#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15884	uniprotkb:P50553	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	intact:EBI-957042|uniprotkb:Q9BQ30|ensembl:ENSP00000266744|uniprotkb:A8K3C4	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:ascl1_human(display_long)|uniprotkb:ASCL1(gene name)|psi-mi:ASCL1(display_short)|uniprotkb:ASH1(gene name synonym)|uniprotkb:BHLHA46(gene name synonym)|uniprotkb:HASH1(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 46(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957051|imex:IM-20085-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	go:"GO:0060487"(lung epithelial cell differentiation)|ensembl:ENSG00000139352(gene)|ensembl:ENST00000266744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003358"(noradrenergic neuron development)|go:"GO:0003359"(noradrenergic neuron fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007507"(heart development)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021530"(spinal cord oligodendrocyte cell fate specification)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0051593"(response to folic acid)|go:"GO:0060163"(subpallium neuron fate commitment)|go:"GO:0060165"(regulation of timing of subpallium neuron differentiation)|go:"GO:0060166"(olfactory pit development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048666"(neuron development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061100"(lung neuroendocrine cell differentiation)|go:"GO:0061102"(stomach neuroendocrine cell differentiation)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061103"(carotid body glomus cell differentiation)|go:"GO:0061104"(adrenal chromaffin cell differentiation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015660(Achaete-scute transcription factor related)|interpro:IPR036638|reactome:R-HSA-9031628|refseq:NP_004307.2	-	-	-	figure legend:1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/06/16	2014/10/16	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	rogid:RFGT3dxB08IBopnYytmfJL1YRmQ9606	intact-crc:51BD16D6339E6FEF|rigid:oiTMTC/lksq2eXeiOGJRyO2Cshw	false	sufficient binding region:567-667	sufficient binding region:1-180	-	-	psi-mi:"MI:0056"(full identification by DNA sequencing)	psi-mi:"MI:0056"(full identification by DNA sequencing)
uniprotkb:P15884	uniprotkb:P50553	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	intact:EBI-957042|uniprotkb:Q9BQ30|ensembl:ENSP00000266744|uniprotkb:A8K3C4	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:ascl1_human(display_long)|uniprotkb:ASCL1(gene name)|psi-mi:ASCL1(display_short)|uniprotkb:ASH1(gene name synonym)|uniprotkb:BHLHA46(gene name synonym)|uniprotkb:HASH1(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 46(gene name synonym)	psi-mi:"MI:0096"(pull down)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957094|imex:IM-20085-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	go:"GO:0060487"(lung epithelial cell differentiation)|ensembl:ENSG00000139352(gene)|ensembl:ENST00000266744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003358"(noradrenergic neuron development)|go:"GO:0003359"(noradrenergic neuron fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007507"(heart development)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021530"(spinal cord oligodendrocyte cell fate specification)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0051593"(response to folic acid)|go:"GO:0060163"(subpallium neuron fate commitment)|go:"GO:0060165"(regulation of timing of subpallium neuron differentiation)|go:"GO:0060166"(olfactory pit development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048666"(neuron development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061100"(lung neuroendocrine cell differentiation)|go:"GO:0061102"(stomach neuroendocrine cell differentiation)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061103"(carotid body glomus cell differentiation)|go:"GO:0061104"(adrenal chromaffin cell differentiation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015660(Achaete-scute transcription factor related)|interpro:IPR036638|reactome:R-HSA-9031628|refseq:NP_004307.2	-	-	-	figure legend:2|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/16	2014/10/16	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	rogid:RFGT3dxB08IBopnYytmfJL1YRmQ9606	intact-crc:3E03A0CD2226FA8D|rigid:oiTMTC/lksq2eXeiOGJRyO2Cshw	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:1-180	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15884	uniprotkb:P50553	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	intact:EBI-957042|uniprotkb:Q9BQ30|ensembl:ENSP00000266744|uniprotkb:A8K3C4	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:ascl1_human(display_long)|uniprotkb:ASCL1(gene name)|psi-mi:ASCL1(display_short)|uniprotkb:ASH1(gene name synonym)|uniprotkb:BHLHA46(gene name synonym)|uniprotkb:HASH1(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 46(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957122|imex:IM-20085-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	go:"GO:0060487"(lung epithelial cell differentiation)|ensembl:ENSG00000139352(gene)|ensembl:ENST00000266744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003358"(noradrenergic neuron development)|go:"GO:0003359"(noradrenergic neuron fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007507"(heart development)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021530"(spinal cord oligodendrocyte cell fate specification)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0051593"(response to folic acid)|go:"GO:0060163"(subpallium neuron fate commitment)|go:"GO:0060165"(regulation of timing of subpallium neuron differentiation)|go:"GO:0060166"(olfactory pit development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048666"(neuron development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061100"(lung neuroendocrine cell differentiation)|go:"GO:0061102"(stomach neuroendocrine cell differentiation)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061103"(carotid body glomus cell differentiation)|go:"GO:0061104"(adrenal chromaffin cell differentiation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015660(Achaete-scute transcription factor related)|interpro:IPR036638|reactome:R-HSA-9031628|refseq:NP_004307.2	-	-	-	figure legend:3|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/06/16	2014/10/16	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	rogid:RFGT3dxB08IBopnYytmfJL1YRmQ9606	intact-crc:B3E9D9D8E08358AF|rigid:oiTMTC/lksq2eXeiOGJRyO2Cshw	false	sufficient binding region:?-?	sufficient binding region:1-180	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50553	uniprotkb:P15884	intact:EBI-957042|uniprotkb:Q9BQ30|ensembl:ENSP00000266744|uniprotkb:A8K3C4	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	psi-mi:ascl1_human(display_long)|uniprotkb:ASCL1(gene name)|psi-mi:ASCL1(display_short)|uniprotkb:ASH1(gene name synonym)|uniprotkb:BHLHA46(gene name synonym)|uniprotkb:HASH1(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 46(gene name synonym)	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957134|imex:IM-20085-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060487"(lung epithelial cell differentiation)|ensembl:ENSG00000139352(gene)|ensembl:ENST00000266744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003358"(noradrenergic neuron development)|go:"GO:0003359"(noradrenergic neuron fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007507"(heart development)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021530"(spinal cord oligodendrocyte cell fate specification)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0051593"(response to folic acid)|go:"GO:0060163"(subpallium neuron fate commitment)|go:"GO:0060165"(regulation of timing of subpallium neuron differentiation)|go:"GO:0060166"(olfactory pit development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048666"(neuron development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061100"(lung neuroendocrine cell differentiation)|go:"GO:0061102"(stomach neuroendocrine cell differentiation)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061103"(carotid body glomus cell differentiation)|go:"GO:0061104"(adrenal chromaffin cell differentiation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015660(Achaete-scute transcription factor related)|interpro:IPR036638|reactome:R-HSA-9031628|refseq:NP_004307.2	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	-	-	-	figure legend:3|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/06/16	2014/10/16	rogid:RFGT3dxB08IBopnYytmfJL1YRmQ9606	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	intact-crc:738D0196E1730481|rigid:oiTMTC/lksq2eXeiOGJRyO2Cshw	false	sufficient binding region:1-180	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15923	uniprotkb:P50553	intact:EBI-769630|uniprotkb:Q2TB40|uniprotkb:P15883|uniprotkb:Q14208|uniprotkb:Q14635|uniprotkb:Q14636|uniprotkb:Q9UPI9|uniprotkb:Q2TB39|intact:EBI-11119608|ensembl:ENSP00000262965	intact:EBI-957042|uniprotkb:Q9BQ30|ensembl:ENSP00000266744|uniprotkb:A8K3C4	psi-mi:tfe2_human(display_long)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 1(gene name synonym)|uniprotkb:Transcription factor ITF-1(gene name synonym)|uniprotkb:Kappa-E2-binding factor(gene name synonym)|uniprotkb:TCF3(gene name)|psi-mi:TCF3(display_short)|uniprotkb:E2A(gene name synonym)|uniprotkb:ITF1(gene name synonym)|uniprotkb:BHLHB21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 21(gene name synonym)	psi-mi:ascl1_human(display_long)|uniprotkb:ASCL1(gene name)|psi-mi:ASCL1(display_short)|uniprotkb:ASH1(gene name synonym)|uniprotkb:BHLHA46(gene name synonym)|uniprotkb:HASH1(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 46(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957142|imex:IM-20085-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129611.1|refseq:NP_003191.1|refseq:XP_016882669.1|refseq:XP_016882670.1|refseq:XP_016882671.1|dip:DIP-74N|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000071564(gene)|ensembl:ENST00000262965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2YPA|rcsb pdb:2YPB|rcsb pdb:3U5V|rcsb pdb:6MGN|reactome:R-HSA-525793|reactome:R-HSA-8939236|rcsb pdb:2MH0|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1HLH	go:"GO:0060487"(lung epithelial cell differentiation)|ensembl:ENSG00000139352(gene)|ensembl:ENST00000266744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003358"(noradrenergic neuron development)|go:"GO:0003359"(noradrenergic neuron fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007507"(heart development)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021530"(spinal cord oligodendrocyte cell fate specification)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0051593"(response to folic acid)|go:"GO:0060163"(subpallium neuron fate commitment)|go:"GO:0060165"(regulation of timing of subpallium neuron differentiation)|go:"GO:0060166"(olfactory pit development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048666"(neuron development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061100"(lung neuroendocrine cell differentiation)|go:"GO:0061102"(stomach neuroendocrine cell differentiation)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061103"(carotid body glomus cell differentiation)|go:"GO:0061104"(adrenal chromaffin cell differentiation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015660(Achaete-scute transcription factor related)|interpro:IPR036638|reactome:R-HSA-9031628|refseq:NP_004307.2	-	-	-	figure legend:3|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/06/16	2014/10/16	rogid:EybpTkEZM4cIWyf25UVHfaOaP3Y9606	rogid:RFGT3dxB08IBopnYytmfJL1YRmQ9606	intact-crc:8B94648B2D4B13D8|rigid:kzxl3Z872UFvjEsjbwDjWjHcd70	false	sufficient binding region:508-654	sufficient binding region:1-180	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50553	uniprotkb:P15923	intact:EBI-957042|uniprotkb:Q9BQ30|ensembl:ENSP00000266744|uniprotkb:A8K3C4	intact:EBI-769630|uniprotkb:Q2TB40|uniprotkb:P15883|uniprotkb:Q14208|uniprotkb:Q14635|uniprotkb:Q14636|uniprotkb:Q9UPI9|uniprotkb:Q2TB39|intact:EBI-11119608|ensembl:ENSP00000262965	psi-mi:ascl1_human(display_long)|uniprotkb:ASCL1(gene name)|psi-mi:ASCL1(display_short)|uniprotkb:ASH1(gene name synonym)|uniprotkb:BHLHA46(gene name synonym)|uniprotkb:HASH1(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 46(gene name synonym)	psi-mi:tfe2_human(display_long)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 1(gene name synonym)|uniprotkb:Transcription factor ITF-1(gene name synonym)|uniprotkb:Kappa-E2-binding factor(gene name synonym)|uniprotkb:TCF3(gene name)|psi-mi:TCF3(display_short)|uniprotkb:E2A(gene name synonym)|uniprotkb:ITF1(gene name synonym)|uniprotkb:BHLHB21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957152|imex:IM-20085-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060487"(lung epithelial cell differentiation)|ensembl:ENSG00000139352(gene)|ensembl:ENST00000266744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003358"(noradrenergic neuron development)|go:"GO:0003359"(noradrenergic neuron fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007507"(heart development)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021530"(spinal cord oligodendrocyte cell fate specification)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0051593"(response to folic acid)|go:"GO:0060163"(subpallium neuron fate commitment)|go:"GO:0060165"(regulation of timing of subpallium neuron differentiation)|go:"GO:0060166"(olfactory pit development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048666"(neuron development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061100"(lung neuroendocrine cell differentiation)|go:"GO:0061102"(stomach neuroendocrine cell differentiation)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061103"(carotid body glomus cell differentiation)|go:"GO:0061104"(adrenal chromaffin cell differentiation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015660(Achaete-scute transcription factor related)|interpro:IPR036638|reactome:R-HSA-9031628|refseq:NP_004307.2	refseq:NP_001129611.1|refseq:NP_003191.1|refseq:XP_016882669.1|refseq:XP_016882670.1|refseq:XP_016882671.1|dip:DIP-74N|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000071564(gene)|ensembl:ENST00000262965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2YPA|rcsb pdb:2YPB|rcsb pdb:3U5V|rcsb pdb:6MGN|reactome:R-HSA-525793|reactome:R-HSA-8939236|rcsb pdb:2MH0|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1HLH	-	-	-	figure legend:3|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/06/16	2014/10/16	rogid:RFGT3dxB08IBopnYytmfJL1YRmQ9606	rogid:EybpTkEZM4cIWyf25UVHfaOaP3Y9606	intact-crc:1BA7C2726AD69246|rigid:kzxl3Z872UFvjEsjbwDjWjHcd70	false	sufficient binding region:1-180	sufficient binding region:508-654	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15884	uniprotkb:P15884	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957162|imex:IM-20085-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:3|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/06/16	2014/10/16	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	intact-crc:0AE73C282106D83B|rigid:e5PpFPWCTX0Y0Fu1kopTcyXeHXE	false	sufficient binding region:?-?	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50553	intact:EBI-957195	intact:EBI-957042|uniprotkb:Q9BQ30|ensembl:ENSP00000266744|uniprotkb:A8K3C4	-	psi-mi:ascl1_human(display_long)|uniprotkb:ASCL1(gene name)|psi-mi:ASCL1(display_short)|uniprotkb:ASH1(gene name synonym)|uniprotkb:BHLHA46(gene name synonym)|uniprotkb:HASH1(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 46(gene name synonym)	psi-mi:dna-1(display_short)|psi-mi:EBI-957195(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957214|imex:IM-20085-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	go:"GO:0060487"(lung epithelial cell differentiation)|ensembl:ENSG00000139352(gene)|ensembl:ENST00000266744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003358"(noradrenergic neuron development)|go:"GO:0003359"(noradrenergic neuron fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007507"(heart development)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021530"(spinal cord oligodendrocyte cell fate specification)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0051593"(response to folic acid)|go:"GO:0060163"(subpallium neuron fate commitment)|go:"GO:0060165"(regulation of timing of subpallium neuron differentiation)|go:"GO:0060166"(olfactory pit development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048666"(neuron development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061100"(lung neuroendocrine cell differentiation)|go:"GO:0061102"(stomach neuroendocrine cell differentiation)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061103"(carotid body glomus cell differentiation)|go:"GO:0061104"(adrenal chromaffin cell differentiation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015660(Achaete-scute transcription factor related)|interpro:IPR036638|reactome:R-HSA-9031628|refseq:NP_004307.2	-	-	-	-	figure legend:4|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/16	2014/10/16	rogid:RFGT3dxB08IBopnYytmfJL1YRmQ9606	crc64:1593552634BAF31A	intact-crc:76B5F535F970E6C2	false	sufficient binding region:1-180	32p radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50553	uniprotkb:P15884	intact:EBI-957042|uniprotkb:Q9BQ30|ensembl:ENSP00000266744|uniprotkb:A8K3C4	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	psi-mi:ascl1_human(display_long)|uniprotkb:ASCL1(gene name)|psi-mi:ASCL1(display_short)|uniprotkb:ASH1(gene name synonym)|uniprotkb:BHLHA46(gene name synonym)|uniprotkb:HASH1(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 46(gene name synonym)	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957214|imex:IM-20085-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060487"(lung epithelial cell differentiation)|ensembl:ENSG00000139352(gene)|ensembl:ENST00000266744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003358"(noradrenergic neuron development)|go:"GO:0003359"(noradrenergic neuron fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007507"(heart development)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021530"(spinal cord oligodendrocyte cell fate specification)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0051593"(response to folic acid)|go:"GO:0060163"(subpallium neuron fate commitment)|go:"GO:0060165"(regulation of timing of subpallium neuron differentiation)|go:"GO:0060166"(olfactory pit development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048666"(neuron development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061100"(lung neuroendocrine cell differentiation)|go:"GO:0061102"(stomach neuroendocrine cell differentiation)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061103"(carotid body glomus cell differentiation)|go:"GO:0061104"(adrenal chromaffin cell differentiation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015660(Achaete-scute transcription factor related)|interpro:IPR036638|reactome:R-HSA-9031628|refseq:NP_004307.2	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	-	-	-	figure legend:4|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/16	2014/10/16	rogid:RFGT3dxB08IBopnYytmfJL1YRmQ9606	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	intact-crc:76B5F535F970E6C2	false	sufficient binding region:1-180	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15884	intact:EBI-957195	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	-	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:dna-1(display_short)|psi-mi:EBI-957195(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957224|imex:IM-20085-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	-	-	-	-	figure legend:4|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/16	2014/10/16	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	crc64:1593552634BAF31A	intact-crc:98B78E09B592F19F	false	-	32p radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15923	intact:EBI-957195	intact:EBI-769630|uniprotkb:Q2TB40|uniprotkb:P15883|uniprotkb:Q14208|uniprotkb:Q14635|uniprotkb:Q14636|uniprotkb:Q9UPI9|uniprotkb:Q2TB39|intact:EBI-11119608|ensembl:ENSP00000262965	-	psi-mi:tfe2_human(display_long)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 1(gene name synonym)|uniprotkb:Transcription factor ITF-1(gene name synonym)|uniprotkb:Kappa-E2-binding factor(gene name synonym)|uniprotkb:TCF3(gene name)|psi-mi:TCF3(display_short)|uniprotkb:E2A(gene name synonym)|uniprotkb:ITF1(gene name synonym)|uniprotkb:BHLHB21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 21(gene name synonym)	psi-mi:dna-1(display_short)|psi-mi:EBI-957195(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957230|imex:IM-20085-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_001129611.1|refseq:NP_003191.1|refseq:XP_016882669.1|refseq:XP_016882670.1|refseq:XP_016882671.1|dip:DIP-74N|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000071564(gene)|ensembl:ENST00000262965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2YPA|rcsb pdb:2YPB|rcsb pdb:3U5V|rcsb pdb:6MGN|reactome:R-HSA-525793|reactome:R-HSA-8939236|rcsb pdb:2MH0|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1HLH	-	-	-	-	figure legend:4|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/06/16	2014/10/16	rogid:EybpTkEZM4cIWyf25UVHfaOaP3Y9606	crc64:1593552634BAF31A	intact-crc:7657B8637DDC0835	false	-	32p radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15884	uniprotkb:P50553	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	intact:EBI-957042|uniprotkb:Q9BQ30|ensembl:ENSP00000266744|uniprotkb:A8K3C4	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:ascl1_human(display_long)|uniprotkb:ASCL1(gene name)|psi-mi:ASCL1(display_short)|uniprotkb:ASH1(gene name synonym)|uniprotkb:BHLHA46(gene name synonym)|uniprotkb:HASH1(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 46(gene name synonym)	psi-mi:"MI:0096"(pull down)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957274|imex:IM-20085-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	go:"GO:0060487"(lung epithelial cell differentiation)|ensembl:ENSG00000139352(gene)|ensembl:ENST00000266744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003358"(noradrenergic neuron development)|go:"GO:0003359"(noradrenergic neuron fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007507"(heart development)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021530"(spinal cord oligodendrocyte cell fate specification)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0051593"(response to folic acid)|go:"GO:0060163"(subpallium neuron fate commitment)|go:"GO:0060165"(regulation of timing of subpallium neuron differentiation)|go:"GO:0060166"(olfactory pit development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048666"(neuron development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061100"(lung neuroendocrine cell differentiation)|go:"GO:0061102"(stomach neuroendocrine cell differentiation)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061103"(carotid body glomus cell differentiation)|go:"GO:0061104"(adrenal chromaffin cell differentiation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015660(Achaete-scute transcription factor related)|interpro:IPR036638|reactome:R-HSA-9031628|refseq:NP_004307.2	-	-	-	figure legend:7B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606("human-sk_n_be(2)")|taxid:9606(Human caucasian neuroblastoma cell line)	-	2006/06/16	2014/10/16	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	rogid:RFGT3dxB08IBopnYytmfJL1YRmQ9606	intact-crc:5CD9B0C1DE9DC55D|rigid:oiTMTC/lksq2eXeiOGJRyO2Cshw	false	-	glutathione s tranferase tag:?-?|sufficient binding region:1-180	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15923	uniprotkb:P50553	intact:EBI-769630|uniprotkb:Q2TB40|uniprotkb:P15883|uniprotkb:Q14208|uniprotkb:Q14635|uniprotkb:Q14636|uniprotkb:Q9UPI9|uniprotkb:Q2TB39|intact:EBI-11119608|ensembl:ENSP00000262965	intact:EBI-957042|uniprotkb:Q9BQ30|ensembl:ENSP00000266744|uniprotkb:A8K3C4	psi-mi:tfe2_human(display_long)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 1(gene name synonym)|uniprotkb:Transcription factor ITF-1(gene name synonym)|uniprotkb:Kappa-E2-binding factor(gene name synonym)|uniprotkb:TCF3(gene name)|psi-mi:TCF3(display_short)|uniprotkb:E2A(gene name synonym)|uniprotkb:ITF1(gene name synonym)|uniprotkb:BHLHB21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 21(gene name synonym)	psi-mi:ascl1_human(display_long)|uniprotkb:ASCL1(gene name)|psi-mi:ASCL1(display_short)|uniprotkb:ASH1(gene name synonym)|uniprotkb:BHLHA46(gene name synonym)|uniprotkb:HASH1(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 46(gene name synonym)	psi-mi:"MI:0096"(pull down)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957282|imex:IM-20085-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129611.1|refseq:NP_003191.1|refseq:XP_016882669.1|refseq:XP_016882670.1|refseq:XP_016882671.1|dip:DIP-74N|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000071564(gene)|ensembl:ENST00000262965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2YPA|rcsb pdb:2YPB|rcsb pdb:3U5V|rcsb pdb:6MGN|reactome:R-HSA-525793|reactome:R-HSA-8939236|rcsb pdb:2MH0|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1HLH	go:"GO:0060487"(lung epithelial cell differentiation)|ensembl:ENSG00000139352(gene)|ensembl:ENST00000266744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003358"(noradrenergic neuron development)|go:"GO:0003359"(noradrenergic neuron fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007507"(heart development)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021530"(spinal cord oligodendrocyte cell fate specification)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0051593"(response to folic acid)|go:"GO:0060163"(subpallium neuron fate commitment)|go:"GO:0060165"(regulation of timing of subpallium neuron differentiation)|go:"GO:0060166"(olfactory pit development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048666"(neuron development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061100"(lung neuroendocrine cell differentiation)|go:"GO:0061102"(stomach neuroendocrine cell differentiation)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061103"(carotid body glomus cell differentiation)|go:"GO:0061104"(adrenal chromaffin cell differentiation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015660(Achaete-scute transcription factor related)|interpro:IPR036638|reactome:R-HSA-9031628|refseq:NP_004307.2	-	-	-	figure legend:7B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606("human-sk_n_be(2)")|taxid:9606(Human caucasian neuroblastoma cell line)	-	2006/06/16	2014/10/16	rogid:EybpTkEZM4cIWyf25UVHfaOaP3Y9606	rogid:RFGT3dxB08IBopnYytmfJL1YRmQ9606	intact-crc:CD794F4085290F4D|rigid:kzxl3Z872UFvjEsjbwDjWjHcd70	false	-	glutathione s tranferase tag:?-?|sufficient binding region:1-180	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15884	uniprotkb:P50553	intact:EBI-533224|uniprotkb:Q08AP3|uniprotkb:Q08AP2|uniprotkb:Q15440|uniprotkb:Q15441|uniprotkb:Q15439|uniprotkb:B4DT37|ensembl:ENSP00000348374|ensembl:ENSP00000457649|uniprotkb:G0LNT9|uniprotkb:G0LNU0|uniprotkb:G0LNU1|uniprotkb:G0LNU2|uniprotkb:G0LNU8|uniprotkb:G0LNU9|uniprotkb:G0LNV0|uniprotkb:G0LNV1|uniprotkb:B3KT62|uniprotkb:B3KUC0|uniprotkb:B4DUG3|uniprotkb:B7Z5M6|uniprotkb:G0LNU5|uniprotkb:H3BPQ1|uniprotkb:B7Z6Y1|uniprotkb:G0LNU4|uniprotkb:G0LNV2	intact:EBI-957042|uniprotkb:Q9BQ30|ensembl:ENSP00000266744|uniprotkb:A8K3C4	psi-mi:itf2_human(display_long)|uniprotkb:Immunoglobulin transcription factor 2(gene name synonym)|uniprotkb:SL3-3 enhancer factor 2(gene name synonym)|uniprotkb:ITF2(gene name synonym)|uniprotkb:SEF2(gene name synonym)|uniprotkb:TCF4(gene name)|psi-mi:TCF4(display_short)|uniprotkb:BHLHB19(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 19(gene name synonym)	psi-mi:ascl1_human(display_long)|uniprotkb:ASCL1(gene name)|psi-mi:ASCL1(display_short)|uniprotkb:ASH1(gene name synonym)|uniprotkb:BHLHA46(gene name synonym)|uniprotkb:HASH1(gene name synonym)|uniprotkb:Class A basic helix-loop-helix protein 46(gene name synonym)	psi-mi:"MI:0096"(pull down)	Persson et al. (2000)	pubmed:10903890|imex:IM-20085	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-957290|imex:IM-20085-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230155.2|refseq:NP_001077431.1|refseq:NP_001230163.1|refseq:NP_003190.1|refseq:XP_005266796.2|ensembl:ENSG00000196628(gene)|ensembl:ENST00000356073(transcript)|ensembl:ENST00000564999(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070888"(E-box binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15884|rcsb pdb:2KWF|rcsb pdb:6OD3|rcsb pdb:6OD4|rcsb pdb:6OD5|reactome:R-HSA-525793|refseq:NP_001335140.1|refseq:NP_001335141.1|refseq:NP_001335142.1|refseq:NP_001335143.1|refseq:NP_001335144.1|refseq:NP_001335145.1|refseq:NP_001335146.1|refseq:NP_001335147.1|refseq:NP_001335148.1|refseq:NP_001335149.1|refseq:NP_001293136.1|refseq:NP_001293137.1|refseq:NP_001230164.1|refseq:NP_001230165.1|refseq:NP_001230160.1|refseq:NP_001230161.1|refseq:NP_001230162.1|refseq:XP_006722599.1|refseq:XP_006722600.1|refseq:NP_001230156.1|refseq:NP_001230157.1|refseq:NP_001230159.1|refseq:XP_016881425.1|refseq:XP_016881429.1|refseq:XP_016881430.1|refseq:XP_016881435.1|refseq:XP_016881445.1|dip:DIP-163N	go:"GO:0060487"(lung epithelial cell differentiation)|ensembl:ENSG00000139352(gene)|ensembl:ENST00000266744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001764"(neuron migration)|go:"GO:0003358"(noradrenergic neuron development)|go:"GO:0003359"(noradrenergic neuron fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007400"(neuroblast fate determination)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007423"(sensory organ development)|go:"GO:0007507"(heart development)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021530"(spinal cord oligodendrocyte cell fate specification)|go:"GO:0021750"(vestibular nucleus development)|go:"GO:0021892"(cerebral cortex GABAergic interneuron differentiation)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050883"(musculoskeletal movement, spinal reflex action)|go:"GO:0051593"(response to folic acid)|go:"GO:0060163"(subpallium neuron fate commitment)|go:"GO:0060165"(regulation of timing of subpallium neuron differentiation)|go:"GO:0060166"(olfactory pit development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048666"(neuron development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0061100"(lung neuroendocrine cell differentiation)|go:"GO:0061102"(stomach neuroendocrine cell differentiation)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061103"(carotid body glomus cell differentiation)|go:"GO:0061104"(adrenal chromaffin cell differentiation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR015660(Achaete-scute transcription factor related)|interpro:IPR036638|reactome:R-HSA-9031628|refseq:NP_004307.2	-	-	-	figure legend:7C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606("human-sk_n_be(2)")|taxid:9606(Human caucasian neuroblastoma cell line)	-	2006/06/16	2014/10/16	rogid:5ofdcOZrL/NXfVfFMVO8GMyh+ZY9606	rogid:RFGT3dxB08IBopnYytmfJL1YRmQ9606	intact-crc:F5175A90658925C1|rigid:oiTMTC/lksq2eXeiOGJRyO2Cshw	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:1-180	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)