#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O54709 uniprotkb:O08603 intact:EBI-1032793|ensembl:ENSMUSP00000032252 intact:EBI-1032784|uniprotkb:A2RS95 psi-mi:nkg2d_mouse(display_long)|uniprotkb:Klrk1(gene name)|psi-mi:Klrk1(display_short)|uniprotkb:Nkg2d(gene name synonym)|uniprotkb:NK cell receptor D(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily K member 1(gene name synonym)|uniprotkb:NKG2-D-activating NK receptor(gene name synonym) psi-mi:rae1b_mouse(display_long)|uniprotkb:Raet1b(gene name)|psi-mi:Raet1b(display_short) psi-mi:"MI:0114"(x-ray crystallography) Li et al. (2002) pubmed:11825567 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1032812|rcsb pdb:1JSK - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001076791.1|refseq:NP_149069.1|ensembl:ENSMUSG00000030149(gene)|ensembl:ENSMUST00000032252(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030887"(positive regulation of myeloid dendritic cell activation)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|interpro:IPR042169|rcsb pdb:1HQ8|rcsb pdb:4PP8|reactome:R-MMU-2424491 refseq:NP_033043.1|interpro:IPR011162(MHC classes I and II-like antigen recognition)|rcsb pdb:1JFM|go:"GO:0002839"(positive regulation of immune response to tumor cell)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071360"(cellular response to exogenous dsRNA)|interpro:IPR029287|rcsb pdb:4PP8|interpro:IPR037055 - - - assembly:monomeric|3d-r-factors:working 68.600%, free 67.00%|3d-resolution:3.5A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:P1SZVQKn3ollojPt5TxqUdefGNc10090 rogid:nwJtHm4ruCjracOgCgpqyGQoUyQ10090 intact-crc:34D24C9D53B3276C|rigid:AKpwef7GP0AFXRIItRAkdJHchR8 false sufficient binding region:110-232 sufficient binding region:31-204 2 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)