#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O46036 uniprotkb:P03255 intact:EBI-159330|uniprotkb:O61283|uniprotkb:Q59DX5|ensemblmetazoa:FBpp0099514|uniprotkb:Q95SQ8|uniprotkb:Q9VG02 intact:EBI-2603114|uniprotkb:P06438|uniprotkb:Q64825|uniprotkb:Q64826 psi-mi:ctbp_drome(display_long)|uniprotkb:CtBP(gene name)|psi-mi:CtBP(display_short)|uniprotkb:CG7583(orf name)|uniprotkb:dCtBP(gene name synonym) psi-mi:e1a_ade05(display_long)|uniprotkb:Early E1A 32 kDa protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Zhang et al. (2001) pubmed:11251081|mint:MINT-5213710 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7796121|mint:MINT-2790003 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014617.1|refseq:NP_524336.2|refseq:NP_731762.1|refseq:NP_731763.1|refseq:NP_731764.1|flybase:FBgn0020496|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0022416"(chaeta development)|go:"GO:0031010"(ISWI-type complex)|go:"GO:0035220"(wing disc development)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043044"|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051287"(NAD binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029753|interpro:IPR036291|interpro:IPR043322|mint:O46036|reactome:R-DME-3769402|go:"GO:0008134"(transcription factor binding)|ensemblmetazoa:FBgn0020496(gene)|ensemblmetazoa:FBtr0100161(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|reactome:R-DME-3899300|reactome:R-DME-4641265|refseq:NP_001262520.1|dip:DIP-17268N|mint:MINT-2790004(identity) refseq:AP_000197.1|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0046719"(regulation by virus of viral protein levels in host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR014410(Adenovirus early E1A)|rcsb pdb:2KJE|rcsb pdb:2R7G|rcsb pdb:6H6D|rcsb pdb:6H6H|go:"GO:0042025"(host cell nucleus)|dip:DIP-40736N|mint:P03255|mint:MINT-2790013(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F7|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/07/12 2014/10/16 rogid:hbMeldNlirFwVr+5QX9bGiPqZ1w7227 rogid:Yj7851FOR0yCEZBF540O97/Oo/M28285 intact-crc:B38453078DB35E9D|rigid:3jZWwlsqqnVopxlWYawv4HSRsok false tag:?-?(MINT-2790011) mutation disrupting interaction:239-254(MINT-2880735)|tag:?-?(MINT-2790021)|mutation disrupting interaction:271-284(MINT-2880732) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y463 uniprotkb:P03255-2 intact:EBI-634187|uniprotkb:O75258|uniprotkb:O75788|uniprotkb:O75789|ensembl:ENSP00000312789|ensembl:ENSP00000469863|ensembl:ENSP00000485915|ensembl:ENSP00000486377 intact:EBI-6859460|intact:EBI-7796221|intact:EBI-8665485|intact:EBI-7796198|intact:EBI-6996423|intact:EBI-7427771|intact:EBI-8679750|intact:EBI-8544261|intact:EBI-8646018|intact:EBI-8646062|intact:EBI-8646168|intact:EBI-7427730|intact:EBI-8053186|intact:EBI-8645976|intact:EBI-8646143|intact:EBI-8665537|intact:EBI-7427512|intact:EBI-8544381|intact:MINT-87562|intact:EBI-8544435|intact:EBI-8679721|intact:EBI-8665366|intact:EBI-7140610|intact:EBI-8646114|intact:EBI-8665567|intact:EBI-7140682|intact:EBI-8544418 psi-mi:dyr1b_human(display_long)|uniprotkb:Mirk protein kinase(gene name synonym)|uniprotkb:Minibrain-related kinase(gene name synonym)|uniprotkb:DYRK1B(gene name)|psi-mi:DYRK1B(display_short)|uniprotkb:MIRK(gene name synonym) psi-mi:p03255-2(display_long)|uniprotkb:Early E1A 32 kDa protein(gene name synonym)|uniprotkb:243R(isoform synonym)|uniprotkb:S-E1A(isoform synonym) psi-mi:"MI:0096"(pull down) Zhang et al. (2001) pubmed:11251081|mint:MINT-5213710 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7796192|mint:MINT-2790161 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004705.1|refseq:NP_006474.1|refseq:NP_006475.1|refseq:XP_005259455.1|ensembl:ENSG00000105204(gene)|ensembl:ENSG00000281320(gene)|ensembl:ENST00000323039(transcript)|ensembl:ENST00000593685(transcript)|ensembl:ENST00000625757(transcript)|ensembl:ENST00000631090(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007520"(myoblast fusion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q9Y463|go:"GO:0106310"(protein serine kinase activity)|mint:MINT-2790162(identity) intact:EBI-2603114(isoform-parent)|mint:MINT-2790168(identity) - comment:"Stoichiometry: 1.0" isoform-comment:No experimental confirmation available.|comment:"Stoichiometry: 1.0" figure legend:F8|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/12 2014/10/16 rogid:MaG/ZUw0KMo5JxQdeIhMu0DebXI9606 rogid:3OSlEpVJ8y6MDaS6uIIUi38tgKM28285 intact-crc:B4C28D055424DFAB|rigid:PeAwFeDntLRB2VXSs7vTj1nD0go false glutathione s tranferase tag:?-?(MINT-2790165) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q9Y463 uniprotkb:P03255 intact:EBI-634187|uniprotkb:O75258|uniprotkb:O75788|uniprotkb:O75789|ensembl:ENSP00000312789|ensembl:ENSP00000469863|ensembl:ENSP00000485915|ensembl:ENSP00000486377 intact:EBI-2603114|uniprotkb:P06438|uniprotkb:Q64825|uniprotkb:Q64826 psi-mi:dyr1b_human(display_long)|uniprotkb:Mirk protein kinase(gene name synonym)|uniprotkb:Minibrain-related kinase(gene name synonym)|uniprotkb:DYRK1B(gene name)|psi-mi:DYRK1B(display_short)|uniprotkb:MIRK(gene name synonym) psi-mi:e1a_ade05(display_long)|uniprotkb:Early E1A 32 kDa protein(gene name synonym) psi-mi:"MI:0096"(pull down) Zhang et al. (2001) pubmed:11251081|mint:MINT-5213710 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7796156|mint:MINT-2790102 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004705.1|refseq:NP_006474.1|refseq:NP_006475.1|refseq:XP_005259455.1|ensembl:ENSG00000105204(gene)|ensembl:ENSG00000281320(gene)|ensembl:ENST00000323039(transcript)|ensembl:ENST00000593685(transcript)|ensembl:ENST00000625757(transcript)|ensembl:ENST00000631090(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007520"(myoblast fusion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q9Y463|go:"GO:0106310"(protein serine kinase activity)|mint:MINT-2790113(identity) refseq:AP_000197.1|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0046719"(regulation by virus of viral protein levels in host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR014410(Adenovirus early E1A)|rcsb pdb:2KJE|rcsb pdb:2R7G|rcsb pdb:6H6D|rcsb pdb:6H6H|go:"GO:0042025"(host cell nucleus)|dip:DIP-40736N|mint:P03255|mint:MINT-2790103(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F8|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/12 2014/10/16 rogid:MaG/ZUw0KMo5JxQdeIhMu0DebXI9606 rogid:Yj7851FOR0yCEZBF540O97/Oo/M28285 intact-crc:A0FD92ACA1BECEEB|rigid:4oBA1bi+Wc7Lu/5oj7M9aIqD2NE false glutathione s tranferase tag:?-?(MINT-2790115) tag:?-?(MINT-2880746) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q63470 uniprotkb:P03255 intact:EBI-7796229|ensembl:ENSRNOP00000042446|intact:MINT-2790195 intact:EBI-2603114|uniprotkb:P06438|uniprotkb:Q64825|uniprotkb:Q64826 psi-mi:dyr1a_rat(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:RP86(gene name synonym) psi-mi:e1a_ade05(display_long)|uniprotkb:Early E1A 32 kDa protein(gene name synonym) psi-mi:"MI:0096"(pull down) Zhang et al. (2001) pubmed:11251081|mint:MINT-5213710 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7796276|mint:MINT-2790218 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_008766785.1|refseq:XP_008766786.1|refseq:XP_008766787.1|ensembl:ENSRNOG00000001662(gene)|ensembl:ENSRNOT00000050342(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q63470|reactome:R-RNO-1538133|rgd:2528|refseq:NP_036923.1|refseq:XP_006248093.1|mint:MINT-2790219(identity) refseq:AP_000197.1|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0046719"(regulation by virus of viral protein levels in host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR014410(Adenovirus early E1A)|rcsb pdb:2KJE|rcsb pdb:2R7G|rcsb pdb:6H6D|rcsb pdb:6H6H|go:"GO:0042025"(host cell nucleus)|dip:DIP-40736N|mint:P03255|mint:MINT-2790225(identity) - comment:mint|comment:homomint|function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F8|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/12 2014/10/16 rogid:A9JxUmJJEpow0xT2+Xp1A5hVGCQ10116 rogid:Yj7851FOR0yCEZBF540O97/Oo/M28285 intact-crc:595AD445466F1707|rigid:nxP1bOZk/VHMng2Sdlvkf9lSb0A false glutathione s tranferase tag:?-?(MINT-2790222) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q63470 uniprotkb:P03255-2 intact:EBI-7796229|ensembl:ENSRNOP00000042446|intact:MINT-2790195 intact:EBI-6859460|intact:EBI-7796221|intact:EBI-8665485|intact:EBI-7796198|intact:EBI-6996423|intact:EBI-7427771|intact:EBI-8679750|intact:EBI-8544261|intact:EBI-8646018|intact:EBI-8646062|intact:EBI-8646168|intact:EBI-7427730|intact:EBI-8053186|intact:EBI-8645976|intact:EBI-8646143|intact:EBI-8665537|intact:EBI-7427512|intact:EBI-8544381|intact:MINT-87562|intact:EBI-8544435|intact:EBI-8679721|intact:EBI-8665366|intact:EBI-7140610|intact:EBI-8646114|intact:EBI-8665567|intact:EBI-7140682|intact:EBI-8544418 psi-mi:dyr1a_rat(display_long)|uniprotkb:Dyrk1a(gene name)|psi-mi:Dyrk1a(display_short)|uniprotkb:Dyrk(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:RP86(gene name synonym) psi-mi:p03255-2(display_long)|uniprotkb:Early E1A 32 kDa protein(gene name synonym)|uniprotkb:243R(isoform synonym)|uniprotkb:S-E1A(isoform synonym) psi-mi:"MI:0096"(pull down) Zhang et al. (2001) pubmed:11251081|mint:MINT-5213710 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7796215|mint:MINT-2790183 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_008766785.1|refseq:XP_008766786.1|refseq:XP_008766787.1|ensembl:ENSRNOG00000001662(gene)|ensembl:ENSRNOT00000050342(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q63470|reactome:R-RNO-1538133|rgd:2528|refseq:NP_036923.1|refseq:XP_006248093.1|mint:MINT-2790188(identity) intact:EBI-2603114(isoform-parent)|mint:MINT-2790184(identity) - comment:mint|comment:homomint|function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates|comment:"Stoichiometry: 1.0" isoform-comment:No experimental confirmation available.|comment:"Stoichiometry: 1.0" figure legend:F8|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2006/07/12 2014/10/16 rogid:A9JxUmJJEpow0xT2+Xp1A5hVGCQ10116 rogid:3OSlEpVJ8y6MDaS6uIIUi38tgKM28285 intact-crc:8408D8D3C576E03A|rigid:GXH7K42O5m8o0EvHGBPS7oj4200 false glutathione s tranferase tag:?-?(MINT-2790190) - 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:P14680 uniprotkb:P03255 intact:EBI-20777|uniprotkb:D6VW43|ensemblfungi:YJL141C intact:EBI-2603114|uniprotkb:P06438|uniprotkb:Q64825|uniprotkb:Q64826 psi-mi:yak1_yeast(display_long)|uniprotkb:J0652(orf name)|uniprotkb:YJL141C(locus name)|uniprotkb:YAK1(gene name)|psi-mi:YAK1(display_short) psi-mi:e1a_ade05(display_long)|uniprotkb:Early E1A 32 kDa protein(gene name synonym) psi-mi:"MI:0398"(two hybrid pooling approach) Zhang et al. (2001) pubmed:11251081|mint:MINT-5213710 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7796298|mint:MINT-2789974 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_012394.1|sgd:S000003677|mint:P14680|ensemblfungi:YJL141C(gene)|ensemblfungi:YJL141C_mRNA(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0032106"(positive regulation of response to extracellular stimulus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061406"(positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-3899300|dip:DIP-1374N|mint:MINT-2789976(identity) refseq:AP_000197.1|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0046719"(regulation by virus of viral protein levels in host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR014410(Adenovirus early E1A)|rcsb pdb:2KJE|rcsb pdb:2R7G|rcsb pdb:6H6D|rcsb pdb:6H6H|go:"GO:0042025"(host cell nucleus)|dip:DIP-40736N|mint:P03255|mint:MINT-2789975(identity) - crc64:E0B7C56FAA35E056|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F7|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2006/07/12 2014/10/16 rogid:LweeqHk6a9SyakRTDkdzgh72Jsc559292 rogid:Yj7851FOR0yCEZBF540O97/Oo/M28285 intact-crc:1F8D4584E6C221C4|rigid:bRQUjUXwdWQ8rkIrw5g+tYSvFZs false binding-associated region:163-807(MINT-2789997)|tag:?-?(MINT-2789991) binding-associated region:187-289(MINT-2789987)|tag:?-?(MINT-2789981)|mutation disrupting interaction:239-284(MINT-2880725)|mutation disrupting interaction:187-221(MINT-2880722) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)