#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P38111 uniprotkb:Q04377 intact:EBI-6668|uniprotkb:Q02580|uniprotkb:D6VQD2|ensemblfungi:YBR136W intact:EBI-35652|uniprotkb:D6VTC1|ensemblfungi:YDR499W psi-mi:atr_yeast(display_long)|uniprotkb:Mitosis entry checkpoint protein 1(gene name synonym)|uniprotkb:ATR homolog(gene name synonym)|uniprotkb:MEC1(gene name)|psi-mi:MEC1(display_short)|uniprotkb:ESR1(gene name synonym)|uniprotkb:SAD3(gene name synonym)|uniprotkb:YBR136W(locus name)|uniprotkb:YBR1012(orf name)|uniprotkb:DNA-damage checkpoint kinase MEC1(gene name synonym) psi-mi:lcd1_yeast(display_long)|uniprotkb:LCD1(gene name)|psi-mi:LCD1(display_short)|uniprotkb:Lethal, checkpoint-defective, DNA damage-sensitive protein 1(gene name synonym)|uniprotkb:DNA damage checkpoint protein 2(gene name synonym)|uniprotkb:YDR499W(locus name)|uniprotkb:DDC2(gene name synonym)|uniprotkb:PIE1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Paciotti et al. (2000) pubmed:10950868|imex:IM-19533 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-970695|imex:IM-19533-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009694.3|sgd:S000000340|dip:DIP-799N|mint:P38111|ensemblfungi:YBR136W(gene)|ensemblfungi:YBR136W_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:2000105"(positive regulation of DNA-dependent DNA replication)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012993(UME)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|rcsb pdb:5X6O|rcsb pdb:6Z2W|rcsb pdb:6Z2X|rcsb pdb:6Z3A refseq:NP_010787.3|sgd:S000002907|mint:Q04377|dip:DIP-2970N|ensemblfungi:YDR499W(gene)|ensemblfungi:YDR499W_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0045184"(establishment of protein localization)|interpro:IPR018622|rcsb pdb:5OMD|rcsb pdb:5X6O|rcsb pdb:6Z2W|rcsb pdb:6Z2X|rcsb pdb:6Z3A go:"GO:0004672"(protein kinase activity)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000077"(DNA damage checkpoint signaling) crc64:C06AEF9F0484A615 crc64:E981C1A38F3310BF figure legend:3A, 3B|comment:The interaction is not affected by a single deletion of RAD9 or a quadruple deletion of RAD17, RAD24, MEC3 and DDC1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2006/07/13 2014/10/16 rogid:BXSOV2x+FVvpAqOdHUGcYrTCN0A559292 rogid:qx0fM2HHwEI/GtbjRXu8kQrSp5w559292 intact-crc:EC7267BC30046102|rigid:QTC8BxVajulQ/dpgaph2wZf+dIY false myc tag:c-c ha tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q04377 uniprotkb:P38111 intact:EBI-35652|uniprotkb:D6VTC1|ensemblfungi:YDR499W intact:EBI-6668|uniprotkb:Q02580|uniprotkb:D6VQD2|ensemblfungi:YBR136W psi-mi:lcd1_yeast(display_long)|uniprotkb:LCD1(gene name)|psi-mi:LCD1(display_short)|uniprotkb:Lethal, checkpoint-defective, DNA damage-sensitive protein 1(gene name synonym)|uniprotkb:DNA damage checkpoint protein 2(gene name synonym)|uniprotkb:YDR499W(locus name)|uniprotkb:DDC2(gene name synonym)|uniprotkb:PIE1(gene name synonym) psi-mi:atr_yeast(display_long)|uniprotkb:Mitosis entry checkpoint protein 1(gene name synonym)|uniprotkb:ATR homolog(gene name synonym)|uniprotkb:MEC1(gene name)|psi-mi:MEC1(display_short)|uniprotkb:ESR1(gene name synonym)|uniprotkb:SAD3(gene name synonym)|uniprotkb:YBR136W(locus name)|uniprotkb:YBR1012(orf name)|uniprotkb:DNA-damage checkpoint kinase MEC1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Paciotti et al. (2000) pubmed:10950868|imex:IM-19533 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-970719|imex:IM-19533-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010787.3|sgd:S000002907|mint:Q04377|dip:DIP-2970N|ensemblfungi:YDR499W(gene)|ensemblfungi:YDR499W_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0045184"(establishment of protein localization)|interpro:IPR018622|rcsb pdb:5OMD|rcsb pdb:5X6O|rcsb pdb:6Z2W|rcsb pdb:6Z2X|rcsb pdb:6Z3A refseq:NP_009694.3|sgd:S000000340|dip:DIP-799N|mint:P38111|ensemblfungi:YBR136W(gene)|ensemblfungi:YBR136W_mRNA(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:2000105"(positive regulation of DNA-dependent DNA replication)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012993(UME)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|rcsb pdb:5X6O|rcsb pdb:6Z2W|rcsb pdb:6Z2X|rcsb pdb:6Z3A go:"GO:0004672"(protein kinase activity)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000077"(DNA damage checkpoint signaling) crc64:E981C1A38F3310BF crc64:C06AEF9F0484A615 figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2006/07/13 2014/10/16 rogid:qx0fM2HHwEI/GtbjRXu8kQrSp5w559292 rogid:BXSOV2x+FVvpAqOdHUGcYrTCN0A559292 intact-crc:2C5A0A2A194D8950|rigid:QTC8BxVajulQ/dpgaph2wZf+dIY false ha tag:c-c myc tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)