#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Z206	uniprotkb:Q6RHR9	intact:EBI-7840997|ensembl:ENSMUSP00000089464|uniprotkb:Q9Z1L7|uniprotkb:Q8C4I0|intact:MINT-1780869	intact:EBI-7440897|uniprotkb:O54894|uniprotkb:O54893|uniprotkb:O54895|intact:MINT-150460|ensembl:ENSMUSP00000086730	psi-mi:arhg8_mouse(display_long)|uniprotkb:Net1(gene name)|psi-mi:Net1(display_short)|uniprotkb:Arhgef8(gene name synonym)|uniprotkb:Rho guanine nucleotide exchange factor 8(gene name synonym)	psi-mi:magi1_mouse(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)	psi-mi:"MI:0399"(two hybrid fragment pooling approach)	- (2001)	pubmed:11350080|mint:MINT-5214003	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7840990|mint:MINT-1780853	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021215(gene)|ensembl:ENSMUST00000091853(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051451"(myoblast migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037853|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|refseq:NP_062645.2|refseq:NP_001040624.1|mint:MINT-1780896(identity)	refseq:NP_034497.1|refseq:NP_001025021.1|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0042995"(cell projection)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071944"(cell periphery)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030033|interpro:IPR036020|interpro:IPR036034|rcsb pdb:2I04|rcsb pdb:5ZYS|mint:MINT-1780858(identity)	-	comment:mint|function:"Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway"|comment:"Stoichiometry: 1.0"	comment:mint|function:May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ACCN3 currents by modulating its expression at the cell surface|comment:"Stoichiometry: 1.0"	figure legend:T2|figure legend:T1|figure legend:F1|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2006/03/09	2014/10/16	rogid:Fwq8UtnkZE8JvSrPFj/viHtk8QY10090	rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090	intact-crc:0500D5A4D3557194|rigid:e4iVPTF6bs6oPQRlQ3JjBSzs/w4	false	binding-associated region:523-595(MINT-1780904)|mutation disrupting interaction:594-594(MINT-1790770)|mutation disrupting interaction:595-595(MINT-1790772)|mutation disrupting interaction:592-592(MINT-1780906)|tag:n-n(MINT-1780897)	tag:n-n(MINT-1780859)|binding-associated region:464-530(MINT-1780866)	-	-	psi-mi:"MI:0056"(full identification by DNA sequencing)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z206	uniprotkb:Q6RHR9	intact:EBI-7840997|ensembl:ENSMUSP00000089464|uniprotkb:Q9Z1L7|uniprotkb:Q8C4I0|intact:MINT-1780869	intact:EBI-7440897|uniprotkb:O54894|uniprotkb:O54893|uniprotkb:O54895|intact:MINT-150460|ensembl:ENSMUSP00000086730	psi-mi:arhg8_mouse(display_long)|uniprotkb:Net1(gene name)|psi-mi:Net1(display_short)|uniprotkb:Arhgef8(gene name synonym)|uniprotkb:Rho guanine nucleotide exchange factor 8(gene name synonym)	psi-mi:magi1_mouse(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	- (2001)	pubmed:11350080|mint:MINT-5214003	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7841091|mint:MINT-1780938	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021215(gene)|ensembl:ENSMUST00000091853(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051451"(myoblast migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037853|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|refseq:NP_062645.2|refseq:NP_001040624.1|mint:MINT-1780940(identity)	refseq:NP_034497.1|refseq:NP_001025021.1|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0042995"(cell projection)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071944"(cell periphery)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030033|interpro:IPR036020|interpro:IPR036034|rcsb pdb:2I04|rcsb pdb:5ZYS|mint:MINT-1780948(identity)	-	comment:mint|function:"Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway"|comment:"Stoichiometry: 1.0"	comment:mint|function:May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ACCN3 currents by modulating its expression at the cell surface|comment:"Stoichiometry: 1.0"	figure legend:F3|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/09	2014/10/16	rogid:Fwq8UtnkZE8JvSrPFj/viHtk8QY10090	rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090	intact-crc:EE274102F13D5363|rigid:e4iVPTF6bs6oPQRlQ3JjBSzs/w4	false	t7 tag:n-n(MINT-1780941)	glutathione s tranferase tag:n-n(MINT-1780949)|binding-associated region:464-530(MINT-1780955)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z206	uniprotkb:Q6RHR9	intact:EBI-7840997|ensembl:ENSMUSP00000089464|uniprotkb:Q9Z1L7|uniprotkb:Q8C4I0|intact:MINT-1780869	intact:EBI-7440897|uniprotkb:O54894|uniprotkb:O54893|uniprotkb:O54895|intact:MINT-150460|ensembl:ENSMUSP00000086730	psi-mi:arhg8_mouse(display_long)|uniprotkb:Net1(gene name)|psi-mi:Net1(display_short)|uniprotkb:Arhgef8(gene name synonym)|uniprotkb:Rho guanine nucleotide exchange factor 8(gene name synonym)	psi-mi:magi1_mouse(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	- (2001)	pubmed:11350080|mint:MINT-5214003	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7841069|mint:MINT-1780912	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021215(gene)|ensembl:ENSMUST00000091853(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051451"(myoblast migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037853|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|refseq:NP_062645.2|refseq:NP_001040624.1|mint:MINT-1780928(identity)	refseq:NP_034497.1|refseq:NP_001025021.1|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0042995"(cell projection)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071944"(cell periphery)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030033|interpro:IPR036020|interpro:IPR036034|rcsb pdb:2I04|rcsb pdb:5ZYS|mint:MINT-1780918(identity)	-	comment:mint|function:"Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway"|comment:"Stoichiometry: 1.0"	comment:mint|function:May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ACCN3 currents by modulating its expression at the cell surface|comment:"Stoichiometry: 1.0"	figure legend:F3|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/09	2014/10/16	rogid:Fwq8UtnkZE8JvSrPFj/viHtk8QY10090	rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090	intact-crc:C06A34756B50889D|rigid:e4iVPTF6bs6oPQRlQ3JjBSzs/w4	false	t7 tag:n-n(MINT-1780934)	glutathione s tranferase tag:n-n(MINT-1780919)|binding-associated region:833-914(MINT-1780925)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z206	uniprotkb:Q6RHR9	intact:EBI-7840997|ensembl:ENSMUSP00000089464|uniprotkb:Q9Z1L7|uniprotkb:Q8C4I0|intact:MINT-1780869	intact:EBI-7440897|uniprotkb:O54894|uniprotkb:O54893|uniprotkb:O54895|intact:MINT-150460|ensembl:ENSMUSP00000086730	psi-mi:arhg8_mouse(display_long)|uniprotkb:Net1(gene name)|psi-mi:Net1(display_short)|uniprotkb:Arhgef8(gene name synonym)|uniprotkb:Rho guanine nucleotide exchange factor 8(gene name synonym)	psi-mi:magi1_mouse(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	- (2001)	pubmed:11350080|mint:MINT-5214003	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7841130|mint:MINT-1780960	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021215(gene)|ensembl:ENSMUST00000091853(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051451"(myoblast migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037853|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|refseq:NP_062645.2|refseq:NP_001040624.1|mint:MINT-1780966(identity)	refseq:NP_034497.1|refseq:NP_001025021.1|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0042995"(cell projection)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071944"(cell periphery)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030033|interpro:IPR036020|interpro:IPR036034|rcsb pdb:2I04|rcsb pdb:5ZYS|mint:MINT-1780978(identity)	-	comment:mint|function:"Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway"|comment:"Stoichiometry: 1.0"	comment:mint|function:May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ACCN3 currents by modulating its expression at the cell surface|comment:"Stoichiometry: 1.0"	figure legend:F4|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/09	2014/10/16	rogid:Fwq8UtnkZE8JvSrPFj/viHtk8QY10090	rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090	intact-crc:039F71AA0DF75301|rigid:e4iVPTF6bs6oPQRlQ3JjBSzs/w4	false	binding-associated region:523-595(MINT-1780973)|mutation disrupting interaction:595-595,594-594(MINT-1780975)|glutathione s tranferase tag:n-n(MINT-1780967)	-	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q9Z206	uniprotkb:Q6RHR9	intact:EBI-7840997|ensembl:ENSMUSP00000089464|uniprotkb:Q9Z1L7|uniprotkb:Q8C4I0|intact:MINT-1780869	intact:EBI-7440897|uniprotkb:O54894|uniprotkb:O54893|uniprotkb:O54895|intact:MINT-150460|ensembl:ENSMUSP00000086730	psi-mi:arhg8_mouse(display_long)|uniprotkb:Net1(gene name)|psi-mi:Net1(display_short)|uniprotkb:Arhgef8(gene name synonym)|uniprotkb:Rho guanine nucleotide exchange factor 8(gene name synonym)	psi-mi:magi1_mouse(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	- (2001)	pubmed:11350080|mint:MINT-5214003	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7841395|mint:MINT-1780986	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021215(gene)|ensembl:ENSMUST00000091853(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051451"(myoblast migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037853|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|refseq:NP_062645.2|refseq:NP_001040624.1|mint:MINT-1780993(identity)	refseq:NP_034497.1|refseq:NP_001025021.1|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0042995"(cell projection)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071944"(cell periphery)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030033|interpro:IPR036020|interpro:IPR036034|rcsb pdb:2I04|rcsb pdb:5ZYS|mint:MINT-1781003(identity)	-	comment:mint|function:"Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway"|comment:"Stoichiometry: 1.0"	comment:mint|function:May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ACCN3 currents by modulating its expression at the cell surface|comment:"Stoichiometry: 1.0"	figure legend:F5|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/03/09	2014/10/16	rogid:Fwq8UtnkZE8JvSrPFj/viHtk8QY10090	rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090	intact-crc:B9A6307CBA205241|rigid:e4iVPTF6bs6oPQRlQ3JjBSzs/w4	false	t7 tag:n-n(MINT-1780994)|mutation disrupting interaction:594-594(MINT-1781001)	flag tag:n-n(MINT-1781004)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z206	uniprotkb:Q6RHR9	intact:EBI-7840997|ensembl:ENSMUSP00000089464|uniprotkb:Q9Z1L7|uniprotkb:Q8C4I0|intact:MINT-1780869	intact:EBI-7440897|uniprotkb:O54894|uniprotkb:O54893|uniprotkb:O54895|intact:MINT-150460|ensembl:ENSMUSP00000086730	psi-mi:arhg8_mouse(display_long)|uniprotkb:Net1(gene name)|psi-mi:Net1(display_short)|uniprotkb:Arhgef8(gene name synonym)|uniprotkb:Rho guanine nucleotide exchange factor 8(gene name synonym)	psi-mi:magi1_mouse(display_long)|uniprotkb:Magi1(gene name)|psi-mi:Magi1(display_short)|uniprotkb:Baiap1(gene name synonym)|uniprotkb:Bap1(gene name synonym)|uniprotkb:BAI1-associated protein 1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	- (2001)	pubmed:11350080|mint:MINT-5214003	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7841451|mint:MINT-1781013	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021215(gene)|ensembl:ENSMUST00000091853(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051451"(myoblast migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037853|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|refseq:NP_062645.2|refseq:NP_001040624.1|mint:MINT-1781023(identity)	refseq:NP_034497.1|refseq:NP_001025021.1|ensembl:ENSMUSG00000045095(gene)|ensembl:ENSMUST00000089317(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0042995"(cell projection)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071944"(cell periphery)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030033|interpro:IPR036020|interpro:IPR036034|rcsb pdb:2I04|rcsb pdb:5ZYS|mint:MINT-1781015(identity)	-	comment:mint|function:"Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway"|comment:"Stoichiometry: 1.0"	comment:mint|function:May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ACCN3 currents by modulating its expression at the cell surface|comment:"Stoichiometry: 1.0"	figure legend:F5|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2006/03/09	2014/10/16	rogid:Fwq8UtnkZE8JvSrPFj/viHtk8QY10090	rogid:mk1dW19+wMHjMLcuieBAQSHEs3U10090	intact-crc:1BDFFB7905E28B05|rigid:e4iVPTF6bs6oPQRlQ3JjBSzs/w4	false	t7 tag:n-n(MINT-1781024)|mutation disrupting interaction:594-594(MINT-1781031)	flag tag:n-n(MINT-1781016)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)