#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P37173	uniprotkb:P10600	intact:EBI-296151|uniprotkb:Q15580|uniprotkb:Q6DKT6|uniprotkb:Q99474|ensembl:ENSP00000295754|uniprotkb:B4DTV5	intact:EBI-1033020|uniprotkb:Q8WV88|ensembl:ENSP00000238682|ensembl:ENSP00000502685	psi-mi:tgfr2_human(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:tgfb3_human(display_long)|uniprotkb:TGFB3(gene name)|psi-mi:TGFB3(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Hart et al. (2002)	pubmed:11850637	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1033040|rcsb pdb:1KTZ	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1KTZ|rcsb pdb:1PLO|rcsb pdb:2PJY|rcsb pdb:1M9Z|rcsb pdb:3KFD|rcsb pdb:4P7U|rcsb pdb:4XJJ|rcsb pdb:5E8V|rcsb pdb:5E8Y|rcsb pdb:5E91|rcsb pdb:5E92|rcsb pdb:5QIN|rcsb pdb:5TX4|rcsb pdb:5TY4|rcsb pdb:7DV6|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-5689603|ensembl:ENSG00000163513(gene)|ensembl:ENST00000295754(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003274"(endocardial cushion fusion)|refseq:NP_001020018.1|refseq:NP_003233.4|dip:DIP-5939N	refseq:NP_003230.1|ensembl:ENSG00000119699(gene)|ensembl:ENST00000238682(transcript)|ensembl:ENST00000556674(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0030315"(T-tubule)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030879"(mammary gland development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032570"(response to progesterone)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042476"(odontogenesis)|go:"GO:0042704"(uterine wall breakdown)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048839"(inner ear development)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060364"(frontal suture morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070483"(detection of hypoxia)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015618(Transforming growth factor beta 3)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KTZ|rcsb pdb:1TGJ|rcsb pdb:1TGK|rcsb pdb:2PJY|rcsb pdb:3EO1|rcsb pdb:4UM9|reactome:R-HSA-114608|reactome:R-HSA-2129379|reactome:R-HSA-3000178|refseq:NP_001316867.1|refseq:NP_001316868.1|dip:DIP-5937N	-	-	-	assembly:, trimeric, multimeric, dimeric, multimeric|3d-r-factors:working 79.900%, free 78.500%|3d-resolution:2.15A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:BhAUE/hzn1B/qAW63HhmI8ST21I9606	rogid:aQcAUgs6CAnHKZqIcOAdqiujRqM9606	intact-crc:3A3C33C994071843|rigid:GHE4avC5L4hqlnHC+9+8Y4p6wJ0	false	sufficient binding region:38-159	sufficient binding region:301-412	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)