#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P23827	uniprotkb:P23827	intact:EBI-1029159|ensemblbacteria:AAC75269|ensemblbacteria:BAA15992	intact:EBI-1029159|ensemblbacteria:AAC75269|ensemblbacteria:BAA15992	psi-mi:ecot_ecoli(display_long)|uniprotkb:eco(gene name)|psi-mi:eco(display_short)|uniprotkb:eti(gene name synonym)|uniprotkb:b2209(locus name)|uniprotkb:JW2197(locus name)	psi-mi:ecot_ecoli(display_long)|uniprotkb:eco(gene name)|psi-mi:eco(display_short)|uniprotkb:eti(gene name synonym)|uniprotkb:b2209(locus name)|uniprotkb:JW2197(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Vargason et al. (2000)	pubmed:10966645	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1029868|rcsb pdb:1FI8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416713.1|interpro:IPR005658(Proteinase inhibitor I11, ecotin)|interpro:IPR023084|rcsb pdb:1AZZ|rcsb pdb:1ECY|rcsb pdb:1ECZ|rcsb pdb:1EZS|rcsb pdb:1EZU|rcsb pdb:1FI8|rcsb pdb:1ID5|rcsb pdb:1IFG|rcsb pdb:1N8O|rcsb pdb:1P0S|rcsb pdb:1SLU|rcsb pdb:1SLV|rcsb pdb:1SLW|rcsb pdb:1SLX|rcsb pdb:1XX9|rcsb pdb:1XXD|rcsb pdb:1XXF|ensemblbacteria:AAC75269(transcript)|ensemblbacteria:b2209(gene)|ensemblbacteria:BAA15992(gene)|ensemblbacteria:BAA15992(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|refseq:WP_000849209.1|interpro:IPR027438|rcsb pdb:4IW4|rcsb pdb:4NIY|interpro:IPR036198|rcsb pdb:7CBK	refseq:NP_416713.1|interpro:IPR005658(Proteinase inhibitor I11, ecotin)|interpro:IPR023084|rcsb pdb:1AZZ|rcsb pdb:1ECY|rcsb pdb:1ECZ|rcsb pdb:1EZS|rcsb pdb:1EZU|rcsb pdb:1FI8|rcsb pdb:1ID5|rcsb pdb:1IFG|rcsb pdb:1N8O|rcsb pdb:1P0S|rcsb pdb:1SLU|rcsb pdb:1SLV|rcsb pdb:1SLW|rcsb pdb:1SLX|rcsb pdb:1XX9|rcsb pdb:1XXD|rcsb pdb:1XXF|ensemblbacteria:AAC75269(transcript)|ensemblbacteria:b2209(gene)|ensemblbacteria:BAA15992(gene)|ensemblbacteria:BAA15992(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|refseq:WP_000849209.1|interpro:IPR027438|rcsb pdb:4IW4|rcsb pdb:4NIY|interpro:IPR036198|rcsb pdb:7CBK	-	-	-	assembly:hexameric, multimeric|3d-r-factors:working 78.200%, free 74.800%|3d-resolution:2.2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:ZzO2zrHSsO5iH2kANpN5qFp+S8w83333	rogid:ZzO2zrHSsO5iH2kANpN5qFp+S8w83333	intact-crc:FFC27445CCC67E1F|rigid:GAi99wHLBdZnNhsiGe2Y+S154D4	false	sufficient binding region:21-100	sufficient binding region:105-162	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23827	uniprotkb:P18291	intact:EBI-1029159|ensemblbacteria:AAC75269|ensemblbacteria:BAA15992	intact:EBI-1029855|ensembl:ENSRNOP00000040429|ensembl:ENSRNOP00000056412	psi-mi:ecot_ecoli(display_long)|uniprotkb:eco(gene name)|psi-mi:eco(display_short)|uniprotkb:eti(gene name synonym)|uniprotkb:b2209(locus name)|uniprotkb:JW2197(locus name)	psi-mi:grab_rat(display_long)|uniprotkb:Gzmb(gene name)|psi-mi:Gzmb(display_short)|uniprotkb:RNKP-1(gene name synonym)|uniprotkb:Fragmentin(gene name synonym)|uniprotkb:Natural killer cell protease 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Vargason et al. (2000)	pubmed:10966645	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1029868|rcsb pdb:1FI8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416713.1|interpro:IPR005658(Proteinase inhibitor I11, ecotin)|interpro:IPR023084|rcsb pdb:1AZZ|rcsb pdb:1ECY|rcsb pdb:1ECZ|rcsb pdb:1EZS|rcsb pdb:1EZU|rcsb pdb:1FI8|rcsb pdb:1ID5|rcsb pdb:1IFG|rcsb pdb:1N8O|rcsb pdb:1P0S|rcsb pdb:1SLU|rcsb pdb:1SLV|rcsb pdb:1SLW|rcsb pdb:1SLX|rcsb pdb:1XX9|rcsb pdb:1XXD|rcsb pdb:1XXF|ensemblbacteria:AAC75269(transcript)|ensemblbacteria:b2209(gene)|ensemblbacteria:BAA15992(gene)|ensemblbacteria:BAA15992(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|refseq:WP_000849209.1|interpro:IPR027438|rcsb pdb:4IW4|rcsb pdb:4NIY|interpro:IPR036198|rcsb pdb:7CBK	rgd:620018|refseq:NP_612526.2|ensembl:ENSRNOG00000045973(gene)|ensembl:ENSRNOG00000049976(gene)|ensembl:ENSRNOT00000041430(transcript)|ensembl:ENSRNOT00000059660(transcript)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019835"(cytolysis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|rcsb pdb:1FI8|reactome:R-RNO-5620971|reactome:R-RNO-75108|go:"GO:0060545"(positive regulation of necroptotic process)|refseq:XP_002728303.2|refseq:XP_017460403.1	-	-	-	assembly:hexameric, multimeric|3d-r-factors:working 78.200%, free 74.800%|3d-resolution:2.2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:ZzO2zrHSsO5iH2kANpN5qFp+S8w83333	rogid:56BDmaE6WzGgKXHNhMyZvMjkNeo10116	intact-crc:FFC27445CCC67E1F|rigid:GAi99wHLBdZnNhsiGe2Y+S154D4	false	sufficient binding region:21-100	sufficient binding region:21-248	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)