#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NZJ5	uniprotkb:Q9NZJ5	intact:EBI-766076|uniprotkb:A0AVH2|uniprotkb:A0AVH1|uniprotkb:B2RCU9|uniprotkb:Q53QY0|uniprotkb:Q53SB1|uniprotkb:O95846|ensembl:ENSP00000307235	intact:EBI-766076|uniprotkb:A0AVH2|uniprotkb:A0AVH1|uniprotkb:B2RCU9|uniprotkb:Q53QY0|uniprotkb:Q53SB1|uniprotkb:O95846|ensembl:ENSP00000307235	psi-mi:e2ak3_human(display_long)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)|uniprotkb:EIF2AK3(gene name)|psi-mi:EIF2AK3(display_short)|uniprotkb:PEK(gene name synonym)|uniprotkb:PERK(gene name synonym)	psi-mi:e2ak3_human(display_long)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)|uniprotkb:EIF2AK3(gene name)|psi-mi:EIF2AK3(display_short)|uniprotkb:PEK(gene name synonym)|uniprotkb:PERK(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Ma et al. (2002)	pubmed:11907036	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1017451	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004827.4|rcsb pdb:4YZS|rcsb pdb:5SV7|rcsb pdb:7MF0|reactome:R-HSA-381042|rcsb pdb:4X7O|ensembl:ENSG00000172071(gene)|ensembl:ENST00000303236(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030282"(bone mineralization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070417"(cellular response to cold)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9NZJ5|rcsb pdb:4G31|rcsb pdb:4G34|rcsb pdb:4M7I|rcsb pdb:4X7H|rcsb pdb:4X7J|rcsb pdb:4X7K|rcsb pdb:4X7L|rcsb pdb:4X7N|go:"GO:0051879"(Hsp90 protein binding)	refseq:NP_004827.4|rcsb pdb:4YZS|rcsb pdb:5SV7|rcsb pdb:7MF0|reactome:R-HSA-381042|rcsb pdb:4X7O|ensembl:ENSG00000172071(gene)|ensembl:ENST00000303236(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030282"(bone mineralization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070417"(cellular response to cold)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9NZJ5|rcsb pdb:4G31|rcsb pdb:4G34|rcsb pdb:4M7I|rcsb pdb:4X7H|rcsb pdb:4X7J|rcsb pdb:4X7K|rcsb pdb:4X7L|rcsb pdb:4X7N|go:"GO:0051879"(Hsp90 protein binding)	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:2	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/09/15	2014/10/16	rogid:sjPIYQzmbvq1fvSgn0HR781yf9w9606	rogid:sjPIYQzmbvq1fvSgn0HR781yf9w9606	intact-crc:218D7B343E308DB2|rigid:PhHrpNXAONz2IcavVxod1rzL/U8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NZJ5	uniprotkb:Q9NZJ5	intact:EBI-766076|uniprotkb:A0AVH2|uniprotkb:A0AVH1|uniprotkb:B2RCU9|uniprotkb:Q53QY0|uniprotkb:Q53SB1|uniprotkb:O95846|ensembl:ENSP00000307235	intact:EBI-766076|uniprotkb:A0AVH2|uniprotkb:A0AVH1|uniprotkb:B2RCU9|uniprotkb:Q53QY0|uniprotkb:Q53SB1|uniprotkb:O95846|ensembl:ENSP00000307235	psi-mi:e2ak3_human(display_long)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)|uniprotkb:EIF2AK3(gene name)|psi-mi:EIF2AK3(display_short)|uniprotkb:PEK(gene name synonym)|uniprotkb:PERK(gene name synonym)	psi-mi:e2ak3_human(display_long)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)|uniprotkb:EIF2AK3(gene name)|psi-mi:EIF2AK3(display_short)|uniprotkb:PEK(gene name synonym)|uniprotkb:PERK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ma et al. (2002)	pubmed:11907036	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1017461	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004827.4|rcsb pdb:4YZS|rcsb pdb:5SV7|rcsb pdb:7MF0|reactome:R-HSA-381042|rcsb pdb:4X7O|ensembl:ENSG00000172071(gene)|ensembl:ENST00000303236(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030282"(bone mineralization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070417"(cellular response to cold)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9NZJ5|rcsb pdb:4G31|rcsb pdb:4G34|rcsb pdb:4M7I|rcsb pdb:4X7H|rcsb pdb:4X7J|rcsb pdb:4X7K|rcsb pdb:4X7L|rcsb pdb:4X7N|go:"GO:0051879"(Hsp90 protein binding)	refseq:NP_004827.4|rcsb pdb:4YZS|rcsb pdb:5SV7|rcsb pdb:7MF0|reactome:R-HSA-381042|rcsb pdb:4X7O|ensembl:ENSG00000172071(gene)|ensembl:ENST00000303236(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030282"(bone mineralization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070417"(cellular response to cold)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9NZJ5|rcsb pdb:4G31|rcsb pdb:4G34|rcsb pdb:4M7I|rcsb pdb:4X7H|rcsb pdb:4X7J|rcsb pdb:4X7K|rcsb pdb:4X7L|rcsb pdb:4X7N|go:"GO:0051879"(Hsp90 protein binding)	-	-	-	figure legend:5	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/09/15	2014/10/16	rogid:sjPIYQzmbvq1fvSgn0HR781yf9w9606	rogid:sjPIYQzmbvq1fvSgn0HR781yf9w9606	intact-crc:308F13318ED44066|rigid:PhHrpNXAONz2IcavVxod1rzL/U8	false	necessary binding region:103-258,259-333,334-408	myc tag:c-c|fusion protein:1062-1116,1-589	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11021	uniprotkb:Q9NZJ5	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	intact:EBI-766076|uniprotkb:A0AVH2|uniprotkb:A0AVH1|uniprotkb:B2RCU9|uniprotkb:Q53QY0|uniprotkb:Q53SB1|uniprotkb:O95846|ensembl:ENSP00000307235	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:e2ak3_human(display_long)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)|uniprotkb:EIF2AK3(gene name)|psi-mi:EIF2AK3(display_short)|uniprotkb:PEK(gene name synonym)|uniprotkb:PERK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ma et al. (2002)	pubmed:11907036	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1017480	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	refseq:NP_004827.4|rcsb pdb:4YZS|rcsb pdb:5SV7|rcsb pdb:7MF0|reactome:R-HSA-381042|rcsb pdb:4X7O|ensembl:ENSG00000172071(gene)|ensembl:ENST00000303236(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030282"(bone mineralization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070417"(cellular response to cold)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9NZJ5|rcsb pdb:4G31|rcsb pdb:4G34|rcsb pdb:4M7I|rcsb pdb:4X7H|rcsb pdb:4X7J|rcsb pdb:4X7K|rcsb pdb:4X7L|rcsb pdb:4X7N|go:"GO:0051879"(Hsp90 protein binding)	-	-	-	figure legend:7  8|inhibition:"Thapsigargin (1 micromolar)"	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/09/15	2014/10/16	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rogid:sjPIYQzmbvq1fvSgn0HR781yf9w9606	intact-crc:CDE830C8BD94A800|rigid:h4KG5QCscdiFQY/1CbV071GkmZI	false	-	necessary binding region:412-482	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NZJ5	uniprotkb:P14625	intact:EBI-766076|uniprotkb:A0AVH2|uniprotkb:A0AVH1|uniprotkb:B2RCU9|uniprotkb:Q53QY0|uniprotkb:Q53SB1|uniprotkb:O95846|ensembl:ENSP00000307235	intact:EBI-359129|uniprotkb:Q96A97|ensembl:ENSP00000299767	psi-mi:e2ak3_human(display_long)|uniprotkb:PRKR-like endoplasmic reticulum kinase(gene name synonym)|uniprotkb:Pancreatic eIF2-alpha kinase(gene name synonym)|uniprotkb:EIF2AK3(gene name)|psi-mi:EIF2AK3(display_short)|uniprotkb:PEK(gene name synonym)|uniprotkb:PERK(gene name synonym)	psi-mi:enpl_human(display_long)|uniprotkb:HSP90B1(gene name)|psi-mi:HSP90B1(display_short)|uniprotkb:TRA1(gene name synonym)|uniprotkb:Heat shock protein 90 kDa beta member 1(gene name synonym)|uniprotkb:94 kDa glucose-regulated protein(gene name synonym)|uniprotkb:GRP94(gene name synonym)|uniprotkb:gp96 homolog(gene name synonym)|uniprotkb:Tumor rejection antigen 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ma et al. (2002)	pubmed:11907036	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1017489	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004827.4|rcsb pdb:4YZS|rcsb pdb:5SV7|rcsb pdb:7MF0|reactome:R-HSA-381042|rcsb pdb:4X7O|ensembl:ENSG00000172071(gene)|ensembl:ENST00000303236(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001525"(angiogenesis)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030282"(bone mineralization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060734"(regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0070417"(cellular response to cold)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9NZJ5|rcsb pdb:4G31|rcsb pdb:4G34|rcsb pdb:4M7I|rcsb pdb:4X7H|rcsb pdb:4X7J|rcsb pdb:4X7K|rcsb pdb:4X7L|rcsb pdb:4X7N|go:"GO:0051879"(Hsp90 protein binding)	refseq:NP_003290.1|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P14625|rcsb pdb:4NH9|reactome:R-HSA-1679131|reactome:R-HSA-3000480|reactome:R-HSA-381183|reactome:R-HSA-381426|reactome:R-HSA-6785807|reactome:R-HSA-8957275|ensembl:ENSG00000166598(gene)|ensembl:ENST00000299767(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031247"(actin rod assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|dip:DIP-36060N	-	-	-	figure legend:7|inhibition:"Thapsigargin (1 micromolar)"	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2006/09/15	2014/10/16	rogid:sjPIYQzmbvq1fvSgn0HR781yf9w9606	rogid:m5CdlplqVyMUWYe75aKDuMzztMY9606	intact-crc:10891A02C31B562B|rigid:5w1oCIS75EGUe/7V48txToh5aSg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)