#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941649|imex:IM-20081-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	kinetics:Free energy change of binding deltaG = -8.3 kcal/mol|kinetics:Enthalpy change of binding deltaH = -6.2 kcal/mol|kinetics:Entropy change of binding TdeltaS = 2.1 kcal/mol|figure legend:Fig. 1 and Table 1|comment:IgG-Fc was titrated into sFcgamma RIIb|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:EF1E4E158B3A4A38|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	-	sufficient binding region:43..43-217..217	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-941671|imex:IM-20081-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	kinetics:Free energy change of binding deltaG = -8.35 kcal/mol|kinetics:Enthapy change of binding deltaH = -6.49 kcal/mol|kinetics:Entropy change of binding TdeltaS = 1.86 kcal/mol|figure legend:Fig. 1 and Table 1|comment:sFcgamma RIIb was titrated into IgG-Fc|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:181C0AB123B34708|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942059|imex:IM-20081-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	kinetics:Free energy change of binding deltaG = -8.4 kcal/mol|kinetics:Enthalpy change of binding deltaH = -6.49 kcal/mol|kinetics:Entropy change of binding TdeltaS = 1.86 kcal/mol|figure legend:Fig. 3 and Table III|comment:sFcgamma RIIb was injected into the calorimeter cell containing various IgG-Fc glycoforms|kinetics:Heat capacity change of binding delta Cp = -160 cal/mol/K|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:C4DA86DDF292E361|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	-	sufficient binding region:43..43-217..217	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942073|imex:IM-20081-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	kinetics:Free energy change of binding deltaG = -8.33 kcal/mol|kinetics:Enthalpy change of binding deltaH = -6.47 kcal/mol|kinetics:Entropy change of binding TdeltaS = 1.85 kcal/mol|figure legend:Fig. 3 and Table III|comment:sFcgamma RIIb was injected into the calorimeter cell containing various IgG-Fc glycoforms|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc  was exposed to sialidase  for 24 hfollowed by beta-galactosidase for 24 h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:9338B3AAA34FFF22|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	protein modification:?-?	sufficient binding region:43..43-217..217	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942091|imex:IM-20081-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0005102"(signaling receptor binding)|go:"GO:0019865"(immunoglobulin binding)	-	-	kinetics:Free energy change of binding deltaG = -8.33 kcal/mol|kinetics:Enthalpy change of binding deltaH = -6.47 kcal/mol|kinetics:Entropy change of binding TdeltaS = 1.85 kcal/mol|figure legend:Fig. 3 and Table III|comment:sFcgamma RIIb was injected into the calorimeter cell containing various IgG-Fc glycoforms|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc  was exposed to sialidase  for 24 h followed by beta-galactosidase for 24 h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:5A4291CD837D4C6B|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	protein modification:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942108|imex:IM-20081-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	kinetics:Free energy change of binding deltaG = -8.21 kcal/mol|kinetics:Enthalpy change of binding deltaH = -6.58 kcal/mol|kinetics:Entropy change of binding TdeltaS = 1.63 kcal/mol|figure legend:Fig. 3 and Table III|comment:sFcgamma RIIb was injected into the calorimeter cell containing various IgG-Fc glycoforms|comment:"For the (M3N2F)2 glycoform, (NGA2F)2 IgG1-Fc was exposed to N-acetyl-beta -D-glucosaminidase for 24 h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:F8D3B4530A5EA23F|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	protein modification:?-?	sufficient binding region:43..43-217..217	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942125|imex:IM-20081-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	kinetics:Free energy change of binding deltaG = -7.63 kcal/mol|kinetics:Enthalpy change of binding deltaH = -5.89 kcal/mol|kinetics:Entropy change of binding TdeltaS = 1.74 kcal/mol|figure legend:Fig. 3 and Table III|comment:sFcgamma RIIb was injected into the calorimeter cell containing various IgG-Fc glycoforms|kinetics:Heat capacity change of binding delta Cp = -250 cal/mol/K|comment:"For the (MN2F)2 glycoform, (M3N2F)2 IgG1-Fc (was exposed to alpha -mannosidase for 48 h to remove the 1,3- and 1,6-arm mannose residues."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:91ED9B8B16AF1F14|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	protein modification:?-?	sufficient binding region:43..43-217..217	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942150|imex:IM-20081-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	kinetics:Free energy change of binding deltaG = -7.5 kcal/mol|kinetics:Enthalpy change of binding deltaH = -6.40 kcal/mol|kinetics:Entropy change of binding TdeltaS = 1.10 kcal/mol|figure legend:Fig. 4 and Table IV|comment:Temparature = 30 C|kinetics:Heat capacity change of binding delta Cp = -170 cal/mol/K|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:2D348CBA5910D595|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	-	sufficient binding region:43..43-217..217	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942165|imex:IM-20081-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	kinetics:Free energy change of binding deltaG = -7.51 kcal/mol|kinetics:Enthalpy change of binding deltaH = -5.70 kcal/mol|kinetics:Entropy change of binding TdeltaS = 1.81 kcal/mol|figure legend:Fig. 4 and Table IV|comment:Temperature = 30 C.|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc  was exposed to sialidase  for 24 hfollowed by beta-galactosidase for 24 h."|kinetics:Heat capacity change of binding deltaCp = -130 kcal/mol|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:5E41E0E25270F33F|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	protein modification:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942192|imex:IM-20081-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	kinetics:Free energy change of binding deltaG = -7.33 kcal/mol|kinetics:Enthalpy change of binding deltaH = -7.16 kcal/mol|kinetics:Entropy change of binding TdeltaS = 0.16 kcal/mol|figure legend:Fig. 4 and Table IV|comment:Temperature = 30 C|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc  was exposed to sialidase  for 24 h followed by beta-galactosidase for 24 h."|kinetics:Change in heat capacity of binding delta Cp = -130 kcal/mol|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:8B446B9747409C5C|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	protein modification:?-?	sufficient binding region:43..43-217..217	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942238|imex:IM-20081-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	kinetics:Free energy change of binding deltaG = -6.93 kcal/mol|kinetics:Enthalpy change of binding deltaH = -7.23 kcal/mol|kinetics:Entropy change of binding TdeltaS = -0.3 kcal/mol|figure legend:Fig. 4 and Table IV|comment:Temperature = 30 C|kinetics:Heat capacity change of binding delta Cp = -220 cal/mol/K|comment:"For the (MN2F)2 glycoform, (M3N2F)2 IgG1-Fc was exposed to alpha -mannosidase for 48 h to remove the 1,3- and 1,6-arm mannose residues."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:915DC221C570E118|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	protein modification:?-?	sufficient binding region:43..43-217..217	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942342|imex:IM-20081-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 5 C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:16EC80DFACA30FB3|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	-	sufficient binding region:43..43-217..217	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942352|imex:IM-20081-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 10 C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:BD94124BD96CA30F|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942362|imex:IM-20081-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 15 C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:BD94124CA96CA30F|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942372|imex:IM-20081-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 20 C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:BD94124BDBBCA30F|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	-	sufficient binding region:43..43-217..217	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942382|imex:IM-20081-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 25 C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:BD94124CABBCA30F|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942392|imex:IM-20081-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 5 C.|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc was exposed to sialidase for 24 hfollowed by beta-galactosidase for 24 h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:D6A9878583E360E9|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	protein modification:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942406|imex:IM-20081-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 10 C.|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc was exposed to sialidase for 24 hfollowed by beta-galactosidase for 24 h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:C4D2AF194E852360|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	protein modification:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942419|imex:IM-20081-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 15 C.|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc was exposed to sialidase for 24 hfollowed by beta-galactosidase for 24 h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:C4D2AF1949F52360|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	protein modification:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942432|imex:IM-20081-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 20 C.|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc was exposed to sialidase for 24h followed by treatment with beta-galactosidase for 24h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:4C2FA2B50579599B|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	protein modification:?-?	sufficient binding region:43..43-217..217	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942445|imex:IM-20081-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 25 C.|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc was exposed to sialidase for 24h followed by treatment with beta-galactosidase for 24 h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:E1D45EDD72F62F37|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	protein modification:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942458|imex:IM-20081-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 5 C|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc  was exposed to sialidase  for 24 h followed by beta-galactosidase for 24 h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:5B370E7255204C52|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	protein modification:?-?	sufficient binding region:43..43-217..217	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942471|imex:IM-20081-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 10 C|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc was exposed to sialidase  for 24h followed by treatment with beta-galactosidase for 24 h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:0BA2DCE191FD383D|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	protein modification:?-?	sufficient binding region:43..43-217..217	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942484|imex:IM-20081-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 15 C|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc was exposed to sialidase  for 24h followed by treatment with beta-galactosidase for 24h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:A7C32117098671BE|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	protein modification:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942497|imex:IM-20081-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0005102"(signaling receptor binding)|go:"GO:0019865"(immunoglobulin binding)	-	-	figure legend:Fig. 4|comment:Temperature = 20 C|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc  was exposed to sialidase  for 24 h followed by beta-galactosidase for 24 h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:3E69C9C57645204C|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	protein modification:?-?	sufficient binding region:43..43-217..217	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942510|imex:IM-20081-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 25 C|comment:"For (NGA2F)2 glycoform, the native IgG1-Fc was exposed to sialidase for 24h followed by treatment with beta-galactosidase for 24h."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:DBC2B50209599B04|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	protein modification:?-?	sufficient binding region:43..43-217..217	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942523|imex:IM-20081-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 5 C|comment:"For the (MN2F)2 glycoform, (M3N2F)2 IgG1-Fc was exposed to alpha -mannosidase for 48 h to remove the 1,3- and 1,6-arm mannose residues."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:0021B7A22B622F67|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	protein modification:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942536|imex:IM-20081-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 10 C|comment:"For the (MN2F)2 glycoform, (M3N2F)2 IgG1-Fc was exposed to alpha -mannosidase for 48 h to remove the 1,3- and 1,6-arm mannose residues."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:1442DF7CA4EB622F|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	protein modification:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942549|imex:IM-20081-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 15 C|comment:"For the (MN2F)2 glycoform, (M3N2F)2 IgG1-Fc was exposed to alpha -mannosidase for 48 h to remove the 1,3- and 1,6-arm mannose residues."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:1442DF7BD4EB622F|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	protein modification:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31994	uniprotkb:P01857	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942562|imex:IM-20081-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 20 C|comment:"For the (MN2F)2 glycoform, (M3N2F)2 IgG1-Fc was exposed to alpha -mannosidase for 48 h to remove the 1,3- and 1,6-arm mannose residues."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	intact-crc:1442DF7CA63B622F|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	sufficient binding region:43..43-217..217	protein modification:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01857	uniprotkb:P31994	intact:EBI-356114|ensembl:ENSP00000374991|ensembl:ENSP00000488387	intact:EBI-724784|uniprotkb:O95649|uniprotkb:Q53X85|uniprotkb:Q5VXA9|uniprotkb:Q8NIA1|uniprotkb:A6H8N3|ensembl:ENSP00000351497	psi-mi:ighg1_human(display_long)|uniprotkb:IGHG1(gene name)|psi-mi:IGHG1(display_short)|uniprotkb:Ig gamma-1 chain C region(gene name synonym)|uniprotkb:Ig gamma-1 chain C region EU(gene name synonym)|uniprotkb:Ig gamma-1 chain C region KOL(gene name synonym)|uniprotkb:Ig gamma-1 chain C region NIE(gene name synonym)	psi-mi:fcg2b_human(display_long)|uniprotkb:FCGR2B(gene name)|psi-mi:FCGR2B(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-b(gene name synonym)|uniprotkb:CDw32(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mimura et al. (2001)	pubmed:11567028|imex:IM-20081	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-942575|imex:IM-20081-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000211896(gene)|ensembl:ENSG00000277633(gene)|ensembl:ENST00000390549(transcript)|ensembl:ENST00000631466(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01857|rcsb pdb:1AJ7|rcsb pdb:1AQK|rcsb pdb:1AXS|rcsb pdb:1BEY|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1DFB|rcsb pdb:1DN2|rcsb pdb:1E4K|rcsb pdb:1FC1|rcsb pdb:1FC2|rcsb pdb:1FCC|rcsb pdb:1GAF|rcsb pdb:1H3T|rcsb pdb:1H3U|rcsb pdb:1H3V|rcsb pdb:1H3W|rcsb pdb:1H3X|rcsb pdb:1H3Y|rcsb pdb:1HKL|rcsb pdb:1HZH|rcsb pdb:1L6X|rcsb pdb:1N7M|rcsb pdb:1OQO|rcsb pdb:1OQX|rcsb pdb:1PG7|rcsb pdb:1T83|rcsb pdb:1T89|rcsb pdb:1VGE|rcsb pdb:2DTS|rcsb pdb:2GJ7|rcsb pdb:2I5Y|rcsb pdb:2IWG|rcsb pdb:2J6E|rcsb pdb:2JB5|rcsb pdb:2JB6|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2OSL|rcsb pdb:2QAD|rcsb pdb:2QL1|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QR0|rcsb pdb:2R56|rcsb pdb:2RCS|rcsb pdb:2VXQ|rcsb pdb:2WAH|rcsb pdb:3AGV|rcsb pdb:3AVE|rcsb pdb:3AY4|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3C2S|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D0V|rcsb pdb:3D6G|rcsb pdb:3D85|rcsb pdb:3DJ9|rcsb pdb:3DNK|rcsb pdb:3DO3|rcsb pdb:3DRO|rcsb pdb:3DRQ|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3FJT|rcsb pdb:3MCL|rcsb pdb:3O11|rcsb pdb:3RY6|rcsb pdb:3S7G|rcsb pdb:3SGJ|rcsb pdb:3SGK|rcsb pdb:3TV3|rcsb pdb:3TWC|rcsb pdb:3TYG|rcsb pdb:3U0W|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3V7M|rcsb pdb:3V8C|rcsb pdb:3V95|rcsb pdb:3WJJ|rcsb pdb:1I7Z|rcsb pdb:3WJL|rcsb pdb:3WN5|rcsb pdb:4ACP|rcsb pdb:4B7I|rcsb pdb:4BM7|rcsb pdb:4BSV|rcsb pdb:4BSW|rcsb pdb:4BYH|rcsb pdb:4CDH|rcsb pdb:4D9Q|rcsb pdb:4D9R|rcsb pdb:4DAG|rcsb pdb:4DZ8|rcsb pdb:4EOW|rcsb pdb:4HIX|rcsb pdb:4J12|rcsb pdb:4KU1|rcsb pdb:4LLD|rcsb pdb:4LLM|rcsb pdb:4LLQ|rcsb pdb:4N0U|rcsb pdb:4NQS|rcsb pdb:4NQT|rcsb pdb:4NQU|rcsb pdb:4NWT|rcsb pdb:4NWU|rcsb pdb:4O4Y|rcsb pdb:4O51|rcsb pdb:4Q6Y|rcsb pdb:4Q74|rcsb pdb:4Q7D|rcsb pdb:3WKN|rcsb pdb:4W4N|rcsb pdb:4W4O|rcsb pdb:4WI2|rcsb pdb:4WI3|rcsb pdb:4WI4|rcsb pdb:4WI5|rcsb pdb:4WI6|rcsb pdb:4WI7|rcsb pdb:4WI8|rcsb pdb:4WI9|rcsb pdb:4X4M|rcsb pdb:4X98|rcsb pdb:4X99|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XXD|rcsb pdb:4ZNE|rcsb pdb:5BW7|rcsb pdb:5D4Q|rcsb pdb:5D6D|rcsb pdb:5DI8|rcsb pdb:5DJ0|rcsb pdb:5DJ2|rcsb pdb:5DJ6|rcsb pdb:5DJ8|rcsb pdb:5DJA|rcsb pdb:5DJC|rcsb pdb:5DJD|rcsb pdb:5DJX|rcsb pdb:5DJY|rcsb pdb:5DJZ|rcsb pdb:5DK0|rcsb pdb:5DK2|rcsb pdb:5DVK|rcsb pdb:5DVL|rcsb pdb:5DVM|rcsb pdb:5DVN|rcsb pdb:5DVO|rcsb pdb:5GSQ|rcsb pdb:5HSF|rcsb pdb:5HY9|rcsb pdb:5HYE|rcsb pdb:5HYF|rcsb pdb:5HYI|rcsb pdb:5IQ7|rcsb pdb:5IQ9|rcsb pdb:5IW3|rcsb pdb:5IW6|rcsb pdb:5JIH|rcsb pdb:5JII|rcsb pdb:5JIK|rcsb pdb:5K33|rcsb pdb:5K64|rcsb pdb:5K65|rcsb pdb:5K8D|rcsb pdb:5KWG|rcsb pdb:5M3V|rcsb pdb:5TPS|rcsb pdb:5U4Y|rcsb pdb:5U52|rcsb pdb:5U66|rcsb pdb:5V43|rcsb pdb:5V4E|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6DE7|rcsb pdb:6F2Z|rcsb pdb:6G1E|rcsb pdb:6N35|rcsb pdb:6YT7|rcsb pdb:7KWO|reactome:R-HSA-166663|rcsb pdb:4XNZ|reactome:R-HSA-173623|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6785807|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|dip:DIP-29187N	refseq:NP_001002273.1|refseq:NP_001002274.1|refseq:NP_001002275.1|refseq:NP_001177757.1|refseq:NP_003992.3|refseq:XP_016856160.1|refseq:XP_016856161.1|dip:DIP-36638N|ensembl:ENSG00000072694(gene)|ensembl:ENST00000358671(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0001814"(negative regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002266"(follicular dendritic cell activation)|go:"GO:0002313"(mature B cell differentiation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002436"(immune complex clearance by monocytes and macrophages)|go:"GO:0002605"(negative regulation of dendritic cell antigen processing and presentation)|go:"GO:0002622"(regulation of B cell antigen processing and presentation)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043197"(dendritic spine)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0090264"(regulation of immune complex clearance by monocytes and macrophages)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2FCB|rcsb pdb:3WJJ|rcsb pdb:5OCC|reactome:R-HSA-198933	go:"GO:0019865"(immunoglobulin binding)|go:"GO:0005102"(signaling receptor binding)	-	-	figure legend:Fig. 4|comment:Temperature = 25 C|comment:"For the (MN2F)2 glycoform, (M3N2F)2 IgG1-Fc was exposed to alpha -mannosidase for 48 h to remove the 1,3- and 1,6-arm mannose residues."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/05/30	2014/10/16	rogid:1YK8rrTDnOYYKW5wHI48/rYlr5o9606	rogid:IfFSt/szCFZQtGRAK7bc1VMwqb09606	intact-crc:1442DF7BD63B622F|rigid:gRFj5ULd8La7uwxF4m7IRY588yE	false	protein modification:?-?	sufficient binding region:43..43-217..217	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)