#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08174	uniprotkb:Q914E0	intact:EBI-1033846|uniprotkb:P09679|uniprotkb:P78361|uniprotkb:B1AP14|uniprotkb:D3DT83|uniprotkb:D3DT84|ensembl:ENSP00000356031|uniprotkb:E7ER69|uniprotkb:Q14UF2|uniprotkb:Q14UF3|uniprotkb:Q14UF4|uniprotkb:Q14UF5|uniprotkb:Q14UF6	intact:EBI-1033812	psi-mi:daf_human(display_long)|uniprotkb:CD55(gene name)|psi-mi:CD55(display_short)|uniprotkb:CR(gene name synonym)|uniprotkb:DAF(gene name synonym)	psi-mi:q914e0_9ento(display_long)	psi-mi:"MI:0040"(electron microscopy)	He et al. (2002)	pubmed:12119400	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:46018(humec)|taxid:46018(Human echovirus 7)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1033874|rcsb pdb:1M11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000565.1|refseq:NP_001108224.1|refseq:NP_001287832.1|refseq:NP_001287833.1|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0030133"(transport vesicle)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045730"(respiratory burst)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|rcsb pdb:6LA5|rcsb pdb:7C9W|reactome:R-HSA-373080|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-977606|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR035976|rcsb pdb:1H03|rcsb pdb:1H04|rcsb pdb:1H2P|rcsb pdb:1H2Q|rcsb pdb:1M11|rcsb pdb:1NWV|rcsb pdb:1OJV|rcsb pdb:1OJW|rcsb pdb:1OJY|rcsb pdb:1OK1|rcsb pdb:1OK2|rcsb pdb:1OK3|rcsb pdb:1OK9|rcsb pdb:1UOT|rcsb pdb:1UPN|rcsb pdb:2C8I|rcsb pdb:2QZD|rcsb pdb:2QZF|rcsb pdb:2QZH|rcsb pdb:3IYP|rcsb pdb:3J24|interpro:IPR000436(Sushi/SCR/CCP)|rcsb pdb:5FOA|rcsb pdb:6ILJ|rcsb pdb:6ILK|ensembl:ENSG00000196352(gene)|ensembl:ENST00000367064(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002456"(T cell mediated immunity)	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR014838(Poliovirus 3A protein like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000081(Peptidase C3, picornavirus core protein 2A)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR003138(Picornavirus coat protein VP4)|interpro:IPR002527(Picornavirus 2B protein)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|rcsb pdb:1M11|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039522"(suppression by virus of host mRNA export from nucleus)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0044694"(pore-mediated entry of viral genome into host cell)|go:"GO:0046872"(metal ion binding)|interpro:IPR033703|interpro:IPR027417|interpro:IPR029053|interpro:IPR036203|interpro:IPR036988|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067	-	-	-	assembly:tetrameric, multimeric|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:5sa2K9j8EDzc3zJAe72+YVHTM/o9606	rogid:FZ4OsuFLPkXAqJUdYes3XqhpPRA46018	intact-crc:7CE53D1EAED19B1C|rigid:groiwnbLLpsARu7/fsSderIIv30	false	sufficient binding region:35-277	sufficient binding region:331-568	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08174	uniprotkb:Q914E0	intact:EBI-1033846|uniprotkb:P09679|uniprotkb:P78361|uniprotkb:B1AP14|uniprotkb:D3DT83|uniprotkb:D3DT84|ensembl:ENSP00000356031|uniprotkb:E7ER69|uniprotkb:Q14UF2|uniprotkb:Q14UF3|uniprotkb:Q14UF4|uniprotkb:Q14UF5|uniprotkb:Q14UF6	intact:EBI-1033812	psi-mi:daf_human(display_long)|uniprotkb:CD55(gene name)|psi-mi:CD55(display_short)|uniprotkb:CR(gene name synonym)|uniprotkb:DAF(gene name synonym)	psi-mi:q914e0_9ento(display_long)	psi-mi:"MI:0040"(electron microscopy)	He et al. (2002)	pubmed:12119400	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:46018(humec)|taxid:46018(Human echovirus 7)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1033874|rcsb pdb:1M11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000565.1|refseq:NP_001108224.1|refseq:NP_001287832.1|refseq:NP_001287833.1|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0030133"(transport vesicle)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045730"(respiratory burst)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|rcsb pdb:6LA5|rcsb pdb:7C9W|reactome:R-HSA-373080|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-977606|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR035976|rcsb pdb:1H03|rcsb pdb:1H04|rcsb pdb:1H2P|rcsb pdb:1H2Q|rcsb pdb:1M11|rcsb pdb:1NWV|rcsb pdb:1OJV|rcsb pdb:1OJW|rcsb pdb:1OJY|rcsb pdb:1OK1|rcsb pdb:1OK2|rcsb pdb:1OK3|rcsb pdb:1OK9|rcsb pdb:1UOT|rcsb pdb:1UPN|rcsb pdb:2C8I|rcsb pdb:2QZD|rcsb pdb:2QZF|rcsb pdb:2QZH|rcsb pdb:3IYP|rcsb pdb:3J24|interpro:IPR000436(Sushi/SCR/CCP)|rcsb pdb:5FOA|rcsb pdb:6ILJ|rcsb pdb:6ILK|ensembl:ENSG00000196352(gene)|ensembl:ENST00000367064(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002456"(T cell mediated immunity)	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR014838(Poliovirus 3A protein like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000081(Peptidase C3, picornavirus core protein 2A)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR003138(Picornavirus coat protein VP4)|interpro:IPR002527(Picornavirus 2B protein)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|rcsb pdb:1M11|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039522"(suppression by virus of host mRNA export from nucleus)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0044694"(pore-mediated entry of viral genome into host cell)|go:"GO:0046872"(metal ion binding)|interpro:IPR033703|interpro:IPR027417|interpro:IPR029053|interpro:IPR036203|interpro:IPR036988|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067	-	-	-	assembly:tetrameric, multimeric|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:5sa2K9j8EDzc3zJAe72+YVHTM/o9606	rogid:FZ4OsuFLPkXAqJUdYes3XqhpPRA46018	intact-crc:7CE53D1EAED19B1C|rigid:groiwnbLLpsARu7/fsSderIIv30	false	sufficient binding region:35-277	sufficient binding region:569-846	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08174	uniprotkb:Q914E0	intact:EBI-1033846|uniprotkb:P09679|uniprotkb:P78361|uniprotkb:B1AP14|uniprotkb:D3DT83|uniprotkb:D3DT84|ensembl:ENSP00000356031|uniprotkb:E7ER69|uniprotkb:Q14UF2|uniprotkb:Q14UF3|uniprotkb:Q14UF4|uniprotkb:Q14UF5|uniprotkb:Q14UF6	intact:EBI-1033812	psi-mi:daf_human(display_long)|uniprotkb:CD55(gene name)|psi-mi:CD55(display_short)|uniprotkb:CR(gene name synonym)|uniprotkb:DAF(gene name synonym)	psi-mi:q914e0_9ento(display_long)	psi-mi:"MI:0040"(electron microscopy)	He et al. (2002)	pubmed:12119400	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:46018(humec)|taxid:46018(Human echovirus 7)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1033874|rcsb pdb:1M11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000565.1|refseq:NP_001108224.1|refseq:NP_001287832.1|refseq:NP_001287833.1|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0030133"(transport vesicle)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045730"(respiratory burst)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0045959"(negative regulation of complement activation, classical pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1903659"(regulation of complement-dependent cytotoxicity)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|rcsb pdb:6LA5|rcsb pdb:7C9W|reactome:R-HSA-373080|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-977606|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR035976|rcsb pdb:1H03|rcsb pdb:1H04|rcsb pdb:1H2P|rcsb pdb:1H2Q|rcsb pdb:1M11|rcsb pdb:1NWV|rcsb pdb:1OJV|rcsb pdb:1OJW|rcsb pdb:1OJY|rcsb pdb:1OK1|rcsb pdb:1OK2|rcsb pdb:1OK3|rcsb pdb:1OK9|rcsb pdb:1UOT|rcsb pdb:1UPN|rcsb pdb:2C8I|rcsb pdb:2QZD|rcsb pdb:2QZF|rcsb pdb:2QZH|rcsb pdb:3IYP|rcsb pdb:3J24|interpro:IPR000436(Sushi/SCR/CCP)|rcsb pdb:5FOA|rcsb pdb:6ILJ|rcsb pdb:6ILK|ensembl:ENSG00000196352(gene)|ensembl:ENST00000367064(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002456"(T cell mediated immunity)	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR014838(Poliovirus 3A protein like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000081(Peptidase C3, picornavirus core protein 2A)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR003138(Picornavirus coat protein VP4)|interpro:IPR002527(Picornavirus 2B protein)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|rcsb pdb:1M11|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039522"(suppression by virus of host mRNA export from nucleus)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0044694"(pore-mediated entry of viral genome into host cell)|go:"GO:0046872"(metal ion binding)|interpro:IPR033703|interpro:IPR027417|interpro:IPR029053|interpro:IPR036203|interpro:IPR036988|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504|interpro:IPR044067	-	-	-	assembly:tetrameric, multimeric|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:5sa2K9j8EDzc3zJAe72+YVHTM/o9606	rogid:FZ4OsuFLPkXAqJUdYes3XqhpPRA46018	intact-crc:7CE53D1EAED19B1C|rigid:groiwnbLLpsARu7/fsSderIIv30	false	sufficient binding region:35-277	sufficient binding region:77-330	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)