#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O88551	uniprotkb:P39447	intact:EBI-7158428|ensembl:ENSMUSP00000023154|intact:MINT-113174	intact:EBI-79508|uniprotkb:E9QK00|ensembl:ENSMUSP00000099652	psi-mi:cld1_mouse(display_long)|uniprotkb:Cldn1(gene name)|psi-mi:Cldn1(display_short)	psi-mi:zo1_mouse(display_long)|uniprotkb:Tjp1(gene name)|psi-mi:Tjp1(display_short)|uniprotkb:Zo1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Hamazaki et al. (2002)	pubmed:11689568|mint:MINT-5214745	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8026386|mint:MINT-1785424	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000022512(gene)|ensembl:ENSMUST00000023154(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007568"(aging)|go:"GO:0008065"(establishment of blood-nerve barrier)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016338"(calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034331"(cell junction maintenance)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042802"(identical protein binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045471"(response to ethanol)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0061772"(xenobiotic transport across blood-nerve barrier)|go:"GO:0070160"(tight junction)|go:"GO:0070673"(response to interleukin-18)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0097421"(liver regeneration)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1903545"(cellular response to butyrate)|interpro:IPR003548(Claudin-1)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR006187(Claudin)|interpro:IPR017974|refseq:NP_057883.1|mint:MINT-1785425(identity)	go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005516"(calmodulin binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0005634"(nucleus)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0005737"(cytoplasm)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0005921"(gap junction)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045471"(response to ethanol)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0071000"(response to magnetism)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0071253"(connexin binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:0014704"(intercalated disc)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:0016020"(membrane)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035597|interpro:IPR036028|interpro:IPR036034|mint:P39447|rcsb pdb:2RRM|reactome:R-MMU-191650|reactome:R-MMU-2028269|reactome:R-MMU-351906|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|ensembl:ENSMUSG00000030516(gene)|ensembl:ENSMUST00000102592(transcript)|go:"GO:0001825"(blastocyst formation)|refseq:NP_033412.2|dip:DIP-30946N|mint:MINT-1785426(identity)	-	comment:mint|function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/03/18	2014/10/16	rogid:ONyJQFdBudkxsHryWmIZ9NWKtio10090	rogid:wvslyL15GCrtwUReZEC9DiNvPEk10090	intact-crc:D470C5C19E29175F|rigid:q+hlo8/XPNpbgGVrWRfAVV58CD0	false	binding-associated region:187-211(MINT-1785435)|tag:n-n(MINT-1785428)	binding-associated region:11-142(MINT-1785446)|tag:n-n(MINT-1785439)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0056"(full identification by DNA sequencing)
uniprotkb:O88551	uniprotkb:Q8VBX6	intact:EBI-7158428|ensembl:ENSMUSP00000023154|intact:MINT-113174	intact:EBI-8026435|uniprotkb:Q8VBV5|uniprotkb:Q6P7U4|uniprotkb:Q8VBY0|uniprotkb:B7ZNA1|uniprotkb:Q9Z1K3|uniprotkb:O08783|uniprotkb:Q8BKJ1|uniprotkb:Q8C0H8|intact:MINT-146667|uniprotkb:Q80ZY8|ensembl:ENSMUSP00000099894	psi-mi:cld1_mouse(display_long)|uniprotkb:Cldn1(gene name)|psi-mi:Cldn1(display_short)	psi-mi:mpdz_mouse(display_long)|uniprotkb:Mpdz(gene name)|psi-mi:Mpdz(display_short)|uniprotkb:Mupp1(gene name synonym)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Hamazaki et al. (2002)	pubmed:11689568|mint:MINT-5214745	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8026430|mint:MINT-1785453	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000022512(gene)|ensembl:ENSMUST00000023154(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007568"(aging)|go:"GO:0008065"(establishment of blood-nerve barrier)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016338"(calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034331"(cell junction maintenance)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042802"(identical protein binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045471"(response to ethanol)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0061772"(xenobiotic transport across blood-nerve barrier)|go:"GO:0070160"(tight junction)|go:"GO:0070673"(response to interleukin-18)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0097421"(liver regeneration)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1903545"(cellular response to butyrate)|interpro:IPR003548(Claudin-1)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR006187(Claudin)|interpro:IPR017974|refseq:NP_057883.1|mint:MINT-1785465(identity)	refseq:NP_001292213.1|refseq:NP_001292215.1|refseq:NP_034950.2|dip:DIP-41165N|ensembl:ENSMUSG00000028402(gene)|ensembl:ENSMUST00000102830(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042552"(myelination)|go:"GO:0043220"(Schmidt-Lanterman incisure)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:Q8VBX6|rcsb pdb:4XH7|mint:MINT-1785454(identity)	-	comment:mint|function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity|comment:"Stoichiometry: 1.0"	comment:mint|function:Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses|comment:"Stoichiometry: 1.0"	figure legend:F1|comment:homomint|comment:mint	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/03/18	2014/10/16	rogid:ONyJQFdBudkxsHryWmIZ9NWKtio10090	rogid:PE6FMj7RyxofEiUpGMu97CF+TX810090	intact-crc:1E29599724F48C9D|rigid:mVVYjphcSnCE22KusjP84QvpiWc	false	binding-associated region:187-211(MINT-1785466)|tag:n-n(MINT-1785473)	tag:n-n(MINT-1785463)|binding-associated region:1600-1698(MINT-1785455)	-	-	psi-mi:"MI:0056"(full identification by DNA sequencing)	psi-mi:"MI:0056"(full identification by DNA sequencing)
uniprotkb:Q8VBX6	uniprotkb:O88551	intact:EBI-8026435|uniprotkb:Q8VBV5|uniprotkb:Q6P7U4|uniprotkb:Q8VBY0|uniprotkb:B7ZNA1|uniprotkb:Q9Z1K3|uniprotkb:O08783|uniprotkb:Q8BKJ1|uniprotkb:Q8C0H8|intact:MINT-146667|uniprotkb:Q80ZY8|ensembl:ENSMUSP00000099894	intact:EBI-7158428|ensembl:ENSMUSP00000023154|intact:MINT-113174	psi-mi:mpdz_mouse(display_long)|uniprotkb:Mpdz(gene name)|psi-mi:Mpdz(display_short)|uniprotkb:Mupp1(gene name synonym)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)	psi-mi:cld1_mouse(display_long)|uniprotkb:Cldn1(gene name)|psi-mi:Cldn1(display_short)	psi-mi:"MI:0096"(pull down)	Hamazaki et al. (2002)	pubmed:11689568|mint:MINT-5214745	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8026572|mint:MINT-1785477	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001292213.1|refseq:NP_001292215.1|refseq:NP_034950.2|dip:DIP-41165N|ensembl:ENSMUSG00000028402(gene)|ensembl:ENSMUST00000102830(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042552"(myelination)|go:"GO:0043220"(Schmidt-Lanterman incisure)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:Q8VBX6|rcsb pdb:4XH7|mint:MINT-1785488(identity)	ensembl:ENSMUSG00000022512(gene)|ensembl:ENSMUST00000023154(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007568"(aging)|go:"GO:0008065"(establishment of blood-nerve barrier)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016338"(calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034331"(cell junction maintenance)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042802"(identical protein binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045471"(response to ethanol)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0061772"(xenobiotic transport across blood-nerve barrier)|go:"GO:0070160"(tight junction)|go:"GO:0070673"(response to interleukin-18)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0097421"(liver regeneration)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1903545"(cellular response to butyrate)|interpro:IPR003548(Claudin-1)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR006187(Claudin)|interpro:IPR017974|refseq:NP_057883.1|mint:MINT-1785478(identity)	-	comment:mint|function:Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses|comment:"Stoichiometry: 1.0"	comment:mint|function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity|comment:"Stoichiometry: 1.0"	figure legend:F2|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/18	2014/10/16	rogid:PE6FMj7RyxofEiUpGMu97CF+TX810090	rogid:ONyJQFdBudkxsHryWmIZ9NWKtio10090	intact-crc:F30F9F3D846BFE0C|rigid:mVVYjphcSnCE22KusjP84QvpiWc	false	maltose binding protein tag:n-n(MINT-1785497)|binding-associated region:1600-1700(MINT-1785489)	binding-associated region:187-211(MINT-1785479)|mutation disrupting interaction:210-211(MINT-1785499)|glutathione s tranferase tag:n-n(MINT-1785486)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88792	uniprotkb:Q8VBX6	intact:EBI-7580837|intact:MINT-247376|uniprotkb:Q8VC39|intact:MINT-4119377|ensembl:ENSMUSP00000041907	intact:EBI-8026435|uniprotkb:Q8VBV5|uniprotkb:Q6P7U4|uniprotkb:Q8VBY0|uniprotkb:B7ZNA1|uniprotkb:Q9Z1K3|uniprotkb:O08783|uniprotkb:Q8BKJ1|uniprotkb:Q8C0H8|intact:MINT-146667|uniprotkb:Q80ZY8|ensembl:ENSMUSP00000099894	psi-mi:jam1_mouse(display_long)|uniprotkb:F11r(gene name)|psi-mi:F11r(display_short)|uniprotkb:Jam1(gene name synonym)|uniprotkb:Jcam(gene name synonym)|uniprotkb:Jcam1(gene name synonym)|uniprotkb:Junctional adhesion molecule 1(gene name synonym)	psi-mi:mpdz_mouse(display_long)|uniprotkb:Mpdz(gene name)|psi-mi:Mpdz(display_short)|uniprotkb:Mupp1(gene name synonym)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hamazaki et al. (2002)	pubmed:11689568|mint:MINT-5214745	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8026621|mint:MINT-1785546	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766235.1|ensembl:ENSMUSG00000038235(gene)|ensembl:ENSMUST00000043839(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035683"(memory T cell extravasation)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050892"(intestinal absorption)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042456|mint:O88792|rcsb pdb:1F97|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-2173791|reactome:R-MMU-420029|go:"GO:0098609"(cell-cell adhesion)|dip:DIP-41166N	refseq:NP_001292213.1|refseq:NP_001292215.1|refseq:NP_034950.2|dip:DIP-41165N|ensembl:ENSMUSG00000028402(gene)|ensembl:ENSMUST00000102830(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042552"(myelination)|go:"GO:0043220"(Schmidt-Lanterman incisure)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:Q8VBX6|rcsb pdb:4XH7|mint:MINT-1785558(identity)	-	comment:mint|function:Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation	comment:mint|function:Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses|comment:"Stoichiometry: 1.0"	figure legend:F6A|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/18	2014/10/16	rogid:eM6EU7qHKBw4lJ4jpg5388hIza010090	rogid:PE6FMj7RyxofEiUpGMu97CF+TX810090	intact-crc:5F452F9ED617CA15|rigid:zXgh9p1l+4wBCIW4YW0nbZx/V2M	false	binding-associated region:260-300	binding-associated region:1456-1551(MINT-1785559)|maltose binding protein tag:n-n(MINT-1785567)	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88792	uniprotkb:Q8VBX6	intact:EBI-7580837|intact:MINT-247376|uniprotkb:Q8VC39|intact:MINT-4119377|ensembl:ENSMUSP00000041907	intact:EBI-8026435|uniprotkb:Q8VBV5|uniprotkb:Q6P7U4|uniprotkb:Q8VBY0|uniprotkb:B7ZNA1|uniprotkb:Q9Z1K3|uniprotkb:O08783|uniprotkb:Q8BKJ1|uniprotkb:Q8C0H8|intact:MINT-146667|uniprotkb:Q80ZY8|ensembl:ENSMUSP00000099894	psi-mi:jam1_mouse(display_long)|uniprotkb:F11r(gene name)|psi-mi:F11r(display_short)|uniprotkb:Jam1(gene name synonym)|uniprotkb:Jcam(gene name synonym)|uniprotkb:Jcam1(gene name synonym)|uniprotkb:Junctional adhesion molecule 1(gene name synonym)	psi-mi:mpdz_mouse(display_long)|uniprotkb:Mpdz(gene name)|psi-mi:Mpdz(display_short)|uniprotkb:Mupp1(gene name synonym)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Hamazaki et al. (2002)	pubmed:11689568|mint:MINT-5214745	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8026712|mint:MINT-1785577	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766235.1|ensembl:ENSMUSG00000038235(gene)|ensembl:ENSMUST00000043839(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035683"(memory T cell extravasation)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050892"(intestinal absorption)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042456|mint:O88792|rcsb pdb:1F97|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-2173791|reactome:R-MMU-420029|go:"GO:0098609"(cell-cell adhesion)|dip:DIP-41166N|mint:MINT-1785578(identity)	refseq:NP_001292213.1|refseq:NP_001292215.1|refseq:NP_034950.2|dip:DIP-41165N|ensembl:ENSMUSG00000028402(gene)|ensembl:ENSMUST00000102830(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042552"(myelination)|go:"GO:0043220"(Schmidt-Lanterman incisure)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:Q8VBX6|rcsb pdb:4XH7|mint:MINT-1785585(identity)	-	comment:mint|function:Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation|comment:"Stoichiometry: 1.0"	comment:mint|function:Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses|comment:"Stoichiometry: 1.0"	figure legend:F6B|comment:mint	taxid:9606(human-l cells)|taxid:9606(Homo sapiens)	-	2006/03/18	2014/10/16	rogid:eM6EU7qHKBw4lJ4jpg5388hIza010090	rogid:PE6FMj7RyxofEiUpGMu97CF+TX810090	intact-crc:3E4147D49C97D189|rigid:zXgh9p1l+4wBCIW4YW0nbZx/V2M	false	-	myc tag:c-c(MINT-1785594)	1	1	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:Q8VBX6	uniprotkb:P39447	intact:EBI-8026435|uniprotkb:Q8VBV5|uniprotkb:Q6P7U4|uniprotkb:Q8VBY0|uniprotkb:B7ZNA1|uniprotkb:Q9Z1K3|uniprotkb:O08783|uniprotkb:Q8BKJ1|uniprotkb:Q8C0H8|intact:MINT-146667|uniprotkb:Q80ZY8|ensembl:ENSMUSP00000099894	intact:EBI-79508|uniprotkb:E9QK00|ensembl:ENSMUSP00000099652	psi-mi:mpdz_mouse(display_long)|uniprotkb:Mpdz(gene name)|psi-mi:Mpdz(display_short)|uniprotkb:Mupp1(gene name synonym)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)	psi-mi:zo1_mouse(display_long)|uniprotkb:Tjp1(gene name)|psi-mi:Tjp1(display_short)|uniprotkb:Zo1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Hamazaki et al. (2002)	pubmed:11689568|mint:MINT-5214745	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8026733|mint:MINT-1785503	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001292213.1|refseq:NP_001292215.1|refseq:NP_034950.2|dip:DIP-41165N|ensembl:ENSMUSG00000028402(gene)|ensembl:ENSMUST00000102830(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042552"(myelination)|go:"GO:0043220"(Schmidt-Lanterman incisure)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:Q8VBX6|rcsb pdb:4XH7|mint:MINT-1785504(identity)	go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005516"(calmodulin binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0005634"(nucleus)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0005737"(cytoplasm)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0005921"(gap junction)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045471"(response to ethanol)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0071000"(response to magnetism)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0071253"(connexin binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:0014704"(intercalated disc)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:0016020"(membrane)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035597|interpro:IPR036028|interpro:IPR036034|mint:P39447|rcsb pdb:2RRM|reactome:R-MMU-191650|reactome:R-MMU-2028269|reactome:R-MMU-351906|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|ensembl:ENSMUSG00000030516(gene)|ensembl:ENSMUST00000102592(transcript)|go:"GO:0001825"(blastocyst formation)|refseq:NP_033412.2|dip:DIP-30946N|mint:MINT-1785514(identity)	-	comment:mint|function:Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4|comment:Since canine UP_IDs the proteins were identified with the murine UP_IDs|comment:homomint|comment:mint	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2006/03/18	2014/10/16	rogid:PE6FMj7RyxofEiUpGMu97CF+TX810090	rogid:wvslyL15GCrtwUReZEC9DiNvPEk10090	intact-crc:9FB7ED00185DBED6|rigid:HWWyWvR0bbXaJsYuvw1kSgHhkYw	false	-	-	1	1	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)