#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q61091 uniprotkb:Q8BH60 intact:EBI-6171689|ensembl:ENSMUSP00000039660|uniprotkb:A2RTK9 intact:EBI-296357|uniprotkb:Q8BSV4|uniprotkb:Q920R1|uniprotkb:Q9ET11 psi-mi:fzd8_mouse(display_long)|uniprotkb:Fzd8(gene name)|psi-mi:Fzd8(display_short) psi-mi:gopc_mouse(display_long)|uniprotkb:Gopc(gene name)|psi-mi:Gopc(display_short)|uniprotkb:PDZ protein interacting specifically with TC10(gene name synonym) psi-mi:"MI:0399"(two hybrid fragment pooling approach) Yao et al. (2001) pubmed:11520064|mint:MINT-5214443 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7938202|mint:MINT-1783006 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000036904(gene)|ensembl:ENSMUST00000041080(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:1IJY|rcsb pdb:4F0A|rcsb pdb:6TFB|rcsb pdb:6TFM|reactome:R-MMU-4608870|reactome:R-MMU-4641263|rcsb pdb:6AHY|refseq:NP_032084.2|dip:DIP-41258N|mint:MINT-1783007(identity) go:"GO:0000139"(Golgi membrane)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043004"(cytoplasmic sequestering of CFTR protein)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|reactome:R-MMU-5627083|reactome:R-MMU-9013406|refseq:NP_001186201.1|refseq:NP_444417.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR038879|mint:Q8BH60|interpro:IPR036034|mint:MINT-1783008(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:NFA|comment:homomint|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/03/11 2014/10/16 rogid:CBc7b1GULb5YzydnpCYV4uXaTmo10090 rogid:g5t7Tcg8R/HEVPryIgPE21/mCsA10090 intact-crc:EFAFA62BB37AA323|rigid:6w3O2sDEEmoY8/TDQrpgftsCoJc false binding-associated region:604-685(MINT-1783017)|tag:n-n(MINT-1783010) tag:n-n(MINT-1783021) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0056"(full identification by DNA sequencing) uniprotkb:Q9EQD0 uniprotkb:Q8BH60 intact:EBI-7938232|uniprotkb:G5E8F0|uniprotkb:Q8CHK9|uniprotkb:Q8BMR2|intact:MINT-1783095|uniprotkb:O08975|ensembl:ENSMUSP00000067783|ensembl:ENSMUSP00000111828 intact:EBI-296357|uniprotkb:Q8BSV4|uniprotkb:Q920R1|uniprotkb:Q9ET11 psi-mi:fzd5_mouse(display_long)|uniprotkb:Fzd5(gene name)|psi-mi:Fzd5(display_short) psi-mi:gopc_mouse(display_long)|uniprotkb:Gopc(gene name)|psi-mi:Gopc(display_short)|uniprotkb:PDZ protein interacting specifically with TC10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yao et al. (2001) pubmed:11520064|mint:MINT-5214443 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7938282|mint:MINT-1783079 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001036124.1|refseq:NP_073558.2|dip:DIP-41260N|ensembl:ENSMUSG00000045005(gene)|ensembl:ENSMUST00000063982(transcript)|ensembl:ENSMUST00000116133(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001944"(vasculature development)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:1901382"(regulation of chorionic trophoblast cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR037441|reactome:R-MMU-4086398|reactome:R-MMU-4608870|reactome:R-MMU-4641262|reactome:R-MMU-4641263|reactome:R-MMU-5140745|mint:MINT-1783080(identity) go:"GO:0000139"(Golgi membrane)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043004"(cytoplasmic sequestering of CFTR protein)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|reactome:R-MMU-5627083|reactome:R-MMU-9013406|refseq:NP_001186201.1|refseq:NP_444417.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR038879|mint:Q8BH60|interpro:IPR036034|mint:MINT-1783086(identity) - comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in yolk sac angiogenesis and in placental vascularization. Binds to Wnt2, Wnt10B, Wnt5A, but not to Wnt2B or Wnt4|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4B|comment:mint taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2006/03/11 2014/10/16 rogid:O3uI77ElZ4+6mCkb8gfIfqe6+jE10090 rogid:g5t7Tcg8R/HEVPryIgPE21/mCsA10090 intact-crc:D50B6D0B85707639|rigid:u3c1ZCRrvW9ohuHQeGGIFdJBeUU false flag tag:?-?(MINT-1783110) ha tag:c-c(MINT-1783092) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q61091 uniprotkb:Q8BH60 intact:EBI-6171689|ensembl:ENSMUSP00000039660|uniprotkb:A2RTK9 intact:EBI-296357|uniprotkb:Q8BSV4|uniprotkb:Q920R1|uniprotkb:Q9ET11 psi-mi:fzd8_mouse(display_long)|uniprotkb:Fzd8(gene name)|psi-mi:Fzd8(display_short) psi-mi:gopc_mouse(display_long)|uniprotkb:Gopc(gene name)|psi-mi:Gopc(display_short)|uniprotkb:PDZ protein interacting specifically with TC10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yao et al. (2001) pubmed:11520064|mint:MINT-5214443 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7938315|mint:MINT-1783116 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000036904(gene)|ensembl:ENSMUST00000041080(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:1IJY|rcsb pdb:4F0A|rcsb pdb:6TFB|rcsb pdb:6TFM|reactome:R-MMU-4608870|reactome:R-MMU-4641263|rcsb pdb:6AHY|refseq:NP_032084.2|dip:DIP-41258N|mint:MINT-1783117(identity) go:"GO:0000139"(Golgi membrane)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043004"(cytoplasmic sequestering of CFTR protein)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|reactome:R-MMU-5627083|reactome:R-MMU-9013406|refseq:NP_001186201.1|refseq:NP_444417.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR038879|mint:Q8BH60|interpro:IPR036034|mint:MINT-1783125(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4B|comment:homomint|comment:mint taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2006/03/11 2014/10/16 rogid:CBc7b1GULb5YzydnpCYV4uXaTmo10090 rogid:g5t7Tcg8R/HEVPryIgPE21/mCsA10090 intact-crc:986B360DD9A2E42E|rigid:6w3O2sDEEmoY8/TDQrpgftsCoJc false flag tag:?-?(MINT-1783123) ha tag:c-c(MINT-1783131) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8BH60 uniprotkb:Q8BH60 intact:EBI-296357|uniprotkb:Q8BSV4|uniprotkb:Q920R1|uniprotkb:Q9ET11 intact:EBI-296357|uniprotkb:Q8BSV4|uniprotkb:Q920R1|uniprotkb:Q9ET11 psi-mi:gopc_mouse(display_long)|uniprotkb:Gopc(gene name)|psi-mi:Gopc(display_short)|uniprotkb:PDZ protein interacting specifically with TC10(gene name synonym) psi-mi:gopc_mouse(display_long)|uniprotkb:Gopc(gene name)|psi-mi:Gopc(display_short)|uniprotkb:PDZ protein interacting specifically with TC10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yao et al. (2001) pubmed:11520064|mint:MINT-5214443 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7938332|mint:MINT-1783134 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043004"(cytoplasmic sequestering of CFTR protein)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|reactome:R-MMU-5627083|reactome:R-MMU-9013406|refseq:NP_001186201.1|refseq:NP_444417.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR038879|mint:Q8BH60|interpro:IPR036034|mint:MINT-1783135(identity) go:"GO:0000139"(Golgi membrane)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043004"(cytoplasmic sequestering of CFTR protein)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|reactome:R-MMU-5627083|reactome:R-MMU-9013406|refseq:NP_001186201.1|refseq:NP_444417.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR038879|mint:Q8BH60|interpro:IPR036034|mint:MINT-1783143(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4C|comment:homomint|comment:mint taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2006/03/11 2014/10/16 rogid:g5t7Tcg8R/HEVPryIgPE21/mCsA10090 rogid:g5t7Tcg8R/HEVPryIgPE21/mCsA10090 intact-crc:1B17C3687F82B689|rigid:WT8xyARTrszNB5XOHoEE6IIX0OA false myc tag:c-c(MINT-1783141) ha tag:c-c(MINT-1783144) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9EQD0 uniprotkb:Q8BH60 intact:EBI-7938232|uniprotkb:G5E8F0|uniprotkb:Q8CHK9|uniprotkb:Q8BMR2|intact:MINT-1783095|uniprotkb:O08975|ensembl:ENSMUSP00000067783|ensembl:ENSMUSP00000111828 intact:EBI-296357|uniprotkb:Q8BSV4|uniprotkb:Q920R1|uniprotkb:Q9ET11 psi-mi:fzd5_mouse(display_long)|uniprotkb:Fzd5(gene name)|psi-mi:Fzd5(display_short) psi-mi:gopc_mouse(display_long)|uniprotkb:Gopc(gene name)|psi-mi:Gopc(display_short)|uniprotkb:PDZ protein interacting specifically with TC10(gene name synonym) psi-mi:"MI:0096"(pull down) Yao et al. (2001) pubmed:11520064|mint:MINT-5214443 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7938357|mint:MINT-1783156 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001036124.1|refseq:NP_073558.2|dip:DIP-41260N|ensembl:ENSMUSG00000045005(gene)|ensembl:ENSMUST00000063982(transcript)|ensembl:ENSMUST00000116133(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001944"(vasculature development)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:1901382"(regulation of chorionic trophoblast cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR037441|reactome:R-MMU-4086398|reactome:R-MMU-4608870|reactome:R-MMU-4641262|reactome:R-MMU-4641263|reactome:R-MMU-5140745|mint:MINT-1783157(identity) go:"GO:0000139"(Golgi membrane)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043004"(cytoplasmic sequestering of CFTR protein)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|reactome:R-MMU-5627083|reactome:R-MMU-9013406|refseq:NP_001186201.1|refseq:NP_444417.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR038879|mint:Q8BH60|interpro:IPR036034|mint:MINT-1783165(identity) - comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in yolk sac angiogenesis and in placental vascularization. Binds to Wnt2, Wnt10B, Wnt5A, but not to Wnt2B or Wnt4|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5A|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/03/11 2014/10/16 rogid:O3uI77ElZ4+6mCkb8gfIfqe6+jE10090 rogid:g5t7Tcg8R/HEVPryIgPE21/mCsA10090 intact-crc:696A0F2F26AAEDFC|rigid:u3c1ZCRrvW9ohuHQeGGIFdJBeUU false binding-associated region:523-577(MINT-1783173)|glutathione s tranferase tag:n-n(MINT-1783163) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8BH60 uniprotkb:Q61091 intact:EBI-296357|uniprotkb:Q8BSV4|uniprotkb:Q920R1|uniprotkb:Q9ET11 intact:EBI-6171689|ensembl:ENSMUSP00000039660|uniprotkb:A2RTK9 psi-mi:gopc_mouse(display_long)|uniprotkb:Gopc(gene name)|psi-mi:Gopc(display_short)|uniprotkb:PDZ protein interacting specifically with TC10(gene name synonym) psi-mi:fzd8_mouse(display_long)|uniprotkb:Fzd8(gene name)|psi-mi:Fzd8(display_short) psi-mi:"MI:0096"(pull down) Yao et al. (2001) pubmed:11520064|mint:MINT-5214443 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7938374|mint:MINT-1783181 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000139"(Golgi membrane)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043004"(cytoplasmic sequestering of CFTR protein)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|reactome:R-MMU-5627083|reactome:R-MMU-9013406|refseq:NP_001186201.1|refseq:NP_444417.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR038879|mint:Q8BH60|interpro:IPR036034|mint:MINT-1783182(identity) ensembl:ENSMUSG00000036904(gene)|ensembl:ENSMUST00000041080(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:1IJY|rcsb pdb:4F0A|rcsb pdb:6TFB|rcsb pdb:6TFM|reactome:R-MMU-4608870|reactome:R-MMU-4641263|rcsb pdb:6AHY|refseq:NP_032084.2|dip:DIP-41258N|mint:MINT-1783187(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F5B|figure legend:F5C|figure legend:F5A|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/03/11 2014/10/16 rogid:g5t7Tcg8R/HEVPryIgPE21/mCsA10090 rogid:CBc7b1GULb5YzydnpCYV4uXaTmo10090 intact-crc:D856CDCBFD6CC1D4|rigid:6w3O2sDEEmoY8/TDQrpgftsCoJc false binding-associated region:253-384(MINT-1783196) glutathione s tranferase tag:n-n(MINT-1783194)|mutation disrupting interaction:683-685(MINT-1783202)|binding-associated region:604-685(MINT-1783188)|mutation disrupting interaction:685-685(MINT-1783200) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9CW79 uniprotkb:Q8BH60 intact:EBI-2270312|uniprotkb:Q80YB0|uniprotkb:A3KGQ9|ensembl:ENSMUSP00000037735|ensembl:ENSMUSP00000139001 intact:EBI-296357|uniprotkb:Q8BSV4|uniprotkb:Q920R1|uniprotkb:Q9ET11 psi-mi:goga1_mouse(display_long)|uniprotkb:Golga1(gene name)|psi-mi:Golga1(display_short)|uniprotkb:Golgin-97(gene name synonym) psi-mi:gopc_mouse(display_long)|uniprotkb:Gopc(gene name)|psi-mi:Gopc(display_short)|uniprotkb:PDZ protein interacting specifically with TC10(gene name synonym) psi-mi:"MI:0428"(imaging technique) Yao et al. (2001) pubmed:11520064|mint:MINT-5214443 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7938416|mint:MINT-1783033 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_084069.1|refseq:NP_001277578.1|ensembl:ENSMUSG00000026754(gene)|ensembl:ENSMUST00000039165(transcript)|ensembl:ENSMUST00000184996(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0016020"(membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000237(GRIP)|reactome:R-MMU-6811440|mint:MINT-1783042(identity) go:"GO:0000139"(Golgi membrane)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043004"(cytoplasmic sequestering of CFTR protein)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|reactome:R-MMU-5627083|reactome:R-MMU-9013406|refseq:NP_001186201.1|refseq:NP_444417.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR038879|mint:Q8BH60|interpro:IPR036034|mint:MINT-1783034(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2|comment:Although the experiment was performed in COS-7 cells the proteins were identified with the murine UP_IDs|comment:homomint|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/03/11 2014/10/16 rogid:Ulkj85aZnJxe6cy2poWp4ud9l/g10090 rogid:g5t7Tcg8R/HEVPryIgPE21/mCsA10090 intact-crc:4F7205AEC465F969|rigid:AOzdWMr1n64L/tari0rxUTuvAmg false - - 1 1 psi-mi:"MI:0661"(experimental participant identification) psi-mi:"MI:0661"(experimental participant identification) uniprotkb:Q9EQD0 uniprotkb:Q8BH60 intact:EBI-7938232|uniprotkb:G5E8F0|uniprotkb:Q8CHK9|uniprotkb:Q8BMR2|intact:MINT-1783095|uniprotkb:O08975|ensembl:ENSMUSP00000067783|ensembl:ENSMUSP00000111828 intact:EBI-296357|uniprotkb:Q8BSV4|uniprotkb:Q920R1|uniprotkb:Q9ET11 psi-mi:fzd5_mouse(display_long)|uniprotkb:Fzd5(gene name)|psi-mi:Fzd5(display_short) psi-mi:gopc_mouse(display_long)|uniprotkb:Gopc(gene name)|psi-mi:Gopc(display_short)|uniprotkb:PDZ protein interacting specifically with TC10(gene name synonym) psi-mi:"MI:0428"(imaging technique) Yao et al. (2001) pubmed:11520064|mint:MINT-5214443 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7938436|mint:MINT-1783208 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001036124.1|refseq:NP_073558.2|dip:DIP-41260N|ensembl:ENSMUSG00000045005(gene)|ensembl:ENSMUST00000063982(transcript)|ensembl:ENSMUST00000116133(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001944"(vasculature development)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:1901382"(regulation of chorionic trophoblast cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR037441|reactome:R-MMU-4086398|reactome:R-MMU-4608870|reactome:R-MMU-4641262|reactome:R-MMU-4641263|reactome:R-MMU-5140745|mint:MINT-1783209(identity) go:"GO:0000139"(Golgi membrane)|go:"GO:0005109"(frizzled binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010360"(negative regulation of anion channel activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043004"(cytoplasmic sequestering of CFTR protein)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|reactome:R-MMU-5627083|reactome:R-MMU-9013406|refseq:NP_001186201.1|refseq:NP_444417.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR038879|mint:Q8BH60|interpro:IPR036034|mint:MINT-1783222(identity) - comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in yolk sac angiogenesis and in placental vascularization. Binds to Wnt2, Wnt10B, Wnt5A, but not to Wnt2B or Wnt4|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F6|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/03/11 2014/10/16 rogid:O3uI77ElZ4+6mCkb8gfIfqe6+jE10090 rogid:g5t7Tcg8R/HEVPryIgPE21/mCsA10090 intact-crc:310CA893F102E3AF|rigid:u3c1ZCRrvW9ohuHQeGGIFdJBeUU false - fusion protein:?-?(MINT-1783230) 1 1 psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0078"(nucleotide sequence identification)