#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q01081 uniprotkb:P26368 intact:EBI-632461|intact:EBI-14082807|ensembl:ENSP00000291552|intact:EBI-1053464|uniprotkb:Q701P4|uniprotkb:Q71RF1 intact:EBI-742339|uniprotkb:Q96HC5|intact:EBI-946034|ensembl:ENSP00000307863 psi-mi:u2af1_human(display_long)|uniprotkb:U2 auxiliary factor 35 kDa subunit(gene name synonym)|uniprotkb:U2 snRNP auxiliary factor small subunit(gene name synonym)|uniprotkb:U2AF1(gene name)|psi-mi:U2AF1(display_short)|uniprotkb:U2AF35(gene name synonym)|uniprotkb:U2AFBP(gene name synonym)|uniprotkb:U2 small nuclear RNA auxiliary factor 1(gene name synonym)|uniprotkb:FP793(orf name) psi-mi:u2af2_human(display_long)|uniprotkb:U2AF2(gene name)|psi-mi:U2AF2(display_short)|uniprotkb:U2AF65(gene name synonym)|uniprotkb:U2 snRNP auxiliary factor large subunit(gene name synonym)|uniprotkb:U2 auxiliary factor 65 kDa subunit(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Kielkopf et al. (2001) pubmed:11551507 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1031973|rcsb pdb:1JMT - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001307575.1|refseq:NP_006749.1|refseq:NP_001307577.1|ensembl:ENSG00000160201(gene)|ensembl:ENST00000291552(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0089701"(U2AF complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR009145(U2 auxiliary factor small subunit)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q01081|rcsb pdb:1JMT|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:NP_001307580.1|refseq:NP_001020374.1|refseq:NP_001020375.1|dip:DIP-1108N go:"GO:0005634"(nucleus)|refseq:NP_001012496.1|refseq:NP_009210.1|ensembl:ENSG00000063244(gene)|ensembl:ENST00000308924(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|rcsb pdb:2HZC|rcsb pdb:2M0G|rcsb pdb:2U2F|rcsb pdb:2YH0|rcsb pdb:2YH1|rcsb pdb:3VAF|rcsb pdb:3VAG|rcsb pdb:3VAH|rcsb pdb:3VAI|rcsb pdb:3VAJ|rcsb pdb:3VAK|rcsb pdb:3VAL|rcsb pdb:3VAM|rcsb pdb:4FXW|rcsb pdb:4TU7|rcsb pdb:4TU8|rcsb pdb:4TU9|rcsb pdb:5EV1|rcsb pdb:5EV2|rcsb pdb:5EV3|rcsb pdb:5EV4|rcsb pdb:5W0G|rcsb pdb:5W0H|rcsb pdb:6TR0|rcsb pdb:6XLV|rcsb pdb:6XLW|rcsb pdb:6XLX|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:2G4B|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0008187"(poly-pyrimidine tract binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0089701"(U2AF complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006529(U2 snRNP auxilliary factor, large subunit, splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P26368|rcsb pdb:1JMT|rcsb pdb:1O0P|rcsb pdb:1OPI|rcsb pdb:1U2F|go:"GO:0005654"(nucleoplasm)|dip:DIP-2154N - - - assembly:octameric, multimeric|3d-r-factors:working 77.400%, free 76.200%|3d-resolution:2.2A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/09/20 2014/10/16 rogid:n7tE+B4qBNnI/hiwspeQKrviXv89606 rogid:HBYwOej94CoGGN7vPbk0AnbO61Q9606 intact-crc:D00E3619F71594F4|rigid:657VZ1cCk54XkCh1Vjbq7vvGn4c false sufficient binding region:43-146 sufficient binding region:85-112 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)