#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P17643	uniprotkb:O14908	intact:EBI-7900408|uniprotkb:Q13721|intact:MINT-1784675|uniprotkb:P78469|uniprotkb:Q15679|uniprotkb:P78468|ensembl:ENSP00000373570	intact:EBI-373132|uniprotkb:Q9BTC9|uniprotkb:A8MZG3|uniprotkb:A8K4I3|ensembl:ENSP00000340698|ensembl:ENSP00000376753|ensembl:ENSP00000466747	psi-mi:tyrp1_human(display_long)|uniprotkb:TYRP1(gene name)|psi-mi:TYRP1(display_short)|uniprotkb:CAS2(gene name synonym)|uniprotkb:TYRP(gene name synonym)|uniprotkb:TYRRP(gene name synonym)|uniprotkb:Catalase B(gene name synonym)|uniprotkb:Tyrosinase-related protein 1(gene name synonym)|uniprotkb:Glycoprotein 75(gene name synonym)|uniprotkb:Melanoma antigen gp75(gene name synonym)	psi-mi:gipc1_human(display_long)|uniprotkb:C19orf3(gene name synonym)|uniprotkb:GIPC(gene name synonym)|uniprotkb:GIPC1(gene name)|psi-mi:GIPC1(display_short)|uniprotkb:RGS19IP1(gene name synonym)|uniprotkb:RGS19-interacting protein 1(gene name synonym)|uniprotkb:GAIP C-terminus-interacting protein(gene name synonym)|uniprotkb:RGS-GAIP-interacting protein(gene name synonym)|uniprotkb:Tax interaction protein 2(gene name synonym)|uniprotkb:Synectin(gene name synonym)	psi-mi:"MI:0399"(two hybrid fragment pooling approach)	Liu et al. (2001)	pubmed:11441007|mint:MINT-5214244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7900447|mint:MINT-1784737	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000541.1|ensembl:ENSG00000107165(gene)|ensembl:ENST00000388918(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043438"(acetoacetic acid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0097708"(intracellular vesicle)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|rcsb pdb:5M8L|rcsb pdb:5M8M|rcsb pdb:5M8N|rcsb pdb:5M8O|rcsb pdb:5M8P|rcsb pdb:5M8Q|rcsb pdb:5M8R|rcsb pdb:5M8S|rcsb pdb:5M8T|reactome:R-HSA-5662702|mint:MINT-1784738(identity)	refseq:NP_005707.1|refseq:NP_974197.1|refseq:NP_974199.1|refseq:NP_974198.1|refseq:NP_974223.1|ensembl:ENSG00000123159(gene)|ensembl:ENST00000345425(transcript)|ensembl:ENST00000393033(transcript)|ensembl:ENST00000586027(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014047"(glutamate secretion)|go:"GO:0016020"(membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045296"(cadherin binding)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR017379(Uncharacterised conserved protein UCP038083, PDZ)|interpro:IPR036034|refseq:XP_016881636.1|refseq:XP_016881637.1|dip:DIP-31142N|mint:MINT-1784739(identity)	-	comment:mint|function:"Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized"|function:"Defects in TYRP1 are the cause of rufous oculocutaneous albinism (ROCA) [MIM:278400]. ROCA occurs in blacks and is characterized by bright copper-red coloration of the skin and hair and dilution of the color of the iris"|function:"Defects in TYRP1 are the cause of oculocutaneous albinism type III (OCA-III) [MIM:203290]; also known as OCA3. OCA-III is a form of albinism with only moderate reduction of pigment. Individuals with OCA-III are recognized by their reddish skin and hair color"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3B|figure legend:F3C|figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/03/14	2014/10/16	rogid:fQBUvTyHWcidi07RoC620E0iWdY9606	rogid:3lbsiL3bZ/h3ISEr/ryTN7FgbQI9606	intact-crc:9F0983F6B636071D|rigid:FcnXK34QlgaIqRaDArzq7XcmKYk	false	tag:n-n(MINT-1784791)|mutation disrupting interaction:534-537(MINT-1784801)|binding-associated region:502-537(MINT-1784798)	tag:n-n(MINT-1784804)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0056"(full identification by DNA sequencing)
uniprotkb:P17643	uniprotkb:O14908	intact:EBI-7900408|uniprotkb:Q13721|intact:MINT-1784675|uniprotkb:P78469|uniprotkb:Q15679|uniprotkb:P78468|ensembl:ENSP00000373570	intact:EBI-373132|uniprotkb:Q9BTC9|uniprotkb:A8MZG3|uniprotkb:A8K4I3|ensembl:ENSP00000340698|ensembl:ENSP00000376753|ensembl:ENSP00000466747	psi-mi:tyrp1_human(display_long)|uniprotkb:TYRP1(gene name)|psi-mi:TYRP1(display_short)|uniprotkb:CAS2(gene name synonym)|uniprotkb:TYRP(gene name synonym)|uniprotkb:TYRRP(gene name synonym)|uniprotkb:Catalase B(gene name synonym)|uniprotkb:Tyrosinase-related protein 1(gene name synonym)|uniprotkb:Glycoprotein 75(gene name synonym)|uniprotkb:Melanoma antigen gp75(gene name synonym)	psi-mi:gipc1_human(display_long)|uniprotkb:C19orf3(gene name synonym)|uniprotkb:GIPC(gene name synonym)|uniprotkb:GIPC1(gene name)|psi-mi:GIPC1(display_short)|uniprotkb:RGS19IP1(gene name synonym)|uniprotkb:RGS19-interacting protein 1(gene name synonym)|uniprotkb:GAIP C-terminus-interacting protein(gene name synonym)|uniprotkb:RGS-GAIP-interacting protein(gene name synonym)|uniprotkb:Tax interaction protein 2(gene name synonym)|uniprotkb:Synectin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2001)	pubmed:11441007|mint:MINT-5214244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7900502|mint:MINT-1784818	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000541.1|ensembl:ENSG00000107165(gene)|ensembl:ENST00000388918(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043438"(acetoacetic acid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0097708"(intracellular vesicle)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|rcsb pdb:5M8L|rcsb pdb:5M8M|rcsb pdb:5M8N|rcsb pdb:5M8O|rcsb pdb:5M8P|rcsb pdb:5M8Q|rcsb pdb:5M8R|rcsb pdb:5M8S|rcsb pdb:5M8T|reactome:R-HSA-5662702|mint:MINT-1784827(identity)	refseq:NP_005707.1|refseq:NP_974197.1|refseq:NP_974199.1|refseq:NP_974198.1|refseq:NP_974223.1|ensembl:ENSG00000123159(gene)|ensembl:ENST00000345425(transcript)|ensembl:ENST00000393033(transcript)|ensembl:ENST00000586027(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014047"(glutamate secretion)|go:"GO:0016020"(membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045296"(cadherin binding)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR017379(Uncharacterised conserved protein UCP038083, PDZ)|interpro:IPR036034|refseq:XP_016881636.1|refseq:XP_016881637.1|dip:DIP-31142N|mint:MINT-1784819(identity)	-	comment:mint|function:"Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized"|function:"Defects in TYRP1 are the cause of rufous oculocutaneous albinism (ROCA) [MIM:278400]. ROCA occurs in blacks and is characterized by bright copper-red coloration of the skin and hair and dilution of the color of the iris"|function:"Defects in TYRP1 are the cause of oculocutaneous albinism type III (OCA-III) [MIM:203290]; also known as OCA3. OCA-III is a form of albinism with only moderate reduction of pigment. Individuals with OCA-III are recognized by their reddish skin and hair color"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2006/03/14	2014/10/16	rogid:fQBUvTyHWcidi07RoC620E0iWdY9606	rogid:3lbsiL3bZ/h3ISEr/ryTN7FgbQI9606	intact-crc:C72CE961004B91AC|rigid:FcnXK34QlgaIqRaDArzq7XcmKYk	false	-	ha tag:n-n(MINT-1784825)|binding-associated region:1-243(MINT-1784839)	1	1	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P17643	uniprotkb:O14908	intact:EBI-7900408|uniprotkb:Q13721|intact:MINT-1784675|uniprotkb:P78469|uniprotkb:Q15679|uniprotkb:P78468|ensembl:ENSP00000373570	intact:EBI-373132|uniprotkb:Q9BTC9|uniprotkb:A8MZG3|uniprotkb:A8K4I3|ensembl:ENSP00000340698|ensembl:ENSP00000376753|ensembl:ENSP00000466747	psi-mi:tyrp1_human(display_long)|uniprotkb:TYRP1(gene name)|psi-mi:TYRP1(display_short)|uniprotkb:CAS2(gene name synonym)|uniprotkb:TYRP(gene name synonym)|uniprotkb:TYRRP(gene name synonym)|uniprotkb:Catalase B(gene name synonym)|uniprotkb:Tyrosinase-related protein 1(gene name synonym)|uniprotkb:Glycoprotein 75(gene name synonym)|uniprotkb:Melanoma antigen gp75(gene name synonym)	psi-mi:gipc1_human(display_long)|uniprotkb:C19orf3(gene name synonym)|uniprotkb:GIPC(gene name synonym)|uniprotkb:GIPC1(gene name)|psi-mi:GIPC1(display_short)|uniprotkb:RGS19IP1(gene name synonym)|uniprotkb:RGS19-interacting protein 1(gene name synonym)|uniprotkb:GAIP C-terminus-interacting protein(gene name synonym)|uniprotkb:RGS-GAIP-interacting protein(gene name synonym)|uniprotkb:Tax interaction protein 2(gene name synonym)|uniprotkb:Synectin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Liu et al. (2001)	pubmed:11441007|mint:MINT-5214244	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7900701|mint:MINT-1784850	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000541.1|ensembl:ENSG00000107165(gene)|ensembl:ENST00000388918(transcript)|go:"GO:0004503"(tyrosinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043438"(acetoacetic acid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0097708"(intracellular vesicle)|interpro:IPR002227(Tyrosinase)|interpro:IPR008922(Di-copper centre-containing)|rcsb pdb:5M8L|rcsb pdb:5M8M|rcsb pdb:5M8N|rcsb pdb:5M8O|rcsb pdb:5M8P|rcsb pdb:5M8Q|rcsb pdb:5M8R|rcsb pdb:5M8S|rcsb pdb:5M8T|reactome:R-HSA-5662702|mint:MINT-1784851(identity)	refseq:NP_005707.1|refseq:NP_974197.1|refseq:NP_974199.1|refseq:NP_974198.1|refseq:NP_974223.1|ensembl:ENSG00000123159(gene)|ensembl:ENST00000345425(transcript)|ensembl:ENST00000393033(transcript)|ensembl:ENST00000586027(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014047"(glutamate secretion)|go:"GO:0016020"(membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045296"(cadherin binding)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR017379(Uncharacterised conserved protein UCP038083, PDZ)|interpro:IPR036034|refseq:XP_016881636.1|refseq:XP_016881637.1|dip:DIP-31142N|mint:MINT-1784857(identity)	-	comment:mint|function:"Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized"|function:"Defects in TYRP1 are the cause of rufous oculocutaneous albinism (ROCA) [MIM:278400]. ROCA occurs in blacks and is characterized by bright copper-red coloration of the skin and hair and dilution of the color of the iris"|function:"Defects in TYRP1 are the cause of oculocutaneous albinism type III (OCA-III) [MIM:203290]; also known as OCA3. OCA-III is a form of albinism with only moderate reduction of pigment. Individuals with OCA-III are recognized by their reddish skin and hair color"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9606(human-melanoma)|taxid:9606(Human melanoma)	-	2006/03/14	2014/10/16	rogid:fQBUvTyHWcidi07RoC620E0iWdY9606	rogid:3lbsiL3bZ/h3ISEr/ryTN7FgbQI9606	intact-crc:627D3D52F0659A90|rigid:FcnXK34QlgaIqRaDArzq7XcmKYk	false	mutation disrupting interaction:523-537(MINT-1784894)	ha tag:n-n(MINT-1784866)	1	1	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)