#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P22288	uniprotkb:P70552	intact:EBI-1032708|ensembl:ENSRNOP00000014821	intact:EBI-1032715|ensembl:ENSRNOP00000016458	psi-mi:gch1_rat(display_long)|uniprotkb:Gch1(gene name)|psi-mi:Gch1(display_short)|uniprotkb:Gch(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:gfrp_rat(display_long)|uniprotkb:Gchfr(gene name)|psi-mi:Gchfr(display_short)|uniprotkb:Gfrp(gene name synonym)|uniprotkb:GTP cyclohydrolase I feedback regulatory protein(gene name synonym)|uniprotkb:p35(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Maita et al. (2002)	pubmed:11818540	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1032731|rcsb pdb:1IS7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:61992|refseq:NP_077332.1|ensembl:ENSRNOG00000011039(gene)|ensembl:ENSRNOT00000014821(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051066"(dihydrobiopterin metabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1IS7|rcsb pdb:1IS8|rcsb pdb:1WPL|reactome:R-RNO-1474151	rgd:621746|refseq:NP_598279.1|ensembl:ENSRNOG00000012290(gene)|ensembl:ENSRNOT00000016458(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009890"(negative regulation of biosynthetic process)|go:"GO:0016597"(amino acid binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042470"(melanosome)|go:"GO:0043105"(negative regulation of GTP cyclohydrolase I activity)|go:"GO:0044549"(GTP cyclohydrolase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR009112(GTP cyclohydrolase I, feedback regulatory protein)|interpro:IPR036717|rcsb pdb:1IS8|rcsb pdb:1JG5|rcsb pdb:1WPL|reactome:R-RNO-1474151|rcsb pdb:1IS7	-	-	-	assembly:eicosameric, multimeric|3d-r-factors:working 77.200%, free 73.600%|3d-resolution:2.8A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:wUXJ2OIKdZcxfGKboGoIr8dG6tI10116	rogid:c5lIISB/yLNtxYVDUtulFa4H7og10116	intact-crc:C876FF5A7F336288|rigid:9wpz8wfK8dY4+Qj+NgG49mX7h5U	false	sufficient binding region:12-241	sufficient binding region:2-84	10	10	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70552	uniprotkb:P22288	intact:EBI-1032715|ensembl:ENSRNOP00000016458	intact:EBI-1032708|ensembl:ENSRNOP00000014821	psi-mi:gfrp_rat(display_long)|uniprotkb:Gchfr(gene name)|psi-mi:Gchfr(display_short)|uniprotkb:Gfrp(gene name synonym)|uniprotkb:GTP cyclohydrolase I feedback regulatory protein(gene name synonym)|uniprotkb:p35(gene name synonym)	psi-mi:gch1_rat(display_long)|uniprotkb:Gch1(gene name)|psi-mi:Gch1(display_short)|uniprotkb:Gch(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Maita et al. (2002)	pubmed:11818540	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1032742|rcsb pdb:1IS8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621746|refseq:NP_598279.1|ensembl:ENSRNOG00000012290(gene)|ensembl:ENSRNOT00000016458(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009890"(negative regulation of biosynthetic process)|go:"GO:0016597"(amino acid binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042470"(melanosome)|go:"GO:0043105"(negative regulation of GTP cyclohydrolase I activity)|go:"GO:0044549"(GTP cyclohydrolase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR009112(GTP cyclohydrolase I, feedback regulatory protein)|interpro:IPR036717|rcsb pdb:1IS8|rcsb pdb:1JG5|rcsb pdb:1WPL|reactome:R-RNO-1474151|rcsb pdb:1IS7	rgd:61992|refseq:NP_077332.1|ensembl:ENSRNOG00000011039(gene)|ensembl:ENSRNOT00000014821(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051066"(dihydrobiopterin metabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1IS7|rcsb pdb:1IS8|rcsb pdb:1WPL|reactome:R-RNO-1474151	-	-	-	assembly:eicosameric, multimeric|3d-r-factors:working 78.100%, free 75.500%|3d-resolution:2.7A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:c5lIISB/yLNtxYVDUtulFa4H7og10116	rogid:wUXJ2OIKdZcxfGKboGoIr8dG6tI10116	intact-crc:0DDC095A7DCE4635|rigid:9wpz8wfK8dY4+Qj+NgG49mX7h5U	false	sufficient binding region:2-84	sufficient binding region:12-241	10	10	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)