#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P40356	uniprotkb:P16649	intact:EBI-13268|uniprotkb:Q6B1W3|uniprotkb:D6VUB3|ensemblfungi:YGL025C	intact:EBI-19654|uniprotkb:P17995|uniprotkb:P18323|uniprotkb:D6VR85|ensemblfungi:YCR084C	psi-mi:med3_yeast(display_long)|uniprotkb:PGD1(gene name)|psi-mi:PGD1(display_short)|uniprotkb:YGL025C(locus name)|uniprotkb:HRS1(gene name synonym)|uniprotkb:MED3(gene name synonym)|uniprotkb:Mediator complex subunit 3(gene name synonym)|uniprotkb:Poly-glutamine domain protein 1(gene name synonym)|uniprotkb:Hyper-recombination suppressor protein 1(gene name synonym)	psi-mi:tup1_yeast(display_long)|uniprotkb:TUP1(gene name)|psi-mi:TUP1(display_short)|uniprotkb:AAR1(gene name synonym)|uniprotkb:AER2(gene name synonym)|uniprotkb:AMM1(gene name synonym)|uniprotkb:CYC9(gene name synonym)|uniprotkb:FLK1(gene name synonym)|uniprotkb:SFL2(gene name synonym)|uniprotkb:UMR7(gene name synonym)|uniprotkb:YCR084C(locus name)|uniprotkb:YCR84C(orf name)|uniprotkb:Glucose repression regulatory protein TUP1(gene name synonym)|uniprotkb:Flocculation suppressor protein(gene name synonym)|uniprotkb:Repressor AER2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papamichos-Chronakis et al. (2000)	pubmed:10722672|imex:IM-19679	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1166695|imex:IM-19679-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011490.2|sgd:S000002993|mint:P40356|dip:DIP-1186N|ensemblfungi:YGL025C(gene)|ensemblfungi:YGL025C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070847"(core mediator complex)|interpro:IPR020998	refseq:NP_010007.1|sgd:S000000680|ensemblfungi:YCR084C(gene)|ensemblfungi:YCR084C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000433"(carbon catabolite repression of transcription from RNA polymerase II promoter by glucose)|go:"GO:0001198"(negative regulation of mating-type specific transcription from RNA polymerase II promoter)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060256"(regulation of flocculation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:1900192"(positive regulation of single-species biofilm formation)|go:"GO:2000217"(regulation of invasive growth in response to glucose limitation)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR013890(Transcriptional repressor Tup1,  N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1ERJ|rcsb pdb:3VP8|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|rcsb pdb:3VP9|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043486"(histone exchange)|dip:DIP-512N|mint:P16649	-	-	crc64:444104AAD63CB944	figure legend:Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/11/15	2014/10/16	rogid:oymzNX+JOJG3JMQDdW+3UHzvGzo559292	rogid:luwCf4aC9uWc9C8Vt2etbCoLcU8559292	intact-crc:E4D2907B0694866F|rigid:ZeZXX2+Q8AkgLYMhun0GaplV6ZU	false	-	binding-associated region:1-200	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14922	uniprotkb:P40356	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	intact:EBI-13268|uniprotkb:Q6B1W3|uniprotkb:D6VUB3|ensemblfungi:YGL025C	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:med3_yeast(display_long)|uniprotkb:PGD1(gene name)|psi-mi:PGD1(display_short)|uniprotkb:YGL025C(locus name)|uniprotkb:HRS1(gene name synonym)|uniprotkb:MED3(gene name synonym)|uniprotkb:Mediator complex subunit 3(gene name synonym)|uniprotkb:Poly-glutamine domain protein 1(gene name synonym)|uniprotkb:Hyper-recombination suppressor protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papamichos-Chronakis et al. (2000)	pubmed:10722672|imex:IM-19679	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1166699|imex:IM-19679-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	refseq:NP_011490.2|sgd:S000002993|mint:P40356|dip:DIP-1186N|ensemblfungi:YGL025C(gene)|ensemblfungi:YGL025C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070847"(core mediator complex)|interpro:IPR020998	-	crc64:FC2D0D0C1B181207	-	figure legend:Table I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/11/15	2014/10/16	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	rogid:oymzNX+JOJG3JMQDdW+3UHzvGzo559292	intact-crc:4E9DE7AB67EDF250|rigid:LqKFaHyTcMXKSBSbBTbHQ2ygchg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40356	uniprotkb:P16649	intact:EBI-13268|uniprotkb:Q6B1W3|uniprotkb:D6VUB3|ensemblfungi:YGL025C	intact:EBI-19654|uniprotkb:P17995|uniprotkb:P18323|uniprotkb:D6VR85|ensemblfungi:YCR084C	psi-mi:med3_yeast(display_long)|uniprotkb:PGD1(gene name)|psi-mi:PGD1(display_short)|uniprotkb:YGL025C(locus name)|uniprotkb:HRS1(gene name synonym)|uniprotkb:MED3(gene name synonym)|uniprotkb:Mediator complex subunit 3(gene name synonym)|uniprotkb:Poly-glutamine domain protein 1(gene name synonym)|uniprotkb:Hyper-recombination suppressor protein 1(gene name synonym)	psi-mi:tup1_yeast(display_long)|uniprotkb:TUP1(gene name)|psi-mi:TUP1(display_short)|uniprotkb:AAR1(gene name synonym)|uniprotkb:AER2(gene name synonym)|uniprotkb:AMM1(gene name synonym)|uniprotkb:CYC9(gene name synonym)|uniprotkb:FLK1(gene name synonym)|uniprotkb:SFL2(gene name synonym)|uniprotkb:UMR7(gene name synonym)|uniprotkb:YCR084C(locus name)|uniprotkb:YCR84C(orf name)|uniprotkb:Glucose repression regulatory protein TUP1(gene name synonym)|uniprotkb:Flocculation suppressor protein(gene name synonym)|uniprotkb:Repressor AER2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Papamichos-Chronakis et al. (2000)	pubmed:10722672|imex:IM-19679	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1166710|imex:IM-19679-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011490.2|sgd:S000002993|mint:P40356|dip:DIP-1186N|ensemblfungi:YGL025C(gene)|ensemblfungi:YGL025C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070847"(core mediator complex)|interpro:IPR020998	refseq:NP_010007.1|sgd:S000000680|ensemblfungi:YCR084C(gene)|ensemblfungi:YCR084C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000433"(carbon catabolite repression of transcription from RNA polymerase II promoter by glucose)|go:"GO:0001198"(negative regulation of mating-type specific transcription from RNA polymerase II promoter)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060256"(regulation of flocculation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:1900192"(positive regulation of single-species biofilm formation)|go:"GO:2000217"(regulation of invasive growth in response to glucose limitation)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR013890(Transcriptional repressor Tup1,  N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1ERJ|rcsb pdb:3VP8|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|rcsb pdb:3VP9|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043486"(histone exchange)|dip:DIP-512N|mint:P16649	-	-	crc64:444104AAD63CB944	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/15	2014/10/16	rogid:oymzNX+JOJG3JMQDdW+3UHzvGzo559292	rogid:luwCf4aC9uWc9C8Vt2etbCoLcU8559292	intact-crc:8F4E4B706214ABB8|rigid:ZeZXX2+Q8AkgLYMhun0GaplV6ZU	false	his tag:?-?|binding-associated region:84-196	glutathione s tranferase tag:?-?|binding-associated region:1-200	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14922	uniprotkb:P40356	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	intact:EBI-13268|uniprotkb:Q6B1W3|uniprotkb:D6VUB3|ensemblfungi:YGL025C	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:med3_yeast(display_long)|uniprotkb:PGD1(gene name)|psi-mi:PGD1(display_short)|uniprotkb:YGL025C(locus name)|uniprotkb:HRS1(gene name synonym)|uniprotkb:MED3(gene name synonym)|uniprotkb:Mediator complex subunit 3(gene name synonym)|uniprotkb:Poly-glutamine domain protein 1(gene name synonym)|uniprotkb:Hyper-recombination suppressor protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Papamichos-Chronakis et al. (2000)	pubmed:10722672|imex:IM-19679	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1166716|imex:IM-19679-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	refseq:NP_011490.2|sgd:S000002993|mint:P40356|dip:DIP-1186N|ensemblfungi:YGL025C(gene)|ensemblfungi:YGL025C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070847"(core mediator complex)|interpro:IPR020998	-	crc64:FC2D0D0C1B181207	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/15	2014/10/16	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	rogid:oymzNX+JOJG3JMQDdW+3UHzvGzo559292	intact-crc:DCA2C3ADEBCED740|rigid:LqKFaHyTcMXKSBSbBTbHQ2ygchg	false	glutathione s tranferase tag:?-?|binding-associated region:1-405	his tag:?-?|binding-associated region:84-196	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16649	uniprotkb:P40356	intact:EBI-19654|uniprotkb:P17995|uniprotkb:P18323|uniprotkb:D6VR85|ensemblfungi:YCR084C	intact:EBI-13268|uniprotkb:Q6B1W3|uniprotkb:D6VUB3|ensemblfungi:YGL025C	psi-mi:tup1_yeast(display_long)|uniprotkb:TUP1(gene name)|psi-mi:TUP1(display_short)|uniprotkb:AAR1(gene name synonym)|uniprotkb:AER2(gene name synonym)|uniprotkb:AMM1(gene name synonym)|uniprotkb:CYC9(gene name synonym)|uniprotkb:FLK1(gene name synonym)|uniprotkb:SFL2(gene name synonym)|uniprotkb:UMR7(gene name synonym)|uniprotkb:YCR084C(locus name)|uniprotkb:YCR84C(orf name)|uniprotkb:Glucose repression regulatory protein TUP1(gene name synonym)|uniprotkb:Flocculation suppressor protein(gene name synonym)|uniprotkb:Repressor AER2(gene name synonym)	psi-mi:med3_yeast(display_long)|uniprotkb:PGD1(gene name)|psi-mi:PGD1(display_short)|uniprotkb:YGL025C(locus name)|uniprotkb:HRS1(gene name synonym)|uniprotkb:MED3(gene name synonym)|uniprotkb:Mediator complex subunit 3(gene name synonym)|uniprotkb:Poly-glutamine domain protein 1(gene name synonym)|uniprotkb:Hyper-recombination suppressor protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Papamichos-Chronakis et al. (2000)	pubmed:10722672|imex:IM-19679	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1166746|imex:IM-19679-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010007.1|sgd:S000000680|ensemblfungi:YCR084C(gene)|ensemblfungi:YCR084C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000433"(carbon catabolite repression of transcription from RNA polymerase II promoter by glucose)|go:"GO:0001198"(negative regulation of mating-type specific transcription from RNA polymerase II promoter)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060256"(regulation of flocculation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:1900192"(positive regulation of single-species biofilm formation)|go:"GO:2000217"(regulation of invasive growth in response to glucose limitation)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR013890(Transcriptional repressor Tup1,  N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1ERJ|rcsb pdb:3VP8|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|rcsb pdb:3VP9|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043486"(histone exchange)|dip:DIP-512N|mint:P16649	refseq:NP_011490.2|sgd:S000002993|mint:P40356|dip:DIP-1186N|ensemblfungi:YGL025C(gene)|ensemblfungi:YGL025C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070847"(core mediator complex)|interpro:IPR020998	-	crc64:444104AAD63CB944	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/15	2014/10/16	rogid:luwCf4aC9uWc9C8Vt2etbCoLcU8559292	rogid:oymzNX+JOJG3JMQDdW+3UHzvGzo559292	intact-crc:F07356E95D5D2402|rigid:GZ5fQImfx5t300kkKiK/pq09bn8	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16649	uniprotkb:P14922	intact:EBI-19654|uniprotkb:P17995|uniprotkb:P18323|uniprotkb:D6VR85|ensemblfungi:YCR084C	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	psi-mi:tup1_yeast(display_long)|uniprotkb:TUP1(gene name)|psi-mi:TUP1(display_short)|uniprotkb:AAR1(gene name synonym)|uniprotkb:AER2(gene name synonym)|uniprotkb:AMM1(gene name synonym)|uniprotkb:CYC9(gene name synonym)|uniprotkb:FLK1(gene name synonym)|uniprotkb:SFL2(gene name synonym)|uniprotkb:UMR7(gene name synonym)|uniprotkb:YCR084C(locus name)|uniprotkb:YCR84C(orf name)|uniprotkb:Glucose repression regulatory protein TUP1(gene name synonym)|uniprotkb:Flocculation suppressor protein(gene name synonym)|uniprotkb:Repressor AER2(gene name synonym)	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Papamichos-Chronakis et al. (2000)	pubmed:10722672|imex:IM-19679	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1166746|imex:IM-19679-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010007.1|sgd:S000000680|ensemblfungi:YCR084C(gene)|ensemblfungi:YCR084C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000433"(carbon catabolite repression of transcription from RNA polymerase II promoter by glucose)|go:"GO:0001198"(negative regulation of mating-type specific transcription from RNA polymerase II promoter)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060256"(regulation of flocculation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:1900192"(positive regulation of single-species biofilm formation)|go:"GO:2000217"(regulation of invasive growth in response to glucose limitation)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR013890(Transcriptional repressor Tup1,  N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|rcsb pdb:1ERJ|rcsb pdb:3VP8|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|rcsb pdb:3VP9|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043486"(histone exchange)|dip:DIP-512N|mint:P16649	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	-	crc64:444104AAD63CB944	crc64:FC2D0D0C1B181207	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/11/15	2014/10/16	rogid:luwCf4aC9uWc9C8Vt2etbCoLcU8559292	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	intact-crc:F07356E95D5D2402|rigid:GZ5fQImfx5t300kkKiK/pq09bn8	false	glutathione s tranferase tag:?-?	his tag:?-?|binding-associated region:1-405	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14922	uniprotkb:Q12124	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	intact:EBI-37542|uniprotkb:D6VRY3|ensemblfungi:YDL005C	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:med2_yeast(display_long)|uniprotkb:MED2(gene name)|psi-mi:MED2(display_short)|uniprotkb:D2930(orf name)|uniprotkb:Mediator complex subunit 2(gene name synonym)|uniprotkb:YDL005C(locus name)	psi-mi:"MI:0096"(pull down)	Papamichos-Chronakis et al. (2000)	pubmed:10722672|imex:IM-19679	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1166764|imex:IM-19679-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	sgd:S000002163|refseq:NP_010279.3|dip:DIP-2335N|mint:Q12124|ensemblfungi:YDL005C(gene)|ensemblfungi:YDL005C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016592"(mediator complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070847"(core mediator complex)|interpro:IPR021017	-	crc64:FC2D0D0C1B181207	crc64:D3B0992B1F1A4892	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/11/15	2014/10/16	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	rogid:pg7IrzDZIzNxuyB+GlZsguqLJEI559292	intact-crc:A3CF01E944C1CE05|rigid:UbPaqJOnzYCoJxEcCtZbrHgcR2k	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14922	uniprotkb:Q12343	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	intact:EBI-31503|uniprotkb:D6W2N0|ensemblfungi:YOR174W	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:med4_yeast(display_long)|uniprotkb:O3630(orf name)|uniprotkb:Mediator complex subunit 4(gene name synonym)|uniprotkb:MED4(gene name)|psi-mi:MED4(display_short)|uniprotkb:YOR174W(locus name)	psi-mi:"MI:0096"(pull down)	Papamichos-Chronakis et al. (2000)	pubmed:10722672|imex:IM-19679	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1166764|imex:IM-19679-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	sgd:S000005700|refseq:NP_014817.3|dip:DIP-1178N|mint:Q12343|ensemblfungi:YOR174W(gene)|ensemblfungi:YOR174W_mRNA(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0070847"(core mediator complex)|interpro:IPR019258|rcsb pdb:5OQM|rcsb pdb:5SVA	-	crc64:FC2D0D0C1B181207	crc64:D42A3C62D465DDAD	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/11/15	2014/10/16	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	rogid:R+wCh3eGS74E+DEQm21XHMd59y0559292	intact-crc:A3CF01E944C1CE05|rigid:UbPaqJOnzYCoJxEcCtZbrHgcR2k	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P14922	uniprotkb:P40356	intact:EBI-18215|uniprotkb:D6VQB2|ensemblfungi:YBR112C	intact:EBI-13268|uniprotkb:Q6B1W3|uniprotkb:D6VUB3|ensemblfungi:YGL025C	psi-mi:cyc8_yeast(display_long)|uniprotkb:CYC8(gene name)|psi-mi:CYC8(display_short)|uniprotkb:CRT8(gene name synonym)|uniprotkb:YBR112C(locus name)|uniprotkb:YBR0908(orf name)|uniprotkb:SSN6(gene name synonym)|uniprotkb:Glucose repression mediator protein CYC8(gene name synonym)	psi-mi:med3_yeast(display_long)|uniprotkb:PGD1(gene name)|psi-mi:PGD1(display_short)|uniprotkb:YGL025C(locus name)|uniprotkb:HRS1(gene name synonym)|uniprotkb:MED3(gene name synonym)|uniprotkb:Mediator complex subunit 3(gene name synonym)|uniprotkb:Poly-glutamine domain protein 1(gene name synonym)|uniprotkb:Hyper-recombination suppressor protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Papamichos-Chronakis et al. (2000)	pubmed:10722672|imex:IM-19679	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1166764|imex:IM-19679-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000000316|ensemblfungi:YBR112C(gene)|ensemblfungi:YBR112C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1900191"(negative regulation of single-species biofilm formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0017053"(transcription repressor complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|go:"GO:0031490"(chromatin DNA binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-SCE-2559580|go:"GO:0042826"(histone deacetylase binding)|reactome:R-SCE-3214842|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_009670.3|dip:DIP-696N|mint:P14922	refseq:NP_011490.2|sgd:S000002993|mint:P40356|dip:DIP-1186N|ensemblfungi:YGL025C(gene)|ensemblfungi:YGL025C_mRNA(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070847"(core mediator complex)|interpro:IPR020998	-	crc64:FC2D0D0C1B181207	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/11/15	2014/10/16	rogid:gpjKszq6Hl6REDcJxD0NlI+WN/8559292	rogid:oymzNX+JOJG3JMQDdW+3UHzvGzo559292	intact-crc:A3CF01E944C1CE05|rigid:UbPaqJOnzYCoJxEcCtZbrHgcR2k	false	glutathione s tranferase tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)