#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49710	uniprotkb:P25911	intact:EBI-924601|uniprotkb:Q922I8|ensembl:ENSMUSP00000023531	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	psi-mi:hcls1_mouse(display_long)|uniprotkb:Hcls1(gene name)|psi-mi:Hcls1(display_short)|uniprotkb:Hs1(gene name synonym)|uniprotkb:Hematopoietic cell-specific LYN substrate 1(gene name synonym)|uniprotkb:LckBP1(gene name synonym)	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Ingley et al. (2000)	imex:IM-14458|pubmed:10713104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-924616|imex:IM-14458-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032251.2|ensembl:ENSMUSG00000022831(gene)|ensembl:ENSMUST00000023531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR028534|interpro:IPR036028|mint:P49710	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/04/10	2014/10/16	rogid:f0+oPP9relryVZzce7RHfggQnGk10090	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	intact-crc:FFDEF26E5BEAE5EA|rigid:CSrsuT2c/dLKQGHqyFfpN+so1jk	false	sufficient binding region:346-486	-	-	-	psi-mi:"MI:0056"(full identification by DNA sequencing)	psi-mi:"MI:0056"(full identification by DNA sequencing)
uniprotkb:P25911	uniprotkb:P49710	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	intact:EBI-924601|uniprotkb:Q922I8|ensembl:ENSMUSP00000023531	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:hcls1_mouse(display_long)|uniprotkb:Hcls1(gene name)|psi-mi:Hcls1(display_short)|uniprotkb:Hs1(gene name synonym)|uniprotkb:Hematopoietic cell-specific LYN substrate 1(gene name synonym)|uniprotkb:LckBP1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ingley et al. (2000)	imex:IM-14458|pubmed:10713104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-924821|imex:IM-14458-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	refseq:NP_032251.2|ensembl:ENSMUSG00000022831(gene)|ensembl:ENSMUST00000023531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR028534|interpro:IPR036028|mint:P49710	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/04/10	2014/10/16	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	rogid:f0+oPP9relryVZzce7RHfggQnGk10090	intact-crc:2CE026D435B42BFC|rigid:CSrsuT2c/dLKQGHqyFfpN+so1jk	false	-	sufficient binding region:346-486|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25911	uniprotkb:P49710	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	intact:EBI-924601|uniprotkb:Q922I8|ensembl:ENSMUSP00000023531	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:hcls1_mouse(display_long)|uniprotkb:Hcls1(gene name)|psi-mi:Hcls1(display_short)|uniprotkb:Hs1(gene name synonym)|uniprotkb:Hematopoietic cell-specific LYN substrate 1(gene name synonym)|uniprotkb:LckBP1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Ingley et al. (2000)	imex:IM-14458|pubmed:10713104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-924914|imex:IM-14458-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	refseq:NP_032251.2|ensembl:ENSMUSG00000022831(gene)|ensembl:ENSMUST00000023531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR028534|interpro:IPR036028|mint:P49710	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/04/10	2014/10/16	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	rogid:f0+oPP9relryVZzce7RHfggQnGk10090	intact-crc:8B197988FF0C2387|rigid:CSrsuT2c/dLKQGHqyFfpN+so1jk	false	necessary binding region:71-126(IPR001452)	necessary binding region:324-350	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49710	uniprotkb:P25911	intact:EBI-924601|uniprotkb:Q922I8|ensembl:ENSMUSP00000023531	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	psi-mi:hcls1_mouse(display_long)|uniprotkb:Hcls1(gene name)|psi-mi:Hcls1(display_short)|uniprotkb:Hs1(gene name synonym)|uniprotkb:Hematopoietic cell-specific LYN substrate 1(gene name synonym)|uniprotkb:LckBP1(gene name synonym)	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ingley et al. (2000)	imex:IM-14458|pubmed:10713104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-925016|imex:IM-14458-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032251.2|ensembl:ENSMUSG00000022831(gene)|ensembl:ENSMUST00000023531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR028534|interpro:IPR036028|mint:P49710	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-j2e)|taxid:10090(Mouse fetal liver cells)	-	2006/04/10	2014/10/16	rogid:f0+oPP9relryVZzce7RHfggQnGk10090	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	intact-crc:D442EFBEE0AA3794|rigid:CSrsuT2c/dLKQGHqyFfpN+so1jk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25911	uniprotkb:P49710	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	intact:EBI-924601|uniprotkb:Q922I8|ensembl:ENSMUSP00000023531	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:hcls1_mouse(display_long)|uniprotkb:Hcls1(gene name)|psi-mi:Hcls1(display_short)|uniprotkb:Hs1(gene name synonym)|uniprotkb:Hematopoietic cell-specific LYN substrate 1(gene name synonym)|uniprotkb:LckBP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ingley et al. (2000)	imex:IM-14458|pubmed:10713104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-925019|imex:IM-14458-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	refseq:NP_032251.2|ensembl:ENSMUSG00000022831(gene)|ensembl:ENSMUST00000023531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR028534|interpro:IPR036028|mint:P49710	psi-mi:"MI:0469"(intact)	-	-	comment:Maximal coimmunoprecipitation of Lyn occurred between 15 and 30 minutes of erythropoietin stimulation.|agonist:Erythropoietin.|dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-j2e)|taxid:10090(Mouse fetal liver cells)	-	2006/04/10	2014/10/16	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	rogid:f0+oPP9relryVZzce7RHfggQnGk10090	intact-crc:45E92E7258003E58|rigid:CSrsuT2c/dLKQGHqyFfpN+so1jk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49710	uniprotkb:P06240	intact:EBI-924601|uniprotkb:Q922I8|ensembl:ENSMUSP00000023531	intact:EBI-1401|ensembl:ENSMUSP00000066209|ensembl:ENSMUSP00000099656|uniprotkb:Q62320|uniprotkb:Q61795|uniprotkb:Q61794|uniprotkb:Q91X65	psi-mi:hcls1_mouse(display_long)|uniprotkb:Hcls1(gene name)|psi-mi:Hcls1(display_short)|uniprotkb:Hs1(gene name synonym)|uniprotkb:Hematopoietic cell-specific LYN substrate 1(gene name synonym)|uniprotkb:LckBP1(gene name synonym)	psi-mi:lck_mouse(display_long)|uniprotkb:Lck(gene name)|psi-mi:Lck(display_short)|uniprotkb:Lsk-t(gene name synonym)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ingley et al. (2000)	imex:IM-14458|pubmed:10713104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-925022|imex:IM-14458-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032251.2|ensembl:ENSMUSG00000022831(gene)|ensembl:ENSMUST00000023531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR028534|interpro:IPR036028|mint:P49710	ensembl:ENSMUSG00000000409(gene)|ensembl:ENSMUST00000067240(transcript)|ensembl:ENSMUST00000102596(transcript)|go:"GO:0000242"(pericentriolar material)|refseq:NP_001155905.1|refseq:NP_034823.1|refseq:XP_006502881.1|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003823"(antigen binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010038"(response to metal ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-6811558|reactome:R-MMU-9013407|reactome:R-MMU-9020558|reactome:R-MMU-9706374	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-j2e)|taxid:10090(Mouse fetal liver cells)	-	2006/04/10	2014/10/16	rogid:f0+oPP9relryVZzce7RHfggQnGk10090	rogid:yjMU0fxTseBSR5/aEXmp2cR7Mts10090	intact-crc:FAB4B99DAF9CA614|rigid:oN24cW6m3ze9XhqU78PBNaXLdf8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P39688	uniprotkb:P49710	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	intact:EBI-924601|uniprotkb:Q922I8|ensembl:ENSMUSP00000023531	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:hcls1_mouse(display_long)|uniprotkb:Hcls1(gene name)|psi-mi:Hcls1(display_short)|uniprotkb:Hs1(gene name synonym)|uniprotkb:Hematopoietic cell-specific LYN substrate 1(gene name synonym)|uniprotkb:LckBP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ingley et al. (2000)	imex:IM-14458|pubmed:10713104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-925025|imex:IM-14458-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	refseq:NP_032251.2|ensembl:ENSMUSG00000022831(gene)|ensembl:ENSMUST00000023531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR028534|interpro:IPR036028|mint:P49710	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-j2e)|taxid:10090(Mouse fetal liver cells)	-	2006/04/10	2014/10/16	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	rogid:f0+oPP9relryVZzce7RHfggQnGk10090	intact-crc:D5CCD58E0401D4DA|rigid:pn6njE7BYo+CZiUd6BUshi2HXxE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49710	uniprotkb:P25911	intact:EBI-924601|uniprotkb:Q922I8|ensembl:ENSMUSP00000023531	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	psi-mi:hcls1_mouse(display_long)|uniprotkb:Hcls1(gene name)|psi-mi:Hcls1(display_short)|uniprotkb:Hs1(gene name synonym)|uniprotkb:Hematopoietic cell-specific LYN substrate 1(gene name synonym)|uniprotkb:LckBP1(gene name synonym)	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ingley et al. (2000)	imex:IM-14458|pubmed:10713104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-925483|imex:IM-14458-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032251.2|ensembl:ENSMUSG00000022831(gene)|ensembl:ENSMUST00000023531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR028534|interpro:IPR036028|mint:P49710	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c11)|taxid:10090(p53-/- mouse fetal liver cells)	-	2006/04/10	2014/10/16	rogid:f0+oPP9relryVZzce7RHfggQnGk10090	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	intact-crc:781E4979DB048AF5|rigid:CSrsuT2c/dLKQGHqyFfpN+so1jk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49710	uniprotkb:P25911	intact:EBI-924601|uniprotkb:Q922I8|ensembl:ENSMUSP00000023531	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	psi-mi:hcls1_mouse(display_long)|uniprotkb:Hcls1(gene name)|psi-mi:Hcls1(display_short)|uniprotkb:Hs1(gene name synonym)|uniprotkb:Hematopoietic cell-specific LYN substrate 1(gene name synonym)|uniprotkb:LckBP1(gene name synonym)	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ingley et al. (2000)	imex:IM-14458|pubmed:10713104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-925522|imex:IM-14458-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032251.2|ensembl:ENSMUSG00000022831(gene)|ensembl:ENSMUST00000023531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR028534|interpro:IPR036028|mint:P49710	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c24)|taxid:10090(p53-/- mouse fetal liver cells)	-	2006/04/10	2014/10/16	rogid:f0+oPP9relryVZzce7RHfggQnGk10090	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	intact-crc:679A3E4BAEDAD5BB|rigid:CSrsuT2c/dLKQGHqyFfpN+so1jk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49710	uniprotkb:P25911	intact:EBI-924601|uniprotkb:Q922I8|ensembl:ENSMUSP00000023531	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	psi-mi:hcls1_mouse(display_long)|uniprotkb:Hcls1(gene name)|psi-mi:Hcls1(display_short)|uniprotkb:Hs1(gene name synonym)|uniprotkb:Hematopoietic cell-specific LYN substrate 1(gene name synonym)|uniprotkb:LckBP1(gene name synonym)	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ingley et al. (2000)	imex:IM-14458|pubmed:10713104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-925554|imex:IM-14458-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032251.2|ensembl:ENSMUSG00000022831(gene)|ensembl:ENSMUST00000023531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR028534|interpro:IPR036028|mint:P49710	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-erythroleukemia)|taxid:10090(Mus musculus)	-	2006/04/10	2014/10/16	rogid:f0+oPP9relryVZzce7RHfggQnGk10090	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	intact-crc:4F09305525581510|rigid:CSrsuT2c/dLKQGHqyFfpN+so1jk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49710	uniprotkb:P25911	intact:EBI-924601|uniprotkb:Q922I8|ensembl:ENSMUSP00000023531	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	psi-mi:hcls1_mouse(display_long)|uniprotkb:Hcls1(gene name)|psi-mi:Hcls1(display_short)|uniprotkb:Hs1(gene name synonym)|uniprotkb:Hematopoietic cell-specific LYN substrate 1(gene name synonym)|uniprotkb:LckBP1(gene name synonym)	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ingley et al. (2000)	imex:IM-14458|pubmed:10713104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-925594|imex:IM-14458-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032251.2|ensembl:ENSMUSG00000022831(gene)|ensembl:ENSMUST00000023531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR028534|interpro:IPR036028|mint:P49710	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-me17)|taxid:10090(Murine erythroid cell line)	-	2006/04/10	2014/10/16	rogid:f0+oPP9relryVZzce7RHfggQnGk10090	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	intact-crc:6042D38BEF60AA74|rigid:CSrsuT2c/dLKQGHqyFfpN+so1jk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25911	uniprotkb:P49710	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	intact:EBI-924601|uniprotkb:Q922I8|ensembl:ENSMUSP00000023531	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:hcls1_mouse(display_long)|uniprotkb:Hcls1(gene name)|psi-mi:Hcls1(display_short)|uniprotkb:Hs1(gene name synonym)|uniprotkb:Hematopoietic cell-specific LYN substrate 1(gene name synonym)|uniprotkb:LckBP1(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Ingley et al. (2000)	imex:IM-14458|pubmed:10713104	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-925721|imex:IM-14458-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	refseq:NP_032251.2|ensembl:ENSMUSG00000022831(gene)|ensembl:ENSMUST00000023531(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR028534|interpro:IPR036028|mint:P49710	psi-mi:"MI:0469"(intact)	-	-	dataset:BioCreative - Critical Assessment of Information Extraction systems in Biology|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-j2e)|taxid:10090(Mouse fetal liver cells)	-	2006/04/10	2014/10/16	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	rogid:f0+oPP9relryVZzce7RHfggQnGk10090	intact-crc:8A3043C408A5939B|rigid:CSrsuT2c/dLKQGHqyFfpN+so1jk	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)