#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O43283 uniprotkb:O43283 intact:EBI-1168480|uniprotkb:Q05BY6|uniprotkb:Q15450|uniprotkb:Q2NKN3|uniprotkb:B2R6U2|uniprotkb:B4DLE3|uniprotkb:B4DMV2|uniprotkb:B4DZJ4|uniprotkb:D3DNU1|ensembl:ENSP00000265026|ensembl:ENSP00000399910 intact:EBI-1168480|uniprotkb:Q05BY6|uniprotkb:Q15450|uniprotkb:Q2NKN3|uniprotkb:B2R6U2|uniprotkb:B4DLE3|uniprotkb:B4DMV2|uniprotkb:B4DZJ4|uniprotkb:D3DNU1|ensembl:ENSP00000265026|ensembl:ENSP00000399910 psi-mi:m3k13_human(display_long)|uniprotkb:MAP3K13(gene name)|psi-mi:MAP3K13(display_short)|uniprotkb:LZK(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine zipper-bearing kinase(gene name synonym) psi-mi:m3k13_human(display_long)|uniprotkb:MAP3K13(gene name)|psi-mi:MAP3K13(display_short)|uniprotkb:LZK(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine zipper-bearing kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ikeda et al. (2001) pubmed:11163770|imex:IM-19685|mint:MINT-5213494 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1168499|imex:IM-19685-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001229243.1|refseq:NP_001229246.1|refseq:NP_004712.1|refseq:XP_011511612.1|refseq:XP_016862945.1|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0106137"(IkappaB kinase complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027258|ensembl:ENST00000265026(transcript)|ensembl:ENST00000424227(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046777"(protein autophosphorylation)|ensembl:ENSG00000073803(gene) refseq:NP_001229243.1|refseq:NP_001229246.1|refseq:NP_004712.1|refseq:XP_011511612.1|refseq:XP_016862945.1|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0106137"(IkappaB kinase complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027258|ensembl:ENST00000265026(transcript)|ensembl:ENST00000424227(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046777"(protein autophosphorylation)|ensembl:ENSG00000073803(gene) go:"GO:0042803"(protein homodimerization activity) - - figure legend:1B, 1C, 1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/11/22 2014/10/16 rogid:zvgJ5iEpo8jNl8FlUyCb4hdPqPU9606 rogid:zvgJ5iEpo8jNl8FlUyCb4hdPqPU9606 intact-crc:E802BB2D1B67A4BC|rigid:G5uggwVkDNw493cv7wtw1sHzYT0 false his tag:?-?|necessary binding region:431-555 ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O43283 uniprotkb:O43283 intact:EBI-1168480|uniprotkb:Q05BY6|uniprotkb:Q15450|uniprotkb:Q2NKN3|uniprotkb:B2R6U2|uniprotkb:B4DLE3|uniprotkb:B4DMV2|uniprotkb:B4DZJ4|uniprotkb:D3DNU1|ensembl:ENSP00000265026|ensembl:ENSP00000399910 intact:EBI-1168480|uniprotkb:Q05BY6|uniprotkb:Q15450|uniprotkb:Q2NKN3|uniprotkb:B2R6U2|uniprotkb:B4DLE3|uniprotkb:B4DMV2|uniprotkb:B4DZJ4|uniprotkb:D3DNU1|ensembl:ENSP00000265026|ensembl:ENSP00000399910 psi-mi:m3k13_human(display_long)|uniprotkb:MAP3K13(gene name)|psi-mi:MAP3K13(display_short)|uniprotkb:LZK(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine zipper-bearing kinase(gene name synonym) psi-mi:m3k13_human(display_long)|uniprotkb:MAP3K13(gene name)|psi-mi:MAP3K13(display_short)|uniprotkb:LZK(gene name synonym)|uniprotkb:Mixed lineage kinase(gene name synonym)|uniprotkb:Leucine zipper-bearing kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ikeda et al. (2001) pubmed:11163770|imex:IM-19685|mint:MINT-5213494 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1168511|imex:IM-19685-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001229243.1|refseq:NP_001229246.1|refseq:NP_004712.1|refseq:XP_011511612.1|refseq:XP_016862945.1|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0106137"(IkappaB kinase complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027258|ensembl:ENST00000265026(transcript)|ensembl:ENST00000424227(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046777"(protein autophosphorylation)|ensembl:ENSG00000073803(gene) refseq:NP_001229243.1|refseq:NP_001229246.1|refseq:NP_004712.1|refseq:XP_011511612.1|refseq:XP_016862945.1|go:"GO:0046872"(metal ion binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0106137"(IkappaB kinase complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017419(Mitogen-activated protein kinase kinase kinase, 12/13)|interpro:IPR027258|ensembl:ENST00000265026(transcript)|ensembl:ENST00000424227(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046777"(protein autophosphorylation)|ensembl:ENSG00000073803(gene) go:"GO:0042803"(protein homodimerization activity) - - figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/11/22 2014/10/16 rogid:zvgJ5iEpo8jNl8FlUyCb4hdPqPU9606 rogid:zvgJ5iEpo8jNl8FlUyCb4hdPqPU9606 intact-crc:2219EB00E92D64FF|rigid:G5uggwVkDNw493cv7wtw1sHzYT0 false his tag:?-? ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)