#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P29459	uniprotkb:P29460	intact:EBI-1029636|uniprotkb:Q96QZ1|ensembl:ENSP00000303231	intact:EBI-1029614|ensembl:ENSP00000231228	psi-mi:il12a_human(display_long)|uniprotkb:IL12A(gene name)|psi-mi:IL12A(display_short)|uniprotkb:NKSF1(gene name synonym)|uniprotkb:IL-12 subunit p35(gene name synonym)|uniprotkb:Cytotoxic lymphocyte maturation factor 35 kDa subunit(gene name synonym)|uniprotkb:NK cell stimulatory factor chain 1(gene name synonym)	psi-mi:il12b_human(display_long)|uniprotkb:IL12B(gene name)|psi-mi:IL12B(display_short)|uniprotkb:NKSF2(gene name synonym)|uniprotkb:IL-12 subunit p40(gene name synonym)|uniprotkb:Cytotoxic lymphocyte maturation factor 40 kDa subunit(gene name synonym)|uniprotkb:NK cell stimulatory factor chain 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Yoon et al. (2000)	pubmed:10899108	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1029655|rcsb pdb:1F45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000873.2|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0042163"(interleukin-12 beta subunit binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0045513"(interleukin-27 binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050709"(negative regulation of protein secretion)|ensembl:ENSG00000168811(gene)|ensembl:ENST00000305579(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005125"(cytokine activity)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010224"(response to UV-B)|go:"GO:0016477"(cell migration)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR004281(Interleukin-12 alpha subunit)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1F45|rcsb pdb:3HMX|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8984722|reactome:R-HSA-9020591|go:"GO:0050830"(defense response to Gram-positive bacterium)|dip:DIP-3772N	refseq:NP_002178.2|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042164"(interleukin-12 alpha subunit binding)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|ensembl:ENSG00000113302(gene)|ensembl:ENST00000231228(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010224"(response to UV-B)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR015528(Interleukin-12 beta chain)|interpro:IPR019482|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1F42|rcsb pdb:1F45|rcsb pdb:3D85|rcsb pdb:3D87|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3DUH|rcsb pdb:3HMX|rcsb pdb:3QWR|rcsb pdb:4GRW|rcsb pdb:5MJ3|rcsb pdb:5MJ4|rcsb pdb:5MXA|rcsb pdb:5MZV|rcsb pdb:5NJD|rcsb pdb:6UIB|rcsb pdb:6WDQ|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-3774N	-	-	-	assembly:tetrameric, multimeric|3d-r-factors:working 75.900%, free 71.600%|3d-resolution:2.8A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/09/20	2014/10/16	rogid:NGpK6IuMMGg9v1dFJB4m29s02Ng9606	rogid:090ptpS0BAD5BZT079b8oOTHmCg9606	intact-crc:48D641090E57970B|rigid:mCsjGqbDiVlpzrzvrQmmUepM3RM	false	sufficient binding region:23-219	sufficient binding region:23-328	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)