#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P78310	uniprotkb:Q66282	intact:EBI-747931|uniprotkb:O00694|uniprotkb:Q8WWT6|uniprotkb:Q8WWT7|uniprotkb:Q8WWT8|uniprotkb:Q9UKV4|ensembl:ENSP00000284878|uniprotkb:B2R8V8|uniprotkb:B7WPI3|uniprotkb:D3YHP0	intact:EBI-1032029	psi-mi:cxar_human(display_long)|uniprotkb:Coxsackievirus B-adenovirus receptor(gene name synonym)|uniprotkb:HCVADR(gene name synonym)|uniprotkb:CVB3-binding protein(gene name synonym)|uniprotkb:CXADR(gene name)|psi-mi:CXADR(display_short)|uniprotkb:CAR(gene name synonym)	psi-mi:polg_cxb3w(display_long)	psi-mi:"MI:0040"(electron microscopy)	He et al. (2001)	pubmed:11573093	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:103904(cxb3w)|taxid:103904("Coxsackievirus B3 (strain Woodruff)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1032053|rcsb pdb:1JEW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001329.1|refseq:NP_001193992.1|refseq:NP_001193993.1|refseq:NP_001193994.1|go:"GO:0045121"(membrane raft)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070633"(transepithelial transport)|ensembl:ENSG00000154639(gene)|go:"GO:0071253"(connexin binding)|ensembl:ENST00000284878(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0014704"(intercalated disc)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|refseq:XP_011527781.1|refseq:NP_001193995.1|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086072"(AV node cell-bundle of His cell adhesion involved in cell communication)|go:"GO:0086082"(cell adhesive protein binding involved in AV node cell-bundle of His cell communication)|go:"GO:0098904"(regulation of AV node cell action potential)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EAJ|rcsb pdb:1F5W|rcsb pdb:1JEW|rcsb pdb:1KAC|rcsb pdb:1P69|rcsb pdb:1P6A|rcsb pdb:1RSF|rcsb pdb:2J12|rcsb pdb:2J1K|rcsb pdb:2NPL|rcsb pdb:2W9L|rcsb pdb:2WBW|rcsb pdb:3J6L|rcsb pdb:3J6M|rcsb pdb:3J6N|rcsb pdb:3J6O|rcsb pdb:7DPZ|rcsb pdb:7DQ1|reactome:R-HSA-198933|reactome:R-HSA-202733	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR014838(Poliovirus 3A protein like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000081(Peptidase C3, picornavirus core protein 2A)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR003138(Picornavirus coat protein VP4)|interpro:IPR002527(Picornavirus 2B protein)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|rcsb pdb:1COV|rcsb pdb:1JEW|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039522"(suppression by virus of host mRNA export from nucleus)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039611"(suppression by virus of host translation initiation factor activity)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0044694"(pore-mediated entry of viral genome into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR044067|interpro:IPR033703|interpro:IPR027417|rcsb pdb:3JD7|interpro:IPR029053|interpro:IPR036203|interpro:IPR036988|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504	-	-	-	dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:rISYMOJkhS94FeOElTtG8w5p4hI9606	rogid:cbcl+UgZ0bkUO71h5fb2umm8oCY103904	intact-crc:567BCE414FF7781A|rigid:BMjw9/l6RAVGYhG738xcz9gvyro	false	sufficient binding region:21-140	sufficient binding region:70-332	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78310	uniprotkb:Q66282	intact:EBI-747931|uniprotkb:O00694|uniprotkb:Q8WWT6|uniprotkb:Q8WWT7|uniprotkb:Q8WWT8|uniprotkb:Q9UKV4|ensembl:ENSP00000284878|uniprotkb:B2R8V8|uniprotkb:B7WPI3|uniprotkb:D3YHP0	intact:EBI-1032029	psi-mi:cxar_human(display_long)|uniprotkb:Coxsackievirus B-adenovirus receptor(gene name synonym)|uniprotkb:HCVADR(gene name synonym)|uniprotkb:CVB3-binding protein(gene name synonym)|uniprotkb:CXADR(gene name)|psi-mi:CXADR(display_short)|uniprotkb:CAR(gene name synonym)	psi-mi:polg_cxb3w(display_long)	psi-mi:"MI:0040"(electron microscopy)	He et al. (2001)	pubmed:11573093	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:103904(cxb3w)|taxid:103904("Coxsackievirus B3 (strain Woodruff)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1032053|rcsb pdb:1JEW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001329.1|refseq:NP_001193992.1|refseq:NP_001193993.1|refseq:NP_001193994.1|go:"GO:0045121"(membrane raft)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070633"(transepithelial transport)|ensembl:ENSG00000154639(gene)|go:"GO:0071253"(connexin binding)|ensembl:ENST00000284878(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0014704"(intercalated disc)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|refseq:XP_011527781.1|refseq:NP_001193995.1|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086072"(AV node cell-bundle of His cell adhesion involved in cell communication)|go:"GO:0086082"(cell adhesive protein binding involved in AV node cell-bundle of His cell communication)|go:"GO:0098904"(regulation of AV node cell action potential)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EAJ|rcsb pdb:1F5W|rcsb pdb:1JEW|rcsb pdb:1KAC|rcsb pdb:1P69|rcsb pdb:1P6A|rcsb pdb:1RSF|rcsb pdb:2J12|rcsb pdb:2J1K|rcsb pdb:2NPL|rcsb pdb:2W9L|rcsb pdb:2WBW|rcsb pdb:3J6L|rcsb pdb:3J6M|rcsb pdb:3J6N|rcsb pdb:3J6O|rcsb pdb:7DPZ|rcsb pdb:7DQ1|reactome:R-HSA-198933|reactome:R-HSA-202733	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR014838(Poliovirus 3A protein like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000081(Peptidase C3, picornavirus core protein 2A)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR003138(Picornavirus coat protein VP4)|interpro:IPR002527(Picornavirus 2B protein)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|rcsb pdb:1COV|rcsb pdb:1JEW|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039522"(suppression by virus of host mRNA export from nucleus)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039611"(suppression by virus of host translation initiation factor activity)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0044694"(pore-mediated entry of viral genome into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR044067|interpro:IPR033703|interpro:IPR027417|rcsb pdb:3JD7|interpro:IPR029053|interpro:IPR036203|interpro:IPR036988|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504	-	-	-	dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:rISYMOJkhS94FeOElTtG8w5p4hI9606	rogid:cbcl+UgZ0bkUO71h5fb2umm8oCY103904	intact-crc:567BCE414FF7781A|rigid:BMjw9/l6RAVGYhG738xcz9gvyro	false	sufficient binding region:21-140	sufficient binding region:333-570	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78310	uniprotkb:Q66282	intact:EBI-747931|uniprotkb:O00694|uniprotkb:Q8WWT6|uniprotkb:Q8WWT7|uniprotkb:Q8WWT8|uniprotkb:Q9UKV4|ensembl:ENSP00000284878|uniprotkb:B2R8V8|uniprotkb:B7WPI3|uniprotkb:D3YHP0	intact:EBI-1032029	psi-mi:cxar_human(display_long)|uniprotkb:Coxsackievirus B-adenovirus receptor(gene name synonym)|uniprotkb:HCVADR(gene name synonym)|uniprotkb:CVB3-binding protein(gene name synonym)|uniprotkb:CXADR(gene name)|psi-mi:CXADR(display_short)|uniprotkb:CAR(gene name synonym)	psi-mi:polg_cxb3w(display_long)	psi-mi:"MI:0040"(electron microscopy)	He et al. (2001)	pubmed:11573093	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:103904(cxb3w)|taxid:103904("Coxsackievirus B3 (strain Woodruff)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1032053|rcsb pdb:1JEW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001329.1|refseq:NP_001193992.1|refseq:NP_001193993.1|refseq:NP_001193994.1|go:"GO:0045121"(membrane raft)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070633"(transepithelial transport)|ensembl:ENSG00000154639(gene)|go:"GO:0071253"(connexin binding)|ensembl:ENST00000284878(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0014704"(intercalated disc)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|refseq:XP_011527781.1|refseq:NP_001193995.1|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086072"(AV node cell-bundle of His cell adhesion involved in cell communication)|go:"GO:0086082"(cell adhesive protein binding involved in AV node cell-bundle of His cell communication)|go:"GO:0098904"(regulation of AV node cell action potential)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EAJ|rcsb pdb:1F5W|rcsb pdb:1JEW|rcsb pdb:1KAC|rcsb pdb:1P69|rcsb pdb:1P6A|rcsb pdb:1RSF|rcsb pdb:2J12|rcsb pdb:2J1K|rcsb pdb:2NPL|rcsb pdb:2W9L|rcsb pdb:2WBW|rcsb pdb:3J6L|rcsb pdb:3J6M|rcsb pdb:3J6N|rcsb pdb:3J6O|rcsb pdb:7DPZ|rcsb pdb:7DQ1|reactome:R-HSA-198933|reactome:R-HSA-202733	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR014838(Poliovirus 3A protein like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000081(Peptidase C3, picornavirus core protein 2A)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR003138(Picornavirus coat protein VP4)|interpro:IPR002527(Picornavirus 2B protein)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|rcsb pdb:1COV|rcsb pdb:1JEW|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039522"(suppression by virus of host mRNA export from nucleus)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039611"(suppression by virus of host translation initiation factor activity)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0044694"(pore-mediated entry of viral genome into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR044067|interpro:IPR033703|interpro:IPR027417|rcsb pdb:3JD7|interpro:IPR029053|interpro:IPR036203|interpro:IPR036988|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504	-	-	-	dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:rISYMOJkhS94FeOElTtG8w5p4hI9606	rogid:cbcl+UgZ0bkUO71h5fb2umm8oCY103904	intact-crc:567BCE414FF7781A|rigid:BMjw9/l6RAVGYhG738xcz9gvyro	false	sufficient binding region:21-140	sufficient binding region:2-69	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78310	uniprotkb:Q66282	intact:EBI-747931|uniprotkb:O00694|uniprotkb:Q8WWT6|uniprotkb:Q8WWT7|uniprotkb:Q8WWT8|uniprotkb:Q9UKV4|ensembl:ENSP00000284878|uniprotkb:B2R8V8|uniprotkb:B7WPI3|uniprotkb:D3YHP0	intact:EBI-1032029	psi-mi:cxar_human(display_long)|uniprotkb:Coxsackievirus B-adenovirus receptor(gene name synonym)|uniprotkb:HCVADR(gene name synonym)|uniprotkb:CVB3-binding protein(gene name synonym)|uniprotkb:CXADR(gene name)|psi-mi:CXADR(display_short)|uniprotkb:CAR(gene name synonym)	psi-mi:polg_cxb3w(display_long)	psi-mi:"MI:0040"(electron microscopy)	He et al. (2001)	pubmed:11573093	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:103904(cxb3w)|taxid:103904("Coxsackievirus B3 (strain Woodruff)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1032053|rcsb pdb:1JEW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001329.1|refseq:NP_001193992.1|refseq:NP_001193993.1|refseq:NP_001193994.1|go:"GO:0045121"(membrane raft)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070633"(transepithelial transport)|ensembl:ENSG00000154639(gene)|go:"GO:0071253"(connexin binding)|ensembl:ENST00000284878(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0014704"(intercalated disc)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|refseq:XP_011527781.1|refseq:NP_001193995.1|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086072"(AV node cell-bundle of His cell adhesion involved in cell communication)|go:"GO:0086082"(cell adhesive protein binding involved in AV node cell-bundle of His cell communication)|go:"GO:0098904"(regulation of AV node cell action potential)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EAJ|rcsb pdb:1F5W|rcsb pdb:1JEW|rcsb pdb:1KAC|rcsb pdb:1P69|rcsb pdb:1P6A|rcsb pdb:1RSF|rcsb pdb:2J12|rcsb pdb:2J1K|rcsb pdb:2NPL|rcsb pdb:2W9L|rcsb pdb:2WBW|rcsb pdb:3J6L|rcsb pdb:3J6M|rcsb pdb:3J6N|rcsb pdb:3J6O|rcsb pdb:7DPZ|rcsb pdb:7DQ1|reactome:R-HSA-198933|reactome:R-HSA-202733	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR000605(Helicase, superfamily 3, single-stranded DNA/RNA virus)|interpro:IPR014759(Helicase, superfamily 3, single-stranded RNA virus)|interpro:IPR014838(Poliovirus 3A protein like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000081(Peptidase C3, picornavirus core protein 2A)|interpro:IPR000199(Peptidase C3A and C3B, picornaviral)|interpro:IPR003138(Picornavirus coat protein VP4)|interpro:IPR002527(Picornavirus 2B protein)|interpro:IPR001676(Picornavirus capsid)|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|rcsb pdb:1COV|rcsb pdb:1JEW|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0018144"(RNA-protein covalent cross-linking)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039522"(suppression by virus of host mRNA export from nucleus)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039611"(suppression by virus of host translation initiation factor activity)|go:"GO:0039618"(T=pseudo3 icosahedral viral capsid)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044162"(host cell cytoplasmic vesicle membrane)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0044694"(pore-mediated entry of viral genome into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR044067|interpro:IPR033703|interpro:IPR027417|rcsb pdb:3JD7|interpro:IPR029053|interpro:IPR036203|interpro:IPR036988|interpro:IPR043128|interpro:IPR043502|interpro:IPR043504	-	-	-	dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:rISYMOJkhS94FeOElTtG8w5p4hI9606	rogid:cbcl+UgZ0bkUO71h5fb2umm8oCY103904	intact-crc:567BCE414FF7781A|rigid:BMjw9/l6RAVGYhG738xcz9gvyro	false	sufficient binding region:21-140	sufficient binding region:571-851	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)