb1(gene name)|psi-mi:Plxnb1(display_short)|uniprotkb:Kiaa0407(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Swiercz et al. (2002) pubmed:12123608|mint:MINT-5215559 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8497078|mint:MINT-1791429 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001003912.1|ensembl:ENSMUSG00000041977(gene)|ensembl:ENSMUST00000039476(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR032919|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037803|interpro:IPR037889|interpro:IPR041020|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|mint:MINT-1791438(identity) refseq:NP_766363.2|refseq:XP_006512138.1|refseq:XP_006512139.1|refseq:XP_006512140.1|refseq:XP_006512141.1|refseq:XP_006512142.1|refseq:XP_006512143.1|ensembl:ENSMUSG00000053646(gene)|ensembl:ENSMUST00000072093(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|mint:Q8CJH3|reactome:R-MMU-416482|reactome:R-MMU-416550|reactome:R-MMU-416572|mint:MINT-1791430(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3B|comment:homomint|comment:mint taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2006/03/28 2014/10/16 rogid:HfOmxaqJCdDnhnAT3fWk9t8MPMs10090 rogid:3owlCeP7yhTsrYoSASDOYA8mWzc10090 intact-crc:99B0E2E9D48048E5|rigid:YXc5gbcVzDS01+VEYbbfMQE54F8 false flag tag:?-?(MINT-1791447) mutation disrupting interaction:2118-2118(MINT-1889592)|mutation disrupting interaction:2117-2117(MINT-1889590)|tag:?-?(MINT-1791436)|mutation disrupting interaction:2119-2119(MINT-1889594)|binding-associated region:2117-2119(MINT-1791456) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8R4H2 uniprotkb:Q8CJH3 intact:EBI-8046267|intact:MINT-1774761|uniprotkb:E9QPW9|uniprotkb:Q80U18|ensembl:ENSMUSP00000072547 intact:EBI-2637650|uniprotkb:E9QKS4|uniprotkb:Q6ZQC3|uniprotkb:Q80ZZ1|ensembl:ENSMUSP00000071966 psi-mi:arhgc_mouse(display_long)|uniprotkb:Arhgef12(gene name)|psi-mi:Arhgef12(display_short)|uniprotkb:Kiaa0382(gene name synonym)|uniprotkb:Larg(gene name synonym)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym) psi-mi:plxb1_mouse(display_long)|uniprotkb:Plxnb1(gene name)|psi-mi:Plxnb1(display_short)|uniprotkb:Kiaa0407(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Swiercz et al. (2002) pubmed:12123608|mint:MINT-5215559 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8497134|mint:MINT-1791458 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006510649.1|ensembl:ENSMUSG00000059495(gene)|ensembl:ENSMUST00000072767(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|mint:Q8R4H2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|mint:MINT-1791471(identity) refseq:NP_766363.2|refseq:XP_006512138.1|refseq:XP_006512139.1|refseq:XP_006512140.1|refseq:XP_006512141.1|refseq:XP_006512142.1|refseq:XP_006512143.1|ensembl:ENSMUSG00000053646(gene)|ensembl:ENSMUST00000072093(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|mint:Q8CJH3|reactome:R-MMU-416482|reactome:R-MMU-416550|reactome:R-MMU-416572|mint:MINT-1791459(identity) - comment:mint|function:"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:NFA|comment:homomint|comment:mint taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2006/03/28 2014/10/16 rogid:5ZclDYjaUBilqiB548/6M5KlhVg10090 rogid:3owlCeP7yhTsrYoSASDOYA8mWzc10090 intact-crc:F4048BCA163659BD|rigid:66pPSnl40Jysd68B5q7Yfhr14fo false flag tag:?-?(MINT-1791472) tag:?-?(MINT-1791469)|binding-associated region:2117-2119(MINT-1791460) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q68FM7 uniprotkb:Q8CJH3 intact:EBI-2365869|ensembl:ENSMUSP00000039900 intact:EBI-2637650|uniprotkb:E9QKS4|uniprotkb:Q6ZQC3|uniprotkb:Q80ZZ1|ensembl:ENSMUSP00000071966 psi-mi:q68fm7_mouse(display_long)|uniprotkb:Arhgef11(gene name)|psi-mi:Arhgef11(display_short) psi-mi:plxb1_mouse(display_long)|uniprotkb:Plxnb1(gene name)|psi-mi:Plxnb1(display_short)|uniprotkb:Kiaa0407(gene name synonym) psi-mi:"MI:0428"(imaging technique) Swiercz et al. (2002) pubmed:12123608|mint:MINT-5215559 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8497181|mint:MINT-1791338 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001003912.1|ensembl:ENSMUSG00000041977(gene)|ensembl:ENSMUST00000039476(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR032919|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037803|interpro:IPR037889|interpro:IPR041020|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|mint:MINT-1791349(identity) refseq:NP_766363.2|refseq:XP_006512138.1|refseq:XP_006512139.1|refseq:XP_006512140.1|refseq:XP_006512141.1|refseq:XP_006512142.1|refseq:XP_006512143.1|ensembl:ENSMUSG00000053646(gene)|ensembl:ENSMUST00000072093(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|mint:Q8CJH3|reactome:R-MMU-416482|reactome:R-MMU-416550|reactome:R-MMU-416572|mint:MINT-1791339(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2J|comment:the colocalisation occurs also in chick retinal ganglion cell growth cone.|comment:homomint|comment:mint|figure legend:F2G taxid:10090(mouse-brain-cortex)|taxid:10090(Mus musculus brain cortex) - 2006/03/28 2014/10/16 rogid:HfOmxaqJCdDnhnAT3fWk9t8MPMs10090 rogid:3owlCeP7yhTsrYoSASDOYA8mWzc10090 intact-crc:E764AD8CA1CB2D85|rigid:YXc5gbcVzDS01+VEYbbfMQE54F8 false - - 1 1 psi-mi:"MI:0661"(experimental participant identification) psi-mi:"MI:0661"(experimental participant identification) uniprotkb:Q8CJH3 uniprotkb:Q68FM7 intact:EBI-2637650|uniprotkb:E9QKS4|uniprotkb:Q6ZQC3|uniprotkb:Q80ZZ1|ensembl:ENSMUSP00000071966 intact:EBI-2365869|ensembl:ENSMUSP00000039900 psi-mi:plxb1_mouse(display_long)|uniprotkb:Plxnb1(gene name)|psi-mi:Plxnb1(display_short)|uniprotkb:Kiaa0407(gene name synonym) psi-mi:q68fm7_mouse(display_long)|uniprotkb:Arhgef11(gene name)|psi-mi:Arhgef11(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Swiercz et al. (2002) pubmed:12123608|mint:MINT-5215559 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8497202|mint:MINT-1791368 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766363.2|refseq:XP_006512138.1|refseq:XP_006512139.1|refseq:XP_006512140.1|refseq:XP_006512141.1|refseq:XP_006512142.1|refseq:XP_006512143.1|ensembl:ENSMUSG00000053646(gene)|ensembl:ENSMUST00000072093(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|mint:Q8CJH3|reactome:R-MMU-416482|reactome:R-MMU-416550|reactome:R-MMU-416572|mint:MINT-1791375(identity) refseq:NP_001003912.1|ensembl:ENSMUSG00000041977(gene)|ensembl:ENSMUST00000039476(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR032919|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037803|interpro:IPR037889|interpro:IPR041020|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|mint:MINT-1791369(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2K|comment:homomint|comment:mint taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2006/03/28 2014/10/16 rogid:3owlCeP7yhTsrYoSASDOYA8mWzc10090 rogid:HfOmxaqJCdDnhnAT3fWk9t8MPMs10090 intact-crc:A376FB9C18E61DB5|rigid:YXc5gbcVzDS01+VEYbbfMQE54F8 false - - 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q8R4H2 uniprotkb:Q8CJH3 intact:EBI-8046267|intact:MINT-1774761|uniprotkb:E9QPW9|uniprotkb:Q80U18|ensembl:ENSMUSP00000072547 intact:EBI-2637650|uniprotkb:E9QKS4|uniprotkb:Q6ZQC3|uniprotkb:Q80ZZ1|ensembl:ENSMUSP00000071966 psi-mi:arhgc_mouse(display_long)|uniprotkb:Arhgef12(gene name)|psi-mi:Arhgef12(display_short)|uniprotkb:Kiaa0382(gene name synonym)|uniprotkb:Larg(gene name synonym)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym) psi-mi:plxb1_mouse(display_long)|uniprotkb:Plxnb1(gene name)|psi-mi:Plxnb1(display_short)|uniprotkb:Kiaa0407(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Swiercz et al. (2002) pubmed:12123608|mint:MINT-5215559 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8497213|mint:MINT-1791388 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006510649.1|ensembl:ENSMUSG00000059495(gene)|ensembl:ENSMUST00000072767(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|mint:Q8R4H2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|mint:MINT-1791389(identity) refseq:NP_766363.2|refseq:XP_006512138.1|refseq:XP_006512139.1|refseq:XP_006512140.1|refseq:XP_006512141.1|refseq:XP_006512142.1|refseq:XP_006512143.1|ensembl:ENSMUSG00000053646(gene)|ensembl:ENSMUST00000072093(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1900220"(semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|mint:Q8CJH3|reactome:R-MMU-416482|reactome:R-MMU-416550|reactome:R-MMU-416572|mint:MINT-1791395(identity) - comment:mint|function:"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2K|comment:homomint|comment:mint taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2006/03/28 2014/10/16 rogid:5ZclDYjaUBilqiB548/6M5KlhVg10090 rogid:3owlCeP7yhTsrYoSASDOYA8mWzc10090 intact-crc:FEB24C60D6816A1D|rigid:66pPSnl40Jysd68B5q7Yfhr14fo false - - 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q8R4H2 uniprotkb:Q8C6B2 intact:EBI-8046267|intact:MINT-1774761|uniprotkb:E9QPW9|uniprotkb:Q80U18|ensembl:ENSMUSP00000072547 intact:EBI-1162441|uniprotkb:Q61192|uniprotkb:Q8VIG7|uniprotkb:E9QM24|ensembl:ENSMUSP00000065571 psi-mi:arhgc_mouse(display_long)|uniprotkb:Arhgef12(gene name)|psi-mi:Arhgef12(display_short)|uniprotkb:Kiaa0382(gene name synonym)|uniprotkb:Larg(gene name synonym)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym) psi-mi:rtkn_mouse(display_long)|uniprotkb:Rtkn(gene name)|psi-mi:Rtkn(display_short) psi-mi:"MI:0096"(pull down) Swiercz et al. (2002) pubmed:12123608|mint:MINT-5215559 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8497252|mint:MINT-1791488 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006510649.1|ensembl:ENSMUSG00000059495(gene)|ensembl:ENSMUST00000072767(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|mint:Q8R4H2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|mint:MINT-1791489(identity) go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0031106"(septin ring organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR012966(Protein of unknown function DUF1709, fungi)|interpro:IPR030471|reactome:R-MMU-5666185|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|ensembl:ENSMUSG00000034930(gene)|ensembl:ENSMUST00000065512(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005826"(actomyosin contractile ring)|refseq:NP_001129699.1|refseq:NP_033132.2|refseq:NP_598396.2|dip:DIP-29983N|mint:MINT-1791497(identity) - comment:mint|function:"May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5A|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/03/28 2014/10/16 rogid:5ZclDYjaUBilqiB548/6M5KlhVg10090 rogid:O0Nil3ml3d/RyrJzS/4fu1G/KYI10090 intact-crc:231BA28C2DD4CB6E|rigid:PCzH161CQ5MRG/Tl40ftIXkVGkU false flag tag:?-?(MINT-1791495) glutathione s tranferase tag:?-?(MINT-1791498)|binding-associated region:23-86(MINT-1791507) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O88643 uniprotkb:P60766 intact:EBI-457240 intact:EBI-81763|ensembl:ENSMUSP00000054634|uniprotkb:A2A9U6|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q3THZ7|uniprotkb:Q3TJK6|uniprotkb:Q545V0|uniprotkb:Q6P201|uniprotkb:Q8BQ51 psi-mi:pak1_mouse(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-A(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)|uniprotkb:Paka(gene name synonym) psi-mi:cdc42_mouse(display_long)|uniprotkb:Cdc42(gene name)|psi-mi:Cdc42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym) psi-mi:"MI:0096"(pull down) Swiercz et al. (2002) pubmed:12123608|mint:MINT-5215559 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8497312|mint:MINT-1791686 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-445144|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|dip:DIP-32847N|mint:O88643|mint:MINT-1791695(identity) ensembl:ENSMUSG00000006699(gene)|ensembl:ENSMUST00000051477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|refseq:NP_033991.1|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0043209"(myelin sheath)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051647"(nucleus localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071944"(cell periphery)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60766|rcsb pdb:3EG5|rcsb pdb:5C2J|reactome:R-MMU-114604|reactome:R-MMU-182971|reactome:R-MMU-2029482|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-525793|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-983231|go:"GO:0048664"(neuron fate determination)|refseq:NP_001230698.1|dip:DIP-32554N|mint:MINT-1791687(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5D|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/03/28 2014/10/16 rogid:96Cg20ZJuaGLWTlK9dOIdVHQLGQ10090 rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU10090 intact-crc:1B349EC463F3C998|rigid:8SLvWv2a/VFyNy05uzjvnAd76Qo false glutathione s tranferase tag:?-?(MINT-1791703)|binding-associated region:74-132(MINT-1791696) myc tag:?-?(MINT-1791693) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P63001 uniprotkb:O88643 intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4 intact:EBI-457240 psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym) psi-mi:pak1_mouse(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-A(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)|uniprotkb:Paka(gene name synonym) psi-mi:"MI:0096"(pull down) Swiercz et al. (2002) pubmed:12123608|mint:MINT-5215559 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8497273|mint:MINT-1791605 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N|mint:MINT-1791606(identity) go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-445144|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|dip:DIP-32847N|mint:O88643|mint:MINT-1791617(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5C|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/03/28 2014/10/16 rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090 rogid:96Cg20ZJuaGLWTlK9dOIdVHQLGQ10090 intact-crc:98FF343C3858A1AA|rigid:y8whV8f6GX+knSVUTl+Jo7qxSfo false myc tag:?-?(MINT-1791615) glutathione s tranferase tag:?-?(MINT-1791620)|binding-associated region:74-132(MINT-1791626) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)