#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16410	uniprotkb:P42081	intact:EBI-1030991|uniprotkb:Q53TD5|uniprotkb:Q8WXJ1|uniprotkb:Q96P43|uniprotkb:Q9UKN9|ensembl:ENSP00000497102|uniprotkb:A0N1S0|uniprotkb:E9PDH0|uniprotkb:Q0PP65|uniprotkb:Q52MC1|uniprotkb:Q5S005|uniprotkb:O95653	intact:EBI-1030956|uniprotkb:A0N0P0|uniprotkb:Q13655|uniprotkb:Q6FHB1|uniprotkb:Q6GTS4|uniprotkb:Q7M4L5|ensembl:ENSP00000332049|uniprotkb:B7Z2F3|uniprotkb:B7Z702|uniprotkb:E7ETN5|uniprotkb:E9PC27	psi-mi:ctla4_human(display_long)|uniprotkb:CTLA4(gene name)|psi-mi:CTLA4(display_short)|uniprotkb:CD152(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte-associated antigen 4(gene name synonym)	psi-mi:cd86_human(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:FUN-1(gene name synonym)|uniprotkb:BU63(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Schwartz et al. (2001)	pubmed:11279501	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1031013|rcsb pdb:1I85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000648405(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|ensembl:ENSG00000163599(gene)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008096(Cytotoxic T-lymphocyte antigen 4)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1AH1|rcsb pdb:1H6E|rcsb pdb:1I85|rcsb pdb:1I8L|rcsb pdb:2X44|rcsb pdb:3BX7|rcsb pdb:3OSK|rcsb pdb:5GGV|rcsb pdb:5TRU|rcsb pdb:5XJ3|rcsb pdb:6RP8|rcsb pdb:6RPJ|rcsb pdb:6RQM|rcsb pdb:6XY2|rcsb pdb:7CIO|rcsb pdb:7ELX|reactome:R-HSA-389513|reactome:R-HSA-8877330|refseq:NP_001032720.1|refseq:NP_005205.2|dip:DIP-35607N	reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|ensembl:ENSG00000114013(gene)|ensembl:ENST00000330540(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042113"(B cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037677|rcsb pdb:1I85|rcsb pdb:1NCN|rcsb pdb:5YXK|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|refseq:NP_001193853.1|refseq:NP_001193854.1|refseq:NP_008820.3|refseq:NP_787058.4|refseq:NP_795711.1|dip:DIP-35606N	-	-	-	assembly:tetrameric, multimeric|3d-r-factors:working 78.300%, free 70.0%|3d-resolution:3.2A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:PeBR/2EG/cFzR4DKWuX80TsgBw49606	rogid:VMDr9AcMwoSX2JyeGy7C0IcHXnY9606	intact-crc:A5D4E0D178E16D8B|rigid:v01YRYbnjRx9qgVVGBEQn9vwRKI	false	sufficient binding region:36-161	sufficient binding region:26-134	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)