#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P29846	uniprotkb:O43889-2	intact:EBI-909718|uniprotkb:A7YCU9	intact:EBI-625022|ensembl:ENSP00000342136	psi-mi:polg_hcvtw(display_long)	psi-mi:o43889-2(display_long)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:LZIP(isoform synonym)|uniprotkb:Leucine zipper protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Jin et al. (2000)	pubmed:10675342|imex:IM-19116|mint:MINT-6594436	taxid:31645(hcvtw)|taxid:31645("Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-909649|imex:IM-19116-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|interpro:IPR043128|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1N64|rcsb pdb:2ZJO|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR042205|interpro:IPR042209|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR027417|mint:P29846|interpro:IPR038170|interpro:IPR038568|interpro:IPR043502|interpro:IPR043504	intact:EBI-625002(creb3_human)|ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|uniprotkb:O43889-2(isoform-parent)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/24	2014/10/16	rogid:P1UWT+FBmj0HSSRuNOrCrO5BWYY31645	rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606	intact-crc:03BB3BD2831E78FE|rigid:2XxZT1/zzTfmCNryzO7d3LkjVzw	false	-	-	-	-	psi-mi:"MI:0056"(full identification by DNA sequencing)	psi-mi:"MI:0056"(full identification by DNA sequencing)
uniprotkb:P29846	uniprotkb:O43889-2	intact:EBI-909718|uniprotkb:A7YCU9	intact:EBI-625022|ensembl:ENSP00000342136	psi-mi:polg_hcvtw(display_long)	psi-mi:o43889-2(display_long)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:LZIP(isoform synonym)|uniprotkb:Leucine zipper protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Jin et al. (2000)	pubmed:10675342|imex:IM-19116|mint:MINT-6594436	taxid:31645(hcvtw)|taxid:31645("Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-909662|imex:IM-19116-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|interpro:IPR043128|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1N64|rcsb pdb:2ZJO|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR042205|interpro:IPR042209|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR027417|mint:P29846|interpro:IPR038170|interpro:IPR038568|interpro:IPR043502|interpro:IPR043504	intact:EBI-625002(creb3_human)|ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|uniprotkb:O43889-2(isoform-parent)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/24	2014/10/16	rogid:P1UWT+FBmj0HSSRuNOrCrO5BWYY31645	rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606	intact-crc:EF69DAD3D799BFCC|rigid:2XxZT1/zzTfmCNryzO7d3LkjVzw	false	sufficient binding region:92-192	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43889-2	uniprotkb:O43889-2	intact:EBI-625022|ensembl:ENSP00000342136	intact:EBI-625022|ensembl:ENSP00000342136	psi-mi:o43889-2(display_long)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:LZIP(isoform synonym)|uniprotkb:Leucine zipper protein(gene name synonym)	psi-mi:o43889-2(display_long)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:LZIP(isoform synonym)|uniprotkb:Leucine zipper protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Jin et al. (2000)	pubmed:10675342|imex:IM-19116|mint:MINT-6594436	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-909856|imex:IM-19116-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-625002(creb3_human)|ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|uniprotkb:O43889-2(isoform-parent)	intact:EBI-625002(creb3_human)|ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|uniprotkb:O43889-2(isoform-parent)	go:"GO:0042803"(protein homodimerization activity)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/24	2014/10/16	rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606	rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606	intact-crc:92F8E8F5A930D680|rigid:n75btINkOy93+Kd5gkJNfMK0Gio	false	-	sufficient binding region:144-371	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29846	uniprotkb:O43889-2	intact:EBI-909718|uniprotkb:A7YCU9	intact:EBI-625022|ensembl:ENSP00000342136	psi-mi:polg_hcvtw(display_long)	psi-mi:o43889-2(display_long)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:LZIP(isoform synonym)|uniprotkb:Leucine zipper protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Jin et al. (2000)	pubmed:10675342|imex:IM-19116|mint:MINT-6594436	taxid:31645(hcvtw)|taxid:31645("Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-909873|imex:IM-19116-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|interpro:IPR043128|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1N64|rcsb pdb:2ZJO|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR042205|interpro:IPR042209|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR027417|mint:P29846|interpro:IPR038170|interpro:IPR038568|interpro:IPR043502|interpro:IPR043504	intact:EBI-625002(creb3_human)|ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|uniprotkb:O43889-2(isoform-parent)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2006/03/24	2014/10/16	rogid:P1UWT+FBmj0HSSRuNOrCrO5BWYY31645	rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606	intact-crc:761B6973DCD1EE3A|rigid:2XxZT1/zzTfmCNryzO7d3LkjVzw	false	-	sufficient binding region:144-371	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29846	uniprotkb:O43889-2	intact:EBI-909718|uniprotkb:A7YCU9	intact:EBI-625022|ensembl:ENSP00000342136	psi-mi:polg_hcvtw(display_long)	psi-mi:o43889-2(display_long)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:LZIP(isoform synonym)|uniprotkb:Leucine zipper protein(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Jin et al. (2000)	pubmed:10675342|imex:IM-19116|mint:MINT-6594436	taxid:31645(hcvtw)|taxid:31645("Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-909690|imex:IM-19116-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|interpro:IPR043128|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1N64|rcsb pdb:2ZJO|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR042205|interpro:IPR042209|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR027417|mint:P29846|interpro:IPR038170|interpro:IPR038568|interpro:IPR043502|interpro:IPR043504	intact:EBI-625002(creb3_human)|ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|uniprotkb:O43889-2(isoform-parent)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/03/24	2014/10/16	rogid:P1UWT+FBmj0HSSRuNOrCrO5BWYY31645	rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606	intact-crc:B182DA4D735E369D|rigid:2XxZT1/zzTfmCNryzO7d3LkjVzw	false	-	tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29846	uniprotkb:O43889-2	intact:EBI-909718|uniprotkb:A7YCU9	intact:EBI-625022|ensembl:ENSP00000342136	psi-mi:polg_hcvtw(display_long)	psi-mi:o43889-2(display_long)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:LZIP(isoform synonym)|uniprotkb:Leucine zipper protein(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Jin et al. (2000)	pubmed:10675342|imex:IM-19116|mint:MINT-6594436	taxid:31645(hcvtw)|taxid:31645("Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-909741|imex:IM-19116-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|interpro:IPR043128|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1N64|rcsb pdb:2ZJO|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR042205|interpro:IPR042209|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR027417|mint:P29846|interpro:IPR038170|interpro:IPR038568|interpro:IPR043502|interpro:IPR043504	intact:EBI-625002(creb3_human)|ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|uniprotkb:O43889-2(isoform-parent)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2006/03/24	2014/10/16	rogid:P1UWT+FBmj0HSSRuNOrCrO5BWYY31645	rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606	intact-crc:EFDD5800AEEB2715|rigid:2XxZT1/zzTfmCNryzO7d3LkjVzw	false	tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29846	uniprotkb:O43889-2	intact:EBI-909718|uniprotkb:A7YCU9	intact:EBI-625022|ensembl:ENSP00000342136	psi-mi:polg_hcvtw(display_long)	psi-mi:o43889-2(display_long)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:LZIP(isoform synonym)|uniprotkb:Leucine zipper protein(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Jin et al. (2000)	pubmed:10675342|imex:IM-19116|mint:MINT-6594436	taxid:31645(hcvtw)|taxid:31645("Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-909781|imex:IM-19116-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|interpro:IPR043128|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1N64|rcsb pdb:2ZJO|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR042205|interpro:IPR042209|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR027417|mint:P29846|interpro:IPR038170|interpro:IPR038568|interpro:IPR043502|interpro:IPR043504	intact:EBI-625002(creb3_human)|ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|uniprotkb:O43889-2(isoform-parent)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2006/03/24	2014/10/16	rogid:P1UWT+FBmj0HSSRuNOrCrO5BWYY31645	rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606	intact-crc:B33F8222B9A055EA|rigid:2XxZT1/zzTfmCNryzO7d3LkjVzw	false	-	tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29846	uniprotkb:O43889-2	intact:EBI-909718|uniprotkb:A7YCU9	intact:EBI-625022|ensembl:ENSP00000342136	psi-mi:polg_hcvtw(display_long)	psi-mi:o43889-2(display_long)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:LZIP(isoform synonym)|uniprotkb:Leucine zipper protein(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Jin et al. (2000)	pubmed:10675342|imex:IM-19116|mint:MINT-6594436	taxid:31645(hcvtw)|taxid:31645("Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-909788|imex:IM-19116-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|interpro:IPR043128|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1N64|rcsb pdb:2ZJO|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR042205|interpro:IPR042209|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR027417|mint:P29846|interpro:IPR038170|interpro:IPR038568|interpro:IPR043502|interpro:IPR043504	intact:EBI-625002(creb3_human)|ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|uniprotkb:O43889-2(isoform-parent)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2006/03/24	2014/10/16	rogid:P1UWT+FBmj0HSSRuNOrCrO5BWYY31645	rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606	intact-crc:ED60006F64154462|rigid:2XxZT1/zzTfmCNryzO7d3LkjVzw	false	tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29846	uniprotkb:O43889-2	intact:EBI-909718|uniprotkb:A7YCU9	intact:EBI-625022|ensembl:ENSP00000342136	psi-mi:polg_hcvtw(display_long)	psi-mi:o43889-2(display_long)|uniprotkb:CREB3(gene name)|psi-mi:CREB3(display_short)|uniprotkb:LZIP(gene name synonym)|uniprotkb:Luman(gene name synonym)|uniprotkb:Transcription factor LZIP-alpha(gene name synonym)|uniprotkb:LZIP(isoform synonym)|uniprotkb:Leucine zipper protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Jin et al. (2000)	pubmed:10675342|imex:IM-19116|mint:MINT-6594436	taxid:31645(hcvtw)|taxid:31645("Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-909815|imex:IM-19116-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|interpro:IPR043128|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1N64|rcsb pdb:2ZJO|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR024350|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR042205|interpro:IPR042209|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR027417|mint:P29846|interpro:IPR038170|interpro:IPR038568|interpro:IPR043502|interpro:IPR043504	intact:EBI-625002(creb3_human)|ensembl:ENSG00000107175(gene)|ensembl:ENST00000353704(transcript)|uniprotkb:O43889-2(isoform-parent)	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2006/03/24	2014/10/16	rogid:P1UWT+FBmj0HSSRuNOrCrO5BWYY31645	rogid:Andi9EyhbV1LcRtj2NFt7+UWJho9606	intact-crc:72C770D6992236DA|rigid:2XxZT1/zzTfmCNryzO7d3LkjVzw	false	necessary binding region:92-192|glutathione s tranferase tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)